Analysis of physiological function of C-type lectin receptor and application to disease control

• Project/Area Number: 18H02671
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 49070:Immunology-related
• Research Institution: Tokyo University of Science
• Principal Investigator: Iwakura Yoichiro 東京理科大学, 研究推進機構生命医科学研究所, 教授 (10089120)
• Co-Investigator(Kenkyū-buntansha): 唐 策 東京理科大学, 研究推進機構生命医科学研究所, 客員教授 (00572166) ; 島津 朋之 宮城大学, 食産業学群, 助教 (20616437)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000); Fiscal Year 2020: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2019: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
• Keywords: C型レクチン / 腸管免疫 / 腫瘍 / 感染防御 / 遺伝子欠損マウス

Outline of Final Research Achievements

The purpose of this study was to analyze the function of C-type lectin Receptors (CLRs) using gene-deficient mice and find clues for the treatment of inflammatory diseases and cancers. We showed that CLRs play important roles in the development of colitis and colorectal tumors. Furthermore, we showed that Treg cells induced in DECTIN-1-deficient mouse colon through modification of intestinal microbiota suppress inflammation not only in the intestinal tract but also in lungs, suggesting that intestinal Tregs can migrate into other organs to suppress inflammation (Han et al., J. Immunol., 2021). We also analyzed the detailed mechanism of autoimmunity in DCIR-deficient mice, and showed that DC differentiation and antigen-presenting ability are enhanced in the mutant mice (Kaifu et al., under revision). From these analyses, we could show the roles of CLRs in inflammation and tumorigenesis and found clues to treat these diseases.

Academic Significance and Societal Importance of the Research Achievements

これまでの解析を基に、CLRファミリーメンバーの生体内での役割とその分子メカニズムを検討し、これらの分子が免疫制御や発癌制御に重要な役割を果たしていることを明らかにした。今後、これらの分子に対する抗体、阻害剤、促進剤などを用いて、自己免疫(関節リウマチや多発性硬化症)やアレルギー(喘息)、癌等に対する予防、治療薬の開発や、機能性食品の開発に繋げたい。

Research Products

• [Journal Article] Dectin-2-mediated initiation of immune responses caused by influenza virus hemagglutinin (2021)
  • Author(s): YAMAMOTO Hideki、TOMIYAMA Chikako、SATO Ko、KASAMATSU Jun、TAKANO Kazuki、UMEKI Aya、NAKAHATA Nana、MIYASAKA Tomomitsu、KANNO Emi、TANNO Hiromasa、YAMASAKI Sho、SAIJO Shinobu、IWAKURA Yoichiro、ISHII Keiko、KAWAKAMI Kazuyoshi
  • Journal Title: Biomedical Research Volume: 42 Issue: 2 Pages: 53-66
  • DOI: 10.2220/biomedres.42.53
  • NAID: 130008023686
  • ISSN: 0388-6107, 1880-313X
  • Year and Date: 2021-04-10
  • Peer Reviewed / Open Access
• [Journal Article] Distinct Roles for Dectin-1 and Dectin-2 in Skin Wound Healing and Neutrophilic Inflammatory Responses (2021)
  • Author(s): Yamaguchi Kenji、Kanno Emi、Tanno Hiromasa、Sasaki Ayako、Kitai Yuki、Miura Takayuki、Takagi Naoyuki、Shoji Miki、Kasamatsu Jun、Sato Ko、Sato Yuka、Niiyama Momoko、Goto Yuka、Ishii Keiko、Imai Yoshimichi、Saijo Shinobu、Iwakura Yoichiro、Tachi Masahiro、Kawakami Kazuyoshi
  • Journal Title: Journal of Investigative Dermatology Volume: 141 Issue: 1 Pages: 164-176
  • DOI: 10.1016/j.jid.2020.04.030
  • Peer Reviewed / Open Access
• [Journal Article] TARM1 contributes to development of arthritis by activating dendritic cells through recognition of collagens (2021)
  • Author(s): Yabe Rikio、Chung Soo-Hyun、Murayama Masanori A.、Kubo Sachiko、Shimizu Kenji、Akahori Yukiko、Maruhashi Takumi、Seno Akimasa、Kaifu Tomonori、Saijo Shinobu、Iwakura Yoichiro
  • Journal Title: Nature Communications Volume: 12 Issue: 1 Pages: 94-94
  • DOI: 10.1038/s41467-020-20307-9
  • Peer Reviewed / Open Access
• [Journal Article] A Vaspin-HSPA1L complex protects proximal tubular cells from organelle stress in diabetic kidney disease (2021)
  • Author(s): Nakatsuka A, Yamaguchi S, Eguchi J, Kakuta S, Iwakura Y, Sugiyama H, Wada J.
