Effects of exosomal miRNAs on pancreatic beta cell function and/or proliferation

• Project/Area Number: 18H02859
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 54040:Metabolism and endocrinology-related
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Yamada TetsEuya 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (90400374)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000); Fiscal Year 2021: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2020: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2018: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
• Keywords: 臓器間相互作用 / マイクロRNA / エクソソーム / 白色脂肪組織 / 膵β細胞 / 糖尿病

Outline of Final Research Achievements

Inducible adipocyte-specific insulin receptor knockout mice show β-cell proliferation and increased β-cell mass in the islets. To explore the exosomal miRNAs involved in β-cell proliferation and function, we comprehensively analyzed increased miRNAs contained in the serum exosomes of these mice. By transfecting the increased miRNAs into pancreatic islet cells, we identified a miRNA that increases gene expression of insulin and transcription factors involved in β-cell function. The expression of the primary form of this miRNA was upregulated in the adipose tissues. These results suggested that organ crosstalk between adipose tissues and islets via the exosomal miRNA affect the function of pancreatic β-cells.

Academic Significance and Societal Importance of the Research Achievements

液性因子や神経に加えて、エクソソームを介したmiRNAの送達による臓器連関が膵β細胞の機能に影響を及ぼす可能性が見出された。今後、同定したmiRNAの糖尿病に対する効果を検討することで、糖尿病に対する新たな治療の開発に繋げることが期待できる。

Research Products

• [Journal Article] Clinical Characteristics Associated with the Development of Diabetic Ketoacidosis in Patients with Type 2 Diabetes (2022)
  • Author(s): Masuda Seizaburo、Ota Kazuki、Okazaki Rei、Ishii Ryoko、Cho Keiho、Hiramatsu Yuki、Adachi Yuko、Koseki Sayo、Ueda Eri、Minami Isao、Yamada Tetsuya、Watanabe Takayuki
  • Journal Title: Internal Medicine Volume: 61 Issue: 8 Pages: 1125-1132
  • DOI: 10.2169/internalmedicine.7266-21
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2022-04-15
  • Peer Reviewed / Open Access
• [Journal Article] A Clinical Case of Insulinoma Presenting with Postprandial Hypoglycemia in a Patient with a History of Gastric Bypass Surgery (2022)
  • Author(s): Hayashida Ryosuke、Tsuchiya Kyoichiro、Sekine Tetsuo、Momose Takashi、Sato Fuminori、Sakurada Maya、Nishida Kenji、Hayashi Tatsuya、Morita Yasuhiro、Okada Haruka、Fukushima Noriyoshi、Yamada Tetsuya、Tsujino Motoyoshi
  • Journal Title: Internal Medicine Volume: 61 Issue: 8 Pages: 1189-1195
  • DOI: 10.2169/internalmedicine.7428-21
  • NAID: 130008103226
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2022-04-15
  • Peer Reviewed
• [Journal Article] Characterisation of Ppy-lineage cells clarifies the functional heterogeneity of pancreatic beta cells in mice (2021)
  • Author(s): Fukaishi Takahiro、Nakagawa Yuko、Fukunaka Ayako、Sato Takashi、Hara Akemi、Nakao Keiko、Saito Michiko、Kohno Kenji、Miyatsuka Takeshi、Tamaki Motoyuki、Matsuhisa Munehide、Matsuoka Taka-aki、Yamada Tetsuya、Watada Hirotaka、Fujitani Yoshio
  • Journal Title: Diabetologia Volume: 64 Issue: 12 Pages: 2803-2816
  • DOI: 10.1007/s00125-021-05560-x
  • Peer Reviewed / Open Access
• [Journal Article] Hemodialysis patients with coronavirus disease 2019: reduced antibody response (2021)
  • Author(s): Beppu Hiroko、Fukuda Tatsuya、Yamada Tetsusya、Kohara Michinori、Wakai Sachiko et. al.
