Imaging neurofibrillary tangles and astrogliosis for the clarification of the pathogenesis of Alzheimer's disease

• Project/Area Number: 18H02771
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Tohoku Medical and Pharmaceutical University
• Principal Investigator: Okamura Nobuyuki 東北医科薬科大学, 医学部, 教授 (40361076)
• Project Period (FY): 2018-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000); Fiscal Year 2022: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2021: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2020: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2019: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000); Fiscal Year 2018: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: アルツハイマー病 / 神経炎症 / アストログリオーシス / イメージング / アミロイド / タウ / モノアミン酸化酵素 / PET / アストロサイト

Outline of Final Research Achievements

[18F]SMBT-1 was successfully developed for in vivo imaging of reactive astrogliosis in the human brain. In the clinical study, [18F]SMBT-1 PET showed positive findings not only in patients with Alzheimer's disease but also in amyloid-positive cognitively normal elderly. These findings suggest that the proliferation of reactive astrocytes is an early event that is closely associated with amyloid-beta accumulation in Alzheimer's disease continuum.
We further developed a novel tau PET probe, [18F]SNFT-1. [18F]SNFT-1 showed high binding affinity and selectivity for tau aggregates in Alzheimer's disease brains, suggesting the potential usefulness for in vivo detection of early tau pathology.

Academic Significance and Societal Importance of the Research Achievements

[18F]SMBT-1 PETは、アルツハイマー病の病初期から発生する神経炎症（反応性アストログリオーシス）を生体脳において優れた感度で検出できることが証明され、今後、多様な神経疾患における神経炎症の把握や、新規治療薬開発におけるバイオマーカーとしての活用が期待できる。新規タウPETプローブ[18F]SNFT-1は既存のタウPETプローブよりも高い感度で、アルツハイマー病の初期タウ病理を描出できる可能性が本研究結果から示唆され、今後の臨床研究の成果が期待される。

Research Products

• [Int'l Joint Research] The University of Melbourne(オーストラリア)
• [Int'l Joint Research] Houston Methodist/University of Pittsburgh(米国)
• [Int'l Joint Research] Institute for Basic Science/Yonsei University(韓国)
• [Int'l Joint Research] McGill University(カナダ)
• [Int'l Joint Research] Karolinska Institutet(スウェーデン)
• [Int'l Joint Research] メルボルン大学(オーストラリア)
• [Int'l Joint Research] メルボルン大学(オーストラリア)
• [Int'l Joint Research] メルボルン大学(オーストラリア)
• [Journal Article] In vivo [18F]THK-5351 imaging detected reactive astrogliosis in argyrophilic grain disease with comorbid pathology: A clinicopathological study (2023)
  • Author(s): Ryota Kobayashi , Tadaho Nakamura, Fumito Naganuma, Ryuichi Harada, Daichi Morioka, Masafumi Kanoto, Shozo Furumoto, Yukitsuka Kudo, Takanobu Kabasawa, Koichi Otani, Mitsuru Futakuchi , Shinobu Kawakatsu, Nobuyuki Okamura
  • Journal Title: J Neuropathol Exp Neurol . Volume: - Issue: 5 Pages: 427-437
  • DOI: 10.1093/jnen/nlad018
  • Peer Reviewed / Open Access
• [Journal Article] In vivo imaging of astrogliosis by PET (2023)
  • Author(s): Harada Ryuichi、Okamura Nobuyuki
  • Journal Title: Folia Pharmacologica Japonica Volume: 158 Issue: 1 Pages: 26-29
  • DOI: 10.1254/fpj.22091
  • ISSN: 0015-5691, 1347-8397
• [Journal Article] First-in-human evaluation of ¹⁸F-SMBT-1, a novel ¹⁸F-labeled MAO-B PET tracer for imaging reactive astrogliosis (2022)
