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Development of a novel vaccine against intracellular bacterial infection by inhibiting immune checkpoint molecules

Research Project

Project/Area Number 18H02818
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 53030:Respiratory medicine-related
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

Suda Takafumi  浜松医科大学, 医学部, 教授 (30291397)

Co-Investigator(Kenkyū-buntansha) 藤澤 朋幸  浜松医科大学, 医学部, 助教 (20402357)
榎本 紀之  浜松医科大学, 医学部附属病院, 講師 (50436961)
中村 祐太郎  浜松医科大学, 医学部附属病院, 講師 (60436962)
永田 年  浜松医科大学, 医学部, 教授 (90275024)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2020: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywords免疫チェックポイント / ワクチン / 樹状細胞 / PD1/PD-L1 / 細胞内寄生菌 / 免疫チェックポイント分子 / PD-1/PD-L1 / 結核 / 免疫チェックポイント阻害薬 / PD-1/PD-L / 細胞内寄生菌感染症 / 免疫チェックポイント療法
Outline of Final Research Achievements

This study was conducted to develop a powerful cell vaccine against intracellular bacterial infection such as tuberculosis by inhibiting immune check-point molecules that acts as an immune brake. Dendritic cells (BMDCs) cultured from mouse bone marrow strongly express PD-L1, and when mice are inoculated with a cell vaccine in which this BMDC is pulsed with the dominant epitope LLO91-99 of Listeria, administration of anti-PD-1 antibody together induced antigen-specific cytotoxic T cells more efficiently, and enhanced the antigen-specific IFNγ-producing ability. However, in the Listeria monocytogenes-infection model, enhanced protective immunity against Listeria by the administration of anti-PD-1 antibody could not be confirmed.

Academic Significance and Societal Importance of the Research Achievements

免疫チェックポイン分子を阻害する治療 (ICI) は,生体の免疫を高めて抗腫瘍免疫を増強する新たながんの治療法として,現在,がん治療のパラダイムシフトを起こしている.我々は,全く新たな視点から,このICIを,がんではなく,感染症に対するワクチンの効果を増強する方法として利用することを考えた.そこで,いまだ有効なワクチンのない結核を含む細胞内寄生菌感染症に対して,生体で最も強力な抗原提示細胞である樹状細胞ワクチンを用いて,その効果をICI併用によって高めるICI併用細胞ワクチンの開発に挑んだ.

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (46 results)

All 2021 2020 2019 2018

All Journal Article (34 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 34 results,  Open Access: 20 results) Presentation (12 results) (of which Int'l Joint Research: 7 results,  Invited: 1 results)

  • [Journal Article] Conventional type 2 lung dendritic cells are potent inducers of follicular helper T cells in the asthmatic lung2021

    • Author(s)
      Sakurai S, Furuhashi K, Horiguchi R, Nihashi F, Yasui H, Karayama M, Suzuki Y, Hozumi H, Enomoto N, Fujisawa T, Nakamura Y, Inui N, Suda T,
    • Journal Title

      Allergology International

      Volume: - Issue: 3 Pages: 351-359

    • DOI

      10.1016/j.alit.2021.01.008

    • NAID

      130008064053

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetic determinants of risk in autoimmune pulmonary alveolar proteinosis2021

    • Author(s)
      Sakaue S, Yamaguchi E, Inoue Y, Handa T, Tanizawa K, Ishii H, Ishida M, Kato T, Takeda N, Yokomura K, Matsui T, Watanabe M, Inoue H, Imaizumi K, Goto Y, Kida H, Fujisawa T, Suda T, Yamada T, Satake Y, Ibata H, Hizawa N, Mochizuki H, Kumanogoh A, Matsuda F, Nakata K, Hirota T, Tamari M, Okada Y
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1 Pages: 1032-1032

    • DOI

      10.1038/s41467-021-21011-y

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ursodeoxycholic acid impairs liver‐infiltrating T‐cell chemotaxis through IFN‐γ and CX3CL1 production in primary biliary cholangitis2021

