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Neuromolecular mechanism of motherhood-specific nurturing motivation

Research Project

Project/Area Number 18H02710
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 51020:Cognitive and brain science-related
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Kuroda Kumi  国立研究開発法人理化学研究所, 脳神経科学研究センター, チームリーダー (90391945)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2021: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2020: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Keywords母性行動 / 養育(子育て)行動 / カルシトニン受容体 / 高架式十字迷路 / 内側視索前野 / Medial preoptic area / 養育行動 / マウス / 行動試験 / 親子関係 / 社会行動 / 母子関係
Outline of Final Research Achievements

Maternal mammals exhibit heightened motivation to care for offspring, but the responsible neuromolecular mechanisms are yet to be clarified. Here we report that the calcitonin receptor (Calcr)-expressing neurons in the central part of the medial preoptic area (cMPOA) are critical for maternal care even under risky conditions. Calcr+ cMPOA neurons are highly activated during parenting, and Calcr molecular expression increased 8-times in mothers. Suppression of Caler neuron firing in the cMPOA abolished maternal care, so that 80% of their offspring could not survive, without affecting general health, mating and normal delivery. Reduction of Calcr molecular expression caused inhibition of risk-taking maternal pup retrieval. Considering the fact that the same brain area exists in primate brain, this study will contribute to understanding and support of human parental care in future.

Academic Significance and Societal Importance of the Research Achievements

母親による子育てはヒトを含む全哺乳類に基本的な部分が共通しており、その神経機構も進化的に保存されていると考えられる。本成果は、マウスの母親が自らの危険を冒して子を助ける子育て意欲を発揮するためのメカニズムの一端を明らかにした。このようなモデル動物を用いた研究は、将来的には人間の子育て意欲低下の理解と支援にも役立つ可能性がある。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (39 results)

All 2022 2021 2020 2019 2018 Other

All Journal Article (17 results) (of which Int'l Joint Research: 1 results,  Open Access: 5 results,  Peer Reviewed: 6 results) Presentation (19 results) (of which Int'l Joint Research: 6 results,  Invited: 7 results) Book (1 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Amylin-Calcitonin receptor signaling in the medial preoptic area mediates affiliative social behaviors in female mice2022

    • Author(s)
      Fukumitsu Kansai、Kaneko Misato、Maruyama Teppo、Yoshihara Chihiro、Huang Arthur J.、McHugh Thomas J.、Itohara Shigeyoshi、Tanaka Minoru、Kuroda Kumi O.
    • Journal Title

      Nature Communications

      Volume: 13 Issue: 1 Pages: 1-19

    • DOI

      10.1038/s41467-022-28131-z

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oxytocin Facilitates Allomaternal Behavior under Stress in Laboratory Mice2022

    • Author(s)
      Tsuneoka Yousuke、Yoshihara Chihiro、Ohnishi Ryuko、Yoshida Sachine、Miyazawa Eri、Yamada Masanobu、Horiguchi Kazuhiko、Young W. Scott、Nishimori Katsuhiko、Kato Tadafumi、Kuroda Kumi O.
    • Journal Title

      eneuro

      Volume: 9(1): ENEURO.0405-21.2022 Issue: 1 Pages: 1-22

    • DOI

      10.1523/eneuro.0405-21.2022

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 同意取得が困難な事例を対象とした症例報告や研究における問題点と課題 児童虐待刑事事件の生物・心理・社会要因に関する質問紙調査 : 妥当性,安全性および倫理的配慮2021

    • Author(s)
      黒田 公美、白石 優子
    • Journal Title

      精神神経学雑誌

      Volume: 123(6) Pages: 333-341

    • Related Report
      2021 Annual Research Report
    • Open Access
  • [Journal Article] 養育行動の神経科学2021

    • Author(s)
      篠塚一貴, 黒田公美
    • Journal Title

      Clinical Neuroscience

      Volume: 39(8) Pages: 988-991

    • Related Report
      2021 Annual Research Report
  • [Journal Article] 攻撃性の行動神経科学と攻撃性・加害性の高い子ども虐待事例2021

    • Author(s)
      宮澤絵里, 白石優子, 黒田公美
    • Journal Title

      子どもの虐待とネグレスト

      Volume: 23(3) Pages: 251-262

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Calcitonin receptor signaling in the medial preoptic area enables risk-taking maternal care.2021

    • Author(s)
      Yoshihara, C., Tokita K., Maruyama, T., Kaneko, M., Tsuneoka, Y., Fukumitsu, K., Miyazawa, E., Shinozuka, K., Huang, A.J., McHugh, T.J., Tanaka, M., Itohara, S., Touhara, K., Miyamichi, K. and Kuroda, K.O.
    • Journal Title

