| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2021: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2020: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2018: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Outline of Final Research Achievements |
To clarify the origin of drug resistance genes in Neisseria gonorrhoeae, we isolated 12 strains of ceftriaxone-resistant nonpathogenic Neisseria spp.(N. polysaccahrea, N. lactamica, N. cinerea and N. subflava). We revealed their genome sequence and characterized resistance genes. All of these ceftriaxone resistant genes were shown to be capable of transforming ceftriaxone susceptible Neisseria gonorrhoeae into resistant by. natural transformation using genome DNA of donors. Ceftriaxone resistant N. subflava, which could not directly transform N. gonorrhoeae into resistant , but could transform N. gonorrhoeae into resistant via other bacteria.
These results indicated that N. polysaccahrea, N. lactamica, N. cinerea and N. subflava formed a resistance gene pool harboring resistance genes of N. gonorrhoeae.
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