  • Journal Title: Clinical and Experimental Nephrology Volume: 26 Issue: 2 Pages: 170-177
  • DOI: 10.1007/s10157-021-02130-8
  • Peer Reviewed
• [Journal Article] Subtype-specific trends in the clinical picture of primary aldosteronism over a 13-year period (2021)
  • Author(s): Saito Kohei、Yamada Tetsuya、Kobayashi Hiroki、Tamura Kouichi、Ogawa Yoshihiro、Kawashima Junji、Inagaki Nobuya、Yamamoto Koichi、Yamada Masanobu、Kamemura Kohei、Fujii Yuichi、Suzuki Tomoko、Yasoda Akihiro、Tanabe Akiyo、Naruse Mitsuhide et. al.
  • Journal Title: Journal of Hypertension Volume: 39 Issue: 11 Pages: 2325-2332
  • DOI: 10.1097/hjh.0000000000002924
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Lower Insulin Secretion Is Associated with Hippocampal and Parahippocampal Gyrus Atrophy in Elderly Patients with Type 2 Diabetes Mellitus (2021)
  • Author(s): Adachi Yuko、Ota Kazuki、Minami Isao、Yamada Tetsuya、Watanabe Takayuki
  • Journal Title: Journal of Diabetes Investigation Volume: Online ahead of print Issue: 10 Pages: 1908-1913
  • DOI: 10.1111/jdi.13554
  • Peer Reviewed / Open Access
• [Journal Article] Age-stratified comparison of clinical outcomes between medical and surgical treatments in patients with unilateral primary aldosteronism. (2021)
  • Author(s): 2.Nakamaru R, Yamamoto K, Akasaka H, Rakugi H, Kurihara I, Yoneda T, Ichijo T, Katabami T, Tsuiki M, Wada N, Yamada T, Kobayashi H, Tamura K, Ogawa Y, Kawashima J, Inagaki N, Fujita M, Watanabe M, Kamemura K, Okamura S, Tanabe A, Naruse M; JPAS/JRAS Study Group.
  • Journal Title: Sci Rep. Volume: 11 Issue: 1 Pages: 6925-6925
  • DOI: 10.1038/s41598-021-86290-3
  • Peer Reviewed / Open Access
• [Journal Article] Importance of Intestinal Environment and Cellular Plasticity of Islets in the Development of Postpancreatectomy Diabetes. (2021)
  • Author(s): Fukuda T, Bouchi R, Takeuchi T, Amo-Shiinoki K, Kudo A, Tanaka S, Tanabe M, Akashi T, Hirayama K, Odamaki T, Igarashi M, Kimura I, Tanabe K, Tanizawa Y, Yamada T, Ogawa Y
  • Journal Title: Diabetes Care Volume: 44(4) Issue: 4 Pages: 1002-1011
  • DOI: 10.2337/dc20-0864
  • Peer Reviewed / Open Access
• [Journal Article] Islet cell dedifferentiation is a pathologic mechanism of long-standing progression of type 2 diabetes. (2021)
  • Author(s): Amo-Shiinoki K, Tanabe K, Hoshii Y, Matsui H, Harano R, Fukuda T, Takeuchi T, Bouchi R, Takagi T, Hatanaka M, Takeda K, Okuya S, Nishimura W, Kudo A, Tanaka S, Tanabe M, Akashi T, Yamada T, Ogawa Y, Ikeda E, Nagano H, Tanizawa Y.