  • Author(s): Villemagne Victor L、Harada Ryuichi、Dore Vincent、Furumoto Shozo、Mulligan Rachel、Kudo Yukitsuka、Burnham Samantha、Krishnadas Natasha、Bozinovski Svetlana、Huang Kun、Lopresti Brian J、Yanai Kazuhiko、Rowe Christopher C、Okamura Nobuyuki
  • Journal Title: Journal of Nuclear Medicine Volume: - Issue: 10 Pages: 1551-1559
  • DOI: 10.2967/jnumed.121.263254
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Assessing reactive astrogliosis with 18F-SMBT-1 across the Alzheimer’s disease spectrum (2022)
  • Author(s): Villemagne Victor L、Harada Ryuichi、Dore Vincent、Furumoto Shozo、Mulligan Rachel、Kudo Yukitsuka、Burnham Samantha、Krishnadas Natasha、Bourgeat Pierrick、Xia Ying、Laws Simon、Bozinovski Svetlana、Huang Kun、Ikonomovic Milos D、Fripp Jurgen、Yanai Kazuhiko、Okamura Nobuyuki、Rowe Christopher C
  • Journal Title: Journal of Nuclear Medicine Volume: - Issue: 10 Pages: 1560-1569
  • DOI: 10.2967/jnumed.121.263255
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Middle Cerebellar Peduncle in Early Stage of Multiple System Atrophy: A THK5351 PET Study (2022)
  • Author(s): Horimoto Yoshihiko、Hayashi Emi、Okamura Nobuyuki、Inagaki Aki、Yasui Keizo、Uchida Yuto、Ito Yoshihiro、Iida Akihiko、Sato Chikako、Anan Chise、Suzuki Ayuko、Tajima Toshihisa、Hibino Hiroaki、Kabasawa Hidehiro、Matsukawa Noriyuki
  • Journal Title: Movement Disorders Volume: 37 Issue: 9 Pages: 1957-1959
  • DOI: 10.1002/mds.29143
  • Peer Reviewed
• [Journal Article] Imaging of Reactive Astrogliosis by Positron Emission Tomography (2022)
  • Author(s): Harada Ryuichi、Furumoto Shozo、Kudo Yukitsuka、Yanai Kazuhiko、Villemagne Victor L.、Okamura Nobuyuki
  • Journal Title: Frontiers in Neuroscience Volume: 16 Pages: 807435-807435
  • DOI: 10.3389/fnins.2022.807435
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The Role of Chirality of [¹⁸F]SMBT-1 in Imaging of Monoamine Oxidase-B (2022)
  • Author(s): Harada Ryuichi、Shimizu Yuki、Du Yiqing、Ishikawa Yoichi、Iwata Ren、Kudo Yukitsuka、Yanai Kazuhiko、Okamura Nobuyuki、Furumoto Shozo
  • Journal Title: ACS Chemical Neuroscience Volume: 13 Issue: 3 Pages: 322-329
  • DOI: 10.1021/acschemneuro.1c00655
  • Peer Reviewed
• [Journal Article] Patterns of Distribution of 18F-THK5351 Positron Emission Tomography in Alzheimer’s Disease Continuum (2022)
  • Author(s): Nihashi Takashi、Sakurai Keita、Kato Takashi、Iwata Kaori、Kimura Yasuyuki、Ikenuma Hiroshi、Yamaoka Akiko、Takeda Akinori、Arahata Yutaka、Washimi Yukihiko、Suzuki Keisuke、Bundo Masahiko、Sakurai Takashi、Okamura Nobuyuki、Yanai Kazuhiko、Ito Kengo、Nakamura Akinori、MULNIAD Study Group
  • Journal Title: Journal of Alzheimer's Disease Volume: 85 Issue: 1 Pages: 223-234
  • DOI: 10.3233/jad-215024
  • Peer Reviewed
• [Journal Article] 18F-THK5351 PET imaging in neurodegenerative tauopathies (2021)
  • Author(s): Ezura M, Kikuchi A, Okamura N, Ishiki A, Hasegawa T, Harada R, Watanuki S, Funaki Y, Hiraoka K, Baba T, Sugeno N, Yoshida S, Kobayashi J, Kobayashi M, Tano O, Ishiyama S, Nakamura T, Nakashima I, Mugikura S, Iwata R, Taki Y, Furukawa K, Arai H, Furumoto S, Tashiro M, Yanai K, Kudo Y, Takeda A, Aoki M
  • Journal Title: Front Aging Neurosci Volume: 13 Pages: 761010-761010
