Fear memory formation mechanisms in sensory cortices.

• Project/Area Number: 18H02714
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 51020:Cognitive and brain science-related
• Research Institution: Keio University
• Principal Investigator: KOIZUMI Ai 慶應義塾大学, 政策・メディア研究科(藤沢), 特任講師 (60588953)
• Co-Investigator(Kenkyū-buntansha): 戸田 裕之 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 精神科学, 准教授 (00610677) ; 柴田 和久 国立研究開発法人理化学研究所, 脳神経科学研究センター, チームリーダー (20505979) ; 土谷 尚嗣 株式会社国際電気通信基礎技術研究所, 脳情報通信総合研究所, 客員研究員 (80517128)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000); Fiscal Year 2021: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2020: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2019: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
• Keywords: 恐怖記憶 / 心的トラウマ / fMRI / 皮質感覚野 / 皮質 / 感覚野 / VR / 身体運動 / トラウマ / 視覚 / モーショントラック / 皮質メカニズム / PTSD / 脳構造 / 恐怖 / 知覚 / 記憶 / 視覚野

Outline of Final Research Achievements

This project examined the mechanisms underlying the formation of human fear memories, especially in the sensory cortices. With 7T-fMRI, we revealed how the early visual cortex interacts with pulvinar in the cortical-layer dependent manner when perceiving fear related stimuli. With ３T-fMRI, we showed the interplay between the auditory cortex and other cortical areas when the participants integrated and consolidated the experimentally induced fear memories. We further developed the research team to target the participants who underwent real-life traumatic events to further investigate the role of sensory cortices in post-traumatic memory dysfunctions.

Academic Significance and Societal Importance of the Research Achievements

自動車事故などのトラウマティックな出来事を経験すると、その出来事を想起して不安を感じやすくなるなど、特徴的な記憶の障害が生じる場合がある。これまで、動物研究の流れに沿って扁桃体を中心とするトラウマ記憶のメカニズムを検証する研究は多く実施されてきたが、一部の研究が皮質感覚野の関与を示唆するものの具体的なメカニズムについてはまだほとんど分かっていない。本研究は皮質感覚野に特に着目してトラウマ記憶形成・定着メカニズムを検証し、トラウマ記憶による障害への示唆を与える成果を上げ、医学的・社会的意義を達成した。

Research Products

• [Int'l Joint Research] Monash University(オーストリア)
• [Int'l Joint Research] Maastricht University(オランダ)
• [Int'l Joint Research] Maastricht University(オランダ)
• [Journal Article] A reciprocal inhibition model of alternations between non-dissociative and dissociative states in patients with PTSD (2021)
  • Author(s): Chiba, T., Ide, K., Boku, S., Taylor, J.E., Ph.D., Toda, H., Kanazawa, T., Kato, S., Horiuchi, Y. Hishimoto, A., Maruyama, T. Yamamoto, T., Shirakawa, M., Sora, I., Kawato, M., and ＊Koizumi, A.
  • Journal Title: Molecular Psychiatry Volume: 26 Issue: 9 Pages: 5023-5039
  • DOI: 10.1038/s41380-020-0827-0
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Atypical spatial frequency dependence of visual metacognition among schizophrenia patients (2020)
  • Author(s): Koizumi Ai、Hori Tomoki、Maniscalco Brian、Hayase Makoto、Mishima Ryou、Kawashima Takahiko、Miyata Jun、Aso Toshihiko、Lau Hakwan、Takahashi Hidehiko、Amano Kaoru
  • Journal Title: NeuroImage: Clinical Volume: 27 Pages: 102296-102296
  • DOI: 10.1016/j.nicl.2020.102296
  • NAID: 120006949375
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Threat anticipation in pulvinar and in superficial layers of primary visual cortex (V1). Evidence from layer-specific ultra-high field 7T fMRI. (2019)
  • Author(s): Koizumi A, Zhan M, Ban H, Kida I, De Martino FJ, Vaessen M, de Gelder B & Amano K
  • Journal Title: eNeuro Volume: 6 Issue: 6 Pages: 0429-19
  • DOI: 10.1523/eneuro.0429-19.2019
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Layer-specific ultra-high field 7T fMRI showing that threat anticipation is mediated by the pulvinar input to the superficial layers of primary visual cortex (V1) (2018)
  • Author(s): Ai Koizumi, Minye Zhan, Hiroshi Ban, Ikuhiro Kida, Federico de Martino, Maarten Vaessen, Beatrice de Gelder, Kaoru Amano
  • Journal Title: BioRxiv Volume: October 2
  • DOI: 10.1101/431270
  • Open Access / Int'l Joint Research
• [Presentation] Emergence and regulation of fear - from mouse behavior to human imagination (2022)
  • Author(s): Koizumi Ai
  • Organizer: 日本神経科学学会大会
  • Int'l Joint Research
• [Presentation] 厄介で素晴らしき不安な脳の働き (2021)
  • Author(s): 小泉愛
  • Organizer: 日本神経科学学会大会
  • Int'l Joint Research / Invited
• [Presentation] 脳から考える心身の痛み・慢性疼痛とその予防・ヘルスケア (2021)
  • Author(s): 小泉愛
  • Organizer: CANS応用脳コンソーシアム
  • Invited
• [Presentation] 不安と恐怖の脳科学 (2021)
  • Author(s): 小泉愛
  • Organizer: 早稲田大学心理学セミナーシリーズ
  • Invited
• [Presentation] Integrating diverse events to form holistic fear memories in the human brain (2020)
  • Author(s): Ai Koizumi、Aurelio Cortese、Ryu Ohata、Norimichi Kitagawa、Hiroshi Imamizu
  • Organizer: 日本神経科学大会
  • Int'l Joint Research
• [Presentation] Pulvinar modulates primary visual cortex in a laminar dependent manner during perception of fear (2018)
  • Author(s): Ai Koizumi, Minye Zhan, Hiroshi Ban, Ikuhiro Kida, Federico de Martino, Maarten Vaessen, Beatrice de Gelder, Kaoru Amano
  • Organizer: The social & affective neuroscience society
  • Int'l Joint Research
• [Book] fMRI Neurofeedback (2021)
  • Author(s): Ai Koizumi, Mitsuo Kawato
  • Publisher: Elsevier
  • ISBN: 9780128224212