      Cell Reports

      Volume: -

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evolutionary‐adaptive and nonadaptive causes of infant attack/desertion in mammals: Toward a systematic classification of child maltreatment2020

    • Author(s)
      Kuroda Kumi O.、Shiraishi Yuko、Shinozuka Kazutaka
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 74 Issue: 10 Pages: 516-526

    • DOI

      10.1111/pcn.13096

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Using maternal rescue of pups in a cup to investigate mother-infant interactions in mice/rodents2019

    • Author(s)
      Esposito Gianluca、Truzzi Anna、Yoshida Sachine、Ohnishi Ryuko、Miyazawa Eri、Kuroda Kumi O.
    • Journal Title

      Behavioural Brain Research

      Volume: 374 Pages: 112081-112081

    • DOI

      10.1016/j.bbr.2019.112081

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 動物行動の脳科学から見る子の愛着と、養育環境の発達への影響2019

    • Author(s)
      村山綾子、黒田公美
    • Journal Title

      そだちの科学

      Volume: 33 Pages: 14-26

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 哺乳類の子育て(養育)行動とオキシトシンの役割2019

    • Author(s)
      吉原千尋、黒田公美
    • Journal Title

      分子精神医学

      Volume: 19(3)

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Corticotropin-Releasing Factor Receptor 1 in the Anterior Cingulate Cortex Mediates Maternal Absence-Induced Attenuation of Transport Response in Mouse Pups2018

    • Author(s)
      Yoshida Sachine、Ohnishi Ryuko、Tsuneoka Yousuke、Yamamoto-Mimura Yuka、Muramatsu Reiko、Kato Tadafumi、Funato Hiromasa、Kuroda Kumi O.
    • Journal Title

      Frontiers in Cellular Neuroscience

      Volume: 12 Pages: 1-14

    • DOI

      10.3389/fncel.2018.00204

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 子育てと児童虐待に関わる脳内回路機構-行動神経科学の視点から-2018

    • Author(s)
      黒田公美
    • Journal Title

      臨床精神医学

      Volume: 47(9) Pages: 1021-1028

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 親和性社会行動と親子支援2 哺乳類の親子の協力とコンフリクト2018

    • Author(s)
      白石優子,黒田公美
    • Journal Title

      子育て支援と心理臨床

      Volume: 15 Pages: 130-135

    • NAID

      40021594099

    • Related Report
      2018 Annual Research Report
  • [Journal Article] おわりに-親と子、それぞれの立場、ほどよい関係への支援2018

    • Author(s)
      黒田公美
    • Journal Title

      子ども虐待対応のネットワークづくり1 メンタルヘルス問題のある親の子育てと暮らしの支援 先駆的支援活動例にみるそのまなざしと機能

      Volume: - Pages: 144-152

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 親和性社会行動と親子支援3 哺乳類の親子と社会2018

    • Author(s)
      白石優子,黒田公美
    • Journal Title

      子育て支援と心理臨床

      Volume: 16 Pages: 82-87

    • NAID

      40021714169

    • Related Report
      2018 Annual Research Report
  • [Journal Article] トピック イヤイヤ期、子の発達と養育者のかかわり2018

    • Author(s)
      白石優子,黒田公美
    • Journal Title

      月刊母子保健

      Volume: 716 Pages: 9-9

    • Related Report
      2018 Annual Research Report
  • [Journal Article] I虐待をめぐって 行動の脳科学からみる子育てとその問題2018

    • Author(s)
      黒田公美,白石優子
    • Journal Title

      発達

      Volume: 157 Pages: 16-22

    • Related Report
      2018 Annual Research Report
  • [Presentation] Infant valence is mediated by the caregivers' medial preoptic area2021

    • Author(s)
      Kuroda, K.O.
    • Organizer
      The 44th Annual Meeting of the Japan Neuroscinece Society・The 1st CJK International Meeting
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 脳科学から見た子ども虐待とその支援2021

    • Author(s)
      黒田公美
    • Organizer
      第40回日本心理臨床学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Two-dimensional model of affiliation and its neural basis in mammals2021

    • Author(s)
      Kuroda, K.O.
    • Organizer
      Mini-Conference, Attachment from a Social Neuroscience Perspective; Society for Emotion and Attachment Studies,
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The neural basis of parental care and infant attachment in mammals2021

