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Elucidation of metabolic reprogramming in the kidney and development of novel therapeutic approaches utilizing HIF against kidney disease

Research Project

Project/Area Number 18H02824
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 53040:Nephrology-related
Research InstitutionThe University of Tokyo

Principal Investigator

Nangaku Masaomi  東京大学, 医学部附属病院, 教授 (90311620)

Co-Investigator(Kenkyū-buntansha) 三村 維真理  東京大学, 医学部附属病院, 助教 (00727084)
平川 陽亮  東京大学, 医学部附属病院, 助教 (10780736)
稲城 玲子  東京大学, 医学部附属病院, 特任教授 (50232509)
田中 哲洋  東京大学, 医学部附属病院, 准教授 (90508079)
西 裕志  東京大学, 医学部附属病院, 講師 (90784174)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2018: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Keywords低酸素 / HIF / 慢性腎臓病 / ミトコンドリア / CKD
Outline of Final Research Achievements

We performed metabolic reprogramming in the tubulointerstitium under hypoxic conditions, which is a final common pathway of progression of chronic kidney disease. We evaluated metabolic reprogramming of cultured tubular cells exposed to hypoxia. By evaluating changes of expression of molecules involved in energy metabolism and products of energy metabolism such as TCA cycle, we clarified roles of molecules involved in metabolic reprogramming. Further, we clarified a role of HIF in metabolic reprogramming by pharmacological activation of HIF. We also clarified a pathogenic role of metabolic reprogramming induced by HIF activation in animal models of kidney disease.

Academic Significance and Societal Importance of the Research Achievements

「低酸素によるCKD 進行機転」は腎臓病のすべての病期における進行機転を説明する独創的かつ合理的な機序であり、そこにおける代謝リプログラミングの詳細を解明することは、これをターゲットとした新しい治療法の確立に繋がる。更に、得られた知見及び方法論は、腎臓病学において重要であるのみならず、脳血管障害、虚血性心疾患などの他の重要分野においても幅広い展開と応用が可能で、社会的貢献度も高く、大いに発展性が期待できる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (77 results)

All 2020 2019 2018 Other

All Int'l Joint Research (3 results) Journal Article (25 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 25 results,  Open Access: 10 results) Presentation (49 results) (of which Int'l Joint Research: 42 results,  Invited: 40 results)

  • [Int'l Joint Research] National Taiwan University(台湾)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Mark D Okusa, Alessia Fornoni/University of Virginia/University of Miami(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Thitinun Anusornvongchai/Lerdsin General Hospital(タイ)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Hypoxia-inducible factor prolyl hydroxylase inhibitor in the treatment of anemia in chronic kidney disease2020

    • Author(s)
      Kurata Y, Tanaka T, Nangaku M
    • Journal Title

      Curr Opin Nephrol Hypertens

      Volume: 29 Issue: 4 Pages: 414-422

    • DOI

      10.1097/mnh.0000000000000617

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prolyl Hydroxylase Domain Inhibitor Protects against Metabolic Disorders and Associated Kidney Disease in Obese Type 2 Diabetic Mice2020

    • Author(s)
      Mai Sugahara、Shinji Tanaka、Tetsuhiro Tanaka、Hisako Saito、Yu Ishimoto、Takeshi Wakashima、Masatoshi Ueda、Kenji Fukui、Akira Shimizu、Reiko Inagi、Toshimasa Yamauchi、Takashi Kadowaki、Masaomi Nangaku
    • Journal Title

      Journal of the American Society of Nephrology

      Volume: 31 Issue: 3 Pages: 560-577

    • DOI

      10.1681/asn.2019060582

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of a prolyl hydroxylase inhibitor on kidney and cardiovascular complications in a rat model of chronic kidney disease.2020

    • Author(s)
      Uchida L, Tanaka T, Saito H, Sugahara M, Wakashima T, Fukui K, Nangaku M.
    • Journal Title

      Am J Physiol Renal Physiol.

      Volume: 318 Issue: 2 Pages: F388-F401

    • DOI

      10.1152/ajprenal.00419.2019

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prolyl hydroxylase inhibition protects the kidneys from ischemia via upregulation of glycogen storage.2020

    • Author(s)
      Ito M, Tanaka T, Ishii T, Wakashima T, Fukui K, Nangaku M.
    • Journal Title

      Kidney Int.

