Development of precise dose measurement for clinical ion beams and quality control system

• Project/Area Number: 18H02775
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: National Institute of Advanced Industrial Science and Technology
• Principal Investigator: Saito Norio 国立研究開発法人産業技術総合研究所, 計量標準総合センター, 研究部門付 (80344191)
• Co-Investigator(Kenkyū-buntansha): 山口 英俊 国立研究開発法人産業技術総合研究所, 計量標準総合センター, 研究員 (10783194) ; 田中 隆宏 国立研究開発法人産業技術総合研究所, 計量標準総合センター, 研究グループ付 (30509667)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000); Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2019: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2018: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
• Keywords: 線量計測 / 医療用粒子線 / 第3者評価手法

Outline of Final Research Achievements

In order to ensure the safety of radiotherapy, dose evaluation by a third party is indispensable. However, as the dose evaluation for ion-beam radiation therapy by a third-party has not been performed, we developed a dose evaluation method using an alanine dosimeters. As a result, it was demonstrated that output dose evaluation of carbon beams can be performed sufficiently by using an alanine dosimeters. We also improved the accuracy of the technique to directly evaluate absorbed dose to water in ion beams.

Academic Significance and Societal Importance of the Research Achievements

粒子線の第三者出力線量評価による品質管理システムを構築するために、アラニン線量計を用いた出力線量評価法の開発を行った。本研究により、アラニン線量計を用いて治療用炭素線の線量測定が可能であることが示された。アラニン線量計を用いて実際に出力線量評価を行うことで、粒子線治療の安全性に寄与することができる。

Research Products

• [Journal Article] アラニン線量計を用いた大強度陽子加速器周辺の線量測定の基礎的検討 (2020)
  • Author(s): 山口英俊、橋本義徳、清水森人、山崎寛仁、中村一、白形政司、酒井浩志
  • Journal Title: Proceedings of the 17th Annual Meeting of Particle Accelerator Society of Japan Volume: - Pages: 93-96
  • Open Access
• [Journal Article] Development of postal dosimetry service using an alanine dosimeter in Japan (2020)
  • Author(s): Yamaguchi Hidetoshi、Shimizu Morihito、Morishita Yuichiro、Okudaira Kuniyasu、Oguchi Hiroshi
  • Journal Title: Radiation Measurements Volume: In press Pages: 106339-106339
  • DOI: 10.1016/j.radmeas.2020.106339
  • Peer Reviewed
• [Journal Article] Feasibility Study of Alanine Dosimeter for Carbon-Beam Dosimetry (2018)
  • Author(s): Yamaguchi H.、Shimizu M.、Morishita Y.、Hirayama K.、Satou Y.、Kato M.、Kurosawa T.、Tanaka T.、Saito N.、Sakama M.、Fukumura A.
  • Journal Title: World Congress on Medical Physics and Biomedical Engineering 2018. IFMBE Proceedings Volume: 68 Pages: 565-569
  • DOI: 10.1007/978-981-10-9023-3_104
  • ISBN: 9789811090226, 9789811090233
  • Peer Reviewed
• [Presentation] アラニン線量計を用いた大強度陽子加速器周辺の線量測定の基礎的検討 (2020)
  • Author(s): 山口英俊、橋本義徳、清水森人、山崎寛仁、中村一、白形政司、酒井浩志
  • Organizer: 第17回日本加速器学会年会
• [Presentation] Development of postal dosimetry service using an alanine dosimeter in Japan (2019)
  • Author(s): Hidetoshi Yamaguchi, Morihito Shimizu, Yuichiro Morishita, Kuniyasu Okudaira, Hiroshi Oguchi
  • Organizer: The 19th International Conference on Solid State Dosimetry
  • Int'l Joint Research
• [Presentation] Feasibility study of alanine dosimeter for carbon-beam dosimetry (2018)
  • Author(s): H. Yamaguchi, M. Shimizu, Y. Morishita, K. Hirayama, Y. Satou, M. Kato, T. Kurosawa, T. Tanaka, N. Saito, M. Sakama, and A. Fukumura
  • Organizer: World Congress on Medical Physics and Biomedical Engineering 2018
  • Int'l Joint Research
• [Remarks] 産業技術総合研究所
  • URL: https://www.aist.go.jp/
• [Remarks] 計量標準総合センター
  • URL: https://unit.aist.go.jp/nmij/
• [Remarks] 分析計測標準研究部門
  • URL: https://unit.aist.go.jp/rima/
• [Remarks] 放射線標準研究グループ
  • URL: https://unit.aist.go.jp/rima/ja/teams/ioniz-rad.html
• [Remarks]
  • URL: https://www.aist.go.jp
• [Remarks]
  • URL: https://www.nmij.jp
• [Remarks]
  • URL: https://unit.aist.go.jp/rima/ioniz-rad