| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2020: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2018: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Outline of Final Research Achievements |
Focusing on the regulation of the intestinal microbiota by antimicrobial peptide alpha-defensin secreted by Paneth cells in the small intestine, secretory responses of Paneth cells were visualized and revealed the site-selective granule secretory stimulation, i.e., lumen side or basal side, and the granule replenishment after secretion. This study clarified for the first time the correlation between abnormalities in quality and quantity of alpha-defensin and disruption of the intestinal microbiota, dysbiosis, associated with disease progression in Crohn's disease model mice, and further presented novel therapeutic strategy for inflammatory bowel disease in the light of regulating the intestinal environment.
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