| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2021: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Outline of Final Research Achievements |
Somatic mutations occur in genomic DNA in the cranial nervous system contribute to the diversity of structures and functions of neural cells. In addition, their frequency and patterns are considered to be deeply related to the pathophysiology of psychiatric disorders. In this project, we established techniques detecting somatic mutation detection and applied them to analysis of postmortem brain of schizophrenia patients. As a result, we established new pipelines to extract somatic mutations from genomic information and identified somatic mutations in the brain samples of schizophrenia patients.
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