  • Journal Title: JCI Insight Volume: 6 Issue: 1 Pages: 143791-143791
  • DOI: 10.1172/jci.insight.143791
  • Peer Reviewed / Open Access
• [Journal Article] Effects of intensive exercise combined with dapagliflozin on body composition in patients with type 2 diabetes: a randomized controlled trial (2021)
  • Author(s): Bouchi Ryotaro、Sonoda Noriyuki、Itoh Jun、Ono Yasuhiro、Fukuda Tatsuya、Takeuchi Takato、Kishimoto Junji、Yamada Tetsuya、Ogawa Yoshihiro
  • Journal Title: Endocrine Journal Volume: 68 Issue: 3 Pages: 329-343
  • DOI: 10.1507/endocrj.EJ20-0599
  • NAID: 130008006353
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed / Open Access
• [Journal Article] Sex Differences in Renal Outcomes After Medical Treatment for Bilateral Primary Aldosteronism (2021)
  • Author(s): Nakamaru R、Yamamoto K、Akasaka H、Rakugi H、Kurihara I、Yoneda T、Ichijo T、Katabami T、Tsuiki M、Wada N、Yamada T、Kobayashi H、Tamura K、Ogawa Y、Kawashima J、Inagaki N、Fujita M、Oki K、Kamemura K、Tanabe A、Naruse M
  • Journal Title: Hypertension Volume: 77 Issue: 2 Pages: 537-545
  • DOI: 10.1161/hypertensionaha.120.16449
  • Peer Reviewed
• [Journal Article] Ascorbic acid during the suckling period is required for proper DNA demethylation in the liver (2020)
  • Author(s): Kawahori Kenichi、Kondo Yoshitaka、Yuan Xunmei、Kawasaki Yuki、Hanzawa Nozomi、Tsujimoto Kazutaka、Wada Fumiko、Kohda Takashi、Ishigami Akihito、Yamada Tetsuya、Ogawa Yoshihiro、Hashimoto Koshi
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 21228-21228
  • DOI: 10.1038/s41598-020-77962-7
  • Peer Reviewed / Open Access
• [Journal Article] Extraordinarily long-inactive solitary fibrous tumor transformed to produce big insulin-like growth factor-2, leading to hypoglycemia and rapid liposarcoma growth: a case report (2020)
  • Author(s): Kaneko Keizo、Sawada Shojiro、Satake Chihiro、Kondo Keiichi、Izumi Tomohito、Tanaka Mamiko、Imai Junta、Yamada Tetsuya、Katsushima Hiroki、Fujishima Fumiyoshi、Katagiri Hideki
  • Journal Title: BMC Endocrine Disorders Volume: 20 Issue: 1 Pages: 148-148
  • DOI: 10.1186/s12902-020-00624-2
  • Peer Reviewed / Open Access
• [Journal Article] UCP1 Dependent and Independent Thermogenesis in Brown and Beige Adipocytes (2020)
  • Author(s): Ikeda Kenji、Yamada Tetsuya
  • Journal Title: Frontiers in Endocrinology Volume: 11 Pages: 498-498
  • DOI: 10.3389/fendo.2020.00498
  • Peer Reviewed / Open Access
• [Journal Article] Associations Between Changes in Plasma Renin Activity and Aldosterone Concentrations and Changes in Kidney Function After Treatment for Primary Aldosteronism. (2020)
  • Author(s): 19.Kobayashi Y, Haze T, Yano Y, Tamura K, Kurihara I, Ichijo T, Yoneda T, Katabami T, Tsuiki M, Wada N, Ogawa Y, Kawashima J, Sone M, Inagaki N, Yamada T, Okamoto R, Fujita M, Kamemura K, Yamamoto K, Izawa S, Tanabe A, Naruse M; JPAS/JRAS Study Group.
  • Journal Title: Kidney Int Rep. Volume: 5 Issue: 8 Pages: 1291-1297
  • DOI: 10.1016/j.ekir.2020.06.012
  • Peer Reviewed / Open Access
• [Journal Article] A case of ezetimibe-effective hypercholesterolemia with a novel heterozygous variant in ABCG5 (2020)
  • Author(s): Nakano Y, Komiya C, Shimizu H, Mishima H, Shiba K, Tsujimoto K, Ikeda K, Kashimada K, Dateki S, Yoshiura KI, Ogawa Y, Yamada T.
