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Unraveling novel pathological mechanism of frailty targeting vascular inflammation

Research Project

Project/Area Number 18H02726
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 52010:General internal medicine-related
Research InstitutionThe University of Tokyo

Principal Investigator

AKISHITA MASAHIRO  東京大学, 医学部附属病院, 教授 (00261975)

Co-Investigator(Kenkyū-buntansha) 小川 純人  東京大学, 医学部附属病院, 准教授 (20323579)
孫 輔卿  東京大学, 医学部附属病院, 届出研究員 (20625256)
小島 太郎  東京大学, 医学部附属病院, 講師 (40401111)
亀山 祐美  東京大学, 医学部附属病院, 助教 (60505882)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2020: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2019: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2018: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Keywords血管炎症 / フレイル / 階層構造 / 老化 / 大動脈瘤 / サルコペニア / 慢性炎症 / 認知症
Outline of Final Research Achievements

Hierarchical relationship between aging and dysfunction of frailty-related tissues might exist via chronic inflammation. In this study, we aimed unravelling the mechanism of this hierarchical relationship focusing on vascular inflammation, as an upstream trigger of chronic inflammation. Furthermore, apoptosis of vascular cells is one of important phenomenon increasing inflammation.

Our results show that in vitro apoptosis of vascular cell was associated with IL-1 upregulation and in vivo inflammation-derived aneurysm formation was enhanced by aging factors such high phosphate or deficiency of sex hormone through apoptosis and inflammation. Furthermore, aneurysm caused increase in activated microglia in hippocampus and decrease in muscle mass and bone mineral density in skeletal muscle, which suggests hierarchical structure started from vascular disease to frailty-related tissues including hippocampus and skeletal muscle.

Academic Significance and Societal Importance of the Research Achievements

老化基盤である慢性炎症からフレイル病態機序を明らかにすることは、フレイル予防・診断及び治療の戦略策に一助となる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (61 results)

All 2021 2020 2019 2018

All Journal Article (27 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 27 results,  Open Access: 7 results) Presentation (33 results) (of which Int'l Joint Research: 7 results,  Invited: 16 results) Book (1 results)

  • [Journal Article] Potential prescribing omissions of anti‐osteoporosis drugs is associated with rehabilitation outcomes after fragility fracture: Retrospective cohort study2021

    • Author(s)
      Shibasaki Koji、Asahi Toshiomi、Kuribayashi Mari、Tajima Yuriko、Marubayashi Miki、Iwama Risa、Akishita Masahiro、Ogawa Sumito
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 21 Issue: 5 Pages: 386-391

    • DOI

      10.1111/ggi.14145

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Screening of Alzheimer’s disease by facial complexion using artificial intelligence2021

    • Author(s)
      Umeda-Kameyama Yumi、Kameyama Masashi、Tanaka Tomoki、Son Bo-Kyung、Kojima Taro、Fukasawa Makoto、Iizuka Tomomichi、Ogawa Sumito、Iijima Katsuya、Akishita Masahiro
    • Journal Title

      Aging

      Volume: 13 Issue: 2 Pages: 1765-1772

    • DOI

      10.18632/aging.202545

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sex-related differences in the effects of nutritional status and body composition on functional disability in the elderly2021

    • Author(s)
      Sawada Mika、Kubota Naoto、Sekine Rie、Yakabe Mitsutaka、Kojima Taro、Umeda-Kameyama Yumi、Usami Satoshi、Akishita Masahiro、Ogawa Sumito
    • Journal Title

      PLOS ONE

      Volume: 16 Issue: 2 Pages: 0246276-0246276

    • DOI

      10.1371/journal.pone.0246276

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Guidelines on the Clinical Evaluation of Medicinal Products for Treatment of Dyslipidemia2020

    • Author(s)
      Yamashita Shizuya、Kouji Kajinami, et al.
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 27 Issue: 11 Pages: 1246-1254

    • DOI

      10.5551/jat.CR004

    • NAID

      130007933950

    • ISSN
      1340-3478, 1880-3873
    • Year and Date
      2020-11-01
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Use of Anti-Dementia Drugs Reduces the Risk of Potentially Inappropriate Medications: A Secondary Analysis of a Nationwide Survey of Prescribing Pharmacies2020

    • Author(s)
      Suzuki Yusuke、Sakakibara Mikio、Shiraishi Nariaki、Komiya Hitoshi、Akishita Masahiro、Kuzuya Masafumi
    • Journal Title