    • Author(s)
      Shimoyama S, Kawata K, Ohta K, Chida T, Suzuki T, Tsuneyama K, Shimoda S, Kurono N, Leung PSC, Gershwin ME, Suda T, Kobayashi Y
    • Journal Title

      European Journal of Immunology

      Volume: - Issue: 6 Pages: 1519-1530

    • DOI

      10.1002/eji.202048589

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a novel T cell‐oriented vaccine using CTL/Th‐hybrid epitope long peptide and biodegradable microparticles, against an intracellular bacterium2020

    • Author(s)
      Tanaka Kazuki、Enomoto Noriyuki, et al.
    • Journal Title

      Microbiology and Immunology

      Volume: 64 Issue: 10 Pages: 666-678

    • DOI

      10.1111/1348-0421.12836

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influenza A virus enhances ciliary activity and mucociliary clearance via TLR3 in airway epithelium.2020

    • Author(s)
      Kamiya Y, Fujisawa T, Katsumata M, Yasui H, Suzuki Y, Karayama M, Hozumi H, Furuhashi K, Enomoto N, Nakamura Y, Inui N, Setou M, Ito M, Suzuki T, Ikegami K, Suda T.
    • Journal Title

      Respir Res.

      Volume: 21 Issue: 1 Pages: 282-282

    • DOI

      10.1186/s12931-020-01555-1

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] CD248 and integrin alpha-8 are candidate markers for differentiating lung fibroblast subtypes2020

    • Author(s)
      Matsushima Sayomi、Aoshima Yoichiro、Akamatsu Taisuke、Enomoto Yasunori、Meguro Shiori、Kosugi Isao、Kawasaki Hideya、Fujisawa Tomoyuki、Enomoto Noriyuki、Nakamura Yutaro、Inui Naoki、Funai Kazuhito、Suda Takafumi、Iwashita Toshihide
    • Journal Title

      BMC Pulmonary Medicine

      Volume: 20 Issue: 1 Pages: 1-1

    • DOI

      10.1186/s12890-020-1054-9

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] CD200 and CD200R1 are differentially expressed and have differential prognostic roles in non-small cell lung cancer2020

    • Author(s)
      Yoshimura Katsuhiro、Suzuki Yuzo、Inoue Yusuke、Tsuchiya Kazuo、Karayama Masato、Iwashita Yuji、Kahyo Tomoaki、Kawase Akikazu、Tanahashi Masayuki、Ogawa Hiroshi、Inui Naoki、Funai Kazuhito、Shinmura Kazuya、Niwa Hiroshi、Sugimura Haruhiko、Suda Takafumi
    • Journal Title

      OncoImmunology

      Volume: 9 Issue: 1 Pages: 1746554-1746554

    • DOI

      10.1080/2162402x.2020.1746554

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of Programmed Death Ligand 1 (PD-L1) Gene Amplification and Response to Nivolumab Monotherapy in Non-small Cell Lung Cancer2020

    • Author(s)
      Inoue Y, Yoshimura K, Nishimoto K, Inui N, Karayama M, Yasui H, Hozumi H, Suzuki Y, Furuhashi K, Fujisawa T, Enomoto N, Nakamura Y, Asada K, Uto T, Fujii M, Matsui T, Matsuura S, Hashimoto D, Toyoshima M, Kusagaya H, Matsuda H, Inami N, Kaida Y, Niwa M, Ito Y, Sugimura H, Suda T.
    • Journal Title

      JAMA Netw Open.

      Volume: 3(9) Issue: 9 Pages: e2011818-e2011818

    • DOI

      10.1001/jamanetworkopen.2020.11818

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] HDAC3 is required for XPC recruitment and nucleotide excision repair of DNA damage induced by UV irradiation2020

    • Author(s)
      1.Koji Nishimoto, Hiroyuki Niida, Chiharu Uchida, Tatsuya Ohhata, Kyoko Kitagawa, Akira Motegi, Takafumi Suda, and Masatoshi Kitagawa
    • Journal Title

      Mol. Cancer Res.

