| Budget Amount *help |
¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2022: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2021: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
In an animal model of Alzheimer's disease, tissue synaptic density was measured after gluCEST measurement and correlated with gluCEST values. In temporal lobe and hippocampus, we found a decrease in gluCEST preceding a decrease in CBF and a correlation between local gluCEST effects and CBF. Furthermore, we applied this technique to humans, developed 2D gluCEST with 7T MRI, confirmed its reproducibility in normal cases, and confirmed the reduction of hippocampal synapses in dementia cases. We are currently improving the pulse sequence and modifying the image calculation program to shorten the imaging time. Furthermore, we created a 3D imaging sequence and verified the reproducibility of whole-brain synaptic density images in normal cases. 3T MRI application and implantation have been started and normal brains have been successfully imaged.
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