Development of minimally invasive diagnostic methods and epigenomic therapies focusing on founder epi-drivers in lung adenocarcinoma.

• Project/Area Number: 18H02894
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 55040:Respiratory surgery-related
• Research Institution: Aichi Cancer Center Research Institute
• Principal Investigator: Imoto Issei 愛知県がんセンター(研究所), 研究所長, 研究所長 (30258610)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000); Fiscal Year 2020: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2019: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000); Fiscal Year 2018: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
• Keywords: 肺腺癌 / エピゲノム / ドライバー / リキッドバイオプシー / 治療標的

Outline of Final Research Achievements

Although various driver mutations have been identified and molecular targeted therapies are being developed in lung adenocarcinoma (LAD), many cases lack these driver mutations and drug-resistance is easily acquired based on the temporal and spatial heterogeneity of cancers. In this study, we focused on the founder epi-driver type tumor suppressor genes (TSGs), which shows frequent tumor-specific hypermethylation from early stage, as a diagnostic and therapeutic target molecule that can overcome these issues. As a result, we have developed epi-markers that can be detected in plasma to detect early stage LAC or recurrence and predict therapeutic efficacy. We also identified therapeutic target epi-driver TSGs and related molecular pathways, and selected chemical compounds that mimic the activation of these pathways by through in silico screening.

Academic Significance and Societal Importance of the Research Achievements

がん領域では、遺伝子パネル検査やエクソーム、全ゲノム解析の結果から、腫瘍の網羅的な解析による癌細胞特異的治療標的検出や血漿を使った早期、再発、治療効果診断に有用な遺伝子変異の同定が進んでいる。特にリキッドバイオプシーは低侵襲で繰り返し行える検査法として臨床実装されており、腫瘍組織のゲノム情報が不要な各癌種に固有のバイオマーカーの同定は、早期のスクリーニング検査や組織のない症例での治療効果の評価、原発不明がんの原発巣予測などに応用可能な重要課題である。本課題の成果は、肺腺癌の早期診断マーカーとその検出法の開発に有用な情報を提供するもので、臨床応用が見込める点で意義がある。

Research Products

• [Journal Article] Six years’ accomplishment of the Initiative on Rare and Undiagnosed Diseases: nationwide project in Japan to discover causes, mechanisms, and cures (2022)
  • Author(s): Takahashi Yuji、Imoto Issei、et al.
  • Journal Title: Journal of Human Genetics Volume: in press Issue: 9 Pages: 505-513
  • DOI: 10.1038/s10038-022-01025-0
  • Peer Reviewed / Open Access
• [Journal Article] Functionally confirmed compound heterozygous ADAM17 missense loss-of-function variants cause neonatal inflammatory skin and bowel disease 1 (2021)
  • Author(s): Imoto I, Saito M, Suga K, Kohmoto T, Otsu M, Horiuchi K, Nakayama H, Higashiyama S, Sugimoto M, Sasaki A, Homma Y, Shono M, Nakagawa R, Hayabuchi Y, Tange S, Kagami S, Masuda K
  • Journal Title: Scientific reports Volume: 11 Issue: 1 Pages: 9552-9552
  • DOI: 10.1038/s41598-021-89063-0
  • NAID: 120007188413
  • Peer Reviewed / Open Access
• [Journal Article] JRAB/MICAL-L2 undergoes liquid-liquid phase separation to form tubular recycling endosomes (2021)
  • Author(s): Sakane Ayuko、Yano Taka-aki、Uchihashi Takayuki、Horikawa Kazuki、Hara Yusuke、Imoto Issei、Kurisu Shusaku、Yamada Hiroshi、Takei Kohji、Sasaki Takuya
  • Journal Title: Communications Biology Volume: 4 Issue: 1 Pages: 551-551
  • DOI: 10.1038/s42003-021-02080-7
  • Peer Reviewed / Open Access