  • Journal Title: Commun Biol . Volume: 4 Issue: 1 Pages: 373-373
  • DOI: 10.1038/s42003-021-01902-y
  • NAID: 120007004153
  • Peer Reviewed / Open Access
• [Journal Article] Vγ6 + γδ T cells are critical for protection against infection by Escherichia coli in mice (2021)
  • Author(s): Tun Xin、Hatano Shinya、Mine Keiichiro、Noguchi Naoto、Iwakura Yoichiro、Sun Xun、Yoshikai Yasunobu
  • Journal Title: European Journal of Immunology Volume: n/a Issue: 8 Pages: 2093-2096
  • DOI: 10.1002/eji.202049010
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Ovalbumin-Induced Airway Inflammation Is Ameliorated in Dectin-1?Deficient Mice, in Which Pulmonary Regulatory T Cells Are Expanded through Modification of Intestinal Commensal Bacteria (2021)
  • Author(s): Han Wei、Tang Ce、Baba Seiya、Hamada Tomofumi、Shimazu Tomoyuki、Iwakura Yoichiro
  • Journal Title: The Journal of Immunology Volume: 206 Issue: 9 Pages: 1991-2000
  • DOI: 10.4049/jimmunol.2001337
  • Peer Reviewed / Open Access
• [Journal Article] Homeostatic regulation of T follicular helper and antibody response to particle antigens by IL-1Ra of medullary sinus macrophage origin (2021)
  • Author(s): Lin Xinwen、Twelkmeyer Trix、Zhu Danming、Zhang Li、Zhao Yang、Zhang Chao、Iwakura Yoichiro、Meng Guangxun、Hua Zhaolin、Yan Bingyu、Liu William J.、Luo Zhongguang、Gong Sitang、Chen Hairong、Li Shuran、Hou Baidong、Tang Hong
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 118 Issue: 17 Pages: 1-10
  • DOI: 10.1073/pnas.2019798118
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Staphylococcus cohnii is a potentially biotherapeutic skin commensal alleviating skin inflammation (2021)
  • Author(s): Ito Y, Sasaki T, Li Y, et al
  • Journal Title: Cell Reports Volume: 35 Issue: 4 Pages: 109052-109052
  • DOI: 10.1016/j.celrep.2021.109052
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] C1q/TNF-related protein 3 regulates chondrogenic cell proliferation via adiponectin receptor 2 (progestin and adipoQ receptor 2) (2020)
  • Author(s): MURAYAMA Masanori A.、IWAKURA Yoichiro
  • Journal Title: Translational and Regulatory Sciences Volume: 2 Issue: 1 Pages: 19-23
  • DOI: 10.33611/trs.2_19
  • NAID: 130007814846
  • ISSN: 2434-4974
  • Peer Reviewed / Open Access
• [Journal Article] Production of IL-17A at innate immune phase leads to decreased Th1 immune response and attenuated host defense against infection with Cryptococcus deneoformans (2020)
  • Author(s): Sato K, Yamamoto H, Nomura T, Kasamatsu J, Miyasaka T, Tanno D, Matsumoto I, Kagesawa T, Miyahara A, Zong T, Oniyama A, Kawamura K, Yokoyama R, Kitai Y, Ishizuka S, Kanno E, Tanno H, Suda H, Morita M, Yamamoto M, Iwakura Y, Ishii K, Kawakami K
  • Journal Title: The Journal of Immunology Volume: 205 Issue: 3 Pages: 686-698
  • DOI: 10.4049/jimmunol.1901238
  • Peer Reviewed
• [Journal Article] Dysregulated skin barrier function in Tmem79 mutant mice promotes IL‐17A‐dependent spontaneous skin and lung inflammation (2020)
  • Author(s): Saunders Sean P.、Floudas Achilleas、Moran Tara、Byrne Ciara M.、Rooney Michael D.、Fahy Caoimhe M. R.、Geoghegan Joan A.、Iwakura Yoichiro、Fallon Padraic G.、Schwartz Christian
  • Journal Title: Allergy Volume: 75 Issue: 12 Pages: 3216-3227
  • DOI: 10.1111/all.14488
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Context-Dependent IL-1 mRNA-Destabilization by TTP Prevents Dysregulation of Immune Homeostasis Under Steady State Conditions (2020)
  • Author(s): Sneezum Lucy、Eislmayr Kevin、Dworak Helene、Sedlyarov Vitaly、Le Heron Anita、Ebner Florian、Fischer Irmgard、Iwakura Yoichiro、Kovarik Pavel
  • Journal Title: Frontiers in Immunology Volume: 11 Pages: 1-16
  • DOI: 10.3389/fimmu.2020.01398
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Psoriasis-like skin disorder in transgenic mice expressing a RIG-I Singleton?Merten syndrome variant (2020)
  • Author(s): Abu Tayeh Ahmed、Funabiki Masahide、Shimizu Shota、Satoh Saya、Sumin Lee、Iwakura Yoichiro、Kato Hiroki、Fujita Takashi
  • Journal Title: International Immunology Volume: 33 Issue: 4 Pages: 211-224
  • DOI: 10.1093/intimm/dxaa071
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] TC10, a Rho family GTPase, is required for efficient axon regeneration in a neuron‐autonomous manner (2020)
  • Author(s): Koinuma Shingo、Negishi Ryota、Nomura Riko、Sato Kazuki、Kojima Takuya、Segi‐Nishida Eri、Goitsuka Ryo、Iwakura Yoichiro、Wada Naoyuki、Koriyama Yoshiki、Kiryu‐Seo Sumiko、Kiyama Hiroshi、Nakamura Takeshi
  • Journal Title: Journal of Neurochemistry Volume: - Issue: 4 Pages: 1196-1206
  • DOI: 10.1111/jnc.15235
  • Peer Reviewed / Open Access
• [Journal Article] Innate Immune Functions of Astrocytes are Dependent Upon Tumor Necrosis Factor-Alpha (2020)
  • Author(s): Rodgers Kyla R.、Lin Yufan、Langan Thomas J.、Iwakura Yoichiro、Chou Richard C.