    • Author(s)
      Kuroda, K.O
    • Organizer
      Broken Sleep ONLINE Conference 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Preoptic signaling as a critical node of affiliative social behaviors in mammals2021

    • Author(s)
      Kuroda, K.O.
    • Organizer
      The 16th International Symposium of the Institute Network for Biomedical Sciences KEY FORUM 2021 International Symposium
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Calcitonin receptor neurons in the MPOA regulate affiliative social contact behaviors2021

    • Author(s)
      Fukumitsu, K., Kuroda, K.O., Kaneko, M., Maruyama, T., Yoshihara, C., Huang, J. A., McHugh T J., Tuneoka Y., Itohara S., and Tanaka M.
    • Organizer
      The SfN Global Connectome
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Neural circuit for fatherhood and motherhood in the medical preoptic area.2020

    • Author(s)
      Kuroda, K.O.
    • Organizer
      Remote programme of Colloquia Series at the Champalimaud Centre for the Unknown (CCU)
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 研究ニッチ+生活の両立=「親子関係の脳科学」:過去・現在・未来2020

    • Author(s)
      黒田公美
    • Organizer
      第43回日本神経科学大会教育シンポジウム
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 哺乳類の親子関係の脳内基盤2020

    • Author(s)
      黒田公美
    • Organizer
      第32回日本行動神経内分泌研究会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 重度の子ども虐待事例における生物心理社会的な背景要因分析2020

    • Author(s)
      黒田公美
    • Organizer
      公開シンポジウム「児童虐待への文理融合アプローチ―世帯の貧困、おやこの支援に着目して―」
    • Related Report
      2020 Annual Research Report
  • [Presentation] 児童虐待事件に関係し受刑中の養育者への質問紙調査:同意取得に関して留意した点2020

    • Author(s)
      黒田公美
    • Organizer
      第116回日本精神神経学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Parental behavior and infanticide mammals; anatomical,endocrinoligical and clinical condsiderations2019

    • Author(s)
      Kumi Kuroda
    • Organizer
      13th World Congress on Neuroypophysial Hormones (WCNH2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Science Media links brain scinece and future society2019

    • Author(s)
      黒田公美
    • Organizer
      Japan SCICOM forum
    • Related Report
      2019 Annual Research Report
  • [Presentation] ほ乳類に共通する、子の親への愛着の行動神経メカニズム2019

    • Author(s)
      黒田公美
    • Organizer
      第115回日本精神神経学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Behavioral examination framework for parental behavior components in rodents, non-human primates and humans2019

    • Author(s)
      黒田公美
    • Organizer
      NEURO2019(第42回日本神経科学大会,第62回日本神経化学会大会)
    • Related Report
      2019 Annual Research Report
  • [Presentation] Role of the medial preoptic area in parental care and infanticide2018

    • Author(s)
      黒田公美
    • Organizer
      New Zealand Medical Sciences Congress 2018 (Queentown,New Zealand)
    • Related Report
      2018 Annual Research Report
  • [Presentation] Circuit mechanisms of fatherhood and motherhood in the medial preoptic area2018

    • Author(s)
      黒田公美
    • Organizer
      Symposium on Systems Neuroscience (NTHU) (Hsinchu,Taiwan)
    • Related Report
      2018 Annual Research Report
  • [Presentation] Neural mechanism of parental care and infanticide in mammals2018

    • Author(s)
      黒田公美
    • Organizer
      New Directions in Systems Neuroscience (Tuebingen,Germany)
    • Related Report
      2018 Annual Research Report
  • [Presentation] Neural basis of infant attachment and separation anxiety2018

    • Author(s)
      黒田公美、吉田さちね
    • Organizer
      The 9th Federation of the Asian and Oceanian Physiological Societies Congress (神戸)
    • Related Report
      2018 Annual Research Report
  • [Book] 遺伝学の百科事典2022

    • Author(s)
      日本遺伝学会
    • Total Pages
      690
    • Publisher
      丸善出版
    • ISBN
      9784621306604
    • Related Report
      2021 Annual Research Report
  • [Remarks] 理化学研究所脳神経科学研究センター親和性社会行動研究チーム

    • URL

      http://asb.brain.riken.jp/index_j.html

    • Related Report
      2021 Annual Research Report
  • [Patent(Industrial Property Rights)] 情報処理システム、情報処理方法、およびプログラム2022

    • Inventor(s)
      黒田公美
    • Industrial Property Rights Holder
      黒田公美
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2022-035010
    • Filing Date
      2022
    • Related Report
      2021 Annual Research Report

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Published: 2018-04-23   Modified: 2023-01-30  

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