  • DOI: 10.3389/fnagi.2021.761010
  • Peer Reviewed / Open Access
• [Journal Article] Characterization of an APP/tau rat model of Alzheimer’s disease by positron emission tomography and immunofluorescent labeling (2021)
  • Author(s): Filip Thomas、Mairinger Severin、Neddens Joerg、Sauberer Michael、Flunkert Stefanie、Stanek Johann、Wanek Thomas、Okamura Nobuyuki、Langer Oliver、Hutter-Paier Birgit、Kuntner Claudia
  • Journal Title: Alzheimer's Research & Therapy Volume: 13 Issue: 1 Pages: 175-175
  • DOI: 10.1186/s13195-021-00916-2
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] [18F]SMBT-1を用いた反応性アストロサイトのPETイメージング (2021)
  • Author(s): 岡村信行，原田龍一
  • Journal Title: Dementia Japan Volume: 35 Pages: 339-345
• [Journal Article] Identification of Heterogeneous Subtypes of Mild Cognitive Impairment Using Cluster Analyses Based on PET Imaging of Tau and Astrogliosis (2021)
  • Author(s): Lee Hyun Jeong、Lee Eun-Chong、Seo Seongho、Ko Kwang-Pil、Kang Jae Myeong、Kim Woo-Ram、Seo Ha-Eun、Lee Sang-Yoon、Lee Yeong-Bae、Park Kee Hyung、Yeon Byeong Kil、Okamura Nobuyuki、Na Duk L.、Seong Joon-Kyung、Noh Young
  • Journal Title: Frontiers in Aging Neuroscience Volume: 12 Pages: 615467-615467
  • DOI: 10.3389/fnagi.2020.615467
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Synthesis and pharmacokinetic characterisation of a fluorine-18 labelled brain shuttle peptide fusion dimeric affibody (2021)
  • Author(s): Morito Takahiro、Harada Ryuichi、Iwata Ren、Du Yiqing、Okamura Nobuyuki、Kudo Yukitsuka、Yanai Kazuhiko
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 2588-2588
  • DOI: 10.1038/s41598-021-82037-2
  • Peer Reviewed / Open Access
• [Journal Article] Synthesis and evaluation of 2-pyrrolopyridinylquinoline derivatives as selective tau PET tracers for the diagnosis of Alzheimer's disease (2021)
  • Author(s): Lerdsirisuk Pradith、Harada Ryuichi、Hayakawa Yoshimi、Shimizu Yuki、Ishikawa Yoichi、Iwata Ren、Kudo Yukitsuka、Okamura Nobuyuki、Furumoto Shozo
  • Journal Title: Nuclear Medicine and Biology Volume: 93 Pages: 11-18
  • DOI: 10.1016/j.nucmedbio.2020.10.002
  • Peer Reviewed
• [Journal Article] 18F-SMBT-1: A Selective and Reversible PET Tracer for Monoamine Oxidase-B Imaging (2020)
  • Author(s): Harada Ryuichi、Hayakawa Yoshimi、Ezura Michinori、Lerdsirisuk Pradith、Du Yiqing、Ishikawa Yoichi、Iwata Ren、Shidahara Miho、Ishiki Aiko、Kikuchi Akio、Arai Hiroyuki、Kudo Yukitsuka、Yanai Kazuhiko、Furumoto Shozo、Okamura Nobuyuki
  • Journal Title: Journal of Nuclear Medicine Volume: 62 Issue: 2 Pages: 253-258
  • DOI: 10.2967/jnumed.120.244400
  • Peer Reviewed
• [Journal Article] 18F-THK5351 PET imaging in patients with progressive supranuclear palsy: associations with core domains and diagnostic certainty (2020)
  • Author(s): Hsu Jung-Lung、Chen Shih-Hsin、Hsiao Ing-Tsung、Lu Chin-Song、Yen Tzu-Chen、Okamura Nobuyuki、Lin Kun-Ju、Weng Yi-Hsin
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 19410-19410
  • DOI: 10.1038/s41598-020-76339-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Investigation of reactive astrogliosis effect on post-stroke cognitive impairment (2020)
  • Author(s): Huang Kuo-Lun、Hsiao Ing-Tsung、Ho Meng-Yang、Hsu Jung-Lung、Chang Yeu-Jhy、Chang Ting-Yu、Liu Chi-Hung、Chang Chien-Hung、Wu Yi-Ming、Wu Kuan-Yi、Wey Shiaw-Pyng、Yen Tzu-Chen、Okamura Nobuyuki、Lee Tsong-Hai、Lin Kun-Ju