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 1-15
  • DOI: 10.1038/s41598-020-63766-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Interleukin 17A: a Janus-faced regulator of osteoporosis (2020)
  • Author(s): Scheffler J. M.、Grahnemo L.、Engdahl C.、Drevinge C.、Gustafsson K. L.、Corciulo C.、Lawenius L.、Iwakura Y.、Sj?gren K.、Lagerquist M. K.、Carlsten H.、Ohlsson C.、Islander U.
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 1-11
  • DOI: 10.1038/s41598-020-62562-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] IL-17A promotes fatty acid uptake through the IL-17A/IL-17RA/p-STAT3/FABP4 axis to fuel ovarian cancer growth in an adipocyte-rich microenvironment (2020)
  • Author(s): Chunyan Yu、 Xiulong Niu、Yongrui Du、Yan Chen、Xiaomei Liu、Lingling Xu、 Yoichiro Iwakura、Xiaoxia Ma、Yan Li、Zhi Yao、 Weimin Deng
  • Journal Title: Cancer Immunology, Immunotherapy Volume: 69 Issue: 1 Pages: 115-126
  • DOI: 10.1007/s00262-019-02445-2
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] IFN-γ and IL-17A regulate intestinal crypt production of CXCL10 in the healthy and inflamed colon (2020)
  • Author(s): Walrath Travis、Malizia Robert A.、Zhu Xinjun、Sharp Stephen P.、D'Souza Shanti S.、Lopez-Soler Reynold、Parr Brian、Kartchner Brittany、Lee Edward C.、Stain Steven C.、Iwakura Yoichiro、O'Connor William
  • Journal Title: American Journal of Physiology-Gastrointestinal and Liver Physiology Volume: 318 Issue: 3 Pages: G479-G489
  • DOI: 10.1152/ajpgi.00208.2019
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] IL-1β Plays an Important Role in Pressure Overload-Induced Atrial Fibrillation in Mice (2019)
  • Author(s): Matsushita N, Ishida N, Ibi M, Saito M, Takahashi M, Taniguchi S, Iwakura Y, Morino Y, Taira E, Sawa Y, Hirose M
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 42 Issue: 4 Pages: 543-546
  • DOI: 10.1248/bpb.b18-00363
  • NAID: 130007622152
  • ISSN: 0918-6158, 1347-5215
  • Year and Date: 2019-04-01
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Defect of interferon γ leads to impaired wound healing through prolonged neutrophilic inflammatory response and enhanced MMP-2 activation. (2019)
  • Author(s): Kanno E, Tanno H, Masaki A, Sasaki A, Sato N, Goto M, Shisai M, Yamaguchi K, Takagi N, Shoji M, Kitai Y, Sato K, Kasamatsu J, Ishii K, Miyasaka T, Kawakami K, Imai Y, Iwakura Y, Maruyama R, Tachi M, Kawakami K.
  • Journal Title: Int. J. Mol. Sci. Volume: 20(22) Issue: 22 Pages: 5657-5657
  • DOI: 10.3390/ijms20225657
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cutaneous p38 mitogen-activated protein kinase activation triggers psoriatic dermatitis. (2019)
  • Author(s): Sakurai K, Dainichi T, Garcet S, Tsuchiya S, Yamamoto Y, Kitoh A, Honda T, Nomura T, Egawa G, Otsuka A, Nakajima S, Matsumoto R, Nakano Y, Otsuka M, Iwakura Y, Grinberg-Bleyer Y, Ghosh S, Sugimoto Y, Guttman-Yassky E, Krueger JG, Kabashima K.
