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Development of minimum invasive real-time markerless image guided radiotherapy technique using minimum space information.

Research Project

Project/Area Number 18H02758
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionHokkaido University

Principal Investigator

Shimizu Shinichi  北海道大学, 医学研究院, 教授 (50463724)

Co-Investigator(Kenkyū-buntansha) 宮本 直樹  北海道大学, 工学研究院, 准教授 (00552879)
高尾 聖心  北海道大学, 大学病院, 助教 (10614216)
梅垣 菊男  北海道大学, 工学研究院, 特任教授 (40643193)
橋本 孝之  北海道大学, 医学研究院, 准教授 (60400678)
木下 留美子  北海道大学, 大学病院, 助教 (70507582)
吉村 高明  北海道大学, 保健科学研究院, 助教 (70807742)
西岡 健太郎  北海道大学, 医学研究院, 助教 (80463743)
加藤 徳雄  北海道大学, 医学研究院, 准教授 (80572495)
田口 大志  北海道大学, 大学病院, 助教 (90374454)
松浦 妙子  北海道大学, 工学研究院, 准教授 (90590266)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywords医学物理(学) / 医学物理(学)
Outline of Final Research Achievements

In the real-time tumor tracking radiotherapy, feature point information, that is used for gating, is obtained by fluoroscopic X-ray images. There still problems exist:1.X-ray exposure from diagnostic X ray that used for gating 2.insertion of a gold marker etc. as a feature pointReduce or eliminate X-ray exposure by making the observing area through diagnostic X-rays as small as possible to acquire target movement information or establishing the method of processing gating information obtained using MRI technology without using fluoroscopy were considered to be the goal of this study.
X-rays are still optimal for acquiring organ motion information within human body necessary for gating treatment in real time, but a method for limiting the range was achieved in this study. In addition, we succeeded in trying to visualize the position of organs with MRI image data without using X-rays when preparing for treatment, and there were expectations for the promotion of future research.

Academic Significance and Societal Importance of the Research Achievements

本研究では実時間画像誘導陽子線治療データを用いることにより、治療中透視画像動画から、特徴点近傍のみを抽出した画像を作成し、この画像を用いて治療放射線制御シミュレーションを行うソフトウェア環境を構築や、実質的にMRIを用いた前立腺の尿道を中心とした特徴点のデータ抽出、可視化を成果として発表するなど、より患者負担の少ない放射線治療の実現に向けて必要な基礎的理論を構築、実証を行った。
MRI画像を用いて放射線治療計画やゲーティング照射を行う海外製品が上市され始める中、日本国内企業との連携、国内製品への展開などを見据え、企業研究者と行った技術要素開発は社会的意義あるものであったと考える。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (53 results)

All 2021 2020 2019 2018 Other

All Int'l Joint Research (10 results) Journal Article (14 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 14 results,  Open Access: 14 results) Presentation (23 results) (of which Int'l Joint Research: 15 results,  Invited: 9 results) Book (3 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 1 results)

  • [Int'l Joint Research] University of Groningen/University Medical Center Utrecht(オランダ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Paul Scherrer Institute(スイス)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] The University of Sydney(オーストラリア)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] MD Anderson Cancer Center/Stanford University/Mayo Clinic(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Ecole Cantrale Paris(フランス)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of Groningen/University Medical Center Utrecht(オランダ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Paul Scherrer Institute(スイス)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] The University of Sydney(オーストラリア)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] MDAnderson Cancer Center/Stanford University(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Ecole Centrale Paris(フランス)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Potential benefits of adaptive intensity-modulated proton therapy in nasopharyngeal carcinomas.2021

    • Author(s)
      Minatogawa H, Yasuda K, Dekura Y, Takao S, Matsuura T, Yoshimura T, Suzuki R, Yokota I, Fujima N, Onimaru R, Shimizu S, Aoyama H, Shirato H.
    • Journal Title

      Journal of Applied Clinical Medical Physics

      Volume: 22 Issue: 1 Pages: 174-183

    • DOI

      10.1002/acm2.13128

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Quantitative analysis of treatments using real‐time image gated spot‐scanning with synchrotron‐based proton beam therapy system log data2020