  • Journal Title: Journal of Neuroinflammation Volume: 17 Issue: 1 Pages: 308-308
  • DOI: 10.1186/s12974-020-01985-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] [18F]THK5351 PET Imaging in Patients with Mild Cognitive Impairment (2020)
  • Author(s): Jeong Hye Jin、Lee Hyon、Lee Sang-Yoon、Seo Seongho、Park Kee Hyung、Lee Yeong-Bae、Shin Dong Jin、Kang Jae Myeong、Yeon Byeong Kil、Kang Seung-Gul、Cho Jaelim、Seong Joon-Kyung、Okamura Nobuyuki、Villemagne Victor L.、Na Duk L.、Noh Young
  • Journal Title: Journal of Clinical Neurology Volume: 16 Issue: 2 Pages: 202-214
  • DOI: 10.3988/jcn.2020.16.2.202
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Plasma pharmacokinetic and metabolism of [18F]THK-5317 are dependent on sex (2020)
  • Author(s): Mairinger Severin、Filip Thomas、Sauberer Michael、Flunkert Stefanie、Wanek Thomas、Stanek Johann、Furtner Sara、Hutter-Paier Birgit、Okamura Nobuyuki、Kuntner Claudia
  • Journal Title: Nuclear Medicine and Biology Volume: 84-85 Pages: 28-32
  • DOI: 10.1016/j.nucmedbio.2020.01.001
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Cholinergic denervation in patients with idiopathic rapid eye movement sleep behaviour disorder (2019)
  • Author(s): Gersel Stokholm M.、Iranzo A.、Ostergaard K.、Serradell M.、Otto M.、Bacher Svendsen K.、Garrido A.、Vilas D.、Fedorova T.D.、Santamaria J.、Moller A.、Gaig C.、Hiraoka K.、Brooks D.J.、Okamura N.、Borghammer P.、Tolosa E.、Pavese N.
  • Journal Title: European Journal of Neurology Volume: 27 Issue: 4 Pages: 644-652
  • DOI: 10.1111/ene.14127
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] PET Imaging of Astrogliosis and Tau Facilitates Diagnosis of Parkinsonian Syndromes (2019)
  • Author(s): Schonecker Sonja、Brendel Matthias、Palleis Carla、Beyer Leonie、Hoglinger Gunter U.、Schuh Elisabeth、Rauchmann Boris-Stephan、Sauerbeck Julia、Rohrer Guido、Sonnenfeld Stefan、Furukawa Katsutoshi、Ishiki Aiko、Okamura Nobuyuki、et al.
  • Journal Title: Frontiers in Aging Neuroscience Volume: 11 Pages: 249-249
  • DOI: 10.3389/fnagi.2019.00249
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Topographical Heterogeneity of Alzheimer’s Disease Based on MR Imaging, Tau PET, and Amyloid PET (2019)
  • Author(s): Jeon Seun、Kang Jae Myeong、Seo Seongho、Jeong Hye Jin、Funck Thomas、Lee Sang-Yoon、Park Kee Hyung、Lee Yeong-Bae、Yeon Byeong Kil、Ido Tatsuo、Okamura Nobuyuki、Evans Alan C.、Na Duk L.、Noh Young
  • Journal Title: Frontiers in Aging Neuroscience Volume: 11 Pages: 211-211
  • DOI: 10.3389/fnagi.2019.00211
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Brain histamine H1 receptor occupancy after oral administration of desloratadine and loratadine (2019)
  • Author(s): Nakamura Tadaho、Hiraoka Kotaro、Harada Ryuichi、Matsuzawa Takuro、Ishikawa Yoichi、Funaki Yoshihito、Yoshikawa Takeo、Tashiro Manabu、Yanai Kazuhiko、Okamura Nobuyuki
  • Journal Title: Pharmacology Research & Perspectives Volume: 7 Issue: 4
  • DOI: 10.1002/prp2.499
  • Peer Reviewed / Open Access
• [Journal Article] Assessment of Amyloid Deposition in Patients With Probable REM Sleep Behavior Disorder as a Prodromal Symptom of Dementia With Lewy Bodies Using PiB-PET (2019)
