| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2020: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2019: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2018: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Outline of Final Research Achievements |
Dermatomyositis is one of the connective tissue diseases and is included in the designated intractable diseases in Japan. Until now, there have been few suitable mouse models for this disease, which has been a barrier to elucidation of its pathophysiology and development of treatment methods. In recent years, disease-specific autoantibodies have been identified in dermatomyositis, and it is considered that this immune response may be the key to clarify the molecular mechanisms of the disease. In this study, we have established a mouse model that induces experimental myositis by immunizing the human TIF1γ protein, which is a major target of such autoantibodies.
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