    • Author(s)
      Yoshimura Takaaki、Shimizu Shinichi、Hashimoto Takayuki、Nishioka Kentaro、Katoh Norio、Taguchi Hiroshi、Yasuda Koichi、Matsuura Taeko、Takao Seishin、Tamura Masaya、Tanaka Sodai、Ito Yoichi M.、Matsuo Yuto、Tamura Hiroshi、Horita Kenji、Umegaki Kikuo、Shirato Hiroki
    • Journal Title

      Journal of Applied Clinical Medical Physics

      Volume: 21 Issue: 12 Pages: 10-19

    • DOI

      10.1002/acm2.13029

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fast spot-scanning proton dose calculation method with uncertainty quantification using a three-dimensional convolutional neural network2020

    • Author(s)
      Nomura Yusuke、Wang Jeff、Shirato Hiroki、Shimizu Shinichi、Xing Lei
    • Journal Title

      Physics in Medicine & Biology

      Volume: 65 Issue: 21 Pages: 215007-215007

    • DOI

      10.1088/1361-6560/aba164

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The impact of dose delivery time on biological effectiveness in proton irradiation with various biological parameters2020

    • Author(s)
      Kasamatsu Koki、Matsuura Taeko、Tanaka Sodai、Takao Seishin、Miyamoto Naoki、Nam Jin‐Min、Shirato Hiroki、Shimizu Shinichi、Umegaki Kikuo
    • Journal Title

      Medical Physics

      Volume: 47 Issue: 9 Pages: 4644-4655

    • DOI

      10.1002/mp.14381

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Use of 3-D Contrast-Enhanced Ultrasound to Evaluate Tumor Microvasculature After Nanoparticle-Mediated Modulation2020

    • Author(s)
      Kwon Jihun、Rajamahendiran Rajalekha M.、Virani Needa A.、Kunjachan Sijumon、Snay Erin、Harlacher Max、Myronakis Marios、Shimizu Shinichi、Shirato Hiroki、Czernuszewicz Tomasz J.、Gessner Ryan、Berbeco Ross
    • Journal Title

      Ultrasound in Medicine & Biology

      Volume: 46 Issue: 2 Pages: 369-376

    • DOI

      10.1016/j.ultrasmedbio.2019.09.019

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Difference in LET‐based biological doses between IMPT optimization techniques: Robust and PTV‐based optimizations2020

    • Author(s)
      Hirayama Shusuke、Matsuura Taeko、Yasuda Koichi、Takao Seishin、Fujii Takaaki、Miyamoto Naoki、Umegaki Kikuo、Shimizu Shinichi
    • Journal Title

      Journal of Applied Clinical Medical Physics

      Volume: - Issue: 4 Pages: 1-9

    • DOI

      10.1002/acm2.12844

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Projection‐domain scatter correction for cone beam computed tomography using a residual convolutional neural network2019

    • Author(s)
      Nomura Yusuke、Xu Qiong、Shirato Hiroki、Shimizu Shinichi、Xing Lei
    • Journal Title

      Medical Physics

      Volume: 46 Issue: 7 Pages: 3142-3155

    • DOI

      10.1002/mp.13583

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Modified fast adaptive scatter kernel superposition (mfASKS) correction and its dosimetric impact on CBCT‐based proton therapy dose calculation2019

    • Author(s)
      Nomura Yusuke、Xu Qiong、Peng Hao、Takao Seishin、Shimizu Shinichi、Xing Lei、Shirato Hiroki
    • Journal Title

      Medical Physics

      Volume: 47 Issue: 1 Pages: 190-200

    • DOI

      10.1002/mp.13878

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Impact of organ motion on volumetric and dosimetric parameters in stomach lymphomas treated with intensity‐modulated radiotherapy2019

    • Author(s)
      Uchinami Yusuke、Suzuki Ryusuke、Katoh Norio、Taguchi Hiroshi、Yasuda Koichi、Miyamoto Naoki、Ito Yoichi M.、Shimizu Shinichi、Shirato Hiroki
    • Journal Title

      Journal of Applied Clinical Medical Physics

      Volume: 20 Issue: 8 Pages: 78-86

    • DOI

      10.1002/acm2.12681

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Quantitative evaluation of image recognition performance of fiducial markers in real-time tumor-tracking radiation therapy2019

    • Author(s)
      Naoki Miyamoto, Kenichiro Maeda, Daisuke Abo, Ryo Morita, Seishin Takao, Taeko Matsuura, Norio Katoh, Kikuo Umegaki, Shinichi Shimizu, Hiroki Shirato
    • Journal Title