  • Author(s): Kobayashi Ryota、Hayashi Hiroshi、Kawakatsu Shinobu、Okamura Nobuyuki、Yoshioka Masanori、Otani Koichi
  • Journal Title: Frontiers in Neurology Volume: 10 Pages: 671-671
  • DOI: 10.3389/fneur.2019.00671
  • Peer Reviewed / Open Access
• [Journal Article] Longitudinal changes in 18F-THK5351 PET in corticobasal syndrome (2019)
  • Author(s): Ezura M, Kikuchi A, Ishiki A, Okamura N, Hasegawa T, Harada R, Watanuki S, Funaki Y, Hiraoka K, Baba T, Sugeno N, Oshima R, Yoshida S, Kobayashi J, Kobayashi M, Tano O, Nakashima I, Mugikura S, Iwata R, Taki Y, Furukawa K, Arai H, Furumoto S, Tashiro M, Yanai K, Kudo Y, Takeda A, Aoki M
  • Journal Title: Eur J Neurol Volume: 26 Issue: 9 Pages: 1205-1211
  • DOI: 10.1111/ene.13966
  • Peer Reviewed / Open Access
• [Journal Article] Characterization of the binding of tau imaging ligands to melanin-containing cells: putative off-target-binding site (2019)
  • Author(s): Tago Tetsuro、Toyohara Jun、Harada Ryuichi、Furumoto Shozo、Okamura Nubuyuki、Kudo Yukitsuka、Takahashi-Fujigasaki Junko、Murayama Shigeo、Ishii Kenji
  • Journal Title: Annals of Nuclear Medicine Volume: 33 Issue: 6 Pages: 1-8
  • DOI: 10.1007/s12149-019-01344-x
  • Peer Reviewed / Open Access
• [Journal Article] Association of deposition of tau and amyloid-β proteins with structural connectivity changes in cognitively normal older adults and Alzheimer’s disease spectrum patients. (2018)
  • Author(s): Shigemoto Y, Sone D, Maikusa N, Okamura N, Furumoto S, Kudo Y, Ogawa M, Takanno H, Yokoi Y, Sakata M, Tsukamoto T, Kato K, Sato N, Matsuda H
  • Journal Title: Brain Behav Volume: 8 Issue: 12
  • DOI: 10.1002/brb3.1145
  • Peer Reviewed / Open Access
• [Journal Article] Involvement of the Precuneus/Posterior Cingulate Cortex Is Significant for the Development of Alzheimer’s Disease: A PET (THK5351, PiB) and Resting fMRI Study (2018)
  • Author(s): Yokoi Takamasa、Watanabe Hirohisa、Ishigaki Shinsuke、Katsuno Masahisa、Miyao Shinichi、Kato Katsuhiko、Naganawa Shinji、Harada Ryuichi、Okamura Nobuyuki、Yanai Kazuhiko、Yoshida Mari、Sobue Gen （ほか9名）
  • Journal Title: Frontiers in Aging Neuroscience Volume: 10 Pages: 304-304
  • DOI: 10.3389/fnagi.2018.00304
  • Peer Reviewed / Open Access
• [Journal Article] Investigation of the quantitative accuracy of low-dose amyloid and tau PET imaging. (2018)
  • Author(s): Nai YH, Watanuki S, Tashiro M, Okamura N, Watabe H.
  • Journal Title: Radiol Phys Technol. Volume: 11 Issue: 4 Pages: 451-459
  • DOI: 10.1007/s12194-018-0485-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Imaging Protein Misfolding in the Brain Using β-Sheet Ligands (2018)
  • Author(s): Harada Ryuichi、Okamura Nobuyuki、Furumoto Shozo、Yanai Kazuhiko
  • Journal Title: Frontiers in Neuroscience Volume: 12 Pages: 585-585
  • DOI: 10.3389/fnins.2018.00585
  • Peer Reviewed / Open Access
• [Journal Article] Targeting metals rescues the phenotype in an animal model of tauopathy (2018)
  • Author(s): Sedjahtera Amelia、Gunawan Lydia、Bray Lisa、Hung Lin Wai、Parsons Jack、Okamura Nobuyuki、Villemagne Victor L.、Yanai Kazuhiko、Liu Xiang M.、Chan Jacky、Bush Ashley I.、Finkelstein David I.、Barnham Kevin J.、Cherny Robert A.、Adlard Paul A.