  • Journal Title: Endocrine Journal Volume: 67 Issue: 11 Pages: 1099-1105
  • DOI: 10.1507/endocrj.ej20-0044
  • NAID: 130007945810
  • Peer Reviewed / Open Access
• [Journal Article] Inhibition of Plasminogen Activator Inhibitor-1 Activation Suppresses High Fat Diet-Induced Weight Gain via Alleviation of Hypothalamic Leptin Resistance (2020)
  • Author(s): Shinichiro Hosaka, Tetsuya Yamada, Kei Takahashi, Takashi Dan, Keizo Kaneko, Shinjiro Kodama, Yoichiro Asai, Yuichiro Munakata, Akira Endo, Hiroto Sugawara, Yohei Kawana, Junpei Yamamoto, Tomohito Izumi, Shojiro Sawada, Junta Imai, Toshio Miyata and Hideki Katagiri
  • Journal Title: Front Pharmacol. Volume: 11 Pages: 943-943
  • DOI: 10.3389/fphar.2020.00943
  • Peer Reviewed / Open Access
• [Journal Article] Nadir Aldosterone Levels After Confirmatory Tests Are Correlated With Left Ventricular Hypertrophy in Primary Aldosteronism. (2020)
  • Author(s): Ohno Y, Sone M, Inagaki N, Kawashima A, Takeda Y, Yoneda T, Kurihara I, Itoh H, Tsuiki M, Ichijo T, Katabami T, Wada N, Sakamoto R, Ogawa Y, Yoshimoto T, Yamada T, Kawashima J, Matsuda Y, Kobayashi H, Kamemura K, Yamamoto K, Otsuki M, Okamura S, Izawa S, Okamoto R, Tamura K, Tanabe A, Naruse M; JPAS/JRAS Study Group*.
  • Journal Title: Hypertension. Volume: - Issue: 6 Pages: 1475-1482
  • DOI: 10.1161/hypertensionaha.119.14601
  • Peer Reviewed
• [Journal Article] Targeted DNA demethylation of the Fgf21 promoter by CRISPR/dCas9-mediated epigenome editing. (2020)
  • Author(s): Hanzawa N, Hashimoto K, Yuan X, Kawahori K, Tsujimoto K, Hamaguchi M, Tanaka T, Nagaoka Y, Nishina H, Morita S, Hatada I, Yamada T, Ogawa Y.
  • Journal Title: Sci Rep. Volume: 10 Issue: 1 Pages: 5181-5181
  • DOI: 10.1038/s41598-020-62035-6
  • Peer Reviewed / Open Access
• [Journal Article] Postoperative renal impairment and longitudinal change in renal function after adrenalectomy in patients with Cushing's syndrome. (2020)
  • Author(s): Nakamura Y, Yokoyama Y, Yoshida S, Tanaka H, Kijima T, Ishioka J, Matsuoka Y, Saito K, Minami I, Yoshimoto T, Naito S, Ogawa Y, Yamada T, Uchida S, Fujii Y.
  • Journal Title: Int J Urol. Volume: 未定 Issue: 5 Pages: 395-400
  • DOI: 10.1111/iju.14205
  • Peer Reviewed
• [Journal Article] Effect of cosyntropin during adrenal venous sampling on subtype of primary aldosteronism: analysis of surgical outcome. (2020)
  • Author(s): Kobayashi H, Nakamura Y, Abe M, Kurihara I, Itoh H, Ichijo T, Takeda Y, Yoneda T, Katabami T, Tsuiki M, Wada N, Ogawa Y, Sakamoto R, Kawashima J, Sone M, Inagaki N, Yoshimoto T, Yamada T, Okamoto R, Matsuda Y, Fujita M, Watanabe M, Tamura K, Tanabe A, Naruse M
  • Journal Title: Eur J Endocrinol. Volume: 182 Issue: 3 Pages: 265-273
  • DOI: 10.1530/eje-19-0860
  • Peer Reviewed
• [Journal Article] Sarcopenic obesity is associated with a faster decline in renal function in people with type 2 diabetes. (2020)
  • Author(s): Fukuda T, Bouchi R, Asakawa M, Takeuchi T, Shiba K, Tsujimoto K, Komiya C, Yoshimoto T, Ogawa Y, Yamada T.
  • Journal Title: Diabet Med Volume: 37 Issue: 1 Pages: 105-113
  • DOI: 10.1111/dme.14153
  • Peer Reviewed / Open Access
• [Journal Article] Diagnostic accuracy of selective arterial calcium injection test for localization of gastrinoma (2020)
  • Author(s): Hayashi R, Minami I, Sasahara Y, Izumiyama H, Yoshimoto T, Kishino M, Kudo A, Tateishi U, Tanabe M, Yamada T.
