Excitatory Inhibitory Imbalance in Treatment-resistant Schizophrenia: TMS-EEG+MRS study

• Project/Area Number: 18H02755
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 52030:Psychiatry-related
• Research Institution: Keio University
• Principal Investigator: NAKAJIMA Shinichiro 慶應義塾大学, 医学部(信濃町), 講師 (60383866)
• Co-Investigator(Kenkyū-buntansha): 三村 將 慶應義塾大学, 医学部(信濃町), 教授 (00190728) ; 野田 賀大 慶應義塾大学, 医学部(信濃町), 特任准教授 (20807226)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000); Fiscal Year 2021: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2020: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2019: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2018: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
• Keywords: 治療抵抗性統合失調症 / グルタミン酸 / GABA / TMS-EEG / MRS / 統合失調症 / 興奮・抑制バランス / TMSーEEG / MRI / 興奮抑制バランス

Outline of Final Research Achievements

In schizophrenia, basal ganglia glutamate concentrations are elevated, glutamate and GABA concentrations in the middle cingulate gyrus are decreased, basal ganglia glutamate concentrations may decrease with disease progression and antipsychotic treatment, and middle cingulate gyrus GABA concentrations may increase with the onset of We found that the mid-cingulate gyrus GABA concentrations may increase with the onset of illness. Next, we reported increased glutamate concentrations in the middle cingulate gyrus in treatment-resistant schizophrenia. However, while significant differences were found between treatment-resistant schizophrenia and healthy subjects, no statistically significant differences were found between treatment-resistant schizophrenia and schizophrenia in remission, a finding that suggests heterogeneity of the condition within each group. The findings regarding elevated GABA concentrations in treatment-resistant schizophrenia are under review.

Academic Significance and Societal Importance of the Research Achievements

約3割の統合失調症患者に対して抗精神病薬は無効であり、その病態は従来のドパミン仮説では説明できない。新たな治療法の開発のために、興奮・抑制バランス異常仮説は治療抵抗例の病態を説明する仮説として注目を集めている。本研究でも治療抵抗例の脳内グルタミン酸神経系とGABA神経系の異常を明らかにした。この結果から、統合失調症の病態の異質性を、ドーパミン仮説と興奮・抑制不均衡仮説に基づいたディープ・フェノタイピングと多変量解析を用いたバイオタイピング、そのバイオタイプに対するバイオマーカーを用いたクローズド・ループ・ニューロモジュレーションの開発することが期待される。

Research Products

• [Int'l Joint Research] トロント大学/マギール大学(カナダ)
• [Int'l Joint Research] トロント大学/マギール大学(カナダ)
• [Int'l Joint Research] トロント大学(カナダ)
• [Int'l Joint Research] マギール大学(カナダ)
• [Journal Article] Recent Advances and Future Directions in Brain MR Imaging Studies in Schizophrenia: Toward Elucidating Brain Pathology and Developing Clinical Tools (2022)
  • Author(s): Shinsuke Koike, Akiko Uematsu, Daiki Sasabayashi, Norihide Maikusa, Tsutomu Takahashi, Kazutaka Ohi, Shinichiro Nakajima, Yoshihiro Noda, Yoji Hirano
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 21 Issue: 4 Pages: 539-552
  • DOI: 10.2463/mrms.rev.2021-0050
  • NAID: 130008076114
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed / Open Access
• [Journal Article] Neuromelanin accumulation in patients with schizophrenia: A systematic review and meta-analysis (2022)
  • Author(s): Ueno Fumihiko、Iwata Yusuke、Nakajima Shinichiro、Caravaggio Fernando、Rubio Jose M.、Horga Guillermo、Cassidy Clifford M.、Torres-Carmona Edgardo、de Luca Vincenzo、Tsugawa Sakiko、Honda Shiori、Moriguchi Sho、Noda Yoshihiro、Gerretsen Philip、Graff-Guerrero Ariel
  • Journal Title: Neuroscience and Biobehavioral Reviews Volume: 132 Pages: 1205-1213
  • DOI: 10.1016/j.neubiorev.2021.10.028
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Neurophysiological biomarkers using transcranial magnetic stimulation in Alzheimer’s disease and mild cognitive impairment: A systematic review and meta-analysis (2021)