• [Journal Article] A Personal Breast Cancer Risk Stratification Model Using Common Variants and Environmental Risk Factors in Japanese Females (2021)
  • Author(s): Oze Isao、Ito Hidemi、Kasugai Yumiko、Yamaji Taiki、Kijima Yuko、Ugai Tomotaka、Kasuga Yoshio、Ouellette Tomoyo K.、Taniyama Yukari、Koyanagi Yuriko N.、Imoto Issei、Tsugane Shoichiro、Koriyama Chihaya、Iwasaki Motoki、Matsuo Keitaro
  • Journal Title: Cancers Volume: 13 Issue: 15 Pages: 3796-3796
  • DOI: 10.3390/cancers13153796
  • Peer Reviewed / Open Access
• [Journal Article] Detection of novel fusion genes by next-generation sequencing-based targeted RNA sequencing analysis in adenoid cystic carcinoma of head and neck (2021)
  • Author(s): Shibata Eri、Morita Kei-ichi、Kayamori Kou、Tange Shoichiro、Shibata Hiroki、Harazono Yosuke、Michi Yasuyuki、Ikeda Tohru、Harada Hiroyuki、Imoto Issei、Yoda Tetsuya
  • Journal Title: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Volume: 132 Issue: 4 Pages: 426-433
  • DOI: 10.1016/j.oooo.2021.03.020
  • Peer Reviewed
• [Journal Article] Siblings with MAN1B1-CDG Showing Novel Biochemical Profiles (2021)
  • Author(s): Okamoto Nobuhiko、Ohto Tatsuyuki、Enokizono Takashi、Wada Yoshinao、Kohmoto Tomohiro、Imoto Issei、Haga Yoshimi、Seino Junichi、Suzuki Tadashi
  • Journal Title: Cells Volume: 10 Issue: 11 Pages: 3117-3117
  • DOI: 10.3390/cells10113117
  • Peer Reviewed / Open Access
• [Journal Article] Fetal Megalencephaly with Cortical Dysplasia at 18 Gestational Weeks Related to Paternal UPD Mosaicism with PTEN Mutation (2021)
  • Author(s): Pooh Ritsuko Kimata、Imoto Issei、et al.
  • Journal Title: Genes Volume: 12 Issue: 3 Pages: 358-358
  • DOI: 10.3390/genes12030358
  • Peer Reviewed / Open Access
• [Journal Article] Establishment and Characterization of a New Malignant Peritoneal Mesothelioma Cell Line, KOG-1, From the Ascitic Fluid of a Patient With Pemetrexed Chemotherapy Resistance (2020)
  • Author(s): Akahane Tomoko, Hirasawa Akira, Imoto Issei, Okubo Aki, Itoh Manabu, Nanki Yoshiko, Yoshihama Tomoko, Tominaga Eichiro, Aoki Daisuke.
  • Journal Title: Hum Cell Volume: 33 Issue: 1 Pages: 272-282
  • DOI: 10.1007/s13577-019-00286-w
  • Peer Reviewed / Open Access
• [Journal Article] Across-Site Differences in the Mechanism of Alcohol-Induced Digestive Tract Carcinogenesis: An Evaluation by Mediation Analysis (2020)
  • Author(s): Koyanagi Yuriko N.、Suzuki Etsuji、Imoto Issei、Kasugai Yumiko、Oze Isao、Ugai Tomotaka、Iwase Madoka、Usui Yoshiaki、Kawakatsu Yukino、Sawabe Michi、Hirayama Yutaka、Tanaka Tsutomu、Abe Tetsuya、Ito Seiji、Komori Koji、Hanai Nobuhiro、Tajika Masahiro、Shimizu Yasuhiro、Niwa Yasumasa、Ito Hidemi、Matsuo Keitaro
  • Journal Title: Cancer Research Volume: 80 Issue: 7 Pages: 1601-1610
  • DOI: 10.1158/0008-5472.can-19-2685
  • Peer Reviewed
• [Journal Article] Claudin-6 is a single prognostic marker and functions as a tumor-promoting gene in a subgroup of intestinal type gastric cancer (2020)
  • Author(s): Kohmoto T, Masuda K, Shoda K, Takahashi R, Ujiro S, Tange S, Ichikawa D, Otsuji E, Imoto I
  • Journal Title: Gastric Cancer Volume: 23 Issue: 3 Pages: 403-417
  • DOI: 10.1007/s10120-019-01014-x
  • NAID: 40022220036
  • Peer Reviewed / Open Access
• [Journal Article] The C-terminal region including the MH6 domain of Msx1 regulates skeletal development. (2020)
  • Author(s): Ichihara A, Yasue A, Mitsui SN, Arai D, Minegishi Y, Oyadomari S, Imoto I, Tanaka E.