  • Journal Title: J Allergy Clin Immunol Volume: 144(4) Issue: 4 Pages: 1036-1049
  • DOI: 10.1016/j.jaci.2019.06.019
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] AIM2 inflammasome-derived IL-1β induces postoperative ileus in mice. (2019)
  • Author(s): Hupa, K. J., Stein, K., Schneider, R., Lysson, M., Schneiker, B., Hornung, V., Latz, E., Iwakura, Y., Kalff, J. C., and Wehner, S.
  • Journal Title: Sci. Rep. Volume: 9 Issue: 1 Pages: 10602-10602
  • DOI: 10.1038/s41598-019-46968-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] CCR8 leads to eosinophil migration and regulates neutrophil migration in murine allergic enteritis. (2019)
  • Author(s): Blanco-Perez, F., Kato, Y., Gonzalez-Menendez, I., Laino, J., Ohbayashi, M., Burggraf, M., Krause, M., Kirberg, J., Iwakura, Y., Martella, M., Quintanilla-Martinez, L., Shibata, N., Vieths, S., Scheurer, S., and Toda, M.
  • Journal Title: Sci. Rep. Volume: 9 Issue: 1 Pages: 9608-9608
  • DOI: 10.1038/s41598-019-45653-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Dectin-2?induced CCL2 production in tissue-resident macrophages ignites cardiac arteritis (2019)
  • Author(s): Miyabe Chie、Miyabe Yoshishige、Bricio-Moreno Laura、Lian Jeffrey、Rahimi Rod A.、Miura Noriko N.、Ohno Naohito、Iwakura Yoichiro、Kawakami Tamihiro、Luster Andrew D.
  • Journal Title: Journal of Clinical Investigation Volume: 129 Issue: 9 Pages: 3610-3624
  • DOI: 10.1172/jci123778
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] arge scale cacium imaging of the cerebellar vermis during sensory stimulus unravels two response’s components that differ in their spatiotemporal properties. (2019)
  • Author(s): Byk, H., Huang, G. J., Iwakura, Y., and Yarom, Y.
  • Journal Title: Front. Syst. Neurosci. Volume: 13 Pages: 18-18
  • DOI: 10.3389/fnsys.2019.00018
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] CARD9+ microglia promote antifungal immunity via IL-1β- and CXCL1-mediated neutrophil recruitment. (2019)
  • Author(s): Drummond, R. A., Swamydas, M., Oikonomou, V., Zhai, B., Dambuza, I. M., Schaefer, B. C., Bohrer, A. C., Mayer-Barber, K. D., Lira, S. A., Iwakura, Y., Filler, S. G., Brown, G. D., Hube, B., Naglik, J. R., Hohl, T. M., and Lionakis, M. S.
  • Journal Title: Nat Immunol. Volume: 20 Issue: 5 Pages: 559-570
  • DOI: 10.1038/s41590-019-0377-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Uncoupling the senescence-associated secretory phenotype from cell cycle exit via IL-1 inactivation unveils its pro-tumorigenic role. (2019)
  • Author(s): Lau, L., Porciuncula, A., Yu, A., Iwakura, Y., and David, G.
  • Journal Title: Mol. Cell Biol. Volume: 39 Issue: 12 Pages: 18-35
  • DOI: 10.1128/mcb.00586-18
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Myeloid C-type lectin receptors in skin/mucoepithelial diseases and tumors. (2019)
  • Author(s): Tang, C., Makusheva, Y., Sun, H., Han, W., and Iwakura, Y.
  • Journal Title: J. Leukoc. Biol. Volume: 106 Issue: 4 Pages: 903-917
  • DOI: 10.1002/jlb.2ri0119-031r
  • Peer Reviewed / Open Access
• [Journal Article] Spontaneous atopic dermataitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1β. (2019)
  • Author(s): Schwartz, C., Moran, T., Saunders, S. P., Kaszlikowska, A., Floudas, A., Bom, J., Nunez, G., Iwakura, Y., O’Neill, L., Irvine, A. D., McKenzie, A. N. J., Ogg, G., Walsh, P. T., Demengeot, J., and Fallon, P. G.
  • Journal Title: Allergy Volume: 74 Issue: 10 Pages: 1920-1933
  • DOI: 10.1111/all.13801
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Epidermal loss of phospholipase Cδ1 attenuates irritant contact dermatitis (2019)
  • Author(s): Shiratori K, Kanemaru K, Ogura T, Nakajima A, Sugizaki Y, Fukuyama T, Iwakura Y, Nakamura Y, Fukami K.