  • Journal Title: Endocrine Journal Volume: 67 Issue: 3 Pages: 305-315
  • DOI: 10.1507/endocrj.EJ19-0413
  • NAID: 130007821362
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed
• [Journal Article] A case of generalized lipodystrophy-associated progeroid syndrome treated by leptin replacement with short and long-term monitoring of the metabolic and endocrine profiles (2020)
  • Author(s): Fukaishi Takahiro、Minami Isao、Masuda Seizaburo、Miyachi Yasutaka、Tsujimoto Kazutaka、Izumiyama Hajime、Hashimoto Koshi、Yoshida Masayuki、Takahashi Sayako、Kashimada Kenichi、Morio Tomohiro、Kosaki Kenjiro、Maezawa Yoshiro、Yokote Koutaro、Yoshimoto Takanobu、Yamada Tetsuya
  • Journal Title: Endocrine Journal Volume: 67 Issue: 2 Pages: 211-218
  • DOI: 10.1507/endocrj.EJ19-0226
  • NAID: 130007802875
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed
• [Journal Article] Upregulation of cancer-associated gene expression in activated fibroblasts in a mouse model of non-alcoholic steatohepatitis (2019)
  • Author(s): Asakawa M, Itoh M, Suganami T, Sakai T, Kanai S, Shirakawa I, Yuan X, Hatayama T, Shimada S, Akiyama Y, Fujiu K, Inagaki Y, Manabe I, Yamaoka S, Yamada T, Tanaka S, Ogawa Y.
  • Journal Title: Sci Rep. Volume: 9 Issue: 1 Pages: 19601-19601
  • DOI: 10.1038/s41598-019-56039-0
  • Peer Reviewed / Open Access
• [Journal Article] miRNA299 involvement in CYP11B2 expression in aldosterone-producing adenoma (2019)
  • Author(s): Nakano Yujiro、Yoshimoto Takanobu、Watanabe Ryo、Murakami Masanori、Fukuda Tatsuya、Saito Kazutaka、Fujii Yasuhisa、Akashi Takumi、Tanaka Toshihiro、Yamada Tetsuya、Naruse Mitsuhide、Ogawa Yoshihiro
  • Journal Title: European Journal of Endocrinology Volume: 181 Issue: 1 Pages: 69-78
  • DOI: 10.1530/eje-18-0882
  • Peer Reviewed
• [Journal Article] Prolyl Isomerase Pin1 Suppresses Thermogenic Programs in Adipocytes by Promoting Degradation of Transcriptional Co-activator PRDM16. (2019)
  • Author(s): Nakatsu Y, Matsunaga Y, Yamamotoya T, Ueda K, Inoue MK, Mizuno Y, Nakanishi M, Sano T, Yamawaki Y, Kushiyama A, Sakoda H, Fujishiro M, Ryo A, Ono H, Minamino T, Takahashi SI, Ohno H, Yoneda M, Takahashi K, Ishihara H, Katagiri H, Nishimura F, Kanematsu T, Yamada T, Asano T.
  • Journal Title: Cell Rep. Volume: 26 Issue: 12 Pages: 3221-3230
  • DOI: 10.1016/j.celrep.2019.02.066
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A Case of Refractory Hypothyroidism due to Poor Compliance Treated with the Weekly Intravenous and Oral Levothyroxine Administration. (2019)
  • Author(s): Nakano Y, Hashimoto K, Ohkiba N, Okuma H, Minami I, Takahashi H, Tanaka Y, Yoshimoto T, Yamada T.
  • Journal Title: Case Rep Endocrinol. Volume: 2019 Pages: 5986014-5986014
  • DOI: 10.1155/2019/5986014
  • Peer Reviewed
• [Journal Article] Enhancement of postprandial endogenous insulin secretion rather than exogenous insulin injection ameliorated insulin antibody-induced unstable diabetes: a case report (2019)
  • Author(s): Kaneko K, Satake C, Izumi T, Tanaka M, Yamamoto J, Asai Y, Sawada S, Imai J, Yamada T, Katagiri H.
