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Development of gene-modified culture cells that reflect the specific infection events of arthropod-borne viruses

Research Project

Project/Area Number 18H02856
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 54030:Infectious disease medicine-related
Research InstitutionNational Institute of Infectious Diseases

Principal Investigator

Isawa Haruhiko  国立感染症研究所, 昆虫医科学部, 室長 (90370965)

Co-Investigator(Kenkyū-buntansha) 深澤 征義  国立感染症研究所, 細胞化学部, 部長 (20291130)
駒形 修  国立感染症研究所, 昆虫医科学部, 主任研究官 (20435712)
沢辺 京子  国立感染症研究所, 昆虫医科学部, 主任研究官 (10215923)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2019: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2018: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Keywords節足動物媒介性ウイルス / 宿主細胞 / ゲノム科学 / ゲノム編集 / バイオインフォマティクス
Outline of Final Research Achievements

We attempted to develop mosquito-derived cultured cell lines useful for mosquito-borne virus research, and succeeded in establishing new cell lines from Aedes aegypti and Aedes albopictus. These cell lines were found to be differentially susceptible to various mosquito-borne viruses. De novo genome assembly was conducted for the NIID-CTR cell culture, which was derived from Culex tritaeniorhynchus. Obtained biological resources will benefit studies of population genetics and molecular mechanisms for virus transmission of this important vector mosquito.
We found that Huh7.5.1-8 cells, isolated from human hepatoma Huh 7 cells by us, were highly permissive to arthropod-borne viruses such as Japanese encephalitis virus, Sindbis virus, and severe fever with thrombocytopenia syndrome virus.

Academic Significance and Societal Importance of the Research Achievements

本研究により樹立に成功した蚊由来培養細胞系は、デングウイルス・ジカウイルス・黄熱ウイルスなど、蚊媒介性ヒト病原ウイルスに対する感受性や宿主範囲ならびに媒介能を規定する分子基盤解明に役立つと期待される。本研究で得られた結果から、NIID-CTR細胞のモデル細胞としての妥当性が示され、コガタアカイエカの生態やウイルスの媒介能に関する分子基盤を明らかにするための重要な情報基盤となると期待される。
我々が分離したHuh7.5.1-8細胞は、既存の昆虫及びダニ媒介性ウイルスの簡便な分離・検出に利用できることが期待され、また、未知の昆虫及びダニ媒介性ウイルスの分離・検出にも有用である可能性がある。

Report

(4 results)
  • 2021 Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (44 results)

All 2022 2021 2020 2019 2018

All Journal Article (20 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 20 results,  Open Access: 14 results) Presentation (24 results) (of which Int'l Joint Research: 5 results)

  • [Journal Article] Detection of Quaranjavirus-Like Sequences from <i>Haemaphysalis hystricis</i> Ticks Collected in Japan2022

    • Author(s)
      Kobayashi Daisuke、Kuwata Ryusei、Kimura Toshiya、Faizah Astri Nur、Higa Yukiko、Hayashi Toshihiko、Sawabe Kyoko、Isawa Haruhiko
    • Journal Title

      Japanese Journal of Infectious Diseases

      Volume: 75 Issue: 2 Pages: 195-198

    • DOI

      10.7883/yoken.JJID.2021.129

    • NAID

      130008080718

    • ISSN
      1344-6304, 1884-2836
    • Year and Date
      2022-03-31
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] L-DOPA, a treatment for Parkinson's disease, and its enantiomer D-DOPA inhibit severe fever with thrombocytopenia syndrome virus infection in vitro2022

    • Author(s)
      Ogawa Motohiko、Murae Mana、Gemba Ryutaro、Irie Takuya、Shimojima Masayuki、Saijo Masayuki、Noguchi Kohji、Fukasawa Masayoshi
    • Journal Title

      Journal of Infection and Chemotherapy

      Volume: 28 Issue: 3 Pages: 373-376

    • DOI

      10.1016/j.jiac.2021.11.005

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Determining vector competence of Aedes aegypti from Ghana in transmitting dengue virus serotypes 1 and 22021