  • Author(s): Mimura Yu、Nishida Hana、Nakajima Shinichiro、Tsugawa Sakiko、Morita Shinji、Yoshida Kazunari、Tarumi Ryosuke、Ogyu Kamiyu、Wada Masataka、Kurose Shin、Miyazaki Takahiro、Blumberger Daniel M.、Daskalakis Zafiris J.、Chen Robert、Mimura Masaru、Noda Yoshihiro
  • Journal Title: Neuroscience & Biobehavioral Reviews Volume: 121 Pages: 47-59
  • DOI: 10.1016/j.neubiorev.2020.12.003
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Frequency drift in MR spectroscopy at 3T (2021)
  • Author(s): Hui SCN,Baltusis L, Barany DA, Dacko M, de la Fuente-Sandoval C, Heise KF, Honda S, Jacobson A, Miller JJ, Mirzakhanian H, Moreno-Ortega M, Mullins PG, Nakajima S
  • Journal Title: NeuroImage Volume: 241 Pages: 118430-118430
  • DOI: 10.1016/j.neuroimage.2021.118430
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Glutathione Levels and Glutathione-Glutamate Correlation in Patients With Treatment-Resistant Schizophrenia (2021)
  • Author(s): Yusuke Iwata, Shinichiro Nakajima, Eric Plitman, Peter Truong, Ali Bani-Fatemi, Fernando Caravaggio, Julia Kim, Parita Shah, Wanna Mar, Sofia Chavez, Gary Remington, Philip Gerretsen, Vincenzo De Luca, Napapon Sailasuta, Ariel Graff-Guerrero
  • Journal Title: Schizophrenia Bulletin Open Volume: 2 Issue: 1
  • DOI: 10.1093/schizbullopen/sgab006
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Dimensional distribution of cortical abnormality across antipsychotics treatment-resistant and responsive schizophrenia (2021)
  • Author(s): Itahashi Takashi、Noda Yoshihiro、Iwata Yusuke、Tarumi Ryosuke、Tsugawa Sakiko、Plitman Eric、Honda Shiori、Caravaggio Fernando、Kim Julia、Matsushita Karin、Gerretsen Philip、Uchida Hiroyuki、Remington Gary、Mimura Masaru、Aoki Yuta Y.、Graff-Guerrero Ariel、Nakajima Shinichiro
  • Journal Title: NeuroImage: Clinical Volume: 32 Pages: 102852-102852
  • DOI: 10.1016/j.nicl.2021.102852
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] TMS-EEG Research to Elucidate the Pathophysiological Neural Bases in Patients with Schizophrenia: A Systematic Review (2021)
  • Author(s): Li Xuemei、Honda Shiori、Nakajima Shinichiro、Wada Masataka、Yoshida Kazunari、Daskalakis Zafiris J.、Mimura Masaru、Noda Yoshihiro
  • Journal Title: Journal of Personalized Medicine Volume: 11 Issue: 5 Pages: 388-388
  • DOI: 10.3390/jpm11050388
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Insights of neurophysiology on unconscious state using combined transcranial magnetic stimulation and electroencephalography: A systematic review (2021)
  • Author(s): Arai Naohiro、Nakanishi Tomoya、Nakajima Shinichiro、Li Xuemei、Wada Masataka、Daskalakis Zafiris J.、Goodman Michelle S.、Blumberger Daniel M.、Mimura Masaru、Noda Yoshihiro
  • Journal Title: Neuroscience and Biobehavioral Reviews Volume: 131 Pages: 293-312
  • DOI: 10.1016/j.neubiorev.2021.09.029
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• [Journal Article] Measuring amphetamine‐induced dopamine release in humans: A comparative meta‐analysis of of [(11) C]-raclopride and [(11) C]-(+)-PHNO studies (2021)
  • Author(s): Caravaggio Fernando、Porco Natasha、Kim Julia、Torres‐Carmona Edgardo、Brown Eric、Iwata Yusuke、Nakajima Shinichiro、Gerretsen Philip、Remington Gary、Graff‐Guerrero Ariel
  • Journal Title: Synapse Volume: 75 Issue: 5
  • DOI: 10.1002/syn.22195
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Development of an Advanced Sham Coil for Transcranial Magnetic Stimulation and Examination of Its Specifications (2021)
  • Author(s): Takano Mayuko、Havlicek Jiri、Phillips Dan、Nakajima Shinichiro、Mimura Masaru、Noda Yoshihiro
  • Journal Title: Journal of Personalized Medicine Volume: 11 Issue: 11 Pages: 1058-1058
  • DOI: 10.3390/jpm11111058
