Understanding of hematopoietic stem cell trafficking across developmental hematopoietic organs

• Project/Area Number: 18H02843
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 54010:Hematology and medical oncology-related
• Research Institution: Kumamoto University
• Principal Investigator: TAKIZAWA Hitoshi 熊本大学, 国際先端医学研究機構, 特別招聘教授 (10630866)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000); Fiscal Year 2020: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2019: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2018: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
• Keywords: 造血幹細胞 / 遊走

Outline of Final Research Achievements

In hematopoietic system, one of somatic tissue, blood forming hematopoietic stem cells (HSCs) are born in aorta-gonad-mesonephros (AGM) region, and migrate to bone marrow (BM) through mutiple organs where adult hematopoiesis is maintained. This project focused on dynamics of HSC colonization in BM, identified HSC subset with different function, and calculated proliferation/differentiation/migration using mathematical model.

Academic Significance and Societal Importance of the Research Achievements

本研究の成果は成体末梢血中に常時遊走している造血幹細胞の生理学的機能、髄外造血の機序、骨髄移植後の骨髄再建能の効率化に向けて有用な知見をもたらすと期待される。

Research Products

• [Int'l Joint Research] University of Zurich(スイス)
• [Int'l Joint Research] University of Cambridge(英国)
• [Journal Article] Hlf expression marks the developmental pathway for hematopoietic stem cells but not for erythroid-myeloid progenitors (2019)
  • Author(s): Yokomizo T*, Watanabe N, Umemoto T, Matsuo J, Harai R, Kihara Y, Nakamura E, Tada N, Sato T, Takaku T, Shimono A, Takizawa H, Nakagata N, Mori S, Kurokawa M, Tenen DG, Osato M, Suda T
  • Journal Title: J Exp Med Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Development of the Hematopoietic System: Role of Inflammatory Factors (2019)
  • Author(s): Hayashi Y#, Sezaki M#, Takizawa H*
  • Journal Title: Wiley Interdiscip Rev Dev Biol Volume: 27 Issue: 4
  • DOI: 10.1002/wdev.341
  • Peer Reviewed / Open Access
• [Presentation] Cross-organ HSC trafficking during definitive hematopoiesis formation (2018)
  • Author(s): 瀬崎真衣子
  • Organizer: 第80回日本血液学会学術集会
• [Remarks] 国際先端医学研究機構 幹細胞ストレス研究室
  • URL: http://ircms.kumamoto-u.ac.jp/research/hitoshi_takizawa/