      Volume: 18 Issue: 9 Pages: 1367-1378

    • DOI

      10.1158/1541-7786.mcr-20-0214

    • NAID

      120007165672

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Macrolide resistant Mycobacterium avium complex pulmonary disease following clarithromycin and ethambutol combination therapy2020

    • Author(s)
      Ito Yasuhiro、Miwa Seiichi、Shirai Masahiro、Kanai Miho、Fujita Kaoru、Ohba Hisano、Iwaizumi Eriko、Oshima Tomoko、Kojima Suguru、Suda Takafumi、Hayakawa Hiroshi
    • Journal Title

      Respiratory Medicine

      Volume: 169 Pages: 106025-106025

    • DOI

      10.1016/j.rmed.2020.106025

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Leucine-Rich α2-Glycoprotein as a Potential Biomarker for Immune-related Colitis After Anti?PD-L1 Therapy: A Report of a Case Series2020

    • Author(s)
      Yoshimura Katsuhiro、Saku Aiko、Karayama Masato、Inui Naoki、Sugimura Haruhiko、Suda Takafumi
    • Journal Title

      Clinical Lung Cancer

      Volume: In press Issue: 6 Pages: e516-e522

    • DOI

      10.1016/j.cllc.2020.04.005

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Imaging mass spectrometry to visualise increased acetylcholine in lungs of asthma model mice2020

    • Author(s)
      Matsuda Takeshi、Suzuki Yuzo、Fujisawa Tomoyuki、Suga Yasunori、Saito Nobuyuki、Suda Takafumi、Yao Ikuko
    • Journal Title

      Analytical and Bioanalytical Chemistry

      Volume: In press Issue: 18 Pages: 4327-4341

    • DOI

      10.1007/s00216-020-02670-0

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Assessment of Immune-Related Interstitial Lung Disease in Patients With NSCLC Treated with Immune Checkpoint Inhibitors: A Multicenter Prospective Study2020

    • Author(s)
      Suzuki Y, Karayama M, Uto T, Fujii M, Matsui T, Asada K, Kusagaya H, Kato M, Matsuda H, Matsuura S, Toyoshima M, Mori K, Ito Y, Koyauchi T, Yasui H, Hozumi H, Furuhashi K, Enomoto N, Fujisawa T, Nakamura Y, Inui N, Suda T.
    • Journal Title

      Journal of Thoracic Oncology

      Volume: S1556 Issue: 8 Pages: 1317-1327

    • DOI

      10.1016/j.jtho.2020.04.002

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intravoxel incoherent motion magnetic resonance imaging for predicting the long-term efficacy of immune checkpoint inhibitors in patients with non-small-cell lung cancer.2020

    • Author(s)
      Karayama M, Yoshizawa N, Sugiyama M, Mori K, Yasui H, Hozumi H, Suzuki Y, Furuhashi K, Fujisawa T, Enomoto N, Nakamura Y, Inui N, Goshima S, Suda T, Takehara Y.
    • Journal Title

      Lung Cancer

      Volume: 143 Pages: 47-54

    • DOI

      10.1016/j.lungcan.2020.03.013

    • NAID

      120007041512

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-resolution CT features distinguishing usual interstitial pneumonia pattern in chronic hypersensitivity pneumonitis from those with idiopathic pulmonary fibrosis2020

    • Author(s)
      Tateishi Tomoya、Johkoh Takeshi、Sakai Fumikazu、Miyazaki Yasunari、Ogura Takashi、Ichikado Kazuya、Suda Takafumi、Taguchi Yoshio、Inoue Yoshikazu、Takemura Tamiko、Colby Thomas V.、Sumikawa Hiromitsu、Fujimoto Kiminori、Arakawa Hiroaki、Raoof Suhail、Inase Naohiko
    • Journal Title

      Japanese Journal of Radiology

      Volume: 38 Issue: 6 Pages: 524-532

    • DOI

      10.1007/s11604-020-00932-6

    • NAID

      50014524561

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elucidation of the relationships of MET protein expression and gene copy number status with PD-L1 expression and the immune microenvironment in non-small cell lung cancer2020

