| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2020: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2019: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2018: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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| Outline of Final Research Achievements |
Elucidation of the mechanism for persistent viral control is a key for the containment of HIV infection. It is important to control proliferation of latent but replication-competent viruses for functional HIV cure. In this study, we examined in vivo kinetics of cells harboring replication-competent viruses in HIV/SIV controllers. We found that enhancement of host immune responses targeting viral variants could be an indicator of viral blip or proliferation in HIV controllers. Furthermore, we obtained results indicating that systemic viral dissemination even in the absence of detectable viremia precedes failure in viral control. These findings provide great insights into our understanding of latent virus kinetics in HIV infection.
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