| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2021: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2020: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Outline of Final Research Achievements |
We previously found genes expressed in a subpopulation of Staphylococcus aureus and named them esp (expression in minor subpopulation) genes. We aimed to determine what kind of genes are expressed in esp-expressing cells and to infer the function of each esp gene from this information. In this study, we have established an experimental system for this purpose. We also made significant progress on esp15 (com gene: related to DNA uptake), and have shown that the com genes are expressed in biofilms under the control of a complex signal transduction system, and that the bacteria efficiently take up the genes by natural transformation.
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