| Budget Amount *help |
¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
Fiscal Year 2020: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Outline of Final Research Achievements |
Synovial fibroblasts (SFs) contribute to the induction and persistence of synovitis in rheumatoid arthritis (RA) by highly expressing inflammatory mediators represented by IL-6. In this research, the applicant was the first in the world to catalog the relationship between gene expression of inflammatory mediators from SFs and chromatin structural changes and disease susceptibility polymorphisms. Moreover, through integrated functional genome analysis, it was clarified that chromatin structural changes in SFs under a complex inflammatory environment are associated with RA susceptibility and high expression of IL-6. The applicant also identified a transcription factor complex crucial for this pathological structure formation and clarified that its constituent, MTF1, is involved in arthritis formation.
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