      Volume: 97 Issue: 4 Pages: 687-701

    • DOI

      10.1016/j.kint.2019.10.020

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] JTZ-951, an HIF prolyl hydroxylase inhibitor, suppresses renal interstitial fibroblast transformation and expression of fibrosis-related factors.2020

    • Author(s)
      Wakashima T, Tanaka T, Fukui K, Komoda Y, Shinozaki Y, Kobayashi H, Matsuo A, Nangaku M.
    • Journal Title

      Am J Physiol Renal Physiol.

      Volume: 318 Issue: 1 Pages: F14-F24

    • DOI

      10.1152/ajprenal.00323.2019

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Munc18-1-interacting protein 3 mitigates renal fibrosis through protection of tubular epithelial cells from apoptosis.2020

    • Author(s)
      Nasu K, Kawakami T, Shinohara A, Sakamoto T, Nangaku M.
    • Journal Title

      Nephrol Dial Transplant

      Volume: 35 Issue: 4 Pages: 576-586

    • DOI

      10.1093/ndt/gfz177

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nuclear factor erythroid 2-related factor 2 as a treatment target of kidney diseases2020

    • Author(s)
      Ito Marie、Tanaka Tetsuhiro、Nangaku Masaomi
    • Journal Title

      Current Opinion in Nephrology and Hypertension

      Volume: 29 Issue: 1 Pages: 128-135

    • DOI

      10.1097/mnh.0000000000000556

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The oral hypoxia-inducible factor prolyl hydroxylase inhibitor enarodustat counteracts alterations in renal energy metabolism in the early stages of diabetic kidney disease2019

    • Author(s)
      Hasegawa Sho、Tanaka Tetsuhiro、Saito Tomoyuki、Fukui Kenji、Wakashima Takeshi、Susaki Etsuo A.、Ueda Hiroki R.、Nangaku Masaomi
    • Journal Title

      Kidney International

      Volume: in press Issue: 5 Pages: 934-950

    • DOI

      10.1016/j.kint.2019.12.007

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mitochondrial damage causes inflammation via cGAS-STING signaling in acute kidney injury2019

    • Author(s)
      Hiroshi Maekawa, Tsuyoshi Inoue, haruki Ouchi, Tzu-Ming Jao, Reiko Inoue, Hiroshi Nishi, Rie Fujii, Fumiyoshi Ishidate, Tetsuhiro Tanaka, Yosuke Tanaka, Nobutaka Hirokawa, Masaomi Nangaku, Reiko Inagi
    • Journal Title

      Cell Reports

      Volume: 29 Issue: 5 Pages: 1261-1273

    • DOI

      10.1016/j.celrep.2019.09.050

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] JTZ-951 (enarodustat), a hypoxia-inducibe factor prolyl hydroxylase inhibitor, stabilizes HIF-α protein and induces erythropoiesis without effects on the function of vascular endothelial growth factor2019

    • Author(s)
      Fukui Kenji、Shinozaki Yuichi、Kobayashi Hatsue、Deai Katsuya、Yoshiuchi Hiromi、Matsui Takuya、Matsuo Akira、Matsushita Mutsuyoshi、Tanaka Tetsuhiro、Nangaku Masaomi
    • Journal Title

      European Journal of Pharmacology

      Volume: 859 Pages: 172532-172532

    • DOI

      10.1016/j.ejphar.2019.172532

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive three-dimensional analysis (CUBIC-kidney) visualizes abnormal renal sympathetic nerves after ischemia/reperfusion injury.2019

    • Author(s)
      Hasegawa S, Susaki EA, Tanaka T, Komaba H, Wada T, Fukagawa M, Ueda HR, Nangaku M
    • Journal Title

      Kidney international

      Volume: AOP Issue: 1 Pages: 129-138

    • DOI

      10.1016/j.kint.2019.02.011

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of prolyl hydroxylase domain (PHD) by JTZ-951 reduces obesity-related diseases in the liver, white adipose tissue, and kidney in mice with a high-fat diet2019

