Vaccine development against tuberculosis and AIDS by the use of lipid immunity
Project/Area Number |
18H02852
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Review Section |
Basic Section 54030:Infectious disease medicine-related
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Research Institution | Kyoto University |
Principal Investigator |
Sugita Masahiko 京都大学, ウイルス・再生医科学研究所, 教授 (80333532)
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Project Period (FY) |
2018-04-01 – 2021-03-31
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Project Status |
Completed (Fiscal Year 2020)
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Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2020: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2018: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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Keywords | リポペプチド / MHC / 脂質免疫 / ワクチン / 結核 / エイズ |
Outline of Final Research Achievements |
Recent evidence indicated that lipopeptides comprise a novel class of antigen recognized by T cells. We aimed at elucidating how this immune pathway functions and establishing valuable small animal models that are suitable for lipopeptide immunity research, hoping to contribute to the development of new type of vaccines. Indeed, we were able to establish murine models equipped with the ability to respond to lipopeptides when sensitized with lipopeptide-loaded BCG vaccines. Therefore, this study served to construct an important basis for developing a new type of lipopeptide vaccines.
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Academic Significance and Societal Importance of the Research Achievements |
ウイルスリポペプチドを標的とした新しい免疫応答がどのようにして起きるのか、そのメカニズムを明らかにしました。またリポペプチド免疫を起こりやすくしたマウスモデルを樹立し、どのようにリポペプチドを接種すればリポペプチド特異的免疫応答が効率的に惹起できるのか、その方法を発見しました。これらの成果は、リポペプチドを主体とした新しいタイプのワクチン開発へと結実する可能性があります。
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] Identification and Structure of an MHC Class I-Encoded Protein with the Potential to Present N-Myristoylated 4-mer Peptides to T Cells2019
Author(s)
Yamamoto Y, Morita D, Shima Y, Midorikawa A, Mizutani T, Suzuki J, Mori N, Shiina T, Inoko H, Tanaka Y, Mikami B, Sugita M.
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Journal Title
Journal of Immunology
Volume: 202
Issue: 12
Pages: 3349-3358
DOI
Related Report
Peer Reviewed
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