  • Journal Title: Biochem Biophys Res Commun. Volume: 511 Issue: 2 Pages: 330-335
  • DOI: 10.1016/j.bbrc.2019.02.046
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Dectin-2-Mediated Signaling Leads to Delayed Skin Wound Healing through Enhanced Neutrophilic Inflammatory Response and Neutrophil Extracellular Trap Formation. (2019)
  • Author(s): Miura T, Kawakami K, Kanno E, Tanno H, Tada H, Sato N, Masaki A, Yokoyama R, Kawamura K, Kitai Y, Takagi N, Yamaguchi K, Yamaguchi N, Kyo Y, Ishii K, Imai Y, Saijo S, Iwakura Y, Tachi M.
  • Journal Title: J Invest Dermatol Volume: 139(3) Issue: 3 Pages: 702-711
  • DOI: 10.1016/j.jid.2018.10.015
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Dectin-1 Contributes to Myocardial Ischemia/Reperfusion Injury by Regulating Macrophage Polarization and Neutrophil Infiltration (2019)
  • Author(s): Fan Qin、Tao Rong、Zhang Hang、Xie Hongyang、Lu Lin、Wang Ting、Su Min、Hu Jian、Zhang Qi、Chen Qiujing、Iwakura Yoichiro、Shen Weifeng、Zhang Ruiyan、Yan Xiaoxiang
  • Journal Title: Circulation Volume: 139 Issue: 5 Pages: 663-678
  • DOI: 10.1161/circulationaha.118.036044
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Role of interleukin-17 in a murine community-associated methicillin-resistant Staphylococcus aureus pneumonia model (2019)
  • Author(s): Shibue Yasushi、Kimura Soichiro、Kajiwara Chiaki、Iwakura Yoichiro、Yamaguchi Keizo、Tateda Kazuhiro
  • Journal Title: Microbes and Infection Volume: 21 Issue: 1 Pages: 33-39
  • DOI: 10.1016/j.micinf.2018.06.006
  • Peer Reviewed / Open Access
• [Journal Article] A dendritic cell-based systemic vaccine induces long-lived lung-resident memory Th17 cells and ameliorates pulmonary mycosis (2018)
  • Author(s): Ueno Keigo、Urai Makoto、Sadamoto Sota、Shinozaki Minoru、Takatsuka Shogo、Abe Masahiro、Otani Yoshiko、Yanagihara Nao、Shimizu Kiminori、Iwakura Yoichiro、Shibuya Kazutoshi、Miyazaki Yoshitsugu、Kinjo Yuki
  • Journal Title: Mucosal Immunology Volume: 12 Issue: 1 Pages: 265-276
  • DOI: 10.1038/s41385-018-0094-4
  • Peer Reviewed / Open Access
• [Journal Article] TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation (2018)
  • Author(s): Zhang Cun-Jin、Jiang Meiling、Zhou Hao、Liu Weiwei、Wang Chenhui、Kang Zizhen、Han Bing、Zhang Quanri、Chen Xing、Xiao Jianxin、Fisher Amanda、Kaiser William J.、Murayama Masanori A.、Iwakura Yoichiro、Gao Ji、Carman Julie、Dongre Ashok、Dubyak George、Abbott Derek W.、Shi Fu-Dong、Ransohoff Richard M.、Li Xiaoxia
  • Journal Title: Journal of Clinical Investigation Volume: 128 Issue: 12 Pages: 5399-5412
  • DOI: 10.1172/jci121901
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Inhibition of interleukin-1 suppresses angiotensin II-induced aortic inflammation and aneurysm formation. (2018)
  • Author(s): Isoda K, Akita K, Kitamura K, Sato-Okabayashi Y, Kadoguchi T, Isobe S, Ohtomo F, Sano M, Shimada K, Iwakura Y, Daida H
  • Journal Title: Int J Cardiol Volume: 270 Pages: 221-227
  • DOI: 10.1016/j.ijcard.2018.05.072
  • Peer Reviewed / Open Access
• [Journal Article] IL-36α is involved in hapten-specific T-cell induction, but not local inflammation, during contact hypersensitivity (2018)
  • Author(s): Numata Takafumi、Yoshizaki Takamichi、Yamaguchi Sachiko、Shimura Eri、Iwakura Yoichiro、Harada Kazutoshi、Sudo Katsuko、Tsuboi Ryoji、Nakae Susumu
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 506 Issue: 3 Pages: 429-436
  • DOI: 10.1016/j.bbrc.2018.10.104
  • Peer Reviewed / Open Access
• [Journal Article] IL-6, IL-17 and Stat3 are required for auto-inflammatory syndrome development in mouse. (2018)
  • Author(s): Oike T, Kanagawa H, Sato Y, Kobayashi T, Nakatsukasa H, Miyamoto K, Nakamura S, Kaneko Y, Kobayashi S, Harato K, Yoshimura A, Iwakura Y, Takeuchi T, Matsumoto M, Nakamura M, Niki Y, Miyamoto T.
