Neuronal circuit mechanisms of memory of temporally organized experiences
| Project/Area Number |
18H02711
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 51020:Cognitive and brain science-related
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Fujisawa Shigeyoshi 国立研究開発法人理化学研究所, 脳神経科学研究センター, チームリーダー (20589395)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2019: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | 海馬 / 時間 / 神経生理学 |
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| Outline of Final Research Achievements |
Hippocampal time cells are known to encode specific moments of temporally organized experiences that may support hippocampal functions for episodic memory. However, little is known about the detailed features of the temporal representation of time cells during changes in temporal structures of episodes. In this research, we investigated CA1 neuronal activity during temporal bisection tasks, in which the sets of time intervals to be discriminated were designed to be extended or contracted across the blocks of trials. We found that CA1 neurons encoded elapsed time during the interval, and the representation was scaled when the set of interval times was varied. In addition, the neuronal activities reflected the rats’ decisions on the basis of their time estimation. These findings indicate that scalable features of time cells may support the capability of flexible temporal representation for memory formation.
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| Academic Significance and Societal Importance of the Research Achievements |
今回の研究では、時間情報をどのように海馬の神経回路が表現しているのかを明らかにした。これらの結果は、相対的表現や位相前進の存在など、空間情報で明らかにされてきた結果と共通する点が多く、海馬は空間と時間を同様の神経回路メカニズムで表現していることを示唆している。海馬は、自分たちが経験した出来事に関する記憶であるエピソードの記憶を形成する中心とも考えられており、エピソード記憶としてある経験の「いつ、どこで、何を」に関する情報をどのように統合しているのかを考える上で、今回の結果は重要だと考えられる。今後、この知見をもとに、エピソード記憶の神経基盤の解明が進展していくと期待できる。
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Report
(4 results)
Research Products
(7 results)