  • Journal Title: Metallomics Volume: 10 Issue: 9 Pages: 1339-1347
  • DOI: 10.1039/c8mt00153g
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] [18F]THK-5351 PET imaging in early-stage semantic variant primary progressive aphasia: a report of two cases and a literature review (2018)
  • Author(s): Kobayashi Ryota、Hayashi Hiroshi、Kawakatsu Shinobu、Ishiki Aiko、Okamura Nobuyuki、Arai Hiroyuki、Otani Koichi
  • Journal Title: BMC Neurology Volume: 18 Issue: 1 Pages: 109-109
  • DOI: 10.1186/s12883-018-1115-3
  • Peer Reviewed / Open Access
• [Journal Article] Dissociation of tau deposits and brain atrophy in early Alzheimer’s disease: A combined positron emission tomography/magnetic resonance imaging study (2018)
  • Author(s): Shigemoto Y, Sone D, Imabayashi E, Maikusa N, Okamura N, Furumoto S, Kudo Y, Ogawa M, Takano H, Yokoi Y, Sakata M, Tsukamoto T, Kato K, Sato N, Matsuda H.
  • Journal Title: Front in Aging Neurosci Volume: 10 Pages: 223-223
  • DOI: 10.3389/fnagi.2018.00223
  • Peer Reviewed / Open Access
• [Journal Article] Visualization of ischemic stroke-related changes on 18F-THK-5351 positron emission tomography (2018)
  • Author(s): Huang Kuo-Lun、Hsu Jung-Lung、Lin Kun-Ju、Chang Chien-Hung、Wu Yi-Ming、Chang Ting-Yu、Chang Yeu-Jhy、Liu Chi-Hung、Ho Meng-Yang、Wey Shiaw-Pyng、Yen Tzu-Chen、Okamura Nobuyuki、Hsiao Ing-Tsung、Lee Tsong-Hai
  • Journal Title: EJNMMI Research Volume: 8 Issue: 1 Pages: 62-62
  • DOI: 10.1186/s13550-018-0417-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] IgLON5: A case with predominant cerebellar tau deposits and leptomeningeal inflammation (2018)
  • Author(s): Schoberl Florian、Levin Johannes、Remi Jan、Goldschagg Nicolina、Eren Ozan、Okamura Nobuyuki、Unterrainer Marcus、Rominger Axel、Albert Nathalie、Brendel Matthias
  • Journal Title: Neurology Volume: 91 Issue: 4 Pages: 180-182
  • DOI: 10.1212/wnl.0000000000005859
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Neuroimaging-pathological correlations of [(18)F]THK5351 PET in progressive supranuclear palsy (2018)
  • Author(s): Ishiki A, Furukawa K, et al.
  • Journal Title: Acta Neuropathol Commun Volume: 6 Issue: 1 Pages: 53-53
  • DOI: 10.1186/s40478-018-0556-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Comparison of 18F-T807 and 18F-THK5117 PET in a Mouse Model of Tau Pathology (2018)
  • Author(s): Brendel Matthias、Yousefi Behrooz H.、Blume Tanja、Herz Michael、Focke Carola、Deussing Maximilian、Peters Finn、Lindner Simon、von Ungern-Sternberg Barbara、Drzezga Alexander、Bartenstein Peter、Haass Christian、Okamura Nobuyuki、Herms Jochen、Yakushev Igor、Rominger Axel
  • Journal Title: Frontiers in Aging Neuroscience Volume: 10 Pages: 174-174
  • DOI: 10.3389/fnagi.2018.00174
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] S-[18F]THK-5117-PET and [11C]PIB-PET Imaging in Idiopathic Normal Pressure Hydrocephalus in Relation to Confirmed Amyloid-β Plaques and Tau in Brain Biopsies (2018)
  • Author(s): Leinonen V, Rauramaa T, Johansson J, Bottelbergs A, Tesseur I, van der Ark P, Pemberton D, Koivisto Anne M., Jskelinen Juha E., Hiltunen M, Herukka Sanna-Kaisa, Blennow K, Zetterberg H, Jokinen P, Rokka J, Helin S, Haaparanta-Solin M, Solin O, Okamura N, Kolb Hartmuth C., Rinne Juha O.