  • Journal Title: Sci Rep. Volume: - Issue: 1 Pages: 15783-15783
  • DOI: 10.1038/s41598-018-34173-5
  • Peer Reviewed / Open Access
• [Journal Article] Interleukin-17-producing γδT (γδ17) cells in inflammatory diseases (2018)
  • Author(s): Aoi Akitsu, Yoichiro Iwakura
  • Journal Title: Immunology Volume: 155 Issue: 4 Pages: 418-426
  • DOI: 10.1111/imm.12993
  • Peer Reviewed
• [Journal Article] MAIT cells protect against pulmonary Legionella longbeachae infection (2018)
  • Author(s): Wang H, D'Souza C, Lim XY, Kostenko L, Pediongco TJ, Eckle SBG, Meehan BS, Shi M, Wang N, Li S, Liu L, Mak JYW, Fairlie DP, Iwakura Y, Gunnersen JM, Stent AW, Godfrey DI, Rossjohn J, Westall GP, Kjer-Nielsen L, Strugnell RA, McCluskey J, Corbett AJ, Hinks TSC, Chen Z.
  • Journal Title: Nature Communications Volume: 9 Issue: 1 Pages: 3350-3350
  • DOI: 10.1038/s41467-018-05202-8
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The ATP Transporter VNUT Mediates Induction of Dectin-1-Triggered Candida Nociception. (2018)
  • Author(s): Maruyama K, Takayama Y, Sugisawa E, Yamanoi Y, Yokawa T, Kondo T, Ishibashi KI, Sahoo BR, Takemura N, Mori Y, Kanemaru H, Kumagai Y, Martino MM, Yoshioka Y, Nishijo H, Tanaka H, Sasaki A, Ohno N, Iwakura Y, Moriyama Y, Nomura M, Akira S, Tominaga M.
  • Journal Title: iScience Volume: 6 Pages: 306-318
  • DOI: 10.1016/j.isci.2018.08.007
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A model of TH17-associated ileal hyperplasia that requires both IL-17A and IFNγ to generate self-tolerance and prevent colitis (2018)
  • Author(s): Jeschke Jonathan C.、Mayne Christopher G.、Ziegelbauer Jennifer、DeCiantis Christopher L.、Singh Selina、Kumar Suresh N.、Suchi Mariko、Iwakura Yoichiro、Drobyski William R.、Salzman Nita H、Williams Calvin B.
  • Journal Title: Mucosal Immunology Volume: 11 Issue: 4 Pages: 1127-1137
  • DOI: 10.1038/s41385-018-0023-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] IL-36α from Skin-Resident Cells Plays an Important Role in the Pathogenesis of Imiquimod-Induced Psoriasiform Dermatitis by Forming a Local Autoamplification Loop. (2018)
  • Author(s): Hashiguchi Y, Yabe R, Chung SH, Murayama MA, Yoshida K, Matsuo K, Kubo S, Saijo S, Nakamura Y, Matsue H, Iwakura Y.
  • Journal Title: J Immunol. Volume: 201 Issue: 1 Pages: 167-182
  • DOI: 10.4049/jimmunol.1701157
  • Peer Reviewed / Open Access
• [Journal Article] BAFF inhibition attenuates fibrosis in scleroderma by modulating the regulatory and effector B cell balance (2018)
  • Author(s): Matsushita Takashi、Kobayashi Tadahiro、Mizumaki Kie、Kano Miyu、Sawada Tomoyo、Tennichi Momoko、Okamura Ai、Hamaguchi Yasuhito、Iwakura Yoichiro、Hasegawa Minoru、Fujimoto Manabu、Takehara Kazuhiko
  • Journal Title: Science Advances Volume: 4 Issue: 7 Pages: 9944-9944
  • DOI: 10.1126/sciadv.aas9944
  • Peer Reviewed / Open Access
• [Journal Article] Suppression of IL-17F, but not of IL-17A, provides protection against colitis by inducing T(reg) cells through modification of the intestinal microbiota. (2018)
  • Author(s): Tang C, Kakuta S, Shimizu K, Kadoki M, Kamiya T, Shimazu T, Kubo S, Saijo S, Ishigame H, Nakae S, Iwakura Y.
