| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2021: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Outline of Final Research Achievements |
To scientifically elucidate the "peripheral-brain-peripheral" linkage-mediated modulation of tumor immunity by pain-stress and enhanced brain reward systems, we attempted to analyze the brain-tumor immune linkage by the stimulation of neuronal networks of stress-responsive neurons in the brain and intracranial reward systems. Activation of hypothalamic “stress-neurons” resulted in worsening of the cancer condition. In contrast, specific activation of nucleus accumbens D1-receptor-expressing neurons, the projection area of mesolimbic dopamine neurons responsible for the brain reward system, produced antitumor effects. These tumor growth regulatory mechanisms may be associated with efferent mechanisms and the regulation of cancer immunity accompanied by the exhaustion of splenic immune cells.
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