    • Author(s)
      Yoshimura Katsuhiro、Inoue Yusuke、Tsuchiya Kazuo、Karayama Masato、Yamada Hidetaka、Iwashita Yuji、Kawase Akikazu、Tanahashi Masayuki、Ogawa Hiroshi、Inui Naoki、Funai Kazuhito、Shinmura Kazuya、Niwa Hiroshi、Suda Takafumi、Sugimura Haruhiko
    • Journal Title

      Lung Cancer

      Volume: 141 Pages: 21-31

    • DOI

      10.1016/j.lungcan.2020.01.005

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thrombomodulin Alfa for Acute Exacerbation of Idiopathic Pulmonary Fibrosis. A Randomized, Double-Blind Placebo-controlled Trial2020

    • Author(s)
      Kondoh Y, Suda T, et al
    • Journal Title

      American Journal of Respiratory and Critical Care Medicine

      Volume: 201 Issue: 9 Pages: 1110-1119

    • DOI

      10.1164/rccm.201909-1818oc

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative computed tomography measures of skeletal muscle mass in patients with idiopathic pulmonary fibrosis according to a multidisciplinary discussion diagnosis: A retrospective nationwide study in Japan2020

    • Author(s)
      Awano Nobuyasu、Inomata Minoru、Kuse Naoyuki、Tone Mari、Yoshimura Hanako、Jo Tatsunori、Takada Kohei、Sugimoto Chikatoshi、Tanaka Tomonori、Sumikawa Hiromitsu、Suzuki Yuzo、Fujisawa Tomoyuki、Suda Takafumi、Izumo Takehiro
    • Journal Title

      Respiratory Investigation

      Volume: 58 Issue: 2 Pages: 91-101

    • DOI

      10.1016/j.resinv.2019.11.002

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Macrophage Mannose Receptor CD206 Predicts Prognosis in Community-acquired Pneumonia2019

    • Author(s)
      Tsuchiya K, Suzuki Y, Yoshimura K, Yasui H, Karayama M, Hozumi H, Furuhashi K, Enomoto N, Fujisawa T, Nakamura Y, Inui N, Yokomura K, Suda T.
    • Journal Title

      Sci Rep.

      Volume: 9(1) Issue: 1 Pages: 55289-2

    • DOI

      10.1038/s41598-019-55289-2

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic factors for primary Sjögren's syndrome-associated interstitial lung diseases.2019

    • Author(s)
      Kamiya Y, Fujisawa T, Kono M, Nakamura H, Yokomura K, Koshimizu N, Toyoshima M, Imokawa S, Sumikawa H, Johkoh T, Yasui H, Hozumi H, Suzuki Y, Karayama M, Furuhashi K, Enomoto N, Nakamura Y, Inui N, Suda T.
    • Journal Title

      Respiratory Medicine

      Volume: 159 Pages: 105811-105811

    • DOI

      10.1016/j.rmed.2019.105811

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of PD-1 inhibitor on exhaled nitric oxide and pulmonary function in non-small cell lung cancer patients with and without COPD.2019

    • Author(s)
      Suzuki Y, Inui N, Karayama M, Imokawa S, Yamada T, Yokomura K, Asada K, Kusagaya H, Kaida Y, Matsuda H, Koshimizu N, Toyoshima M, Masuda M, Hayakawa H, Hozumi H, Furuhashi K, Enomoto N, Fujisawa T, Nakamura Y, Suda T.
    • Journal Title

      International Journal of Chronic Obstructive Pulmonary Disease

      Volume: 14 Pages: 1867-1877

    • DOI

      10.2147/copd.s214610

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of rifampicin and clarithromycin on the CYP3A activity in patients with Mycobacterium avium complex2019

    • Author(s)
      Akiyama Norimichi、Inui Naoki、Mori Kazutaka、Nakamura Yutaro、Hayakawa Hiroshi、Tanaka Shimako、Uchida Shinya、Namiki Noriyuki、Watanabe Hiroshi、Suda Takafumi
    • Journal Title

