| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2018: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Outline of Final Research Achievements |
In the analysis of bone marrow (BM) lipid mediators, the stimulation of sympathetic nervous system (SNS) leads to the increased expression of receptor type transcription factor, PPARδ in BM neutrophil precursors. ω3 fatty acids in the food stimulate PPARδ and induce the production of a regulator of BM vascular permeability. In addition, SNS signal induces the hypoxia in the BM microenvironment, which leads to the production of FGF23 from erythroblasts. FGF23 in the BM microenvironment suppresses the function of CXCR4 in hematopoietic stem/progenitor cells, which regulates the trafficking of these cells between BM and circulation.
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