    • Author(s)
      Amoa-Bosompem Michael、Kobayashi Daisuke、Itokawa Kentaro、Murota Katsunori、Faizah Astri Nur、Azerigyik Faustus Akankperiwen、Hayashi Takaya、Ohashi Mitsuko、Bonney Joseph H. Kofi、Dadzie Samuel、Tran Cuong Chi、Tran Phong Vu、Fujita Ryosuke、Maekawa Yoshihide、Kasai Shinji、Yamaoka Shoji、Ohta Nobuo et al.
    • Journal Title

      Parasites & Vectors

      Volume: 14 Issue: 1 Pages: 228-228

    • DOI

      10.1186/s13071-021-04728-z

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Toyo virus, a novel member of the Kaisodi group in the genus Uukuvirus (family Phenuiviridae) found in Haemaphysalis formosensis ticks in Japan2021

    • Author(s)
      Kobayashi Daisuke、Kuwata Ryusei、Kimura Toshiya、Faizah Astri Nur、Higa Yukiko、Hayashi Toshihiko、Sawabe Kyoko、Isawa Haruhiko
    • Journal Title

      Archives of Virology

      Volume: 166 Issue: 10 Pages: 2751-2762

    • DOI

      10.1007/s00705-021-05193-w

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Detection of Jingmenviruses in Japan with Evidence of Vertical Transmission in Ticks2021

    • Author(s)
      Kobayashi Daisuke、Kuwata Ryusei、Kimura Toshiya、Shimoda Hiroshi、Fujita Ryosuke、Faizah Astri Nur、Kai Izumi、Matsumura Ryo、Kuroda Yudai、Watanabe Shumpei、Kuniyoshi Sawako、Yamauchi Takeo、Watanabe Mamoru、Higa Yukiko、Hayashi Toshihiko、Shinomiya Hiroto、Maeda Ken、Kasai Shinji、Sawabe Kyoko、Isawa Haruhiko
    • Journal Title

      Viruses

      Volume: 13 Issue: 12 Pages: 2547-2547

    • DOI

      10.3390/v13122547

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Screening for tick-borne and tick-associated viruses in ticks collected in Ghana2021

    • Author(s)
      Amoa-Bosompem Michael、Kobayashi Daisuke、Faizah Astri Nur、Kimura Shohei、Antwi Ama、Agbosu Esinam、Pratt Deborah、Ohashi Mitsuko、Bonney Joseph H. Kofi、Dadzie Samuel、Ejiri Hiroko、Ohta Nobuo、Sawabe Kyoko、Iwanaga Shiroh、Isawa Haruhiko
    • Journal Title

      Archives of Virology

      Volume: 167 Issue: 1 Pages: 123-130

    • DOI

      10.1007/s00705-021-05296-4

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Antiviral Effects of the Anti-Occludin Monoclonal Antibody on Persistent Hepatitis C Virus Infection in a Human Liver Chimeric Mouse Model2021

    • Author(s)
      Shimizu Yoshimi、Suzuki Takeru、Shirasago Yoshitaka、Kondoh Masuo、Suzuki Tetsuro、Wakita Takaji、Fukasawa Masayoshi
    • Journal Title

      BPB Reports

      Volume: 4 Issue: 5 Pages: 142-147

    • DOI

      10.1248/bpbreports.4.5_142

    • NAID

      130008089064

    • ISSN
      2434-432X
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structural basis of antiviral activity of caffeic acid against severe fever with thrombocytopenia syndrome virus2021

    • Author(s)
      Ogawa Motohiko、Shirasago Yoshitaka、Tanida Isei、Kakuta Soichiro、Uchiyama Yasuo、Shimojima Masayuki、Hanada Kentaro、Saijo Masayuki、Fukasawa Masayoshi
    • Journal Title

      Journal of Infection and Chemotherapy

      Volume: 27 Issue: 2 Pages: 397-400

    • DOI

      10.1016/j.jiac.2020.10.015

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Several catechins and flavonols from green tea inhibit severe fever with thrombocytopenia syndrome virus infection in vitro2021

    • Author(s)
      Ogawa Motohiko、Shimojima Masayuki、Saijo Masayuki、Fukasawa Masayoshi
    • Journal Title