  • Journal Title: Journal of Alzheimer's Disease Volume: 64 Issue: 1 Pages: 171-179
  • DOI: 10.3233/jad-180071
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Dual tracer tau PET imaging reveals different molecular targets for 11C-THK5351 and 11C-PBB3 in the Alzheimer brain (2018)
  • Author(s): Chiotis Konstantinos、Stenkrona Per、Almkvist Ove、Stepanov Vladimir、Ferreira Daniel、Arakawa Ryosuke、Takano Akihiro、Westman Eric、Varrone Andrea、Okamura Nobuyuki、Shimada Hitoshi、Higuchi Makoto、Halldin Christer、Nordberg Agneta
  • Journal Title: European Journal of Nuclear Medicine and Molecular Imaging Volume: 45 Issue: 9 Pages: 1605-1617
  • DOI: 10.1007/s00259-018-4012-5
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Quantitative evaluation of tau PET tracers 18F-THK5351 and 18F-AV-1451 in Alzheimer’s disease with standardized uptake value peak-alignment (SUVP) normalization (2018)
  • Author(s): Chen Jingyun、Alzheimer’s Disease Neuroimaging Initiative、Li Yi、Pirraglia Elizabeth、Okamura Nobuyuki、Rusinek Henry、de Leon Mony J.
  • Journal Title: European Journal of Nuclear Medicine and Molecular Imaging Volume: 45 Issue: 9 Pages: 1596-1604
  • DOI: 10.1007/s00259-018-4040-1
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Tau PET imaging: current status and future direction (2018)
  • Author(s): Okamura N, Harada R, Ishiki A, Kikuchi A, Nakamura T, Kudo Y
  • Journal Title: Clin Transl Imaging Volume: 6 Issue: 4 Pages: 305-316
  • DOI: 10.1007/s40336-018-0290-y
  • Peer Reviewed / Open Access
• [Presentation] Visualizing reactive astrogliosis using positron emission tomography. (2023)
  • Author(s): Okamura N.
  • Organizer: The 13th BRI International Symposium
  • Int'l Joint Research
• [Presentation] Development of a highly sensitive tau tracer 18F-SNFT-1 for imaging early tau pathology in Alzheimer's disease. (2023)
  • Author(s): Okamura N, Harada R, Lerdsirisuk P, Shimizu Y, Yokoyama Y, Du Y, Ezura M, Arai H, Kudo Y, Furumoto S.
  • Organizer: AD/PD2023
  • Int'l Joint Research
• [Presentation] Development of novel PET tracer [18F]SMBT-1 for imaging reactive astrogliosis. (2022)
  • Author(s): Okamura N.
  • Organizer: Invited Lecture, Center for Cognition and Sociality, Institute for Basic Science, South Korea
  • Int'l Joint Research / Invited
• [Presentation] PET imaging of reactive astrocytes with [18F]SMBT-1 in dementia. (2022)
  • Author(s): Okamura N.
  • Organizer: 13th Congress of the World Federation of Nuclear Medicine and Biology
  • Int'l Joint Research
• [Presentation] ヒト脳内の神経炎症を非侵襲的に可視化する画像診断技術 (2022)
  • Author(s): 岡村信行
  • Organizer: 第96回日本薬理学会年会
• [Presentation] PHFタウへの感度・特異度を高めた新規タウプローブ[18F]SNFT-1の開発 (2021)
  • Author(s): 岡村信行、原田龍一、清水悠暉、Pradith Lerdsirisuk、堵怡青、石川洋一、荒井啓行、谷内一彦、工藤幸司、古本祥三
  • Organizer: 第40回日本認知症学会学術集会
• [Presentation] アルツハイマー病患者における反応性アストロサイトの画像化 (2021)
  • Author(s): 岡村信行、原田龍一、古本祥三、石木愛子、工藤幸司、荒井啓行、Christopher C Rowe、Victor L Villemagne
  • Organizer: 第10回日本認知症予防学会学術集会
• [Presentation] アルツハイマー病におけるアストログリオーシスの画像化 (2021)
  • Author(s): 岡村信行、原田龍一
  • Organizer: 第36回日本老年精神医学会大会
• [Presentation] 中枢神経系病理を可視化するPETトレーサー開発の現状 (2021)
  • Author(s): 岡村信行
  • Organizer: 第10回日本認知症予防学会学術集会
• [Presentation] Development of novel imaging biomarker for reactive astrogliosis. (2021)
  • Author(s): Okamura N
  • Organizer: Joint Symposium on Nuclear Cardiology & Neurology Taiwan Society of Nuclear Medicine
  • Int'l Joint Research / Invited
• [Presentation] Evaluation of the novel 18F-labeled PET tracer SMBT-1 for imaging astrogliosis in Alzheimer’s disease. (2020)
  • Author(s): Okamura N, Harada R, Dore V, Furumoto S, Mulligan R, Kudo Y, Krishnadas N, Huang K, Yanai K, Rowe CC, Villemagne VL.