      Journal of Thoracic Disease

      Volume: 11 Issue: 9 Pages: 3814

    • DOI

      10.21037/jtd.2019.09.06

    • URL

      https://localhost/en/publications/e7e614d8-4316-419e-b9fa-7a57c13738b2

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of serum S100 calcium-binding protein A4 in idiopathic pulmonary fibrosis.2019

    • Author(s)
      Akiyama N, Hozumi H, Isayama T, Okada J, Sugiura K, Yasui H, Suzuki Y, Kono M, Karayama M, Furuhashi K, Enomoto N, Fujisawa T, Inui N, Nakamura Y, Suda T.
    • Journal Title

      Respirology

      Volume: 0 Issue: 7 Pages: 0-0

    • DOI

      10.1111/resp.13707

    • NAID

      120007097006

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Once-daily fluticasone furoate/vilanterol combination versus twice-daily budesonide/formoterol combination in the treatment of controlled stable asthma: a randomized crossover trial.2019

    • Author(s)
      Furuhashi K, Fujisawa T, Hashimoto D, Kamiya Y, Yasui H, Karayama M, Suzuki Y, Hozumi H, Enomoto N, Nakamura Y, Inui N, Suda T.
    • Journal Title

      Journal of Asthma and Allergy

      Volume: 12 Pages: 253-261

    • DOI

      10.2147/jaa.s223093

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic impact of an early marginal decline in forced vital capacity in idiopathic pulmonary fibrosis patients treated with pirfenidone.2019

    • Author(s)
      Kono M, Nakamura Y, Enomoto N, Saito G, Koyanagi Y, Miyashita K, Tsutsumi A, Kobayashi T, Yasui H, Hozumi H, Karayama M, Suzuki Y, Furuhashi K, Miki Y, Hashimoto D, Fujisawa T, Inui N, Suda T, Nakamura H.
    • Journal Title

      Respir Investig.

      Volume: 57 Issue: 6 Pages: 552-560

    • DOI

      10.1016/j.resinv.2019.07.003

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Body composition changes successfully classify prognosis in patients with mycobacterium avium complex lung disease.2019

    • Author(s)
      Akahori D, Suzuki Y, Yokomura K, Shirai M, Yasui H, Hozumi H, Karayama M, Furuhashi K, Enomoto N, Fujisawa T, Nakamura Y, Inui N, Hayakawa H, Suda T.
    • Journal Title

      Journal of Infection

      Volume: 79 Issue: 4 Pages: 341-348

    • DOI

      10.1016/j.jinf.2019.07.014

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of serum adiponectin and leptin in patients with acute exacerbation of idiopathic pulmonary fibrosis.2019

    • Author(s)
      Enomoto N, Oyama Y, Yasui H, Karayama M, Hozumi H, Suzuki Y, Kono M, Furuhashi K, Fujisawa T, Inui N, Nakamura Y, Suda T.
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 10484-10484

    • DOI

      10.1038/s41598-019-46990-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Heterogeneity analysis of PD-L1 expression and copy number status in EBUS-TBNA biopsy specimens of non-small cell lung cancer: Comparative assessment of primary and metastatic sites2019

    • Author(s)
      Yoshimura Katsuhiro、Inoue Yusuke、Karayama Masato、Tsuchiya Kazuo、Mori Kazutaka、Suzuki Yuzo、Iwashita Yuji、Kahyo Tomoaki、Kawase Akikazu、Tanahashi Masayuki、Ogawa Hiroshi、Yokomura Koushi、Inui Naoki、Funai Kazuhito、Shinmura Kazuya、Niwa Hiroshi、Suda Takafumi、Sugimura Haruhiko
    • Journal Title

      Lung Cancer

      Volume: 134 Pages: 202-209

    • DOI

      10.1016/j.lungcan.2019.06.002

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical features of three-dimensional computed tomography-based radiologic phenotypes of chronic obstructive pulmonary disease.2019