      Journal of Infection and Chemotherapy

      Volume: 27 Issue: 1 Pages: 32-39

    • DOI

      10.1016/j.jiac.2020.08.005

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Discovery of a Novel Flavivirus (Flaviviridae) From the Horse Fly, Tabanus rufidens (Diptera: Tabanidae): The Possible Coevolutionary Relationships Between the Classical Insect-Specific Flaviviruses and Host Dipteran Insects2020

    • Author(s)
      Kobayashi Daisuke、Watanabe Mamoru、Faizah Astri Nur、Amoa-Bosompem Michael、Higa Yukiko、Tsuda Yoshio、Sawabe Kyoko、Isawa Haruhiko
    • Journal Title

      Journal of Medical Entomology

      Volume: 58 Issue: 2 Pages: 880-890

    • DOI

      10.1093/jme/tjaa193

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Entomological Assessment of the Status and Risk of Mosquito-borne Arboviral Transmission in Ghana2020

    • Author(s)
      Amoa-Bosompem M, Kobayashi D, Murota K, Faizah A N、Itokawa K、Fujita R、Osei Joseph H N、Agbosu E、Pratt D、Kimura S、Kwofie Kofi D、Ohashi M、Bonney Joseph H. K、Dadzie S、Sasaki T、Ohta N、Isawa H、Sawabe K、Iwanaga S
    • Journal Title

      Viruses

      Volume: 12 Issue: 2 Pages: 147-147

    • DOI

      10.3390/v12020147

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Deciphering the Virome of Culex vishnui Subgroup Mosquitoes, the Major Vectors of Japanese Encephalitis, in Japan2020

    • Author(s)
      Faizah Astri Nur、Kobayashi Daisuke、Isawa Haruhiko、Amoa-Bosompem Michael、Murota Katsunori、Higa Yukiko、Futami Kyoko、Shimada Satoshi、Kim Kyeong Soon、Itokawa Kentaro、Watanabe Mamoru、Tsuda Yoshio、Minakawa Noboru、Miura Kozue、Hirayama Kazuhiro、Sawabe Kyoko
    • Journal Title

      Viruses

      Volume: 12 Issue: 3 Pages: 264-264

    • DOI

      10.3390/v12030264

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Establishment and characterization of a cell line from Ghanaian Aedes aegypti (Diptera: Culicidae) focusing on Aedes-borne flavivirus susceptibility2020

    • Author(s)
      Amoa-Bosompem Michael、Kobayashi Daisuke、Itokawa Kentaro、Faizah Astri Nur、Kuwata Ryusei、Dadzie Samuel、Hayashi Takaya、Yamaoka Shoji、Sawabe Kyoko、Iwanaga Shiroh、Isawa Haruhiko
    • Journal Title

      In Vitro Cellular & Developmental Biology - Animal

      Volume: 56 Issue: 9 Pages: 792-798

    • DOI

      10.1007/s11626-020-00504-y

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] RNA virome analysis of questing ticks from Hokuriku District, Japan, and the evolutionary dynamics of tick-borne phleboviruses2020

    • Author(s)
      Kobayashi Daisuke、Murota Katsunori、Itokawa Kentaro、Ejiri Hiroko、Amoa-Bosompem Michael、Faizah Astri Nur、Watanabe Mamoru、Maekawa Yoshihide、Hayashi Toshihiko、Noda Shinichi、Yamauchi Takeo、Komagata Osamu、Sawabe Kyoko、Isawa Haruhiko
    • Journal Title

      Ticks and Tick-borne Diseases

      Volume: 11 Issue: 2 Pages: 101364-101364

    • DOI

      10.1016/j.ttbdis.2019.101364

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evaluating the competence of the primary vector, Culex tritaeniorhynchus, and the invasive mosquito species, Aedes japonicus japonicus, in transmitting three Japanese encephalitis virus genotypes2020

    • Author(s)
      Faizah Astri Nur、Kobayashi Daisuke、Amoa-Bosompem Michael、Higa Yukiko、Tsuda Yoshio、Itokawa Kentaro、Miura Kozue、Hirayama Kazuhiro、Sawabe Kyoko、Isawa Haruhiko
    • Journal Title