    • Author(s)
      Saito Hisako、Tanaka Tetsuhiro、Sugahara Mai、Tanaka Shinji、Fukui Kenji、Wakashima Takeshi、Nangaku Masaomi
    • Journal Title

      Laboratory Investigation

      Volume: 99 Issue: 8 Pages: 1217-1232

    • DOI

      10.1038/s41374-019-0239-4

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prolyl hydroxylase domain inhibitors: a new era in the management of renal anemia2019

    • Author(s)
      Kurata Yu、Tanaka Tetsuhiro、Nangaku Masaomi
    • Journal Title

      Annals of Translational Medicine

      Volume: 7 Issue: S8 Pages: S334-S334

    • DOI

      10.21037/atm.2019.09.118

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The role of oxidative stress and hypoxia in renal disease2019

    • Author(s)
      Honda Tomoko、Hirakawa Yosuke、Nangaku Masaomi
    • Journal Title

      Kidney Research and Clinical Practice

      Volume: 38 Issue: 4 Pages: 414-426

    • DOI

      10.23876/j.krcp.19.063

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hypoxia-Inducible Factor-Prolyl Hydroxylase Domain Inhibitors to Treat Anemia in Chronic Kidney Disease2019

    • Author(s)
      Sakashita Midori、Tanaka Tetsuhiro、Nangaku Masaomi
    • Journal Title

      Contributions to Nephrology

      Volume: 198 Pages: 112-123

    • DOI

      10.1159/000496531

    • ISBN
      9783318064230, 9783318064247
    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Placebo-Controlled, Randomized Trial of Enarodustat in Patients with Chronic Kidney Disease Followed by Long-Term Trial2019

    • Author(s)
      Akizawa Tadao、Nangaku Masaomi、Yamaguchi Takuhiro、Arai Masanobu、Koretomo Ryosuke、Matsui Atsushi、Hirakata Hideki
    • Journal Title

      American Journal of Nephrology

      Volume: 49 Issue: 2 Pages: 165-174

    • DOI

      10.1159/000496929

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Non-canonical cholinergic anti-inflammatory pathway-mediated activation of peritoneal macrophages induces Hes1 and blocks ischemia/ reperfusion injury in the kidney.2019

    • Author(s)
      Inoue T,Abe C, Kohro T, Tanaka S, Huang L, Yao J, Zheng S, Ye H, Inagi R, Stornetta RL, Rosin DL, Nangaku M, Wada Y, Okusa MD
    • Journal Title

      Kidney International

      Volume: 95(3) Issue: 3 Pages: 563-576

    • DOI

      10.1016/j.kint.2018.09.020

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] ATF6α downregulation of PPARα promotes lipotoxicity-induced tubulointerstitial fibrosis2019

    • Author(s)
      Jao Tzu-Ming、Nangaku Masaomi、Wu Chia-Hsien、Sugahara Mai、Saito Hisako、Maekawa Hiroshi、Ishimoto Yu、Aoe Mari、Inoue Tsuyoshi、Tanaka Tetsuhiro、Staels Bart、Mori Kazutoshi、Inagi Reiko
    • Journal Title

      Kidney International

      Volume: 95 Issue: 3 Pages: 577-589

    • DOI

      10.1016/j.kint.2018.09.023

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sodium glucose cotransporter 2 inhibition normalizes glucose metabolism and suppresses oxidative stress in the kidneys of diabetic mice2018

    • Author(s)
      Tanaka Shinji、Sugiura Yuki、Saito Hisako、Sugahara Mai、Higashijima Yoshiki、Yamaguchi Junna、Inagi Reiko、Suematsu Makoto、Nangaku Masaomi、Tanaka Tetsuhiro
    • Journal Title

      Kidney International

      Volume: 94 Issue: 5 Pages: 912-925

    • DOI

      10.1016/j.kint.2018.04.025

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Palmitate deranges erythropoietin production via transcription factor ATF4 activation of unfolded protein response2018

    • Author(s)
      Anusornvongchai Thitinun、Nangaku Masaomi、Jao Tzu-Ming、Wu Chia-Hsien、Ishimoto Yu、Maekawa Hiroshi、Tanaka Tetsuhiro、Shimizu Akira、Yamamoto Masayuki、Suzuki Norio、Sassa Ryoji、Inagi Reiko
    • Journal Title

