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Analysis of novel polypeptides involved in brain and neurological diseases

Research Project

Project/Area Number 18H02707
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 51010:Basic brain sciences-related
Research InstitutionKyushu University

Principal Investigator

Matsumoto Akinobu  九州大学, 生体防御医学研究所, 准教授 (60741519)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2019: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
KeywordsLong non-coding RNA / ポリペプチド / 脳・神経疾患 / 脳 / 精神疾患
Outline of Final Research Achievements

Long non-coding RNAs (lncRNAs) are RNAs that do not encode proteins by definition, but we have identified novel polypeptides translated from lncRNAs and shown that they have important functions. In this project, we focused on polypeptides that are expressed specifically in the brain and whose expression is altered in diseases such as autism and depression. During this research period, we generated tag knock-in mice of these novel polypeptides to prove their endogenous expression and to identify their binding proteins, and also generated knock-out mice to show various behavioral abnormalities.

Academic Significance and Societal Importance of the Research Achievements

Long non-coding RNA(lncRNA)はその定義によるとタンパク質をコードしないRNAであるが、われわれはこれまでにlncRNAから翻訳される新規ポリペプチドを同定し、それらが重要な機能を持つことを明らかにした。本研究課題では、脳特異的に発現して、自閉症や鬱病などで発現が変化しているポリペプチドの焦点を当てて解析を行ない、マウスにおいてそれらを欠損すると社会行動の変化などを引き起こすことなどを明らかにした。これらlncRNA由来の新規ポリペプチドという全く新しい因子の解析により、新たな治療法の開拓へとつながる可能性が示された。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (11 results)

All 2021 2020 2019 2018

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (7 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results)

  • [Journal Article] The autism-related protein CHD8 contributes to the stemness and differentiation of mouse hematopoietic stem cells2021

    • Author(s)
      Nita Akihiro、Muto Yoshiharu、Katayama Yuta、Matsumoto Akinobu、Nishiyama Masaaki、Nakayama Keiichi I.
    • Journal Title

      Cell Reports

      Volume: 34 Issue: 5 Pages: 108688-108688

    • DOI

      10.1016/j.celrep.2021.108688

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cell cycle-dependent localization of the proteasome to chromatin2020

    • Author(s)
      Kito Yuki、Matsumoto Masaki、Hatano Atsushi、Takami Tomoyo、Oshikawa Kiyotaka、Matsumoto Akinobu、Nakayama Keiichi I.
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 5801-5801

    • DOI

      10.1038/s41598-020-62697-2

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intragenic antagonistic roles of protein and circRNA in tumorigenesis2019

    • Author(s)
      Guarnerio J, Zhang Y, Cheloni G, Panella R, Mae Katon J, Simpson M, Matsumoto A, Papa A, Loretelli C, Petri A, Kauppinen S, Garbutt C, Nielsen GP, Deshpande V, Castillo-Martin M, Cordon-Cardo C, Dimitrios S, Clohessy JG, Batish M, Pandolfi PP.
    • Journal Title

      Cell Research

      Volume: 29 Issue: 8 Pages: 628-640

    • DOI

      10.1038/s41422-019-0192-1

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Hidden Peptides Encoded by Putative Noncoding RNAs2018

    • Author(s)
      Matsumoto A, Nakayama KI.
    • Journal Title

      Cell Structure and Function

      Volume: 43 Issue: 1 Pages: 75-83

    • DOI

      10.1247/csf.18005

    • NAID

      130006742309

    • ISSN
      0386-7196, 1347-3700
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Long non-coding RNAの翻訳と精神疾患2020

    • Author(s)
      松本 有樹修
    • Organizer
      NPBPPP2020合同年会(第50回日本神経精神薬理学会年会、第42回日本生物学的精神医学会年会、第4回日本精神薬学会総会・学術集会)
    • Related Report
      2020 Annual Research Report
  • [Presentation] Long non-coding RNAの翻訳2020

    • Author(s)
      松本 有樹修
    • Organizer
      第93回日本生化学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 新規ポリペプチドによる恒常性維持機構2019

    • Author(s)
      松本 有樹修
    • Organizer
      第71回日本細胞生物学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Long non-coding RNAの解析から明らかとなった新規ポリペプチドワールド2019

    • Author(s)
      松本 有樹修
    • Organizer
      第37回日本骨代謝学会学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Polypeptides world revealed by analyses of long non-coding RNAs2019

    • Author(s)
      松本 有樹修
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Long non-coding RNAから翻訳される機能性ポリペプチド群の同定2018

    • Author(s)
      松本 有樹修
    • Organizer
      日本筋学会第4回学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Functional polypeptides encoded by putative long non-coding RNAs2018

    • Author(s)
      松本 有樹修
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report

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Published: 2018-04-23   Modified: 2022-01-27  

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