      PLOS Neglected Tropical Diseases

      Volume: 14 Issue: 12 Pages: e0008986-e0008986

    • DOI

      10.1371/journal.pntd.0008986

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Occludin‐binding single‐chain variable fragment and antigen‐binding fragment antibodies prevent hepatitis C virus infection2020

    • Author(s)
      Shimizu Yoshimi、Shinoda Takehiro、Shirasago Yoshitaka、Kondoh Masuo、Shinya Naoko、Hanada Kentaro、Yagi Kiyohito、Suzuki Tetsuro、Wakita Takaji、Kimura‐Someya Tomomi、Shirouzu Mikako、Fukasawa Masayoshi
    • Journal Title

      FEBS Letters

      Volume: 595 Issue: 2 Pages: 220-229

    • DOI

      10.1002/1873-3468.13975

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibition Mechanisms of Hepatitis C Virus Infection by Caffeic Acid and Tannic Acid2019

    • Author(s)
      Shirasago Yoshitaka、Inamori Yoko、Suzuki Takeru、Tanida Isei、Suzuki Tetsuro、Sugiyama Kazuo、Wakita Takaji、Hanada Kentaro、Fukasawa Masayoshi
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 42 Issue: 5 Pages: 770-777

    • DOI

      10.1248/bpb.b18-00970

    • NAID

      130007641446

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2019-05-01
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human-rat chimeric anti-occludin monoclonal antibodies inhibit hepatitis C virus infection2019

    • Author(s)
      Shimizu Yoshimi、Yoneda Kohei、Shirasago Yoshitaka、Suzuki Takeru、Tada Minoru、Ishii-Watabe Akiko、Sugiyama Kazuo、Suzuki Tetsuro、Wakita Takaji、Yagi Kiyohito、Kondoh Masuo、Fukasawa Masayoshi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 514 Issue: 3 Pages: 785-790

    • DOI

      10.1016/j.bbrc.2019.05.019

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of monoclonal antibodies recognizing each extracellular loop domain of occludin2019

    • Author(s)
      Shimizu Yoshimi、Shirasago Yoshitaka、Suzuki Takeru、Hata Tomoyuki、Kondoh Masuo、Hanada Kentaro、Yagi Kiyohito、Fukasawa Masayoshi
    • Journal Title

      The Journal of Biochemistry

      Volume: 166 Issue: 4 Pages: 297-308

    • DOI

      10.1093/jb/mvz037

    • NAID

      40022023629

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Persistent viruses in mosquito cultured cell line suppress multiplication of flaviviruses2018

    • Author(s)
      Fujita Ryosuke、Kato Fumihiro、Kobayashi Daisuke、Murota Katsunori、Takasaki Tomohiko、Tajima Shigeru、Lim Chang-Kweng、Saijo Masayuki、Isawa Haruhiko、Sawabe Kyoko
    • Journal Title

      Heliyon

      Volume: 4 Issue: 8 Pages: e00736-e00736

    • DOI

      10.1016/j.heliyon.2018.e00736

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] キンイロヌマカのRNAウイルス叢解析および分離された新規フラビウイルスの性状解析2022

    • Author(s)
      松村凌, 小林大介, 渡辺護, 比嘉由紀子, 沢辺京子, 伊澤晴彦, 糸山享
    • Organizer
      第66回日本応用動物昆虫学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] アオダイショウ由来培養細胞の性状解析2021

    • Author(s)
      鍬田龍星, 黒木俊郎, 松井利康, 石嶋慧多, 立本完吾, 小林大介, 伊澤晴彦, 高野愛, 下田宙, 藤井ひかる, 畑明寿, 宇根有美, 森川茂, 前田健, 吉川泰弘
    • Organizer
      第73回日本衛生動物学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] キンイロヌマカから分離された新規フラビウイルスの性状解析2021

    • Author(s)
      松村凌, 小林大介, 渡辺護, 比嘉由紀子, 沢辺京子, 糸山享, 伊澤晴彦
    • Organizer
      第73回日本衛生動物学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ガーナ産ネッタイシマカ由来新規培養細胞系の樹立と性状解析2021

