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Establishment of biological marker and pathophysiological study of depression using omics analysis

Research Project

Project/Area Number 18H02751
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 52030:Psychiatry-related
Research InstitutionThe University of Tokushima

Principal Investigator

OHMORI Tetsuro  徳島大学, 大学院医歯薬学研究部(医学域), 教授 (00221135)

Co-Investigator(Kenkyū-buntansha) 沼田 周助  徳島大学, 大学院医歯薬学研究部(医学域), 准教授 (10403726)
渡部 真也  徳島大学, 大学院医歯薬学研究部(医学域), 助教 (90563825)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2020: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywords臨床精神分子遺伝学 / オミックス解析 / うつ病 / 診断マーカー
Outline of Final Research Achievements

We attempted to make diagnostic markers for depression by introducing omics analysis technology, and also investigated a customized and simple measurement method. We established an enzymatic method for the practical measurement of glutamate, a candidate marker. The specificity of glutamate alone was low, and no significant association with therapeutic response was observed. We attempted to develop a method to measure candidate marker sites by methylation modification changes using Loop-Mediated Isothermal Amplification (LAMP), but it proved difficult to detect small differences between depressed and healthy subjects. In bipolar disorder, it was found that the methylation differences compared with the normal group were small, the differences were not similar to those of depression, and certain gene groups were affected by mood stabilizers.

Academic Significance and Societal Importance of the Research Achievements

先端的オミックス解析を使用して複数の指標を抽出し、それをうつ病の診断補助マーカーとする国際的にみても先駆的な試みであり、学術的意義は高い。これまでの生物学的指標はひとつの測定値に依拠していたため、感度と特異性に限界があり、実用レベルには至っていない。本研究は、先端的測定技術を用いて、複数の指標を検討して、それらを組み合わせることによって、うつ病の診断評価を高い精度で可能とする道を開いた。技術的進歩によって解析は安価で迅速となり、しかも被験者負担が数mlの採血のみなので患者の同意を得やすく、どこの診察室でも施行可能な検査となる可能性を持っている。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (21 results)

All 2021 2020 2019 2018

All Journal Article (11 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 11 results,  Open Access: 10 results) Presentation (10 results) (of which Int'l Joint Research: 2 results,  Invited: 4 results)

  • [Journal Article] Role of an Atypical Cadherin Gene, Cdh23 in Prepulse Inhibition and Implication of CDH23 in Schizophrenia2021

    • Author(s)
      Balan S, Ohnishi T, Watanabe A, Ohba H, Iwayama Y, Toyoshima M, Hara T, Hisano Y, Miyasaka Y, Toyota T, Shimamoto-Mitsuyama C, Maekawa M, Numata S, Ohmori T, Shimogori T, Kikkawa Y, Hayashi T, Yoshikawa T
    • Journal Title

      Schizophr Bull

      Volume: - Issue: 4 Pages: 1190-1200

    • DOI

      10.1093/schbul/sbab007

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association between serum folate levels and schizophrenia based on sex.2020

    • Author(s)
      Tomioka Y, Kinoshita M, Umehara H, Nakayama T, Watanabe SY, Nakataki M, Numata S, Ohmori T.
    • Journal Title

      Psychiatry Clin Neurosci.

      Volume: 74 Issue: 9 Pages: 466-471

    • DOI

      10.1111/pcn.13074

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decelerated Epigenetic Aging Associated With Mood Stabilizers in the Blood of Patients With Bipolar Disorder.2020

    • Author(s)
      Okazaki S, Numata S, Otsuka I, Horai T, Kinoshita M, Sora I, Ohmori T, Hishimoto A.
    • Journal Title

      Translational Psychiatry

      Volume: 10 Issue: 1 Pages: 129-129

    • DOI

      10.1038/s41398-020-0813-y

    • NAID

      120006850492

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] <p>ABCA7 Gene Expression and Genetic Association Study in Schizophrenia</p>2020

    • Author(s)
      Yamazaki Kiyohiro、Yoshino Yuta、Kawabe Kentaro、Ibuki Tomomasa、Ochi Shinichiro、Mori Yoko、Ozaki Yuki、Numata Shusuke、Iga Jun-ichi、Ohmori Tetsuro、Ueno Shu-ichi
    • Journal Title

      Neuropsychiatric Disease and Treatment

      Volume: Volume 16 Pages: 441-446

    • DOI

      10.2147/ndt.s238471

    • NAID

      120006999410

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structural variation in the glycogen synthase kinase 3β and brain-derived neurotrophic factor genes in Japanese patients with bipolar disorders.2020

    • Author(s)
      Suga Y, Yoshimoto K, Numata S, Shimodera S, Takamura S, Kamimura N, Sawada K, Kazui H, Ohmori T, Morinobu S.
    • Journal Title

      Neuropsychopharmacol Rep.