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Photobiological Neuromodulation of Resting-State EEG and Steady-State Visual-Evoked Potentials by 40 Hz Violet Light Optical Stimulation in Healthy Individuals (2021)
  • Author(s): Noda Yoshihiro、Takano Mayuko、Hayano Motoshi、Li Xuemei、Wada Masataka、Nakajima Shinichiro、Mimura Masaru、Kondo Shinichiro、Tsubota Kazuo
  • Journal Title: Journal of Personalized Medicine Volume: 11 Issue: 6 Pages: 557-557
  • DOI: 10.3390/jpm11060557
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Polygenic risk scores for major psychiatric and neurodevelopmental disorders contribute to sleep disturbance in childhood: Adolescent Brain Cognitive Development (ABCD) Study (2021)
  • Author(s): Ohi Kazutaka、Ochi Ryo、Noda Yoshihiro、Wada Masataka、Sugiyama Shunsuke、Nishi Akira、Shioiri Toshiki、Mimura Masaru、Nakajima Shinichiro
  • Journal Title: Translational Psychiatry Volume: 11 Issue: 1 Pages: 187-187
  • DOI: 10.1038/s41398-021-01308-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association between resilience and cortical thickness in the posterior cingulate cortex and the temporal pole in Japanese older people: A population-based cross-sectional study (2021)
  • Author(s): Shikimoto Ryo、Noda Yoshihiro、Kida Hisashi、Nakajima Shinichiro、Tsugawa Sakiko、Mimura Yu、Ochi Ryo、Takayama Midori、Niimura Hidehito、Mimura Masaru
  • Journal Title: Journal of Psychiatric Research Volume: 142 Pages: 89-100
  • DOI: 10.1016/j.jpsychires.2021.07.026
  • Peer Reviewed
• [Journal Article] Glutamatergic and GABAergic metabolite levels in schizophrenia-spectrum disorders: a meta-analysis of 1H-magnetic resonance spectroscopy studies (2021)
  • Author(s): Nakahara T, Tsugawa S, Noda Y, Ueno F, Honda S, Kinjo M, Segawa H, Hondo N, Mori Y, Watanabe H, Nakahara K, Yoshida K, Wada M, Tarumi R, Iwata Y, Plitman E, Moriguchi S, de la Fuente-Sandoval C, Nakajima S.
  • Journal Title: Molecular Psychiatry Volume: 27 Issue: 1 Pages: 744-757
  • DOI: 10.1038/s41380-021-01297-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Gut microbiota and major depressive disorder: A systematic review and meta-analysis (2020)
  • Author(s): Sanada K, Nakajima S, Kurokawa S, et al
  • Journal Title: Journal of Affective Disorders Volume: 266 Pages: 1-13
  • DOI: 10.1016/j.jad.2020.01.102
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• [Journal Article] Insight and medication adherence in schizophrenia: An analysis of the CATIE trial (2020)
  • Author(s): Kim Julia、Ozzoude Miracle、Nakajima Shinichiro、Shah Parita、Caravaggio Fernando、Iwata Yusuke、De Luca Vincenzo、Graff-Guerrero Ariel、Gerretsen Philip
  • Journal Title: Neuropharmacology Volume: 168 Pages: 107634-107634
  • DOI: 10.1016/j.neuropharm.2019.05.011
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Pharmacological management of behavioral disturbances in patients with Alzheimer’s disease (2020)
  • Author(s): Nagata T, Shinagawa S, Nakajima S, Noda Y, Mimura M
  • Journal Title: Expert Opinion on Pharmacotherapy Volume: 21 Issue: 9 Pages: 1093-1102
  • DOI: 10.1080/14656566.2020.1745186
  • Peer Reviewed / Open Access
• [Journal Article] Neuroanatomical profiles of treatment-resistance in patients with schizophrenia spectrum disorders (2020)
  • Author(s): Kim J, Plitman E, Iwata Y, Nakajima S, Mar W, Patel R, Chavez S, Chung JK, Caravaggio F, Chakravarty MM, Remington G, Gerretsen P, Graff-Guerrero A
  • Journal Title: Progress in Neuro-Psychopharmacology and Biological Psychiatry Volume: 99 Pages: 109839-109839
  • DOI: 10.1016/j.pnpbp.2019.109839
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effects on Depression and Anxiety After Mid-Urethral Sling Surgery for Female Stress Urinary Incontinence (2020)
  • Author(s): Kinjo M, Masuda K, Nakamura Y, Taguchi S, Tambo M, Okegawa T, Fukuhara H.
