| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2019: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2018: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Outline of Final Research Achievements |
“Niches” play important roles in supporting hematopoiesis and are constituted with various cells including mesenchymal stem cells in bone marrow. This study aimed to classify the mesenchymal stem cells according to their functions such as niches for hematopoiesis, regenerative capability, differentiating capacity, etc., which will lead to development of new methods for tissue regeneration.
Furthermore, genetic insults including tissue injuries and aging on bone marrow mesenchymal stem cells might raise “tumorigenic microenvironments” that promote malignant transformation or selection of malignant clones. Therefore, understanding of the mutual interaction between hematopoietic cells and their microenvironments is essential. The anatomical and functional interactions between tumor cells and their microenvironments are essential to efficiently control tumor cells. The outcome that this study has achieved may add new concept as “anti-cancer niche” to cancer therapy.
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