    • Author(s)
      伊澤晴彦, マイケル・アモア-ボソムペム, 小林大介, 鍬田龍星, 糸川健太郎, アシトリ・ヌー・ファイザー, 岩永史朗
    • Organizer
      第73回日本衛生動物学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Evaluation of the growth kinetics of Getah virus in a scope of mosquito cell lines2021

    • Author(s)
      Azerigyik F, Kobayashi D, Amoa-Bosompem M, Faizah AN, Iwanaga S, Isawa H
    • Organizer
      第73回日本衛生動物学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] アオダイショウおよびシマヘビ由来培養細胞の性状解析2021

    • Author(s)
      鍬田龍星,黒木俊郎,松井利康,石嶋慧多,立本完吾,小林大介,伊澤晴彦,高野愛,下田宙,藤井ひかる,宇根有美,森川茂,前田健,吉川泰弘
    • Organizer
      第164回日本獣医学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Evaluation of the growth kinetics of Getah virus in a scope of mammalian and mosquito cell cultures2021

    • Author(s)
      Azerigyik FA, Kobayashi D, Amoa-Bosompem M, Faizah AN, Iwanaga S, Isawa H
    • Organizer
      American Society of Tropical Medicine & Hygiene 70th Annual Meeting
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Arbovirus surveillance and Japanese encephalitis virus genotype IV isolation from Culex vishnui mosquitoes collected on Bali Island, Indonesia2021

    • Author(s)
      Faizah AN, Kobayashi D, Maekawa Y, Amoa-Bosompem M, Fauziyah S, Mulyatno KC, Subekti S, Rohmah EA, Lusida MI, Mori Y, Miura K, Hirayama K, Isawa H, Sawabe K
    • Organizer
      American Society of Tropical Medicine & Hygiene 70th Annual Meeting
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 蚊・マダニ由来培養細胞に潜在感染するウイルスの探索と同定2020

    • Author(s)
      松村凌, 小林大介, Astri Nur Faizah, 糸山享, 伊澤晴彦
    • Organizer
      第72回日本衛生動物学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ネッタイシマカのデングウイルス感受性関連遺伝子の解析2020

    • Author(s)
      佐々木年則, ベルツーソ・G・アーリン,伊澤晴彦,高崎智彦, 皆川昇, 沢辺京子
    • Organizer
      第72回日本衛生動物学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 本邦産ヒトスジシマカのデングウイルス感受性2019

    • Author(s)
      佐々木年則,小滝徹,田島茂,モイ・メンリン,斎藤一三,林昌宏,小林大介,伊澤晴彦,高崎智彦,沢辺京子
    • Organizer
      第71回日本衛生動物学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Comparing the competence of Ghanaian and Vietnamese Aedes mosquitoes as vectors of the dengue virus2019

    • Author(s)
      Michael Amoa-Bosompem, Daisuke Kobayashi, Katsunori Murota, Astri Nur Faizah, Mitsuko Ohashi, Toshinori Sasaki, Haruhiko Isawa, Kyoko Sawabe, Shiro Iwanaga
    • Organizer
      第71回日本衛生動物学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] コガタアカエイカ NIID-CTR 細胞の新規全ゲノムアセンブリ2019

    • Author(s)
      糸川健太郎,小林大介,伊澤晴彦,比嘉由紀子,葛西真治,駒形修,冨田隆史,黒田誠, 沢辺京子
    • Organizer
      第71回日本衛生動物学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Virome analysis of Japanese encephalitis vector, Culex tritaeniorhynchus, collected from three prefectures in Japan2019

    • Author(s)
      Astri Nur Faizah, Daisuke Kobayashi, Michael Amoa-Bosompem, Haruhiko Isawa, Kyeong Soon Kim, Mamoru Watanabe, Kozue Miura, Kazuhiro Hirayama, Kyoko Sawabe
    • Organizer
      第71回日本衛生動物学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 次世代シークエンサーを用いたマダニ保有ウイルスのサーベイランス2019