      Kidney International

      Volume: 94 Issue: 3 Pages: 536-550

    • DOI

      10.1016/j.kint.2018.03.011

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Persistent expression of neutrophil gelatinase-associated lipocalin and M2 macrophage markers and chronic fibrosis after acute kidney injury2018

    • Author(s)
      Saito Hisako、Tanaka Tetsuhiro、Tanaka Shinji、Higashijima Yoshiki、Yamaguchi Junna、Sugahara Mai、Ito Marie、Uchida Lisa、Hasegawa Sho、Wakashima Takeshi、Fukui Kenji、Nangaku Masaomi
    • Journal Title

      Physiological Reports

      Volume: 6 Issue: 10 Pages: e13707-e13707

    • DOI

      10.14814/phy2.13707

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intravital phosphorescence lifetime imaging of the renal cortex accurately measures renal hypoxia.2018

    • Author(s)
      Hirakawa Y, Mizukami K, Yoshihara T, Takahashi I, Khulan P, Honda T, Mimura I, Tanaka T, Tobita S, Nangaku M.
    • Journal Title

      Kidney Int.

      Volume: 印刷中 Issue: 6 Pages: 1483-1489

    • DOI

      10.1016/j.kint.2018.01.015

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Genome-wide analysis revealed that DZNep reduces tubulointerstitial fibrosis via down-regulation of pro-fibrotic genes.2018

    • Author(s)
      Mimura I, Hirakawa Y, Kanki Y, Nakaki R, Suzuki Y, Tanaka T, Aburatani H, Nangaku M.
    • Journal Title

      Sci Rep.

      Volume: 28 Issue: 1 Pages: 3779-3779

    • DOI

      10.1038/s41598-018-22180-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hypoxia-inducible factor stabilizers for treating anemia of chronic kidney disease2018

    • Author(s)
      Hasegawa Sho、Tanaka Tetsuhiro、Nangaku Masaomi
    • Journal Title

      Current Opinion in Nephrology and Hypertension

      Volume: 27 Issue: 5 Pages: 331-338

    • DOI

      10.1097/mnh.0000000000000431

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Introduction: Kidney Disease and Cardiovascular Disease2018

    • Author(s)
      Nangaku Masaomi
    • Journal Title

      Seminars in Nephrology

      Volume: 38 Issue: 3 Pages: 207-207

    • DOI

      10.1016/j.semnephrol.2018.03.001

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] Molecular treatment strategies for AKI - a look into the crystal ball2020

    • Author(s)
      Masaomi Nangaku
    • Organizer
      European Renal Association/European Dialysis and Transplantation
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] HIF-PH inhibitor and the Nobel prize2020

    • Author(s)
      Masaomi Nangaku
    • Organizer
      Asian Pacific Congress of Nephrology
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] AKI transition to CKD2020

    • Author(s)
      Masaomi Nangaku
    • Organizer
      Asian Pacific Congress of Nephrology
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] New Era of Anemia Treatment2020

    • Author(s)
      Masaomi Nangaku
    • Organizer
      American Society of Nephrology
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development and clinical application of HIF-PHI in Japan2020

    • Author(s)
      Masaomi Nangaku
    • Organizer
      Fudan HIF forum
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Latest Evidence of Treatment in CKD Anemia with Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors2020

    • Author(s)
      Masaomi Nangaku
    • Organizer
      Taiwan Society of Nephrology
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Renal Repair Mechanisms Post-AKI: Targets for Intervention?2020

    • Author(s)
      Masaomi Nangaku
    • Organizer
      Asia Pacific AKI and CRRT conference
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] potential benefits and harms of HIF-PH inhibitor2020

    • Author(s)
      Masaomi Nangaku
    • Organizer
      Chinese Society of Nephrology
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Kidney disease in Japan2019

    • Author(s)
      Masaomi Nangaku
    • Organizer
      Berliner DialyseSeminar
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Treatment strategies targeting hypoxia and oxidative stress - HIF and Nrf22019