      Dementia and Geriatric Cognitive Disorders

      Volume: 49 Issue: 5 Pages: 1-7

    • DOI

      10.1159/000512043

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between low muscle mass and metabolic syndrome in elderly Japanese women2020

    • Author(s)
      Nomura Kazushi、Eto Masato、Ogawa Sumito、Kojima Taro、Iijima Katsuya、Nakamura Tetsuro、Araki Atsushi、Ouchi Yasuyoshi、Akishita Masahiro
    • Journal Title

      PLOS ONE

      Volume: 15 Issue: 12 Pages: 0243242-0243242

    • DOI

      10.1371/journal.pone.0243242

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation2020

    • Author(s)
      Okumura Ken、Akao Masaharu、Yoshida Tetsuro、Kawata Masahito、Okazaki Osamu、Akashi Shintaro、Eshima Kenichi、Tanizawa Kimihiko、Fukuzawa Masayuki、Hayashi Takuya、Akishita Masahiro、Lip Gregory Y.H.、Yamashita Takeshi
    • Journal Title

      New England Journal of Medicine

      Volume: 383 Issue: 18 Pages: 1735-1745

    • DOI

      10.1056/nejmoa2012883

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Potential prescribing omissions may have no influence on cause of death in care‐dependent older adults with percutaneous endoscopic gastrostomy tube2020

    • Author(s)
      Hattori Yukari、Abe Takayuki、Kojima Taro、Hamada Shota、Ogawa Sumito、Ura Nobuyuki、Akishita Masahiro
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 20 Issue: 10 Pages: 961-966

    • DOI

      10.1111/ggi.14009

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cognitive function has a stronger correlation with perceived age than with chronological age2020

    • Author(s)
      Umeda‐Kameyama Yumi、Kameyama Masashi、Kojima Taro、Ishii Masaki、Kidana Kiwami、Yakabe Mitsutaka、Ishii Shinya、Urano Tomohiko、Ogawa Sumito、Akishita Masahiro
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 20 Issue: 8 Pages: 779-784

    • DOI

      10.1111/ggi.13972

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Validation of the Neuropsychiatric Inventory Based on Item Response Theory2020

    • Author(s)
      Wada-Isoe Kenji、Kikuchi Takashi、Umeda-Kameyama Yumi、Mori Takahiro、Akishita Masahiro、Nakamura Yu
    • Journal Title

      Journal of Alzheimer's Disease Reports

      Volume: 4 Issue: 1 Pages: 151-159

    • DOI

      10.3233/adr-200172

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between comprehensive geriatric assessment and short-term outcomes among older adult patients with stroke: A nationwide retrospective cohort study using propensity score and instrumental variable methods2020

    • Author(s)
      Hosoi Tatsuya、Yamana Hayato、Tamiya Hiroyuki、Matsui Hiroki、Fushimi Kiyohide、Akishita Masahiro、Yasunaga Hideo、Ogawa Sumito
    • Journal Title

      EClinicalMedicine

      Volume: 23 Pages: 100411-100411

    • DOI

      10.1016/j.eclinm.2020.100411

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Drug prescription patterns and factors associated with polypharmacy in >1?million older adults in Tokyo2020

    • Author(s)
      Ishizaki Tatsuro、Mitsutake Seigo、Hamada Shota、Teramoto Chie、Shimizu Sayuri、Akishita Masahiro、Ito Hideki
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 20 Issue: 4 Pages: 304-311

    • DOI

      10.1111/ggi.13880

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Utilization of drugs for the management of cardiovascular diseases at intermediate care facilities for older adults in Japan2020

    • Author(s)
      Hamada Shota、Kojima Taro、Maruoka Hiroshi、Ishii Shinya、Hattori Yukari、Okochi Jiro、Akishita Masahiro
    • Journal Title

      Archives of Gerontology and Geriatrics

      Volume: 88 Pages: 104016-104016

    • DOI

      10.1016/j.archger.2020.104016

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in use of high‐priced new drugs and drug costs among residents of long‐term care facilities under a bundled payment system: Case studies of dipeptidyl peptidase‐4 inhibitors and direct oral anticoagulants2020

    • Author(s)
      Hamada Shota、Kojima Taro、Sakata Nobuo、Maruoka Hiroshi、Hattori Yukari、Okochi Jiro、Akishita Masahiro
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 20 Issue: 9 Pages: 842-844