  • Journal Title: BMC Endocr Disord. Volume: 19 Issue: 1 Pages: 5-5
  • DOI: 10.1186/s12902-018-0326-3
  • Peer Reviewed / Open Access
• [Journal Article] Clinical outcomes of 20 Japanese patients with insulinoma treated with diazoxide (2019)
  • Author(s): Niitsu Y, Minami I, Izumiyama H, Hashimoto K, Yoshimoto T, Satou F, Tsujino M, Ota K, Kudo A, Tanabe M, Yamada T, Ogawa Y.
  • Journal Title: Endocrine Journal Volume: 66 Issue: 2 Pages: 149-155
  • DOI: 10.1507/endocrj.EJ18-0353
  • NAID: 130007605355
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed
• [Journal Article] Vagus-macrophage-hepatocyte link promotes post-injury liver regeneration and whole-body survival through hepatic FoxM1 activation. (2018)
  • Author(s): Izumi T, Imai J, Yamamoto J, Kawana Y, Endo A, Sugawara H, Kohata M, Asai Y, Takahashi K, Kodama S, Kaneko K, Gao J, Uno K, Sawada S, Kalinichenko VV, Ishigaki Y, Yamada T, Katagiri H.
  • Journal Title: Nat Commun. Volume: 9 Issue: 1 Pages: 5300-5300
  • DOI: 10.1038/s41467-018-07747-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Deficient ganglioside synthesis restores responsiveness to leptin and melanocortin signaling in obese KKAy mice. (2018)
  • Author(s): Inamori K, Ito H, Tamura Y, Nitta T, Yang X, Nihei W, Shishido F, Imazu S, Tsukita S, Yamada T, Katagiri H, Inokuchi J
  • Journal Title: Journal of Lipid Research Volume: 59 Issue: 8 Pages: 1472-1481
  • DOI: 10.1194/jlr.m085753
  • Peer Reviewed
• [Journal Article] Selective insulin resistance with differential expressions of IRS-1 and IRS-2 in human NAFLD livers. (2018)
  • Author(s): Honma M, Sawada S, Ueno Y, Murakami K, Yamada T, Gao J, Kodama S, Izumi T, Takahashi K, Tsukita S, Uno K, Imai J, Kakazu E, Kondo Y, Mizuno K, Kawagishi N, Shimosegawa T, Katagiri H.
  • Journal Title: Int J Obes (Lond). Volume: 印刷中 Issue: 9 Pages: 1544-1555
  • DOI: 10.1038/s41366-018-0062-9
  • Peer Reviewed / Open Access
• [Journal Article] Glial Fatty Acid-Binding Protein 7 (FABP7) Regulates Neuronal Leptin Sensitivity in the Hypothalamic Arcuate Nucleus (2018)
  • Author(s): Yasumoto Yuki、Miyazaki Hirofumi、Ogata Masaki、Kagawa Yoshiteru、Yamamoto Yui、Islam Ariful、Yamada Tetsuya、Katagiri Hideki、Owada Yuji
  • Journal Title: Molecular Neurobiology Volume: - Issue: 12 Pages: 9016-9028
  • DOI: 10.1007/s12035-018-1033-9
  • Peer Reviewed / Open Access
• [Journal Article] Serum cystatin C level is associated with carotid arterial wall elasticity in subjects with type 2 diabetes mellitus: A potential marker of early-stage atherosclerosis. (2018)