    • Author(s)
      Masaomi Nangaku
    • Organizer
      International Diabetes Federation Congress 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Oxygen metabolism in AKI and CKD2019

    • Author(s)
      Masaomi Nangaku
    • Organizer
      American Society of Nephrology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mechanisms of AKI-on-CKD2019

    • Author(s)
      Masaomi Nangaku
    • Organizer
      2019 Asia-Pacific AKI to/on CKD Summit
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Therapy of diabetic kidney disease: current and future2019

    • Author(s)
      Masaomi Nangaku
    • Organizer
      International Cogress of Diabetes and Metabolism 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The Molecular Mechanisms of AKI to CKD Transition and Its Clinical Implication2019

    • Author(s)
      Masaomi Nangaku
    • Organizer
      3rd Asia Pacific AKI CRRT Congress
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] New era of diabetic kidney disease2019

    • Author(s)
      Masaomi Nangaku
    • Organizer
      Hong Kong Society of Nephrology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Update on anemia management in patients with CKD2019

    • Author(s)
      Masaomi Nangaku
    • Organizer
      APSN/HKSN CME course
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] AKI-to-CKD transition2019

    • Author(s)
      Masaomi Nangaku
    • Organizer
      Chinese Society of Nephrology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Pathogenesis and treatment of CKD and its complications2019

    • Author(s)
      Masaomi Nangaku
    • Organizer
      Asia Pacific Chapter Meeting of the ISPD
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Anemia in CKD/ESKD: Is it still EPO?2019

    • Author(s)
      Masaomi Nangaku
    • Organizer
      Asian Colloquium in Nephrology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Oxidative stress and hypoxia as novel therapeutic targets in kidney disease2019

    • Author(s)
      Masaomi Nangaku
    • Organizer
      Korean Society of Nephrology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] New therapies for diabetic nephropathy2019

    • Author(s)
      Masaomi Nangaku
    • Organizer
      Nephrology Biennial Review Course of WCN 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] HIF stabilizer in management of renal anemia2019

    • Author(s)
      Masaomi Nangaku
    • Organizer
      Nephrology Biennial Review Course of WCN 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Targeting oxidative stress and inflammation in diabetic kidney disease2019

    • Author(s)
      Masaomi Nangaku
    • Organizer
      Satellite Symposium of WCN 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The Role of Hypoxia and HIF in Tubule Injury2019

    • Author(s)
      Masaomi Nangaku
    • Organizer
      Keystone Symposium: Unraveling the Secrets of Kidney Disease
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Nrf2活性化薬の可能性2018

    • Author(s)
      南学正臣
    • Organizer
      第30回日本糖尿病性腎症研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] AKI to CKD Transition2018

    • Author(s)
      Masaomi Nangaku
    • Organizer
      American Society of Nephrology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The Burden of CKD; Challenges and Successes2018

    • Author(s)
      Masaomi Nangaku
    • Organizer
      American Society of Nephrology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mitochondrial DNA Leakage Causes Inflammation via the cGAS-STING Axis in Cisplatin-Mediated Tubular Damage2018

    • Author(s)
      Maekawa H, Jao T-Z, Inoue R, Nishi H, Inoue T, Nangaku M, Inagi R.
    • Organizer
      American Society of Nephrology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Efficacy and Safety of Daprodustat on Anemia Management in Japanese Hemodialysis Patients Not Using Erythropoiesis-Stimulating Agents2018

    • Author(s)
      Fujii T, Tsubakihara Y, Akizawa T, Nangaku M, Onoue T, Yonekawa T, Endo Y, Cobitz AR.
    • Organizer
      American Society of Nephrology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Randomized, Placebo-Controlled Phase 2 Trials of Vadadustat, an Oral Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor (HIF-PHI), to Treat Anemia of CKD2018

    • Author(s)
      Nangaku M, Khawaja Z, Luo W, Garafola S, deGoma E, Komatsu Y.
    • Organizer
      American Society of Nephrology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Whole-Kidney Three-Dimensional Imaging Reveals the Progression of Renal Sympathetic Denervation after Ischemia-Reperfusion Injury2018