    • DOI

      10.1111/ggi.13994

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] COVID‐19 and older people in Asia: Asian Working Group for Sarcopenia calls to action2020

    • Author(s)
      Lim Wee‐Shiong、Liang Chih‐Kuang、Assantachai Prasert、et al.,
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 20 Issue: 6 Pages: 547-558

    • DOI

      10.1111/ggi.13939

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The Japan Geriatrics Society consensus statement “recommendations for older persons to receive the best medical and long‐term care during the COVID ‐19 outbreak?considering the timing of advance care planning implementation”2020

    • Author(s)
      The Japan Geriatrics Society Subcommittee on End‐of‐Life Issues and New Coronavirus Countermeasure Team
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 20 Issue: 12 Pages: 1112-1119

    • DOI

      10.1111/ggi.14075

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Japan Geriatrics Society “Recommendations for the Promotion of Advance Care Planning”: End‐of‐Life Issues Subcommittee consensus statement2020

    • Author(s)
      The Japan Geriatrics Society Subcommittee on End‐of‐Life Issues、Kuzuya Masafumi、Aita Kaoruko、Katayama Yoko、Katsuya Tomohiro、Nishikawa Mitsunori、Hirahara Satoshi、Miura Hisayuki、Rakugi Hiromi、Akishita Masahiro
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 20 Issue: 11 Pages: 1024-1028

    • DOI

      10.1111/ggi.14042

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Geriatric management of older patients with multimorbidity2020

    • Author(s)
      Kojima Taro、Mizokami Fumihiro、Akishita Masahiro
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 20 Issue: 12 Pages: 1105-1111

    • DOI

      10.1111/ggi.14065

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ginsenoside Rb1 inhibits vascular calcification as a selective androgen receptor modulator2019

    • Author(s)
      Nanao-Hamai M, Son BK, Komuro A, Asari Y, Hashizume T, Takayama KI, Ogawa S, Akishita M
    • Journal Title

      Eur J Pharmacol

      Volume: 859 Pages: 172546-172546

    • DOI

      10.1016/j.ejphar.2019.172546

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Low-Intensity Exercise Suppresses CCAAT/Enhancer-Binding Protein δ/Myostatin Pathway Through Androgen Receptor in Muscle Cells2019

    • Author(s)
      Son BK, Eto M, Oura M, Ishida Y, Taniguchi S, Ito K, Umeda-Kameyama Y, Kojima T, Akishita M
    • Journal Title

      Gerontology

      Volume: 65 Issue: 4 Pages: 397-406

    • DOI

      10.1159/000499826

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Testosterone inhibits aneurysm formation and vascular inflammation in male mice2019

    • Author(s)
      Son BK, Kojima T, Ogawa S, Akishita M
    • Journal Title

      J Endocrinol

      Volume: 241 Issue: 3 Pages: 307-317

    • DOI

      10.1530/joe-18-0646

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of Novel Murine Model showing Vascular Inflammation-derived Cognitive Dysfunction.2019

    • Author(s)
      Hashizume T, Son BK, Taniguchi S, Ito K, Noda Y, Endo T, Nanao-Hamai M, Ogawa S, Akishita M.
    • Journal Title

      Sci Rep.

      Volume: 9 Issue: 1 Pages: 4023-4034

    • DOI

      10.1038/s41598-019-40726-z

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sex difference in the association of androgens with aortic calcification.2018

    • Author(s)
      Hashizume T, Son BK, Kojima T, Nanao-Hamai M, Asari Y, Umeda-Kameyama Y, Ogawa S, Akishita M.
    • Journal Title

      Geriatr Gerontol Int.

      Volume: 18 Issue: 7 Pages: 1137-1138

    • DOI

      10.1111/ggi.13306

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rehabilitation strategy for hip fracture, focused on behavioral psychological symptoms of dementia for older people with cognitive impairment: A nationwide Japan rehabilitation database.2018

    • Author(s)
      Shibasaki K, Asahi T, Mizobuchi K, Akishita M, Ogawa S.
    • Journal Title

      PLoS One.

