Development of a preventive strategy for allergic diseases
| Project/Area Number |
18H02850
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 54020:Connective tissue disease and allergy-related
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| Research Institution | National Center for Child Health and Development |
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Principal Investigator |
Saito Hirohisa 国立研究開発法人国立成育医療研究センター, 所長室, 研究所長補佐 (40130166)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2020: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2019: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2018: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Keywords | 発症予防 / アレルギー疾患 / 抗IgE抗体 |
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| Outline of Final Research Achievements |
We found that the administration of anti-IgE antibody to pregnant mouse suppressed the production of antigen-specific IgE antibody in pups and thus prevent the development of food allergy. On the other hand, other immune responses such as antigen-specific T cell responses and IgG antibody production were not altered, which indicated the effect of anti-IgE antibody is IgE specific. Although the duration of the effect of anti-IgE antibody varied depending on the mouse strains, inhibition of IgE antibody production was observed in all strains. In addition, the administration of anti-IgE antibody during the neonatal period showed comparable effect with those in the pregnancy period. Taken together, the administration of anti-IgE antibody during pregnancy or neonatal period could be a promising strategy to prevent allergic diseases in children.
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| Academic Significance and Societal Importance of the Research Achievements |
アレルギー疾患の患者数が増え続けており、現在では国民の3人に1人が何らかのアレルギーを持っていると言われています。一旦発症したアレルギー疾患を完全に治すことができる治療は存在しないため、アレルギー疾患の発症を抑制する方法の開発が期待されています。本研究では、妊娠中のマウスに抗IgE抗体を投与すると、生まれてきた仔マウスが一定期間IgE抗体を産生しないこと、その結果、仔マウスにおいて食物アレルギーの発症を予防できることを明らかにしました。本方法はIgE抗体以外の免疫系には影響がないことから、実現可能なアレルギー疾患発症予防法になり得る可能性がある。今後、臨床応用を目指した検討を行う必要がある。
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Report
(4 results)
Research Products
(4 results)
