| Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2020: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Outline of Final Research Achievements |
Recently, it has been considered that cryptococcosis may be developed by reactivation of latently infected Cryptococcus neoformans in lungs. In the present study, we succeeded in establishing a mouse model of latent pulmonary infection with C. neoformans using a transgenic mouse expressing T cell receptor for chitin deacetylase 2, which is a major T cell antigen in this fungal pathogen. During the latent infection stage, the granulomatous lesions were developed in lungs, which contained multinucleated giant cells engulfing these fungi, and B cells and T cells expressing MCP-1 as well as macrophages expressing TNF-α were observed in these granulomas. Using this model, the immunological mechanisms for latent infection with C. neoformans and its reactivation under immunocompromised conditions will be expected to be unveiled.
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