      Physica Medica

      Volume: 65 Pages: 33-39

    • DOI

      10.1016/j.ejmp.2019.08.004

    • NAID

      120006890334

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lambda-Carrageenan Enhances the Effects of Radiation Therapy in Cancer Treatment by Suppressing Cancer Cell Invasion and Metastasis through Racgap1 Inhibition2019

    • Author(s)
      Wu Ping-Hsiu、Onodera Yasuhito、Recuenco Frances C.、Giaccia Amato J.、Le Quynh-Thu、Shimizu Shinichi、Shirato Hiroki、Nam Jin-Min
    • Journal Title

      Cancers

      Volume: 11 Issue: 8 Pages: 1192-1192

    • DOI

      10.3390/cancers11081192

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Literature Review of Proton Beam Therapy for Prostate Cancer in Japan2019

    • Author(s)
      Hoshina R M, Matsuura T, Umegaki K, Shimizu S
    • Journal Title

      Journal of Clinical Medicine

      Volume: 8 Issue: 1 Pages: 48-48

    • DOI

      10.3390/jcm8010048

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Patterns of proton therapy use in pediatric cancer management in 2016: An international survey2019

    • Author(s)
      Journy N, Indelicato DJ, Withrow DR, Akimoto T, Alapetite C, Araya M, Chang A, Chang JH, Chon B, Confer ME, Demizu Y, Dendale R, Doyen J, Ermoian R, Gurtner K, Hill-Kayser C, Iwata H, Kim JY, Kwok Y,... Shimizu S...
    • Journal Title

      Radiotherapy and Oncology

      Volume: 132 Pages: 155-161

    • DOI

      10.1016/j.radonc.2018.10.022

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] An analytical dose-averaged LET calculation algorithm considering the off-axis LET enhancement by secondary protons for spot-scanning proton therapy.2018

    • Author(s)
      Hirayama S, Matsuura T, Ueda H, Fujii Y, Fujii T, Takao S, Miyamoto N, Shimizu S, Fujimoto R, Umegaki K, Shirato H.
    • Journal Title

      Med Phys.

      Volume: 45 Issue: 7 Pages: 3404-3416

    • DOI

      10.1002/mp.12991

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] アフターコロナ時代を見据えた医療負荷軽減に資する適応治療支援システムの開発2020

    • Author(s)
      清水 伸一
    • Organizer
      日本放射線腫瘍学会学術大会報文集
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Automatic bladder delineation on MR images using a convolution neural network for online image-guided radiotherapy2020

    • Author(s)
      西岡健太郎
    • Organizer
      62nd American Society of Radiation Oncology
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Proton Beam Therapy for Patients with Intracranial Ependymoma under 3 Years Old: Initial Clinical Outcomes2020

    • Author(s)
      橋本 孝之
    • Organizer
      The 19th International Symposium on Pediatric Neuro-Oncology
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Visualizing the prostatic urinary tract with post-urination MRI : Inter-operator contouring accuracy2020

    • Author(s)
      吉村 高明
    • Organizer
      Proceedings of the Annual Meeting of JASTRO
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 陽子線治療の現在・これから2019

    • Author(s)
      清水 伸一
    • Organizer
      第48回放射線による制癌シンポジウム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Overview about clinical indications of moving targets-state of the art photon and proton treatment2019

    • Author(s)
      清水 伸一
    • Organizer
      Visiting Professor Talk at Mayo Clinic
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 高リスク前立に対する陽子線治療・現状と可能性2019

    • Author(s)
      清水 伸一
    • Organizer
      日本泌尿器腫瘍学会第5回学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Quantitative analysis of treatment process flow using real-time-image gated-spot-scanning proton-beam delivery log system2019

    • Author(s)
      吉村 高明
    • Organizer
      58th Annual Meeting for the Particle Therapy Co-operative Group (PTCOG)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prospective data registration in proton beam therapy nation-wide evaluation trial (PROTON-NET) using unified treatment protocols with central and onsite monitoring2019

    • Author(s)
      清水 伸一
    • Organizer
      Particle Therapy Co-Operative Group58(PTCOG)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Four-dimensional Radiation Oncology, Real-time-image Guided Radiation therapy2019

    • Author(s)
      清水 伸一
    • Organizer
      The 6th GI-CoRE Summer School for Medical Physics 2019 and Hokkaido Summer Institute 2019 -Medical Physics School
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] スポットスキャニング陽子線治療における照射中線量分布モニタリング技術の開発2018