    • Author(s)
      Karayama M, Inui N, Yasui H, Kono M, Hozumi H, Suzuki Y, Furuhashi K, Hashimoto D, Enomoto N, Fujisawa T, Nakamura Y, Watanabe H, Suda T.
    • Journal Title

      International Journal of Chronic Obstructive Pulmonary Disease

      Volume: 14 Pages: 1333-1342

    • DOI

      10.2147/copd.s207267

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nationwide cloud-based integrated database of idiopathic interstitial pneumonias for multidisciplinary discussion.2019

    • Author(s)
      Fujisawa T, Mori K, Mikamo M, Ohno T, Kataoka K, Sugimoto C, Kitamura H, Enomoto N, Egashira R, Sumikawa H, Iwasawa T, Matsushita S, Sugiura H, Hashisako M, Tanaka T, Terasaki Y, Kunugi S, Kitani M, Okuda R, Horiike Y, Enomoto Y, Yasui H, Hozumi H, Suzuki Y, Nakamura Y, Fukuoka J, Johkoh T, Kondoh Y, Ogura T,,, Suda T.
    • Journal Title

      Eur Respir J.

      Volume: 3 Issue: 5 Pages: 1802243-1802243

    • DOI

      10.1183/13993003.02243-2018

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Distinct profile and prognostic impact of body composition changes in idiopathic pulmonary fibrosis and idiopathic pleuroparenchymal fibroelastosis2018

    • Author(s)
      Suzuki Yuzo、Yoshimura Katsuhiro、Enomoto Yasunori、Yasui Hideki、Hozumi Hironao、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Nakamura Yutaro、Inui Naoki、Suda Takafumi
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 14074-14074

    • DOI

      10.1038/s41598-018-32478-z

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] LTBP2 is secreted from lung myofibroblasts and is a potential biomarker for idiopathic pulmonary fibrosis2018

    • Author(s)
      Enomoto Yasunori、Matsushima Sayomi、Shibata Kiyoshi、Aoshima Yoichiro、Yagi Haruna、Meguro Shiori、Kawasaki Hideya、Kosugi Isao、Fujisawa Tomoyuki、Enomoto Noriyuki、Inui Naoki、Nakamura Yutaro、Suda Takafumi、Iwashita Toshihide
    • Journal Title

      Clinical Science

      Volume: 132 Issue: 14 Pages: 1565-1580

    • DOI

      10.1042/cs20180435

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Macrophage mannose receptor, CD206, predict prognosis in patients with pulmonary tuberculosis2018

    • Author(s)
      Suzuki Yuzo、Shirai Masahiro、Asada Kazuhiro、Yasui Hideki、Karayama Masato、Hozumi Hironao、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Nakamura Yutaro、Inui Naoki、Shirai Toshihiro、Hayakawa Hiroshi、Suda Takafumi
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 13129-13129

    • DOI

      10.1038/s41598-018-31565-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] IL-17A Attenuates IFN-λ Expression by Inducing Suppressor of Cytokine Signaling Expression in Airway Epithelium2018

    • Author(s)
      Niwa Mitsuru、Fujisawa Tomoyuki、Mori Kazutaka、Yamanaka Katsumasa、Yasui Hideki、Suzuki Yuzo、Karayama Masato、Hozumi Hironao、Furuhashi Kazuki、Enomoto Noriyuki、Nakamura Yutaro、Inui Naoki、Suzuki Tetsuro、Maekawa Masato、Suda Takafumi
    • Journal Title

      The Journal of Immunology

      Volume: 201 Issue: 8 Pages: 2392-2402

    • DOI

      10.4049/jimmunol.1800147

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Development of a Novel T-Cell-Oriented Vaccine, Which Is Composed of Biodegradable Microparticles and T-Cell-Hybrid Epitope Long Peptide, Against Intracellular Bacteria2020