  • Journal Title: Res Rep Urol Volume: 19 Issue: 1 Pages: 495-501
  • DOI: 10.1017/s0033291720004729
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Treatment effects on neurometabolite levels in schizophrenia: A systematic review and meta-analysis of proton magnetic resonance spectroscopy studies. (2020)
  • Author(s): Manabu Kubota, Sho Moriguchi, Keisuke Takahata, Shinichiro Nakajima, Nobuyuki Horita
  • Journal Title: Schizophrenia Research Volume: - Pages: 122-132
  • DOI: 10.1016/j.schres.2020.03.069
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Visualization of AMPA receptors in living human brain with positron emission tomography. (2020)
  • Author(s): Miyazaki T, Nakajima W, Hatano M, Shibata Y, Kuroki Y, Arisawa T, Mimura M, Yuzaki M, Kato H, Higuchi M, Uchida H, Takahashi T.
  • Journal Title: Nature Medicine Volume: 26 Issue: 2 Pages: 281-288
  • DOI: 10.1038/s41591-019-0723-9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Glutamatergic neurometabolites and cortical thickness in treatment-resistant schizophrenia: Implications for glutamate-mediated excitotoxicity (2020)
  • Author(s): Shah P, Plitman E, Iwata Y, Kim J, Nakajima S, Chan N, Brown E, Caravaggio F, Torres E, Hahn M, Chakravarty M, Remington G, Gerretsen P, Graff-Guerrero A
  • Journal Title: Journal of Psychiatric Research Volume: 124 Pages: 151-158
  • DOI: 10.1016/j.jpsychires.2020.02.032
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Approach‐oriented coping strategy level may be related to volume of the whole hippocampus in the elderly (2020)
  • Author(s): Kida H, Nakajima S, Shikimoto R, Ochi R, Noda Y, Tsugawa S, Fujii S, Takayama M, Mimura M, Niimura H
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 74 Issue: 4 Pages: 270-276
  • DOI: 10.1111/pcn.12981
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• [Journal Article] Increased blood COASY DNA methylation levels a potential biomarker for early pathology of Alzheimer’s disease (2020)
  • Author(s): Kobayashi N, Shinagawa S, Niimura H, Kida H, Nagata T, Tagai K, Shimada K, Oka N, Shikimoto R, Noda Y, Nakajima S, Mimura M, Shigeta M, Kondo K
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 12217-12217
  • DOI: 10.1038/s41598-020-69248-9
  • Peer Reviewed / Open Access
• [Journal Article] Treatment effects on neurometabolite levels in schizophrenia: A meta-analysis dataset of proton magnetic resonance spectroscopy (2020)
  • Author(s): Kubota Manabu、Moriguchi Sho、Takahata Keisuke、Nakajima Shinichiro、Horita Nobuyuki
  • Journal Title: Data in Brief Volume: 31 Pages: 105862-105862
  • DOI: 10.1016/j.dib.2020.105862
  • NAID: 120006956392
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] White matter microstructural organizations in patients with severe treatment-resistant schizophrenia: A diffusion tensor imaging study (2020)
  • Author(s): Ochi R, Noda Y, Tsuchimoto S, Tarumi R, Honda S, Matsushita K, Tsugawa S, Plitman E, Masuda F, Ogyu K, Wada M, Miyazaki T, Fujii S, Chakravarty MM, Graff-Guerrero A, Uchida H, Mimura M, Nakajima S
  • Journal Title: Progress in Neuro-Psychopharmacology and Biological Psychiatry Volume: 100 Pages: 109871-109871
  • DOI: 10.1016/j.pnpbp.2020.109871
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Early improvements of individual symptoms as a predictor of treatment response to asenapine in patients with schizophrenia (2020)
  • Author(s): Ogyu K, Noda Y, Yoshida K, Kurose S, Masuda F, Mimura Y, Nishida H, Plitman E, Tarumi R, Tsugawa S, Wada M, Miyazaki T, Uchida H, Graff-Guerrero A, Mimura M, Nakajima S
  • Journal Title: Neuropsychopharmacology Reports Volume: 40 Issue: 2 Pages: 138-149
  • DOI: 10.1002/npr2.12103
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Thalamic and striato-pallidal volumes in schizophrenia patients and individuals at risk for psychosis: A multi-atlas segmentation study. (2020)
  • Author(s): Takahashi T, Tsugawa S, Nakajima S, Plitman E, Chakravarty MM, Masuda F, Wada M, Kurose S, Ochi R, Matsushita K, Sasabayashi D, Nakamura M, Nishikawa Y, Takayanagi Y, Nishiyama S, Higuchi Y, Mizukami Y, Furuichi A, Kido M, Hashimoto R, Noguchi K, Fujii S, Mimura M, Noda Y, Suzuki M.
