Roe of polarity switching of cancer cell clusters in metastasis
| Project/Area Number |
18H02648
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 49030:Experimental pathology-related
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| Research Institution | Kyoto University |
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Principal Investigator |
INOUE Masahiro 京都大学, 医学研究科, 特定教授 (10342990)
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| Co-Investigator(Kenkyū-buntansha) |
近藤 純平 京都大学, 医学研究科, 特定助教 (80624593)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2020: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2018: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
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| Keywords | 細胞極性 / 転移 / 微小乳頭がん / 微小乳頭癌 / micropapillary carcinoma / micropapillary carcinoma |
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| Outline of Final Research Achievements |
Using our methods for preparing and culturing primary 3D cancer cells, in which 3D structure in the tumor is preserved, we demonstrated that apico-basal polarity switches depending on culture conditions and clarified the role of polarity switching in metastasis. In addition, we revealed that micropapillary carcinoma, a pathological pattern with poor prognosis, is a polarity unswitchable status, and clarified the underlying molecular mechanisms.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、極性転換ががんの病態に深く関与していることを明らかにした。特に、予後不良の組織型であるmicropapillary carcinomaの病態とその分子メカニズムを明らかにすることができたことは意義深い。がんの転移能を極性転換能からアプローチした研究はこれまでになく、本研究成果はがんの進展・転移の制御による新たな診断・治療法の発展につながることが期待できる。
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Report
(4 results)
Research Products
(47 results)
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[Journal Article] Heterogenous chemosensitivity of organoid cell lines derived from small cell neuroendocrine carcinoma of the uterine cervix2021
Author(s)
Tanaka, M., Kondo, J., Kaneko, K., Endo, H., Onuma, K., Coppo, R., Kamiura, S., Yoshino, K., Ueda, Y., Kakeya, H. Kimura, T., Inoue, M.
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Journal Title
Human Cell
Volume: -
Issue: 3
Pages: 889-900
DOI
Related Report
Peer Reviewed
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[Journal Article] Novel functional anti-HER3 monoclonal antibodies with potent anti- cancer effects on various human epithelial cancers.2020
Author(s)
Okita K, Okazaki S, Uejima S, Yamada E, Kaminaka H, Kondo M, Ueda S, Tokiwa R, Iwata R, Yamasaki A, Hayashi N, Ogura D, Hirotani K, Yoshioka T, Inoue M, Masuko K, Masuko T
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Journal Title
Oncotarget
Volume: 11
Issue: 1
Pages: 31-45
DOI
NAID
Related Report
Peer Reviewed / Open Access
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