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Elucidating the mechanisms of split-brain by the information-theoretic analysis of brain activity

Research Project

Project/Area Number 18H02713
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 51020:Cognitive and brain science-related
Research InstitutionThe University of Tokyo

Principal Investigator

Oizumi Masafumi  東京大学, 大学院総合文化研究科, 准教授 (30715371)

Co-Investigator(Kenkyū-buntansha) 小村 豊  京都大学, 人間・環境学研究科, 教授 (80357029)
笹井 俊太朗  国立研究開発法人情報通信研究機構, 脳情報通信融合研究センター脳情報通信融合研究室, 協力研究員 (00789612)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2021: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Keywords意識 / 分離脳 / 統合情報理論 / 情報理論 / ECoG
Outline of Final Research Achievements

A brain in which the corpus callosum connecting the left and right hemispheres has been severed for the treatment of epilepsy is called a "split-brain," and the patient behaves as if he or she has two independent consciousnesses in the left and right hemispheres. Understanding the split-brain is important to understand how we can have one consciousness integrating the left and right brains. In this study, we recorded monkey ECoG data and developed an algorithm to extract neural network structure from neural activity data with the goal of understanding the neural mechanisms of the split-brain. The algorithm is capable of efficiently searching for the subnetwork with the largest amount of integrated information, which enables us to judge the split of networks from brain activity.

Academic Significance and Societal Importance of the Research Achievements

分離脳の神経メカニズムの理解は、なぜ我々が左脳と右脳の情報が統合された意識経験を持てるのかを理解する上で重要である。本研究成果は、この分離脳の理解に向けた、数理基盤の開発に成功した点と、実際のサルの行動実験、及び脳活動の記録を行った点で意義がある。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (18 results)

All 2022 2021 2020 2019 2018

All Journal Article (8 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 8 results,  Open Access: 7 results) Presentation (10 results) (of which Int'l Joint Research: 4 results,  Invited: 6 results)

  • [Journal Article] Quantifying brain state transition cost via Schr?dinger Bridge2022

    • Author(s)
      Kawakita Genji、Kamiya Shunsuke、Sasai Shuntaro、Kitazono Jun、Oizumi Masafumi
    • Journal Title

      Network Neuroscience

      Volume: 6 Issue: 1 Pages: 118-134

    • DOI

      10.1162/netn_a_00213

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bidirectionally connected cores in a mouse connectome: Towards extracting the brain subnetworks essential for consciousness2022

    • Author(s)
      Jun Kitazono, Yuma Aoki, Masafumi Oizumi
    • Journal Title

      Cerebral Cortex

      Volume: -

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Information flow in the rat thalamo-cortical system: spontaneous vs. stimulus-evoked activities2021

    • Author(s)
      Ishizu Kotaro、Shiramatsu Tomoyo I.、Hitsuyu Rie、Oizumi Masafumi、Tsuchiya Naotsugu、Takahashi Hirokazu
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 19252-19252

    • DOI

      10.1038/s41598-021-98660-y

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fast, cell-resolution, contiguous-wide two-photon imaging to reveal functional network architectures across multi-modal cortical areas2021

    • Author(s)
      K. Ota, Y. Oisi, T. Suzuki, M. Ikeda, Y. Ito, T. Ito, H. Uwamori, K. Kobayashi, M. Kobayashi, M. Odagawa, C. Matsubara, Y. Kuroiwa, M. Horikoshi, J. Matsushita, H. Hioki, M. Ohkura, J. Nakai, M. Oizumi, A. Miyawaki, T. Aonishi, T. Ode and M. Murayama
    • Journal Title

      Neuron

      Volume: - Issue: 11 Pages: 1-15

    • DOI

      10.1016/j.neuron.2021.03.032

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Efficient search for informational cores in complex systems: Application to brain networks2020

    • Author(s)
      Jun Kitazono, Ryota Kanai, Masafumi Oizumi
    • Journal Title

      Neural Networks

      Volume: 132 Pages: 232-244

    • DOI

      10.1016/j.neunet.2020.08.020

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Unified framework for the entropy production and the stochastic interaction based on information geometry2020

    • Author(s)
      Sosuke Ito, Masafumi Oizumi, Shun-ichi Amari
    • Journal Title

      Physical Review Research

      Volume: 2 Issue: 3 Pages: 033048-033048

    • DOI

      10.1103/physrevresearch.2.033048

    • URL

      https://pure.teikyo.jp/en/publications/84c42d78-4019-4ed9-9b56-c9142cfb7347

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A general spectral decomposition of causal influences applied to integrated information2020

    • Author(s)
      Dror Cohen, Shuntaro Sasai, Naotsugu Tsuchiya, Masafumi Oizumi
    • Journal Title

      The Journal of Neuroscience Methods

      Volume: 330 Pages: 108443-108443

    • DOI

      10.1016/j.jneumeth.2019.108443

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 「意識の神経相関」を超えて : 「意識の構造」と「情報の構造」の特徴づけ,そして「構造間の関係性の同定」を目指して2020

    • Author(s)
      土谷尚嗣, 大泉匡史, 山田真希子, 西郷 甲矢人
    • Journal Title

      臨床精神医学

      Volume: 49 Pages: 319-326

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Bidirectionally connected cores in a mouse connectome: Towards extracting the brain subnetworks essential for consciousness2021

    • Author(s)
      Jun Kitazono, Yuma Aoki, Masafumi Oizumi
    • Organizer
      Sydney University Systems Neuroscience and Complexity Seminars
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Network cores of the human functional connectome2021

    • Author(s)
      Tomoya Taguchi, Jun Kitazono, Shuntaro Sasai, Masafumi Oizumi
    • Organizer
      神経回路学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Network cores of the human functional connectome2021

    • Author(s)
      Tomoya Taguchi, Jun Kitazono, Shuntaro Sasai, Masafumi Oizumi
    • Organizer
      ニューロコンピューティング研究会(NC)
    • Related Report
      2020 Annual Research Report
  • [Presentation] Bidirectionally connected cores in a mouse connectome2021

    • Author(s)
      Jun Kitazono, Yuma Aoki, Masafumi Oizumi
    • Organizer
      Computational and Systems Neuroscience 2021
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 統合情報理論の数理2020

    • Author(s)
      大泉匡史
    • Organizer
      数理生物セミナー
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Recurrently connected cores in a mouse connectome2020

    • Author(s)
      Jun Kitazono, Yuma Aoki, Masafumi Oizumi
    • Organizer
      第30回 日本神経回路学会 全国大会 (JNNS2020)
    • Related Report
      2020 Annual Research Report
  • [Presentation] 意識の場所と境界―理論的アプローチの紹介2019

    • Author(s)
      大泉匡史
    • Organizer
      生理研研究会「視覚・認知脳機能研究の先端」
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Towards Identifying Places and Boundaries of consciousness: An Approach from Integrated Information Theory2019

    • Author(s)
      Masafumi Oizumi
    • Organizer
      Conference on Complex Systems, Workshop on Information Processing in Complex Systems
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Towards Identifying Places and Boundaries of consciousness: An Approach from Integrated Information Theory2019

    • Author(s)
      Masafumi Oizumi
    • Organizer
      Statistical Physics and Neural Computation
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 脳内ネットワークの情報コアの探索―意識の場所の同定に向けて2018

    • Author(s)
      大泉匡史
    • Organizer
      ネットワーク科学セミナー
    • Related Report
      2018 Annual Research Report
    • Invited

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Published: 2018-04-23   Modified: 2023-01-30  

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