    • Author(s)
      小林大介, Astri Nur Faizah, Michael Amoa-bosompem, 室田勝功, 糸川健太郎, 渡辺護, 比嘉由紀子, 前川芳秀, 沢辺京子, 伊澤晴彦
    • Organizer
      第71回日本衛生動物学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 愛媛県で捕集されたマダニから分離された新規トゴトウイルスの性状解析2019

    • Author(s)
      伊澤晴彦, 江尻寛子, 林昌宏,藤田龍介,室田勝功,小林大介,鍬田龍星,下田宙,前田健, 菅美樹,木村俊也,四宮博人,沢辺京子
    • Organizer
      第71回日本衛生動物学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ツシマヤマネコ咬着タカサゴキララマダニからの Jingmen tick virus の分離2019

    • Author(s)
      藤田龍介, 江尻寛子, 山内健生, 糸川健太郎, 伊澤晴彦, 小林大介, 室田勝功, 前川芳秀, 沢辺京子
    • Organizer
      第71回日本衛生動物学会大会
    • Related Report
      2019 Annual Research Report
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    • Author(s)
      室田勝功,白藤浩明,石井圭子,小林大介,伊澤晴彦,梁瀬徹
    • Organizer
      第71回日本衛生動物学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 北陸三県の渡り鳥飛来地におけるマダニ相調査2019

    • Author(s)
      沢辺京子,比嘉由紀子,小林大介,前川芳秀,今西望,林利彦,伊澤晴彦,渡辺 護
    • Organizer
      第71回日本衛生動物学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 蚊ゲノムに内在化したウイルス様配列の遺伝子構造解析2019

    • Author(s)
      鳥井駿, 鍬田龍星, Spriyono, 下田宙,Thanmaporn Phichitraslip,Sathaporn Jittapalapong, Worawut Rerkamnuaychoke,Upik Kesumawati Hadi,Agus Setiyono,Srihadi Agungpriyono,糸川健太郎,伊澤晴彦,沢辺京子,前田健
    • Organizer
      第71回日本衛生動物学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ヒトスジシマカのデングウイルス感受性に見られる地域性2019

    • Author(s)
      佐々木年則, 小滝徹, 田島茂, モイ メンリン, 斎藤一三, 林 昌宏, 小林大介, 伊澤晴彦, 高崎智彦, 澤邉京子
    • Organizer
      日本比較免疫学会第31回学術集会・第30回日本生体防御学会学術総会合同大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Functional investigation of endogenous flaviviral elements in Aedes mosquitoes2019

    • Author(s)
      Yasutsugu Suzuki, Artem Baidaliuk, Lionel Frangeul, Daisuke Kobayashi, Herv&eacute; Blanc, Haruhiko Isawa, Louis Lambrechts, Maria-Carla Saleh
    • Organizer
      The 18th Workshop 〝Cell Biology of Viral Infections" of the German Research Platform for Zoonoses and German Society of Virology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] COMPARING THE COMPETENCE OF GHANAIAN AND VIETNAMESE AEDES MOSQUITOES AS VECTORS OF THE DENGUE VIRUS2019

    • Author(s)
      Michael Amoa-Bosompem, Daisuke Kobayashi, Katsunori Murota, Astri Nur Faizah, Kentaro Itokawa, Mitsuko Ohashi, Samuel Dadzie, Kofi J. Bonney, Toshinori Sasaki, Haruhiko Isawa, Kyoko Sawabe, Shiroh Iwanaga
    • Organizer
      ASTMH 68th Annual Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] DISEASE SURVEILLANCE AND VIROME ANALYSIS STUDY OF JAPANESE ENCEPHALITIS VECTOR, CULEX TRITAENIORHYNCHUS, COLLECTED FROM THREE PREFECTURES IN JAPAN2019

    • Author(s)
      Astri Nur Faizah, Daisuke Kobayashi, Michael Amoa-Bosompem, Haruhiko Isawa, Kyeong Soon Kim, Mamoru Watanabe, Kozue Miura, Kazuhiro Hirayama, Kyoko Sawabe
    • Organizer
      ASTMH 68th Annual Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2023-01-30  

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