      Volume: 13 Issue: 7 Pages: e0200143-e0200143

    • DOI

      10.1371/journal.pone.0200143

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identifying drug substances of screening tool for older persons’ appropriate prescriptions for Japanese2018

    • Author(s)
      Nomura Kaori、Kojima Taro、Ishii Shinya、Yonekawa Takuto、Akishita Masahiro、Akazawa Manabu
    • Journal Title

      BMC Geriatrics

      Volume: 18 Issue: 1 Pages: 154-154

    • DOI

      10.1186/s12877-018-0835-y

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The role of autonomic nervous activity, as measured by heart rate variability, on the effect of mortality in disabled elderly with low blood pressure in long-term care.2018

    • Author(s)
      Koji Shibasaki, Sumito Ogawa, Shizuru Yamada, Yasuyoshi Ouchi,Masahiro Akishita
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 印刷中 Issue: 8 Pages: 1153-1158

    • DOI

      10.1111/ggi.13328

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prescription of potentially inappropriate medications to older adults. A nationwide survey at dispensing pharmacies in Japan2018

    • Author(s)
      Suzuki Y, Sakakibara M, Shiraishi N, Hirose T, Akishita M, Kuzuya M.
    • Journal Title

      Arch Gerontol Geriatr.

      Volume: 77 Pages: 8-12

    • DOI

      10.1016/j.archger.2017.12.010

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] 卵巣摘出は大動脈瘤形成と局所炎症を促進する:マウスモデルを用いた検討 ―最優秀演題賞―2021

    • Author(s)
      七尾道子, 孫輔卿, 豊島弘一, 大浦美弥, 小室絢, 小川純人, 秋下雅弘
    • Organizer
      第14回日本性差医学・医療学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 精巣摘出による筋量低下と炎症関連因子の発現上昇:マウスモデルを用いた検討2021

    • Author(s)
      大浦美弥, 孫輔卿, 七尾道子, 小川純人, 秋下雅弘
    • Organizer
      第14回日本性差医学・医療学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] フレイル・サルコペニアの性差と漢方2021

    • Author(s)
      七尾道子, 孫輔卿, 秋下雅弘
    • Organizer
      第14回日本性差医学・医療学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] How to~ポリファーマシー2020

    • Author(s)
      秋下雅弘
    • Organizer
      日本サルコペニア・フレイル学会大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 高齢者の医薬品適正使用の指針に基づく薬剤師の関わり2020

    • Author(s)
      秋下雅弘
    • Organizer
      日本病院薬剤師会関東ブロック学術大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 超高齢社会の高齢者透析医療を考える2020

    • Author(s)
      秋下雅弘
    • Organizer
      日本透析医学会学術大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 高齢者のポリファーマシー対策のガイドライン2020

    • Author(s)
      秋下雅弘
    • Organizer
      日本老年医学会学術集会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Multimorbidityの老年医学的管理2020

    • Author(s)
      秋下雅弘
    • Organizer
      日本老年薬学会学術大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 動脈硬化性疾患の予防と治療における性差」性ホルモンの血管保護作用:基礎研究の最新知見2020

    • Author(s)
      孫輔卿
    • Organizer
      第52回日本動脈硬化学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 食事の炎症誘導能がサルコペニア有病率および血中hsCRP値に及ぼす影響-食事性炎症指数を用いた検討- 優秀演題賞2020

    • Author(s)
      孫輔卿, 秋下雅弘, 豊島弘一, 田中友規, スタッヴォラヴットアンヤポーン, 呂偉達, 飯島勝矢
    • Organizer
      第7回日本サルコペニア、フレイル学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 慢性炎症に基づく高齢者食の評価とフレイル予防食・食環境の提案2020

    • Author(s)
      孫輔卿
    • Organizer
      第62回日本老年医学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] オーラルフレイルと栄養-慢性炎症に着目して-2020

    • Author(s)
      孫輔卿
    • Organizer
      第27回日本未病学会学術総会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 基調講演:健康寿命の性差を考える2020

    • Author(s)
      秋下雅弘
    • Organizer
      日本性差医学・医療学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Low-intensity exercise enhances muscular androgen/ androgen receptor to inhibit myostatin pathway.2019

    • Author(s)
      Son BK, Eto M, Oura M, Akishita M.
    • Organizer
      the Gerontological Society of America. Texas
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 「シンポジウム: 男性ホルモンの分子生物学」テストステロンの抗炎症作用による大動脈瘤の抑制効果2019

    • Author(s)
      孫輔卿
    • Organizer
      第30回日本性機能学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 「シンポジウム: Aging in Vascular Diseases」Direct and remote effect of vascular inflammation on the development of vascular pathologies and dysfunction of frail-related tissue.2019

