| Project/Area Number |
18H02879
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 55020:Digestive surgery-related
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| Research Institution | Aichi Cancer Center Research Institute (2020-2021)
Nagoya University (2018-2019) |
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Principal Investigator |
Nagino Masato 愛知県がんセンター(研究所), 副総長, 副総長 (20237564)
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| Co-Investigator(Kenkyū-buntansha) |
山口 淳平 名古屋大学, 医学部附属病院, 病院講師 (00566987)
江畑 智希 名古屋大学, 医学系研究科, 教授 (60362258)
國料 俊男 名古屋大学, 医学部附属病院, 病院准教授 (60378023)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2021: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2020: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2019: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2018: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
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| Keywords | 融合遺伝子 / 胆管癌 / 核酸医薬 / ノンコーディングRNA |
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| Outline of Final Research Achievements |
In the metachronous cholangiocarcinoma, the gene mutation in the secondary lesion has additional gene mutations to the gene mutation in the primary lesion, and their accumulations were considered to be one of the causes of the carcinogenesis in cholangiocarcinoma. Analysis of breakpoint on the coding region of the gene as somatic gene structure, demonstrated that total number is 3499 (3326-3655), the DEL (deletion) number is 2678 (2620-2781), the INV (inversion) number is 152 (136-170), INS (insertion) number 384 (364-406), DUP (tandem duplication) number 225 (192-253), and BND (breakend, interchromosomal translocation) number 58 (42-71). In addition, we revealed somatic structural variations on 320 genes, which detected in patients of the bile duct cancer in the GDC portal.
These somatic structural variations were considered to be involved in the carcinogenesis of bile duct cancer.
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| Academic Significance and Societal Importance of the Research Achievements |
異時性胆管癌の初発病変と次発病変の遺伝子変異を明らかにし、発癌機序を明らかにした。また融合遺伝子のbreakpointが遺伝子のコーディング領域上にある体細胞構造の変異を明らかにした。これら体細胞構造の変異は新規診断治療法の開発において重要な知見であり学術的意義が大きい。また本研究により新規治療法開発の可能性が示唆され、治療法が可能になれば、生存率を含めた治療成績の向上が期待され社会的意義は大きい。
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