| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2019: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2018: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
|
|---|
| Outline of Final Research Achievements |
This study has demonstrated the usefulness of synthetic polymer scaffolds as a tool for comprehensively elucidating glioma stem cell niche, by revealing iron that regulates glioma stem cell maintenance and glioma expansion. This finding provides a new self-expanding strategy of glioma stem cells that systemically exploits erythroid lineages to reconstruct GSC-friendly niche. In this study, it is also revealed that glioma stem cell-derived necrotic particles designated as autoschizis-like products play a key role in developing a glioma stem cell-supportive subset of tumor-associated macrophages. This finding thus demonstrates that glioma necrosis is not a meaningless death but is a tumor-beneficial event. Taken together, a series of these studies will provide new insights into the mechanisms underlying glioma stem cell-driven niche development as well as glioma progression and recurrence.
|