  • Author(s): Kaneko R, Sawada S, Tokita A, Honkura R, Tamura N, Kodama S, Izumi T, Takahashi K, Uno K, Imai J, Yamada T, Miyachi Y, Hasegawa H, Kanai H, Ishigaki Y, Katagiri H
  • Journal Title: Diabetes Research and Clinical Practice Volume: 139 Pages: 43-51
  • DOI: 10.1016/j.diabres.2018.02.003
  • Peer Reviewed / Open Access
• [Journal Article] Olfactory receptors are expressed in pancreatic beta-cells and promote glucose-stimulated insulin secretion. (2018)
  • Author(s): Munakata Y, Yamada T, Imai J, Takahashi K, Tsukita S, Shirai Y, Kodama S, Asai Y, Sugisawa T, Chiba Y, Kaneko K, Uno K, Sawada S, Hatakeyama H, Kanzaki M, Miyazaki JI, Oka Y, Katagiri H
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 1499-1499
  • DOI: 10.1038/s41598-018-19765-5
  • Peer Reviewed / Open Access
• [Presentation] 良い脂肪蓄積と悪い脂肪蓄積～臓器連関の視点からの考察～ (2022)
  • Author(s): 山田哲也、高橋 圭、片桐秀樹
  • Organizer: 第４２回日本肥満学会・第３９回日本肥満症治療学会学術集会
  • Invited
• [Presentation] 臓器連関による糖・エネルギー代謝調節機構の解明 (2022)
  • Author(s): 山田哲也、高橋 圭、片桐秀樹
  • Organizer: 第５６回 糖尿病学の進歩
  • Invited
• [Presentation] 肝臓のインスリン作用の減弱に起因し個体レベルのエネルギー代謝を制御する新規の肝臓－脳－褐色脂肪組織連関の発見 (2021)
  • Author(s): 高橋 圭、山田哲也、片桐秀樹
  • Organizer: 第６４回日本糖尿病学会年次学術集会
• [Presentation] ベージュ脂肪細胞のカルシウムサイクリングによる熱産生機構 (2021)
  • Author(s): 池田賢司、山田哲也
  • Organizer: 第６４回日本糖尿病学会年次学術集会
• [Presentation] 肝臓－脳－褐色脂肪組織（BAT）連関よるエネルギー代謝調節機構の解明 (2021)
  • Author(s): 山田哲也、高橋 圭、片桐秀樹
  • Organizer: 第６４回日本糖尿病学会年次学術集会
  • Invited
• [Presentation] 肥満におけるレプチン抵抗性の薬物治療の可能性 (2021)
  • Author(s): 山田哲也
  • Organizer: 日本薬学会第141年会 シンポジウム 生活習慣病研究の進展と創薬への展開
• [Presentation] 肥満関連疾患の病態解明および新規抗肥満薬の開発 (2021)
  • Author(s): 山田哲也
  • Organizer: 第４１回日本肥満学会・第38回日本肥満症治療学会 教育講演 5
  • Invited
• [Presentation] ２型糖尿病の薬物療法 Up-date ～血糖コントロールの、その先へ～ (2021)
  • Author(s): 山田哲也
  • Organizer: 第１５８回山口県医師会生涯研修セミナー（日本医師会生涯教育講座）特別講演
  • Invited
• [Presentation] 肥満・２型糖尿病の病態と新規治療法の開発～臓器連関の観点から～ (2021)
  • Author(s): 山田哲也
  • Organizer: 第５５回 糖尿病学の進歩
  • Invited
• [Presentation] 糖・エネルギー代謝調節における臓器連関の解明 (2020)
  • Author(s): 山田哲也
  • Organizer: 第７回先端糖尿病研究会 特別講演
  • Invited
• [Presentation] 糖尿病と脳・自律神経代謝連関 (2020)
  • Author(s): 山田哲也
  • Organizer: 第５４回 糖尿病学の進歩
  • Invited
• [Presentation] microRNAによる膵β細胞の増殖制御 (2020)
  • Author(s): 山田哲也
  • Organizer: 第９３回日本薬理学会年会 シンポジウム 生体恒常性を司る神経系・内分泌系ネットワーク制御の新知見
• [Presentation] 嗅覚受容体は膵β細胞に発現しグルコース応答性インスリン分泌を促進する (2019)
  • Author(s): 山田哲也 宗像佑一郎 片桐秀樹
  • Organizer: 第９２回日本生化学会大会
  • Invited
• [Presentation] Lower Insulin Secretion Is Associated with Parahippocampal Gyrus Atrophy in Elderly Patients with Type 2 Diabetes Mellitus. (2019)
  • Author(s): Adachi Y, Ota K, Ishi R, Cho K, Hiramatsu Y, Masuda S, Koseki S, Hayashi T, Komatsu N, Mizoguchi Y, Minami I, Yamada T, Watanabe T.