    • Author(s)
      Tanaka K, Enomoto N, Yasui H, Karayama M, Suzuki Y, Hozumi H, Furuhashi K, Fujisawa T, Nakamura Y, Inui N, Nagata T, Suda T
    • Organizer
      American Thoracic Society 2020 International Conference
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Conventional Type 2 Lung Dendritic Cells in Asthma Mouse Model Significantly Induce Follicular Helper T Cells Than Conventional Type 12020

    • Author(s)
      Sakurai S, Furuhashi K, Horiguchi R, Hozumi H, Suzuki Y, Karayama M, Enomoto N, Fujisawa T, Nakamura Y, Inui N, Suda T:
    • Organizer
      American Thoracic Society 2020 International Conference
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Diagnostic Utility of Web-Based Multidisciplinary Discussions Using Nationwide Cloud-Based Integrated Database of Idiopatihc Interstitial Pneumonias2019

    • Author(s)
      Fujisawa T, Suda T, et al
    • Organizer
      American Thoracic Society
    • Related Report
      2019 Annual Research Report
  • [Presentation] Overview of ILDs - etiologies/classifications2019

    • Author(s)
      Suda T
    • Organizer
      Asian Pacific Society of Respirology
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Prognostic Significance of Macrophage-Mannose Receptor, CD206, in Anti-MDA5 Antibody-Positive Dermatomyositis-Associated Interstitial Lung Disease2019

    • Author(s)
      Suzuki Y, Suda T, et al.
    • Organizer
      American Thoracic Society
    • Related Report
      2019 Annual Research Report
  • [Presentation] rognostic Significance of Pneumothorax in Patients with Connective Tissue Disease Associated Interstitial Lung Diseases2019

    • Author(s)
      Nishimoto K, Suda T, et al.
    • Organizer
      American Thoracic Society
    • Related Report
      2019 Annual Research Report
  • [Presentation] Analysis of Clinical Features by Both Diagnosis and Types of Antibodies in Patients with Myositis Related Interstitial Lung Disease: A Retrospective Multicenter Study2019

    • Author(s)
      Hozumi H, Suda T, et al.
    • Organizer
      American Thoracic Society
    • Related Report
      2019 Annual Research Report
  • [Presentation] Mutlidisciplinary Analysis of Thoracic Lesions in patients with Systemic Lupus Erythematosus: A Retrospective Multicenter Study2018

    • Author(s)
      Enomoto N, Egashira R, Tabata K, Hashisako M, Waseda Y, Ishizuka T, Watanabe S, Kasahara K, Izumi S, Shiraki A, Miyamoto A, Kishi K, Kishaba T, Sugimoto C, Inoue Y, Kataoka K, Kondoh Y, Tsuchiya Y, Baba T, Kitani M, Sugiura H, Tanaka T, Sumikawa H, Suda T
    • Organizer
      American Thoracic Society
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clinical Features and Prognostic Factors for Dermatomyositis-Associated Intertitial Lung Diseases with Anti-MDA5 Anibody2018

    • Author(s)
      Fujisawa T, Hozumi H, Yasui H, Suzuki Y, Karayama M, Furuhashi K, Enomoto N, Nakamura Y, Inui N, Suda T
    • Organizer
      American Thoracic Society
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Comparison of Clinical Features between Th2-high and Th2-low Asthma2018

    • Author(s)
      Fukada A, Toyoshima M, Akahori D, Suda T
    • Organizer
      American Thoracic Society
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prognostic Factors in Patients with Chronic Pulmonary Aspergillosis2018

    • Author(s)
      Furuhashi K, Sakurai S, Kamiya Y, Yasui H, Karayama M, Suzuki Y, Hozumi H, Enomoto N, Fujisawa T, Nakamura Y, Inui N, Suda T
    • Organizer
      American Thoracic Society
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Myeloperoxidase-Antineutrophil Cytoplasmic Antibody in Patients with Idiopathic Interstitial Pneumonias2018

    • Author(s)
      Hozumi H, Yasui H, Suzuki Y, Kono M, Karayama M, Furuhashi K, Enomoto N, Fujisawa T, Nakamura Y, Inui N, Suda T
    • Organizer
      American Thoracic Society
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2022-01-27  

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