| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2018: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Outline of Final Research Achievements |
In this study, we tried to understand the relationship between the innate immune responses triggered by the intracellular viral infection sensors, RIG-I-like receptors (RLRs), and the stress responses regulated by the antiviral stress granules (avSG), which are formed by sensing infection as stresses. We focused on the RNA-binding proteins (RBPs) that are commonly involved in these two responses. We identified RBPs localized in avSG in response to viral infection and involved in positive and negative regulation of antiviral defenses.
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