  • Journal Title: Nat Immunol. Volume: 19 Issue: 7 Pages: 755-765
  • DOI: 10.1038/s41590-018-0134-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] IL-25 enhances Th17 cell-mediated contact dermatitis by promoting IL-1b production by dermal dendritic cells (2018)
  • Author(s): Suto H, Nambu A, Morita H, Yamaguchi S, Numata T, Yoshizaki T, Shimura E, Arae K, Asada Y, Motomura K, Kaneko M, Abe T, Matsuda A, Iwakura Y, Okumura K, Saito H, Matsumoto K, Sudo K, Nakae S
  • Journal Title: J Allergy Clin Immunol Volume: In press Issue: 5 Pages: 1500-1509
  • DOI: 10.1016/j.jaci.2017.12.1007
  • Peer Reviewed / Open Access
• [Journal Article] HER2 overexpression triggers an IL-1α pro-inflammatory circuit to drive tumorigenesis and promote chemotherapy resistance. (2018)
  • Author(s): Liu, S., Lee, J. S., Jie, C., Park, M. H., Iwakura, Y., Patel, Y., Soni, M., Reisman, D., and Chen, H.
  • Journal Title: Cancer Res. Volume: 78 Pages: 2040-2051
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Production of low-molecular weight soluble yeast β-glucans by an acid degradation method. (2017)
  • Author(s): Ishimoto, Y., Ishibashi, K. I., Yamanaka, D., Adachi, Y., Kanzaki, K., Iwakura, Y., and Ohno, N.
  • Journal Title: Int. J. Biol. Macromol. Volume: 107 Issue: 3 Pages: 2269-2278
  • DOI: 10.1038/mi.2017.86
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 低分子βグルカンによる腸管免疫の制御 (2020)
  • Author(s): 岩倉洋一郎
  • Organizer: βグルカン協議会セミナー
  • Invited
• [Presentation] βグルカンの腸管免疫に及ぼす影響について (2019)
  • Author(s): 岩倉洋一郎
  • Organizer: 日本農芸化学会2019年度大会
  • Invited
• [Presentation] The role of CTRP family members in the immune system. (2019)
  • Author(s): Yoichiro Iwakura
  • Organizer: The 30th Anniversary International Symposium of Research Institute for Biomedical Sciences, Tokyo University of Science
  • Int'l Joint Research / Invited
• [Presentation] The role of CTRP6 in renal tubulointerstitial lesion progression. (2019)
  • Author(s): Hsi Hua Chi, Masanori A. Murayama and Yoichiro Iwakura
  • Organizer: Innate immune receptors: Roles in immunology and beyond (M1), 2019 Keystone Symposia
  • Int'l Joint Research
• [Presentation] 糖鎖修飾酵素の投与による免疫制御法の開発. (2019)
  • Author(s): 鄭琇絢、岩倉洋一郎
  • Organizer: 第66回日本実験動物学会総会
• [Presentation] Elucidating the role of CTRP6 in renal fibrosis and acute kidney failure. (2019)
  • Author(s): 紀 熙華, 村山 正承, 岩倉 洋一郎
  • Organizer: 第84回日本インターフェロン・サイトカイン学会学術集会
• [Presentation] Suppression of IL-17F, but not of IL-17A, provides protection against colitis by inducing Treg cells through modification of the intestinal microbiota (2019)
  • Author(s): Ce Tang, Shigeru Kakuta, and Yoichiro Iwakura
  • Organizer: The 17th International Congress of Immunology (IUIS)
  • Int'l Joint Research
• [Presentation] 腸管Tregを誘導するLactobacillus murinusのTreg誘導成分探索 (2019)
  • Author(s): 島津朋之
  • Organizer: 第125回日本畜産学会
• [Presentation] The role of Dectin-1-IL-17F axis in the homeostasis of the intestinal immune system. (2018)
  • Author(s): 岩倉洋一郎
  • Organizer: 第14回日本基礎老化学会大会、第９回東京理科大学総合研究院トランスレーショナルリサーチシンポジウム
  • Invited
• [Presentation] 関節炎における骨免疫相関 (2018)
  • Author(s): 岩倉洋一郎
  • Organizer: 第36回日本骨代謝学会学術集会／日本炎症再生学会合同シンポジウム
  • Invited
• [Presentation] 炎症性疾患発症におけるIL－17の役割 (2018)
  • Author(s): 岩倉洋一郎
  • Organizer: 第33回日本乾癬学会学術大会特別講演
  • Invited
• [Presentation] Inhibition of Dectin-1 signaling ameliorates colitis by inducing Lactobacillus-mediated regulatory T cell expansion in the intestine. (2018)
  • Author(s): 唐策
  • Organizer: 第83回日本インターフェロン・サイトカイン学会
  • Invited
• [Presentation] Suppression of IL-17F, but not IL-17A, provides protection against colitis by inducing Treg cell through modification of the intestinal microbiota (2018)
  • Author(s): Ce Tang, Shigeru Kakuta, Yoichiro Iwakura
  • Organizer: The 6th Annual Meeting of the International Cytokine & Interferon Society (ICIS)
  • Int'l Joint Research
• [Presentation] Validation the role of CTRP6 in chronic kidney disease progression. (2018)
  • Author(s): Hsi Hua Chi Masanori A Murayama, Yoichiro Iwakura.