  • Journal Title: Schizophr Res. Volume: 20 Pages: 268-275
  • DOI: 10.1016/j.schres.2020.04.016
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Resting-State Isolated Effective Connectivity of the Cingulate Cortex as a Neurophysiological Biomarker in Patients with Severe Treatment-Resistant Schizophrenia (2020)
  • Author(s): Wada M, Nakajima S, Tarumi R, Masuda F, Miyazaki T, Tsugawa S, Ogyu K, Honda S, Matsushita K, Kikuchi Y, Fujii S, Blumberger DM, Daskalakis ZJ, Mimura M, Noda Y
  • Journal Title: Journal of Personalized Medicine Volume: 10 Issue: 3 Pages: 89-89
  • DOI: 10.3390/jpm10030089
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Neural correlates of delay discount alterations in addiction and psychiatric disorders: A systematic review of magnetic resonance imaging studies (2020)
  • Author(s): Noda Yoshihiro、Barr Mera S.、ElSalhy Muhammad、Masuda Fumi、Tarumi Ryosuke、Ogyu Kamiyu、Wada Masataka、Tsugawa Sakiko、Miyazaki Takahiro、Nakajima Shinichiro、Mimura Masaru
  • Journal Title: Progress in Neuro-Psychopharmacology and Biological Psychiatry Volume: 99 Pages: 109822-109822
  • DOI: 10.1016/j.pnpbp.2019.109822
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Early Improvements of Individual Symptoms With Antipsychotics Predict Subsequent Treatment Response of Neuropsychiatric Symptoms in Alzheimer’s Disease (2020)
  • Author(s): Nagata T, Shinagawa S, Yoshida K, Noda Y, Shigeta M, Mimura M. Nakajima S
  • Journal Title: The Journal of Clinical Psychiatry Volume: 81 Issue: 2
  • DOI: 10.4088/jcp.19m12961
  • Peer Reviewed / Open Access
• [Journal Article] Levels of glutamatergic neurometabolites in patients with severe treatment-resistant schizophrenia: a proton magnetic resonance spectroscopy study (2019)
  • Author(s): Tarumi Ryosuke、Tsugawa Sakiko、Noda Yoshihiro、Plitman Eric、Honda Shiori、Matsushita Karin、Chavez Sofia、Sawada Kyosuke、Wada Masataka、Matsui Mie、Fujii Shinya、Miyazaki Takahiro、Chakravarty M. Mallar、Uchida Hiroyuki、Remington Gary、Graff-Guerrero Ariel、Mimura Masaru、Nakajima Shinichiro
  • Journal Title: Neuropsychopharmacology Volume: 45 Issue: 4 Pages: 632-640
  • DOI: 10.1038/s41386-019-0589-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Glutathione levels and activities of glutathione metabolism enzymes in patients with schizophrenia: A systematic review and meta-analysis (2019)
  • Author(s): Tsugawa Sakiko、Noda Yoshihiro、Tarumi Ryosuke、Mimura Yu、Yoshida Kazunari、Iwata Yusuke、Elsalhy Muhammad、Kuromiya Minori、Kurose Shin、Masuda Fumi、Morita Shinji、Ogyu Kamiyu、Plitman Eric、Wada Masataka、Miyazaki Takahiro、Graff-Guerrero Ariel、Mimura Masaru、Nakajima Shinichiro
  • Journal Title: Journal of Psychopharmacology Volume: 33 Issue: 10 Pages: 1199-1214
  • DOI: 10.1177/0269881119845820
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Motor cortex excitability and inhibitory imbalance in autism spectrum disorder assessed with transcranial magnetic stimulation: a systematic review (2019)
  • Author(s): Masuda Fumi、Nakajima Shinichiro、Miyazaki Takahiro、Yoshida Kazunari、Tsugawa Sakiko、Wada Masataka、Ogyu Kamiyu、Croarkin Paul E.、Blumberger Daniel M.、Daskalakis Zafiris J.、Mimura Masaru、Noda Yoshihiro
  • Journal Title: Translational Psychiatry Volume: 9 Issue: 1
