| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2020: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2019: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2018: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Outline of Final Research Achievements |
The aim of this research is the identification of intracellular travel of Legionella that causes pneumonia. Particularly, I have conducted 3 subjects of research including “identification of LCV transport to the ER”, “identification of Legionella behavior into the ER”, and “identification of inhibition of LCV trafficking to the lysosome”. Upon this research, I have successfully identified key Legionella effectors (bacterial factor in which Legionella secretes into the host) as well as host factors in all subjects. I should examine the molecular relationship between the host factor and Legionella effector in the future.
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