    • Author(s)
      清水伸一
    • Organizer
      第83回日本核医学会北日本地方会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ハイリスク前立腺がんに対する強度変調放射線治療・陽子線治療・現状と可能性2018

    • Author(s)
      清水 伸一
    • Organizer
      第56回日本癌治療学会学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Clinical application of gated X-ray and particle beam therapy using real-time images2018

    • Author(s)
      清水 伸一
    • Organizer
      The 6th Taiwan-Japan Radiation Oncology Symposium (TJROS)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Four-dimensional Radiation Oncology, Real-time-image Guided Radiotherapy2018

    • Author(s)
      清水 伸一
    • Organizer
      The 2nd GI-CoRE GSQ, GSB, & IGM JOINT SYMPOSIUM
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Analysis of Beam Delivery Times and Dose Rates for the Treatment of Mobile Tumors Using Real Time Image Gated Spot-Scanning Proton Beam Therapy2018

    • Author(s)
      清水 伸一
    • Organizer
      ASTRO
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 実時間画像誘導技術と放射線治療2018

    • Author(s)
      清水 伸一
    • Organizer
      第55回生態応用科学研究セミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Four-year treatment experience and efficiency with real timeimagegated proton therapy (RGPT) and IGRT system2018

    • Author(s)
      清水 伸一
    • Organizer
      MD AndersonStanford Conference(post-ASTRO meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Overview about clinical indications of moving targets - state of the art photon and proton treatment2018

    • Author(s)
      清水 伸一
    • Organizer
      4D Treatment Workshop for Particle Therapy
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dosimetric and beam delivery time analysis of pediatric intensity-modulated spot-scanning craniospinal proton irradiation with or without anterior vertebral body sparing2018

    • Author(s)
      橋本 孝之
    • Organizer
      57th Annual Meeting for the Particle Therapy Cooperative Group (PTCOG) and the 5th Annual Meeting of PTCOG
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Real-Time Volumetric Image Generation with CT Image Deformation Driven by Displacement of Internal Fiducial2018

    • Author(s)
      宮本 直樹
    • Organizer
      2018 AAPM Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Real-time volumetric image generation with CT image deformation driven by displacement of internal fiducial markers2018

    • Author(s)
      宮本 直樹
    • Organizer
      第116回日本医学物理学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 北海道大学病院における強度変調陽子線治療(IMPT)の経験2018

    • Author(s)
      吉村 高明
    • Organizer
      第15回日本粒子線治療臨床研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Big Data Analysis of Treatment Process Time for the Real-time-image Gated-spot-scanning Proton-beam Therapy (RGPT) System2018

    • Author(s)
      吉村 高明
    • Organizer
      The 60th Annual meeting for American Society for Radiation Oncology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Book] 泌尿器科Vol.11 No.42020

    • Author(s)
      清水伸一,橋本孝之,西岡健太郎
    • Total Pages
      5
    • Publisher
      科学評論社
    • Related Report
      2020 Annual Research Report
  • [Book] 日本臨床 第78巻第6号2020

    • Author(s)
      清水伸一,西岡健太郎,橋本孝之
    • Total Pages
      5
    • Publisher
      日本臨牀社
    • Related Report
      2020 Annual Research Report
  • [Book] 高齢者がん医療Q&A(膀胱癌-放射線治療)2020

    • Author(s)
      清水伸一,西岡健太郎
    • Total Pages
      3
    • Publisher
      金原出版
    • ISBN
      9784307204187
    • Related Report
      2020 Annual Research Report
  • [Patent(Industrial Property Rights)] 動体追跡装置とそれを備えた放射線治療システム、プログラム、および動体の追跡方法2019

    • Inventor(s)
      清水伸一
    • Industrial Property Rights Holder
      清水伸一
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] 粒子線治療システム2018

    • Inventor(s)
      清水 伸一
    • Industrial Property Rights Holder
      清水 伸一
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Acquisition Date
      2019
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] 放射線照射計画装置、臨床判断支援装置およびプログラム2018

    • Inventor(s)
      清水 伸一
    • Industrial Property Rights Holder
      清水 伸一
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Acquisition Date
      2019
    • Related Report
      2019 Annual Research Report
    • Overseas

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Published: 2018-04-23   Modified: 2022-01-27  

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