  • Organizer: SNMMI 2020 Annual Meeting
  • Int'l Joint Research
• [Presentation] 反応性アストロサイトのPETイメージング (2020)
  • Author(s): 岡村信行
  • Organizer: 第39回日本認知症学会学術集会
• [Presentation] アミロイド・タウPETの現状と新規プローブ開発 (2020)
  • Author(s): 岡村信行
  • Organizer: 第38回日本神経治療学会総会
  • Invited
• [Presentation] 反応性アストロサイトのPETイメージング (2020)
  • Author(s): 岡村信行
  • Organizer: 第61回日本神経学会学術集会
  • Invited
• [Presentation] Assessment of reactive astrogliosis in patients with Alzheimer’s disease using novel PET tracer 18F-SMBT-1. (2020)
  • Author(s): 岡村信行、原田龍一、Vincent Dore、古本祥三、Rachel Mulligan、工藤幸司、Natasha Krishnadas、Kun Huang、谷内一彦、Christopher C Rowe、Victor L Villemagne
  • Organizer: Neuroscience 2020
• [Presentation] Imaging astrogliosis and non-TSPO microglial activation. (2019)
  • Author(s): Okamura Nobuyuki
  • Organizer: Society of Nuclear Medicine and Molecular Imaging 2019 Annual Meeting
  • Int'l Joint Research
• [Presentation] Development of a novel 18F-labeled PET tracer for imaging astrogliosis. (2019)
  • Author(s): Okamura Nobuyuki, Harada Rryuichi, Ezura Michinori, Arai Hiroyuki, Yanai Kazuhiko, Furumoto Syozo, Kudo Yukitsuka
  • Organizer: AAIC 2019
  • Int'l Joint Research
• [Presentation] 認知症の画像診断 Update (2019)
  • Author(s): 岡村信行
  • Organizer: 第61回日本老年医学会学術集会
  • Invited
• [Presentation] アストログリオーシスを生体画像化する新規PETプローブ[18F]SMBT-1の開発 (2019)
  • Author(s): 岡村信行、原田龍一、江面道典、古本祥三、谷内一彦、荒井啓行、工藤幸司
  • Organizer: 第38回日本認知症学会学術集会
• [Presentation] PET imaging of neuropathology in Alzheimer’s disease. (2019)
  • Author(s): Okamura Nobuyuki
  • Organizer: 3th International Symposium on Molecular Imaging, Havana, Cuba
  • Int'l Joint Research / Invited
• [Presentation] Toward the development of novel imaging agents for protein misfolding diseases. (2018)
  • Author(s): Okamura Nobuyuki
  • Organizer: 2018 International Conference on Neurodegenerative Disorders, CGMH
  • Int'l Joint Research / Invited
• [Presentation] Potential application of 18F-THK5351 and its derivatives for PET imaging of astrogliosis in human brain. (2018)
  • Author(s): Okamura Nobuyuki、Harada Ryuichi
  • Organizer: AAIC 2018
  • Int'l Joint Research
• [Presentation] 認知症の画像診断の最先端 (2018)
  • Author(s): 岡村信行、原田龍一
  • Organizer: 第33回日本老年精神医学会
  • Invited
• [Presentation] Development of PET tracers for imaging amyloid, tau and gliosis. (2018)
  • Author(s): 岡村信行、原田龍一
  • Organizer: 第58回日本核医学会学術集会
• [Book] Aging Mechanisms II Longevity, Metabolism, and Brain Aging (2022)
  • Author(s): Nobuyuki Okamura, Ryuichi Harada
  • Total Pages: 17
  • Publisher: Springer
  • ISBN: 9789811679773
• [Remarks] 反応性アストロサイトを生体画像化する新規PETプローブ [18F]SMBT-1 の開発
  • URL: https://tmpu-pharmacol.org/%e7%a0%94%e7%a9%b6%e7%b4%b9%e4%bb%8b/
• [Patent(Industrial Property Rights)] モノアミンオキシダーゼBイメージングプローブ (2018)
  • Inventor(s): 原田龍一、古本祥三、工藤幸司、岡村信行
  • Industrial Property Rights Holder: 国立大学法人東北大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2018