  • Journal Title: Biochem Biophys Res Commun Volume: 526 Issue: 1 Pages: 62-69
  • DOI: 10.1016/j.bbrc.2020.03.068
  • NAID: 120006881395
  • Peer Reviewed / Open Access
• [Journal Article] Genome-wide association study of semen volume, sperm concentration, testis size, and plasma inhibin B levels (2020)
  • Author(s): Sato Youichi、Tajima Atsushi、Kiguchi Misaki、Kogusuri Suzu、Fujii Aki、Sato Takehiro、Nozawa Shiari、Yoshiike Miki、Mieno Makiko、Kojo Kosuke、Uchida Masahiro、Tsuchiya Haruki、Yamasaki Kazumitu、Imoto Issei、Iwamoto Teruaki
  • Journal Title: Journal of Human Genetics Volume: 65 Issue: 8 Pages: 683-691
  • DOI: 10.1038/s10038-020-0757-3
  • Peer Reviewed / Open Access
• [Journal Article] Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases (2020)
  • Author(s): Ishigaki K, Akiyama M, Kanai M, Takahashi A, Kawakami E, Sugishita H, Sakaue S, Matoba N, Low SK, Okada Y, Yamaji T, et al
  • Journal Title: Nature Genetics Volume: 52 Issue: 7 Pages: 669-679
  • DOI: 10.1038/s41588-020-0640-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer (2020)
  • Author(s): Lin Y, Nakatochi M, Hosono Y, Ito H, Kamatani Y, Inoko A, Sakamoto H, Kinoshita F, Kobayashi Y, Ishii H, Yamaji T,et al.
  • Journal Title: Nature Communications Volume: 11 Issue: 1 Pages: 3175-3175
  • DOI: 10.1038/s41467-020-16711-w
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Attitudes toward and current status of disclosure of secondary findings from next-generation sequencing: a nation-wide survey of clinical genetics professionals in Japan (2020)
  • Author(s): Tsuchiya Mio、Imoto Issei、et al.
  • Journal Title: Journal of Human Genetics Volume: 65 Issue: 12 Pages: 1045-1053
  • DOI: 10.1038/s10038-020-0802-2
  • Peer Reviewed
• [Journal Article] Molecular diagnosis of an infant with TSC2/PKD1 contiguous gene syndrome (2020)
  • Author(s): Osumi Keita、Suga Kenichi、Ono Akemi、Goji Aya、Mori Tatsuo、Kinoshita Yukiko、Sugano Mikio、Toda Yoshihiro、Urushihara Maki、Nakagawa Ryuji、Hayabuchi Yasunobu、Imoto Issei、Kagami Shoji
  • Journal Title: Human Genome Variation Volume: 7 Issue: 1 Pages: 21-21
  • DOI: 10.1038/s41439-020-0108-0
  • NAID: 120007144491
  • Peer Reviewed / Open Access
• [Journal Article] Next-generation sequencing for the diagnosis of patients with congenital multiple anomalies and / or intellectual disabilities (2020)
  • Author(s): Suga Kenichi、Imoto Issei、Ito Hiromichi、Naruto Takuya、Goji Aya、Osumi Keita、Tokaji Narumi、Homma Yukako、Ono Akemi、Ichihara Yuko、Shono Miki、Mori Tatsuo、Urushihara Maki、Nakagawa Ryuji、Hayabuchi Yasunobu、Kagami Shoji
  • Journal Title: The Journal of Medical Investigation Volume: 67 Issue: 3.4 Pages: 246-249
  • DOI: 10.2152/jmi.67.246
  • NAID: 130007936868
  • ISSN: 1343-1420, 1349-6867
  • Peer Reviewed / Open Access
• [Journal Article] Verifying nomenclature of DNA variants in submitted manuscripts: Guidance for journals (2020)
  • Author(s): Higgins Jan、Imoto Issei、et al.
