| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2021: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2018: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
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| Outline of Final Research Achievements |
In this research project, we performed functional analyses of TBK1, which has been identified as a causative gene of ALS. TBK1 has been suggested to possess a dual role in neuroinflammation and protein metabolism. To clarify the role of TBK1 in motor neurodegeneration, we generated a TBK1 double deletion model (TBK1-DKO) in mouse models of ALS and nerve injury, and performed functional analysis of TBK1-DKO. We also investigated the role of TBK1 in proteostasis. We found that TBK1 is activated in the mitochondria-associated membrane (MAM) and that the active form of TBK1 localized in the MAM is involved in the protein homeostatic stress response.
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