  • Organizer: The 6th Annual Meeting of the International Cytokine & Interferon Society (ICIS)
  • Int'l Joint Research
• [Presentation] Analysis of IL-17A and IL-17F expression in APCMin mouse intestinal cancer__model. (2018)
  • Author(s): Yulia Makusheva, Shigeru Kakuta, Ce Tang, Yoichiro Iwakura
  • Organizer: The 6th Annual Meeting of the International Cytokine & Interferon Society (ICIS)
  • Int'l Joint Research
• [Presentation] C型レクチンの真菌感染防御における役割 (2018)
  • Author(s): 鄭_絢、岩倉洋一郎
  • Organizer: 第47回日本免疫学会学術集会
• [Presentation] Suppression of IL-17F, but not IL-17A, provides protection against colitis by inducing Treg cells through modification of the intestinal microbiota (2018)
  • Author(s): Ce Tang, Shigeru Kakuta, Yoichiro Iwakura
  • Organizer: 第47回日本免疫学会学術集会
• [Presentation] The role of CTRP6 in chronic kidney disease progression. (2018)
  • Author(s): 紀 熙華, 村山 正承, 岩倉 洋一郎
  • Organizer: 第47回日本免疫学会学術集会
• [Presentation] Recognition of budding yeast by a C-type lectin gene and its roles in host defense to fungal infection. (2018)
  • Author(s): Soo-Hyun Chung, Yoichiro Iwakura
  • Organizer: 第47回日本免疫学会学術集会
• [Book] 消化器外科 2020年1月号 「癌と炎症を学ぶ 解説１ IL-17，Th17」 (2020)
  • Author(s): 唐策、岩倉洋一郎
  • Total Pages: 128
  • Publisher: へるす出版
• [Book] 医学のあゆみ 食品成分による腸管Tregの制御 (2019)
  • Author(s): 岩倉洋一郎
  • Total Pages: 264
  • Publisher: 医歯薬出版株式会社
• [Book] 医学のあゆみ IL-17ファミリー分子の生体における役割 (2019)
  • Author(s): 岩倉洋一郎
  • Total Pages: 120
  • Publisher: 医歯薬出版株式会社
• [Patent(Industrial Property Rights)] h17細胞誘導性疾患の予防又は治療剤、およびTh17細胞誘導性疾患の予防又は治療剤のスクリーニング法 (2019)
  • Inventor(s): 岩倉洋一郎、村山正承、小野貴裕、松岡眞子
  • Industrial Property Rights Holder: 岩倉洋一郎、村山正承、小野貴裕、松岡眞子
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2019-148054
  • Filing Date: 2019
• [Patent(Industrial Property Rights)] 自己免疫疾患の治療薬および治療方法 (2019)
  • Inventor(s): 岩倉洋一郎、村山正承
  • Industrial Property Rights Holder: 岩倉洋一郎、村山正承
  • Industrial Property Rights Type: 特許
  • Filing Date: 2019
  • Acquisition Date: 2019
• [Patent(Industrial Property Rights)] Method for the treatment of an autoimmune disease with an agent comprising CTRP3 (2019)
  • Inventor(s): Y. Iwakura, M. Murayama
  • Industrial Property Rights Holder: Y. Iwakura, M. Murayama
  • Industrial Property Rights Type: 特許
  • Filing Date: 2019
  • Acquisition Date: 2019
  • Overseas
• [Patent(Industrial Property Rights)] 抗IL－17F中和抗体の炎症性腸疾患に対する治療・予防効果 (2018)
  • Inventor(s): 岩倉洋一郎、唐策
  • Industrial Property Rights Holder: 岩倉洋一郎、唐策
  • Industrial Property Rights Type: 特許
  • Filing Date: 2018
  • Overseas
• [Patent(Industrial Property Rights)] 樹状細胞の成熟抑制剤及び成熟抑制方法、並びに医薬組成物 (2018)
  • Inventor(s): 岩倉洋一郎、矢部力朗
  • Industrial Property Rights Holder: 岩倉洋一郎、矢部力朗
  • Industrial Property Rights Type: 特許
  • Filing Date: 2018
• [Patent(Industrial Property Rights)] 乳酸菌増殖促進剤、制御性T細胞T細胞増加剤、乳酸菌増殖促進方法、制御性T細胞を増加させる方法、制御性T細胞増加効果の評価方法、および乳酸菌増殖促進効果の評価方法 (2018)
  • Inventor(s): 岩倉洋一郎、唐策、大野尚仁
  • Industrial Property Rights Holder: 岩倉洋一郎、唐策、大野尚仁
  • Industrial Property Rights Type: 特許
  • Filing Date: 2018
  • Acquisition Date: 2018