  • Journal Title: Human Mutation Volume: 42 Issue: 1 Pages: 3-7
  • DOI: 10.1002/humu.24144
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Toll‐Like Receptor 9 Plays a Pivotal Role in Angiotensin II Induced Atherosclerosis (2019)
  • Author(s): Fukuda Daiju、Nishimoto Sachiko、Aini Kunduziayi、Tanaka Atsushi、Nishiguchi Tsuyoshi et al.
  • Journal Title: Journal of the American Heart Association Volume: 8 Issue: 7
  • DOI: 10.1161/jaha.118.010860
  • NAID: 120006602927
  • Peer Reviewed / Open Access
• [Journal Article] Array comparative genomic hybridization analysis discloses chromosome copy number alterations as indicators of patient outcome in lymph node-negative breast cancer (2019)
  • Author(s): Ryoko Kikuchi-Koike, Kazunori Nagasaka, Hitoshi Tsuda, Yasuyuki Ishii, Masaru Sakamoto, Yoshihiro Kikuchi, Shiho Fukui, Yuko Miyagawa, Haruko Hiraike, Takayuki Kobayashi, Takayuki Kinoshita, Yae Kanai, Tatsuhiro Shibata, Issei Imoto, Johji Inazawa, Osamu Matsubara and Takuya Ayabe
  • Journal Title: BMC Cancer Volume: 19 Issue: 1 Pages: 521-521
  • DOI: 10.1186/s12885-019-5737-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prognostic significance of GAD1 overexpression in patients with resected lung adenocarcinoma (2019)
  • Author(s): Tsuboi M, Kondo K, Masuda K, Tange S, Kajiura K, Kohmoto T, Takizawa H, Imoto I, Tangoku A
  • Journal Title: Cancer Medicine Volume: 8 Issue: 9 Pages: 4189-4199
  • DOI: 10.1002/cam4.2345
  • Peer Reviewed / Open Access
• [Journal Article] Attitudes of clinical geneticists and certified genetic counselors to genome editing and its clinical applications: A nation-wide questionnaire survey in Japan (2019)
  • Author(s): Taguchi Iku、Yamada Takahiro、Akaishi Rina、Imoto Issei、Kurosawa Kenji、Nakatani Kaname、Nomura Fumio、Hamanoue Haruka、Hyodo Maki、Murakami Hiromi、Yoshihashi Hiroshi、Yotsumoto Junko、Kosugi Shinji
  • Journal Title: Journal of Human Genetics Volume: 64 Issue: 9 Pages: 945-954
  • DOI: 10.1038/s10038-019-0635-z
  • Peer Reviewed
• [Journal Article] A 16q22.2-q23.1 deletion identified in a male infant with West syndrome (2019)
  • Author(s): Mori Tatsuo, Goji Aya, Toda Yoshihiro, Ito Hiromichi, Mori Kenji, Kohmoto Tomohiro, Imoto Issei, Kagami Shoji
  • Journal Title: Brain and Development Volume: 41 Issue: 10 Pages: 888-893
  • DOI: 10.1016/j.braindev.2019.07.005
  • Peer Reviewed
• [Journal Article] Actin Cytoskeletal Reorganization Function of JRAB/MICAL-L2 Is Fine-tuned by Intramolecular Interaction between First LIM Zinc Finger and C-terminal Coiled-coil Domains. (2019)
  • Author(s): Miyake K, Sakane A, Tsuchiya Y, Sagawa I, Tomida Y, Kasahara J, Imoto I, Watanabe S, Higo D, Mizuguchi K, Sasaki T.
  • Journal Title: Sci Rep. Volume: 9 Issue: 1 Pages: 12794-12794
  • DOI: 10.1038/s41598-019-49232-8
  • Peer Reviewed / Open Access
• [Journal Article] Novel compound heterozygous CDH23 variants in a patient with Usher syndrome type I. (2019)
  • Author(s): Okano S, Makita Y, Katada A, Harabuchi Y, Kohmoto T, Naruto T, Masuda K, Imoto I.