      Volume: 40 Issue: 1 Pages: 46-51

    • DOI

      10.1002/npr2.12083

    • NAID

      120007027667

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epigenetic clock analysis of blood samples from Japanese schizophrenia patients.2019

    • Author(s)
      Okazaki S, Otsuka I, Numata S, Horai T, Mouri K, Boku S, Ohmori T, Sora I, Hishimoto A.
    • Journal Title

      NPJ Schizophrenia

      Volume: 5 Issue: 1 Pages: 4-4

    • DOI

      10.1038/s41537-019-0072-1

    • NAID

      120006629323

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Negative and positive self-thought predict subjective QOL in people with schizophrenia2019

    • Author(s)
      Takeda T, Nakataki M, Ohta M, Hamatani S, Matsuura K, Yoshida R, Kameoka N, Tominaga T, Umehara H, Kinoshita M, Watanabe S, Numata S, Sumitani S, Ohmori T.
    • Journal Title

      Neuropsychiatric Disease and Treatment

      Volume: 15 Pages: 293-301

    • DOI

      10.2147/ndt.s190381

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical factors influencing resilience in patients with anorexia nervosa2019

    • Author(s)
      Kane C, Tomotake M, Hamatani S, Chiba S, Kameoka N, Watanabe S, Nakataki M, Numata S, Ohmori T.
    • Journal Title

      Neuropsychiatric Disease and Treatment

      Volume: 15 Pages: 391-395

    • DOI

      10.2147/ndt.s190725

    • NAID

      120006999411

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Elevated peripheral blood glutamate levels in major depressive disorder.2018

    • Author(s)
      Inoshita M, Umehara H, Watanabe SY, Nakataki M, Kinoshita M, Tomioka Y, Tajima A, Numata S, Ohmori T.
    • Journal Title

      Neuropsychiatr Dis Treat.

      Volume: 14 Pages: 945-953

    • DOI

      10.2147/ndt.s159855

    • NAID

      120006772557

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship between social and cognitive functions in people with schizophrenia.2018

    • Author(s)
      Tominaga T, Tomotake M, Takeda T, Ueoka Y, Tanaka T, Watanabe SY, Kameoka N, Nakataki M, Numata S, Izaki Y, Sumitani S, Kubo H, Kaneda Y, Ohmori T.
    • Journal Title

      Neuropsychiatr Dis Treat.

      Volume: 14 Pages: 2215-2224

    • DOI

      10.2147/ndt.s171207

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clozapine Pharmacogenetic Studies in Schizophrenia: Efficacy and Agranulocytosis.2018

    • Author(s)
      Numata S, Umehara H, Ohmori T, Hashimoto R.
    • Journal Title

      Front Pharmacol

      Volume: 9 Pages: 1049-1049

    • DOI

      10.3389/fphar.2018.01049

    • NAID

      120006869522

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] うつ病診断の現状と今後2019

    • Author(s)
      大森哲郎
    • Organizer
      第16回日本うつ病学会総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Effects of processing conditions on plasma L-glutamate levels in non-psychiatrichealthy subjects.2019

    • Author(s)
      Watanabe S, Umehara H, Tomioka Y, Kinoshita M, Nakataki M, Numata S, Ohmori T.
    • Organizer
      6th Congress of AsCNP
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Causal relationship between salience network dysfunction, depressed mood, and subjective quality of life in schizophrenia.2019

    • Author(s)
      Masashi Ohta, Masahito Nakataki, Tomoya Takeda, Shusuke Numata, Takeo Tominaga, Naomi Kameoka, Hiroko Kubo, Makoto Kinoshita, Kanae Matsuura, Maki Ohtomo, Naoya Takeichi, Masafumi Harada, Tetsuro Ohmori.
    • Organizer
      6th Congress of AsCNP
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] うつ病の末梢白血球におけるSGK1遺伝子発現2018

    • Author(s)
      梅原英裕、渡部真也、中瀧理仁、沼田周助、大森哲郎
    • Organizer
      第15回日本うつ病学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] うつ病患者の末梢血グルタミン酸濃度のメタ解析2018

    • Author(s)
      井下真利、梅原英裕、渡部真也、中瀧理仁、木下誠、富岡有紀子、田嶋敦、沼田周助、大森哲郎
    • Organizer
      第15回日本うつ病学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 双極性障害患者におけるアミノ酸系神経伝達物質の異常2018

    • Author(s)
      中瀧理仁、久保弘子、住谷さつき、沼田周助、亀岡尚美、渡部真也、梅原英裕、大田将史、原田雅史、大森哲郎
    • Organizer
      第15回日本うつ病学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Plasma metabolomics of major depressive disorder.2018

    • Author(s)
      沼田周助
    • Organizer
      第40回日本生物学的精神医学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Elevated glutamate levels in blood in mood disorders.2018

    • Author(s)
      Shusuke Numata
    • Organizer
      WFSBP Asia Pacific Regional Congress of Biological Psychiatry
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] The future prospect on postmortem brain research; from the point of view of similarity and dissimilarity between blood and brain.2018

    • Author(s)
      Shusuke Numata
    • Organizer
      第40回日本生物学的精神医学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Altered plasma metabolites related to one-carbon metabolism in schizophrenia.2018

    • Author(s)
      Yukiko Tomioka, Hidehiro Umehara, Shin-ya Watanabe, Masahito Nakataki, Rumiko Masuda, Kazuaki Mawatari, Takeshi Nikawa, Akira Takahashi, Shusuke Numata, Tetsuro Ohmori.
    • Organizer
      WFSBP Asia Pacific Regional Congress of Biological Psychiatry
    • Related Report
      2018 Annual Research Report

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Published: 2018-04-23   Modified: 2022-01-27  

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