Next generation therapy of podocytopathy developed by renal organoid
| Project/Area Number |
18H02827
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 53040:Nephrology-related
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| Research Institution | Tokai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
荒岡 利和 京都大学, iPS細胞研究所, 特定研究員 (40437661)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2019: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2018: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
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| Keywords | 腎臓病 / オルガノイド / ポドサイト / ネフローゼ症候群 / ネフロン前駆細胞 |
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| Outline of Final Research Achievements |
Kidney cells change dramatically their character when they are cultured in dishes. Utilizing recently developed techniques, we generated kidney organoids from mouse kidney progenitor cells and established a method to induce injury and analyze the responses. We previously found that when a portion of kidney cells are injured, other cells are secondarily damaged in a mouse model. In the present study, we found this damage spreading is reproduced in kidney organoids.
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| Academic Significance and Societal Importance of the Research Achievements |
試験管内で腎臓病を再現可能になったので、薬剤の効果検証やスクリーニングが容易になり、腎臓病の治療法の開発に役立つと期待される。
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithelial cells2020
Author(s)
Matsuda J, Takahashi A, Takabatake Y, Sakai S, Minami S, Yamamoto T, Fujimura R, Namba-Hamano T, Yonishi H, Nakamura J, Kimura T, Kaimori JY, Matsui I, Takahashi M, Nakao M, Izumi Y, Bamba T, Matsusaka T, Niimura F, Yanagita M, Yoshimori T, Isaka Y.
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Journal Title
Autophagy
Volume: -
Pages: 1-16
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Proximal Tubule Autophagy Differs in Type 1 and 2 Diabetes2019
Author(s)
Sakai S, Yamamoto T, Takabatake Y, Takahashi A, Namba-Hamano T, Minami S, Fujimura R, Yonishi H, Matsuda J, Hesaka A, Matsui I, Matsusaka T, Niimura F, Yanagita M, Isaka Y.
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Journal Title
J Am Soc Nephrol
Volume: 30(6)
Issue: 6
Pages: 929-945
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Autophagy protects kidney from phosphate-induced mitochondrial injury2019
Author(s)
Fujimura R, Yamamoto T, Takabatake Y, Takahashi A, Namba-Hamano T, Minami S, Sakai S, Matsuda J, Hesaka A, Yonishi H, Nakamura J, Matsui I, Matsusaka T, Niimura F, Yanagita M, Isaka Y.
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Journal Title
Biochem Biophys Res Commun
Volume: S0006-291X(20)
Issue: 3
Pages: 30220-5
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Autophagy Protects Kidney Proximal Tubules from Phosphate-Mediated Mitochondrial Dysfunction2018
Author(s)
Ryuta Fujimura, Takeshi Yamamoto, Yoshitsugu Takabatake, Satoshi Minami, Atsushi Takahashi, Tomoko Namba, Jun Matsuda, Shinsuke Sakai, Isao Matsui, Fumio Niimura, Taiji Matsusaka, Yoshitaka Isaka
Organizer
ASN Kidney Week
Related Report
Int'l Joint Research
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