  • Organizer: 79th Scientific Sessions American Diabetes Association
  • Int'l Joint Research
• [Presentation] ２型糖尿病の薬物療法における体重管理 (2019)
  • Author(s): 山田哲也
  • Organizer: 第６２回 日本糖尿病学会年次学術集会
  • Invited
• [Presentation] 脳・自律神経から見える新たな糖尿病の治療 (2019)
  • Author(s): 山田哲也 片桐秀樹
  • Organizer: 第９２回 日本内分泌学会学術総会
  • Invited
• [Presentation] Systemic glucose oxidation is enhanced in acquired liver and muscle insulin receptor knockout mice. (2019)
  • Author(s): Takahashi K, Yamada T, Sugisawa T, Kawata K, Asai Y, Munakata Y, Kodama S, Sawada S, Imai J, Inada M, Katagiri H.
  • Organizer: The 9th Federation of sian and Oceanian Physiological Societies Congress
  • Int'l Joint Research
• [Presentation] 血糖と体重コントロールの両立をめざす２型糖尿病の薬物療法 (2019)
  • Author(s): 山田哲也
  • Organizer: 第１０回肥満症総合治療セミナー
  • Invited
• [Presentation] 血糖・体重調節における臓器連関 (2019)
  • Author(s): 山田哲也
  • Organizer: 第５３回糖尿病学の進歩
  • Invited
• [Presentation] 多剤併用時代における２型糖尿病の薬物療法 (2019)
  • Author(s): 山田哲也
  • Organizer: 日本内科学会東北地方会 第７２回生涯教育講演会
  • Invited
• [Presentation] Systemic glucose oxidation is enhanced in acquired liver and muscle insulin receptor knockout mice. (2019)
  • Author(s): Takahashi K, Yamada T, Sugisawa T, Kawata K, Asai Y, Munakata Y, Kodama S, Sawada S, Imai J, Inada M, Katagiri H.
  • Organizer: The 9th Federation of Asian and Oceanian Physiological Societies Congress
  • Int'l Joint Research
• [Presentation] 病態生理に基づく２型糖尿病、メタボリックシンドロームの薬物療法 (2018)
  • Author(s): 山田哲也
  • Organizer: 日本糖尿病学会 第５６回東北地方会 指定講演①
  • Invited
• [Presentation] 肝臓からの臓器連関によるエネルギー代謝調節とメタボリックシンドロームの病態解明 (2018)
  • Author(s): 山田哲也 片桐秀樹
  • Organizer: 第３９回日本肥満学会
  • Invited
• [Presentation] 血糖と体重コントロールの両立をめざす２型糖尿病の薬物療法～臓器連関の理解を基に～ (2018)
  • Author(s): 山田哲也
  • Organizer: 第１９回日本内分泌学会 関東甲信越支部学術集会
  • Invited
• [Presentation] MicroRNAs improve hyperglycemia in a mouse model of insulin-deficient diabetes via pancreatic β-cell proliferation. (2018)
  • Author(s): Tetsuya Yamada, Hideki Katagiri
  • Organizer: The 61th Annual Meeting of the Japan Diabetes Society
  • Invited
• [Presentation] 糖代謝と体温調節をつなぐ臓器連関の解明 (2018)
  • Author(s): 山田哲也、片桐秀樹
  • Organizer: 第５６回日本実験動物学会総会
  • Invited
• [Presentation] 臓器/細胞連関から肥満・糖尿病の病態および治療を考える (2018)
  • Author(s): 山田哲也、片桐秀樹
  • Organizer: 第９１回日本内分泌学会学術総会
  • Invited
• [Presentation] microRNAによる膵β細胞の増殖制御 (2018)
  • Author(s): 山田哲也、片桐秀樹
  • Organizer: 第３２回 日本糖尿病・肥満動物学会年次学術集会
  • Invited