    • Author(s)
      孫輔卿
    • Organizer
      第51回日本動脈硬化学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 加齢に伴う血管炎症が骨格筋量および骨密度の低下を誘導する2019

    • Author(s)
      大浦美弥, 孫輔卿, 小室絢, 小川純人, 秋下雅弘.
    • Organizer
      第51回日本動脈硬化学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 高リン食が血管炎症を介して大動脈瘤の形成を促進する2019

    • Author(s)
      小室絢, 孫輔卿, 大浦美弥, 浅利雄介, 小川純人, 秋下雅弘.
    • Organizer
      第51回日本動脈硬化学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 「シンポジウム: 健康長寿と東洋医学」Ginsenoside Rb1の心血管保護作用の機序解明2019

    • Author(s)
      孫輔卿
    • Organizer
      第42回日本基礎老化学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] New perspectives: Japan’s policies on long-term care for the aged: past, present and future (Keynote Speech)2019

    • Author(s)
      Akishita M
    • Organizer
      International Symposium on Geriatric Care
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Principles of drug therapy in the elderly (Joint Session)2019

    • Author(s)
      Akishita M
    • Organizer
      Asia Pacific Congress on Cardiovascular Disease Prevention
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Low-intensity exercise suppresses myostatin pathway through androgen receptor in muscle cells2019

    • Author(s)
      Son BK, Eto M, Ishida Y, Oura M, Akishita M
    • Organizer
      International Conference on Sarcopenia & Frailty Research
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] テストステロンは炎症抑制作用を介して大動脈瘤の形成を抑制する (最優秀演題賞)2019

    • Author(s)
      孫輔卿, 小川純人, 秋下雅弘
    • Organizer
      第12回日本性差医学・医療学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 雄マウスでの低強度運動は筋内のテストステロン分泌を亢進し、筋分解を抑制する2019

    • Author(s)
      孫輔卿, 江頭正人, 大浦美弥, 秋下雅弘
    • Organizer
      第12回日本性差医学・医療学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Guidelines and health care system for polypharmacy in Japan (Lecture)2018

    • Author(s)
      Akishita M
    • Organizer
      Taiwan-Japan Conference for Geriatric Medicine
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 女性の動脈硬化性疾患予防のための管理方針(学会指定プログラム)2018

    • Author(s)
      秋下雅弘
    • Organizer
      日本女性医学学会学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 脳心血管病と性差:高齢者における脳心血管病のリスクと治療における性差.(Cutting-Edge Symposium)2018

    • Author(s)
      秋下雅弘
    • Organizer
      日本動脈硬化学会総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] フレイル・サルコペニアと慢性疾患管理(招請講演)2018

    • Author(s)
      秋下雅弘
    • Organizer
      日本消化器病学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] サルコペニアの科学と臨床:高齢者薬物療法とサルコペニア(シンポジウム)2018

    • Author(s)
      秋下雅弘
    • Organizer
      日本内科学会総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Testosterone inhibits aortic aneurysm formation through suppression of inflammation2018

    • Author(s)
      Son BK, Ogawa S, Akishita M
    • Organizer
      the Gerontological Society of America
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Sex difference in the association of androgens with aortic calcification2018

    • Author(s)
      Hashizume T, Son BK, Kojima T, Nanao-Hamai M, Asari Y, Umeda-Kameyama Y, Ogawa S, Akishita M
    • Organizer
      XIX ISA world congress of society
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 加齢に伴う血管炎症の認知機能への影響 ―大動脈瘤マウスモデルを用いた検討―2018

    • Author(s)
      橋詰剛、孫輔卿、濵井道子、小川純人、秋下雅弘
    • Organizer
      第50回日本動脈硬化学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] テストステロンの炎症抑制作用を介した大動脈瘤形成の抑制効果2018

    • Author(s)
      孫輔卿、小川純人、秋下雅弘
    • Organizer
      第50回日本動脈硬化学会
    • Related Report
      2018 Annual Research Report
  • [Book] シリーズ超高齢社会のデザイン 老化と老年病2020

    • Author(s)
      秋下 雅弘
    • Total Pages
      232
    • Publisher
      東京大学出版会
    • ISBN
      9784130343121
    • Related Report
      2019 Annual Research Report

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Published: 2018-04-23   Modified: 2022-01-27  

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