| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
|
|---|
| Outline of Final Research Achievements |
This study aimed to clarify the molecular mechanism of individual difference in stress adaptation. To this end, we performed a comprehensive gene expression analysis with stress-susceptible and -resilient mice and in clinical depression. We found increased KDM5C expression in depressed individual and stress-susceptible mice. We generated transgenic mice overexpressing KDM5C and found that these TgM has stress-vulnerability. Conversely, KDM5C knockout mice showed stress resilient phenotypes. We also identified two genes as KDM5C target genes, which are also involved in behavioral response to stress. These data suggest that KDM5C-mediated epigenetic gene expression could be involved in behavioral response to stress.
|
