Role of mucosal tissue microbiota in neurotropic virus infection
Project/Area Number |
18H02857
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Review Section |
Basic Section 54030:Infectious disease medicine-related
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Research Institution | National Institutes of Biomedical Innovation, Health and Nutrition |
Principal Investigator |
IIJIMA NORIFUMI 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所 細胞核輸送ダイナミクスプロジェクト, サブプロジェクトリーダー (40612552)
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Co-Investigator(Kenkyū-buntansha) |
戸田 知得 北海道大学, 獣医学研究院, 助教 (70571199)
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Project Period (FY) |
2018-04-01 – 2022-03-31
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Project Status |
Completed (Fiscal Year 2021)
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Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2021: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
|
Keywords | B 細胞応答 / 組織局在型メモリー T 細胞 / 粘膜感染 / 末梢組織免疫応答 / 微生物叢 |
Outline of Final Research Achievements |
Herpes simplex virus (HSV), one of the neurotropic viruses, is impossible to cure latently infected nerve tissue because there is currently no vaccine that can prevent infection. Therefore, we aimed to establish a new treatment method by clarifying the importance and limitations of the defense mechanisms that are constructed in mucosal tissues, the site of HSV infection. In this study, we analyzed the details of the unresolved mechanism by which tissue-localized memory T cells (TRMs) accumulating in the mucosa completely inhibit the retrograde transport of HSV from the mucosa to the nerves.
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Academic Significance and Societal Importance of the Research Achievements |
性感染症を発症する病原体として知られている単純ヘルペスウイルス2型 (HSV-2) は、生殖器の粘膜から感染し、神経組織へと移行する神経向性ウイルスである。HSVー2 感染を防御するワクチン開発の研究が進められているが、現在も HSV-2 感染を防御できる方法は全くない。それ故、一度神経組織に侵入したウイルスを除去できないため、HSV-2 感染部位における生体防御機構の詳細を明らかにすることにより、新たな治療標的を同定することができる可能性が高い。それ故、申請者は生殖粘膜組織に集積する免疫細胞群や常在微生物群の役割に着目し、粘膜組織に構築される生体防御機構の詳細を明らかにした。
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Report
(5 results)
Research Products
(27 results)
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[Journal Article] Prostaglandin in the ventromedial hypothalamus regulates peripheral glucose metabolism2021
Author(s)
LeeML, Matsunaga H, Sugiura Y, Hayasaka T, Yamamoto I, Imoto D, SuematsuM, Iijima N, Kimura K, Diano S, Toda C.
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Journal Title
Nature Communications
Volume: Not determined
Issue: 1
Pages: 2330-2330
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Refeeding activates neurons in the dorsomedial hypothalamus to inhibit food intake and promote positive valence2021
Author(s)
Daigo Imoto, Izumi Yamamoto, Hirokazu Matsunaga, Toya Yonekura, Ming-Liang Lee, Kan X Kato, Takeshi Yamasaki, Shucheng Xu, Taiga Ishimoto, Satoshi Yamagata, Ken-Ichi Otsuguro, Motohiro Horiuchi , Norifumi Iijima, Kazuhiro Kimura, Chitoku Toda
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Journal Title
Molecular Metabiolism
Volume: 54
Pages: 101366-101366
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Activation of prodynorphin neurons in the dorsomedial hypothalamus inhibits food intake and promotes positive valence2020
Author(s)
Imoto D, Yamamoto I, Matsunaga H, Yonekura T, Lee ML, Kato KX, Yamasaki T, Otsuguro K, Horiuchi M, Iijima N, Kimura K, Toda C.
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Journal Title
bioRxiv
Volume: 0
Pages: 1-17
DOI
Related Report
Open Access
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[Journal Article] Prostaglandin in the ventromedial hypothalamus regulates peripheral glucose metabolism2020
Author(s)
LeeML, Matsunaga H, Sugiura Y, Hayasaka T, Yamamoto I, Imoto D, SuematsuM, Iijima N, Kimura K, Diano S, Toda C.
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Journal Title
bioRxiv
Volume: 0
Pages: 1-40
DOI
Related Report
Open Access
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[Journal Article] Effector TH17 Cells Give Rise to Long-Lived TRM Cells that Are Essential for an Immediate Response against Bacterial Infection.2019
Author(s)
Amezcua Vesely MC, Pallis P, Bielecki P, Low JS, Zhao J, Harman CCD, Kroehling L, Jackson R, Bailis W, Licona-Limon P, Xu H, Iijima N, Pillai PS, Kaplan DH, Weaver CT, Kluger Y, Kowalczyk MS, Iwasaki A, Pereira JP, Esplugues E, Gagliani N, Flavell RA.
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Journal Title
Cell
Volume: 178
Issue: 5
Pages: 1176-1188
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Immunological association of inducible bronchus-associated lymphoid tissue organogenesis in Ag85B-rHPIV2 vaccine-induced anti-tuberculosis mucosal immune responses in mice.2018
Author(s)
Nagatake T, Suzuki H, Hirata S, Matsumoto N, Wada Y, Morimoto S, Nasu A, Shimojou M, Kawano M, Ogami K, Tsujimura Y, Kuroda E, Iijima N, Hosomi K, Ishii KJ, Nosaka T, Yasutomi Y, Kunisawa J.
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Journal Title
Int Immunol
Volume: 30
Issue: 10
Pages: 471-481
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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