  • Journal Title: Hum Genome Var. Volume: 6 Issue: 1 Pages: 8-8
  • DOI: 10.1038/s41439-019-0037-y
  • Peer Reviewed / Open Access
• [Journal Article] Genome-wide association study to identify a new susceptibility locus for central serous chorioretinopathy in the Japanese population. (2018)
  • Author(s): Miki A, Sakurada Y, Tanaka K, Semba K, Mitamura Y, Yuzawa M, Tajima A, Nakatochi M, Yamamoto K, Matsuo K, Imoto I, Honda S.
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 59(13) Issue: 13 Pages: 5542-5547
  • DOI: 10.1167/iovs.18-25497
  • Peer Reviewed / Open Access
• [Journal Article] Genome-wide association study identifies gastric cancer susceptibility loci at 12q24.11-12 and 20q11.21 (2018)
  • Author(s): Tanikawa C, Kamatani Y, Toyoshima O, Sakamoto H, Ito H, Takahashi A, et al.
  • Journal Title: Cancer Science Volume: 109 Issue: 12 Pages: 4015-4024
  • DOI: 10.1111/cas.13815
  • Peer Reviewed / Open Access
• [Journal Article] Protease-Activated Receptor-2 Plays a Critical Role in Vascular Inflammation and Atherosclerosis in Apolipoprotein E?Deficient Mice (2018)
  • Author(s): Hara Tomoya、Phuong Pham Tran、Fukuda Daiju、Yamaguchi Koji、Murata Chie、Nishimoto Sachiko、Yagi Shusuke、Kusunose Kenya、Yamada Hirotsugu、Soeki Takeshi、Wakatsuki Tetsuzo、Imoto Issei、Shimabukuro Michio、Sata Masataka
  • Journal Title: Circulation Volume: 138 Issue: 16 Pages: 1706-1719
  • DOI: 10.1161/circulationaha.118.033544
  • NAID: 120006546436
  • Peer Reviewed
• [Journal Article] Primary microcephaly caused by novel compound heterozygous mutations in ASPM. (2018)
  • Author(s): Okamoto N, Kohmoto T, Naruto T, Masuda K, Imoto I.
  • Journal Title: Hum Genome Var. Volume: 5 Issue: 1 Pages: 18015-18015
  • DOI: 10.1038/hgv.2018.15
  • Peer Reviewed / Open Access
• [Journal Article] Genome-wide association study identifies ERBB4 on 2q34 as a novel locus associated with sperm motility in Japanese men (2018)
  • Author(s): Sato Y, Tajima A, Sato T, Nozawa S, Yoshiike M, Imoto I, Yamauchi A, Iwamoto T
  • Journal Title: J Med Genet Volume: - Issue: 6 Pages: 415-21
  • DOI: 10.1136/jmedgenet-2017-104991
  • Peer Reviewed / Open Access
• [Presentation] がんゲノムプロファイリング検査におけるGermline findingsの取り扱いの現状とこれから (2022)
  • Author(s): 井本逸勢
  • Organizer: 第19回日本臨床腫瘍学会学術総会
  • Invited
• [Presentation] がん領域の全ゲノム解析時代に求められる遺伝診療部門の役割 (2021)
  • Author(s): 井本逸勢
  • Organizer: 第6回クリニカルバイオバンク学会シンポジウム
  • Invited
• [Presentation] 遺伝性腫瘍症候群診断における多遺伝子パネル検査のバリアントの解釈と課題 (2021)
  • Author(s): 井本逸勢
  • Organizer: 第80回日本癌学会学術総会
  • Invited
• [Presentation] がんゲノムプロファイリング検査におけるpresumed germline pathogenic variants (2021)
  • Author(s): 井本逸勢
  • Organizer: 日本人類遺伝学会第66回大会/第28回日本遺伝子診療学会大会