    • Author(s)
      Hasegawa S, Fukagawa M, Ueda HR, Nangaku M, Tanaka T, Susaki EA, Komaba H, Wada T, Saito H, Sugahara M, Uchida L, Ito M.
    • Organizer
      American Society of Nephrology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Multiple, Systemic Effects of PHD Inhibitors Signify an Anti-Fibrotic and Anti-Inflammatory Impact on Cardiovascular Complications in the Remnant Kidney2018

    • Author(s)
      Uchida L, Tanaka T, Saito H, Sugahara M, Fukui K, Wakashima T, Nangaku M.
    • Organizer
      American Society of Nephrology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mitochondrial Morphological Abnormality in Cyst Epithelial Cells of Autosomal Dominant Polycystic Kidney Disease Patients2018

    • Author(s)
      Ishimoto Y, Shimizu A, Kugita M, Nagao S, Honda K, Inagi R, Nangaku M, Nishio S, Kawano H, Horie S, Kasahara T, Osafune K, Hoshino J, Ubara Y.
    • Organizer
      American Society of Nephrology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] PHD Inhibition Reduces Reactive Oxidative Stress in In Vitro Ischemia Model2018

    • Author(s)
      Ito M, Tanaka T, Wakashima T, Nangaku M, Fukui K.
    • Organizer
      American Society of Nephrology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Hes1, a Newly Identified Downstream Mediator of α7nAChR on Macrophages in the Cholinergic Anti-Inflammatory Pathway, Plays a Protective Role in AKI2018

    • Author(s)
      Inoue T, Abe C, Tanaka S, Rosin DL, Nangaku M, Wada Y, Okusa MD.
    • Organizer
      American Society of Nephrology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ATF6α and PPARα Cross-Talk Provides New Insights into Lipotoxicity-Induced Tubulointerstitial Fibrosis2018

    • Author(s)
      Jao T-M, Inoue T, Sugahara M, Maekawa H, Ishimoto Y, Tanaka T, Nangaku M, Inagi R.
    • Organizer
      American Society of Nephrology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Anti-oxidative stress therapy against DKD2018

    • Author(s)
      南学正臣
    • Organizer
      第33回日本糖尿病合併症学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] The Molecular Machanisms of AKI to CKD Transition and Its Clinical Implication2018

    • Author(s)
      Masaomi Nangaku
    • Organizer
      2nd Asia-Pacific AKI CRRT Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Can Biomarker Based Management for AKI Improve Outcomes?2018

    • Author(s)
      Masaomi Nangaku
    • Organizer
      2nd Asia-Pacific AKI CRRT Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The AKI to CKD Continuum: a Clinical Perspective2018

    • Author(s)
      Masaomi Nangaku
    • Organizer
      Hong Kong Society of Nephrology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Anemia treatment in CKD: Update2018

    • Author(s)
      Masaomi Nangaku
    • Organizer
      Malaysian Society of Nephrology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Diabetic nephropathy: Is there anything new?2018

    • Author(s)
      Masaomi Nangaku
    • Organizer
      Malaysian Society of Nephrology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 慢性腎臓病における心・血管障害2018

    • Author(s)
      南学正臣
    • Organizer
      第10回日本下肢救済・足病学会学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 腎性貧血とHIF2018

    • Author(s)
      南学正臣
    • Organizer
      第10回日本下肢救済・足病学会学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 慢性腎不全治療薬の開発 その課題と今後への期待2018

    • Author(s)
      南学正臣
    • Organizer
      第61回日本腎臓学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 糖尿病性腎臓病(DKD):新たな疾患概念:オーバービュー2018

    • Author(s)
      南学正臣
    • Organizer
      第61回日本腎臓学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 糖尿病性腎臓病DKDの抑制を目指して2018

    • Author(s)
      南学正臣
    • Organizer
      第61回日本糖尿病学会年次学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Update of management of diabetic nephropathy2018

    • Author(s)
      Masaomi Nangaku
    • Organizer
      Korean Soceity of Nephrology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] New insights into AKI to CKD continuum and the role of maladaptive repair2018

    • Author(s)
      Masaomi Nangaku
    • Organizer
      Korean Soceity of Nephrology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited

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Published: 2018-04-23   Modified: 2022-08-22  

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