| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2019: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
|
|---|
| Outline of Final Research Achievements |
Long non-coding RNAs (lncRNAs) are RNAs that do not encode proteins by definition, but we have identified novel polypeptides translated from lncRNAs and shown that they have important functions. In this project, we focused on polypeptides that are expressed specifically in the brain and whose expression is altered in diseases such as autism and depression. During this research period, we generated tag knock-in mice of these novel polypeptides to prove their endogenous expression and to identify their binding proteins, and also generated knock-out mice to show various behavioral abnormalities.
|