  • Invited
• [Presentation] がんゲノム医療の現況―がん遺伝子パネル検査と遺伝性腫瘍診療― (2020)
  • Author(s): 井本逸勢
  • Organizer: 第44回日本遺伝カウンセリング学会学術集会
  • Invited
• [Presentation] がんゲノムプロファイリング検査におけるGermline findings (2020)
  • Author(s): 井本逸勢
  • Organizer: 第44回日本遺伝カウンセリング学会学術集会
  • Invited
• [Presentation] がんの遺伝医療とゲノム医療 (2020)
  • Author(s): 井本逸勢
  • Organizer: 日本人類遺伝学会第65回大会
  • Invited
• [Presentation] 生殖細胞系列多遺伝子パネル検査の結果開示にどうコミットするか (2020)
  • Author(s): 井本逸勢
  • Organizer: 日本人類遺伝学会第65回大会
  • Invited
• [Presentation] Identification of CLDN6 as a novel tumor-promoting gene in gastric cancer. (2019)
  • Author(s): Imoto I, Kohmoto T, Masuda K, Shoda K, Otsuji E
  • Organizer: Annual meeting of American Society of Human Genetics
  • Int'l Joint Research
• [Presentation] ゲノム解析に基づいた個別化医療 (2019)
  • Author(s): 井本逸勢
  • Organizer: 第71回日本産科婦人科学会学術講演会
  • Invited
• [Presentation] がんのクリニカルシーケンスから次世代の治療戦略へ (2019)
  • Author(s): 井本逸勢
  • Organizer: 第25回日本家族性腫瘍学会学術集会
  • Invited
• [Presentation] がんのクリニカルシーケンスから次世代の治療戦略へ (2019)
  • Author(s): 井本逸勢
  • Organizer: 第25回日本家族性腫瘍学会学術集会、東京
  • Invited
• [Presentation] ゲノム解析に基づいた個別化医療 (2019)
  • Author(s): 井本逸勢
  • Organizer: 第71回日本産科婦人科学会学術講演会、名古屋
  • Invited
• [Presentation] Prevalence of ｐathogenic ｇermline ｖariants of ｃancer ｓusceptibility ｇenes in Japanese ｐatients with ovarian cancer. (2018)
  • Author(s): Imoto I, Hirasawa A, Akahane T, Yamagami W, Nomura H, Susumu N, Tsuda H, Aoki D.
  • Organizer: BRCA2018, Mont-Royal, Canada
  • Int'l Joint Research
• [Presentation] Compound heterozygous missense variants in the ADAM17 gene cause neonatal inflammatory skin and bowel disease 1. (2018)
  • Author(s): Imoto I, Saito M, Suga K, Naruto T, Kohmoto T, Otsu M, Horiuchi K, Nakayama H, Higashiyama S, Nakagawa R, Tange S, Masuda K, Kagami S.
  • Organizer: Annual meeting of American Society of Human Genetics 2018, SanDiego, USA
  • Int'l Joint Research
• [Presentation] 肺腺癌の予後を予測可能な遺伝子群の探索 (2018)
  • Author(s): 丹下正一郎, 河本知大, 増田清士, 井本逸勢
  • Organizer: 第77回日本癌学会学術総会, 大阪
• [Presentation] in ｓilico解析による新規治療標的候補遺伝子OEGC1の同定と機能解析 (2018)
  • Author(s): 河本知大, 藤田悠司, 庄田勝俊, 丹下正一郎, 増田清士, 市川大輔, 大辻英吾, 井本逸勢
  • Organizer: 第77回日本癌学会学術総会, 大阪
• [Presentation] KHSRPは癌促進型miRNA発現を誘導し食道癌の進展を促進する (2018)
  • Author(s): 増田清士, 藤田悠司, 河本知大, 濱田隼一, 庄田勝俊, 丹下正一郎, 井本逸勢
  • Organizer: 第77回日本癌学会学術総会, 大阪
• [Remarks] 愛知県がんセンター研究所
  • URL: https://cancer-c.pref.aichi.jp/cancer-center/ri/index.html
• [Remarks] 愛知県がんセンター研究所分子遺伝学分野
  • URL: https://www.pref.aichi.jp/cancer-center/ri/01bumon/10bunshi_idengaku/index.html
• [Remarks] 愛知県がんセンター研究所 分野紹介 分子遺伝学分野
  • URL: https://www.pref.aichi.jp/cancer-center/ri/01bumon/10bunshi_idengaku/index.html