  • DOI: 10.1038/s41398-019-0444-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical effectiveness of repetitive transcranial magnetic stimulation treatment in children and adolescents with neurodevelopmental disorders: A systematic review (2019)
  • Author(s): Masuda Fumi、Nakajima Shinichiro、Miyazaki Takahiro、Tarumi Ryosuke、Ogyu Kamiyu、Wada Masataka、Tsugawa Sakiko、Croarkin Paul E、Mimura Masaru、Noda Yoshihiro
  • Journal Title: Autism Volume: なし Issue: 7 Pages: 1614-1629
  • DOI: 10.1177/1362361318822502
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Glutamatergic Neurometabolite Levels in Patients With Ultra-Treatment-Resistant Schizophrenia: A Cross-Sectional 3T Proton Magnetic Resonance Spectroscopy Study (2019)
  • Author(s): Iwata Yusuke、Nakajima Shinichiro、Plitman Eric、Caravaggio Fernando、Kim Julia、Shah Parita、Mar Wanna、Chavez Sofia、De Luca Vincenzo、Mimura Masaru、Remington Gary、Gerretsen Philip、Graff-Guerrero Ariel
  • Journal Title: Biological Psychiatry Volume: 85 Issue: 7 Pages: 596-605
  • DOI: 10.1016/j.biopsych.2018.09.009
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Effectiveness of the prefrontal repetitive transcranial magnetic stimulation on cognitive profiles in depression, schizophrenia, and Alzheimer's disease: A systematic review (2019)
  • Author(s): Iimori Takashi、Nakajima Shinichiro、Miyazaki Takahiro、Tarumi Ryosuke、Ogyu Kamiyu、Wada Masataka、Tsugawa Sakiko、Masuda Fumi、Daskalakis Zafiris J.、Blumberger Daniel M.、Mimura Masaru、Noda Yoshihiro
  • Journal Title: Progress in Neuro-Psychopharmacology and Biological Psychiatry Volume: 88 Pages: 31-40
  • DOI: 10.1016/j.pnpbp.2018.06.014
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Glutamatergic neurometabolite levels in major depressive disorder: a systematic review and meta-analysis of proton magnetic resonance spectroscopy studies (2018)
  • Author(s): Moriguchi Sho、Takamiya Akihiro、Noda Yoshihiro、Horita Nobuyuki、Wada Masataka、Tsugawa Sakiko、Plitman Eric、Sano Yasunori、Tarumi Ryosuke、ElSalhy Muhammad、Katayama Nariko、Ogyu Kamiyu、Miyazaki Takahiro、Kishimoto Taishiro、Graff-Guerrero Ariel、Nakajima Shinichiro
  • Journal Title: Molecular Psychiatry Volume: in press Issue: 7 Pages: 952-964
  • DOI: 10.1038/s41380-018-0252-9
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The impact of delay in clozapine initiation on treatment outcomes in patients with treatment-resistant schizophrenia: A systematic review (2018)
  • Author(s): Shah Parita、Iwata Yusuke、Plitman Eric、Brown Eric E.、Caravaggio Fernando、Kim Julia、Nakajima Shinichiro、Hahn Margaret、Remington Gary、Gerretsen Philip、Graff-Guerrero Ariel
  • Journal Title: Psychiatry Research Volume: 268 Pages: 114-122
  • DOI: 10.1016/j.psychres.2018.06.070
  • Peer Reviewed / Int'l Joint Research
• [Presentation] 治療抵抗性統合失調症とクロザピン (2021)
  • Author(s): 中島振一郎
  • Organizer: 藤沢家族会
  • Invited
• [Presentation] 精神疾患治療におけるニューロモジュレーションの現状と開発の動向 (2021)
  • Author(s): 中島振一郎
  • Organizer: 第43回日本生物学的精神医学会・第51回日本神経精神薬理学会合同年会
• [Presentation] NPPR が向かうべき未来：オープンサイエンス時代の学会誌のあり方を考える (2021)
  • Author(s): 中島振一郎
  • Organizer: 第43回日本生物学的精神医学会・第51回日本神経精神薬理学会合同年会
• [Presentation] Excitability/Inhibitory Imbalance in Patients with Treatment-resistant Mental Illness ; a Trans-diagnostic Study, 2021 Brain-periphery interactions in health and diseases (2021)
  • Author(s): 中島振一郎
  • Organizer: 上原国際シンポジウム
  • Invited
• [Presentation] 統合失調症の脳画像研究最新知見―病態解明および臨床応用に向けて (2021)
  • Author(s): 中島振一郎
  • Organizer: 第15回日本統合失調症学会