Fundamental studies for application of small linear accelerator to in-hospital BNCT

• Project/Area Number: 18H02909
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 56010:Neurosurgery-related
• Research Institution: University of Tsukuba
• Principal Investigator: Matsumura Akira 筑波大学, 医学医療系, 客員教授 (90241819)
• Co-Investigator(Kenkyū-buntansha): 熊田 博明 筑波大学, 医学医療系, 准教授 (30354913) ; 中井 啓 筑波大学, 医学医療系, 准教授 (50436284) ; 鶴淵 隆夫 筑波大学, 医学医療系, 講師 (70778901)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000); Fiscal Year 2021: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2020: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2019: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2018: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 小型加速器中性子線源 / 病院内BNCT / 基礎的・臨床的研究 / 病院併設型小型加速器中性子源 / 中性子捕捉療法 / 悪性脳腫瘍 / 新規ホウ素化合物の基礎的研究 / 小型加速器型中性子源 / 病院併設型加速器の開発 / ホウ素化合物 / 脳腫瘍 / 病院併設型 / 加速器型中性子源 / 基礎的研究 / 臨床的研究

Outline of Final Research Achievements

We conducted a series of fundamental experiments using a small neutron source based on a linear accelerator for in-hospital boron neutron capture therapy (BNСT). We have also developed a new patient positioning system that allows easy and correct orientation of the therapeutic target on the patient's head using real-time laser beams in combination with a treatment planning system called Tsukuba Plan. We have also accomplished preclinical studies using new promising boron compound candidates, alpha-d-mannopyranoside and eBNPs. These two stable compounds have shown proper tumoricidal effects.

Academic Significance and Societal Importance of the Research Achievements

悪性神経膠腫は未だ治癒に至らない難治性疾患である。本研究において、病院内併設用に開発された、小型中性子源を用いた中性子捕捉療法(Boron Neutron Capture Therapy)は今後の臨床応用にむけて非常に有望である。今後は、当院発のエビデンスを発信することで、悪性神経膠腫の治療発展および治療成績向上に貢献できることが多いに期待される。

Research Products

• [Journal Article] Boron Neutron Capture Therapy for Recurrent Glioblastoma Multiforme: Imaging Evaluation of a Case With Long-Term Local Control and Survival (2023)
  • Author(s): S Shimizu, K Nakai, Y Li, M Mizumoto, H Kumada, E Ishikawa, T Yamamoto, A Matsumura, H Sakurai
  • Journal Title: Cureus Volume: 15 Pages: 1-7
  • DOI: 10.7759/cureus.33898
  • Peer Reviewed
• [Journal Article] Initiatives Toward Clinical Boron Neutron Capture Therapy in Japan. (2023)
  • Author(s): Matsumura A, Asano T, Hirose K, Igaki H, Kawabata S, Kumada H
  • Journal Title: Cancer biotherapy & radiopharmaceuticals Volume: 38 Issue: 3 Pages: 201-207
  • DOI: 10.1089/cbr.2022.0056
  • Peer Reviewed
• [Journal Article] Current development status of iBNCT001, demonstrator of a LINAC-based neutron source for BNCT (2023)
  • Author(s): Kumada Hiroaki、Li Yinuo、Yasuoka Kiyoshi、Naito Fujio、Kurihara Toshikazu、Sugimura Takashi、Sato Masaharu、Matsumoto Yoshitaka、Matsumura Akira、Sakurai Hideki、Sakae Takeji
  • Journal Title: Journal of Neutron Research Volume: 24 Issue: 3-4 Pages: 347-358
  • DOI: 10.3233/jnr-220029
  • Peer Reviewed
• [Journal Article] Polymer-Stabilized Elemental Boron Nanoparticles for Boron Neutron Capture Therapy: Initial Irradiation Experiments (2022)
  • Author(s): Zaboronok Alexander、Khaptakhanova Polina、Uspenskii Sergey、Bekarevich Raman、Mechetina Ludmila、Volkova Olga、Mathis Bryan J.、Kanygin Vladimir、Ishikawa Eiichi、Kasatova Anna、Kasatov Dmitrii、Shchudlo Ivan、Sycheva Tatiana、Taskaev Sergey、Matsumura Akira
  • Journal Title: Pharmaceutics Volume: 14 Issue: 4 Pages: 761-761
  • DOI: 10.3390/pharmaceutics14040761
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Commisioning Status of the iBNCT Accelerator (2022)
  • Author(s): Sato M, Fang Z, Fukuda MK, Fukui Y, Futatsukawa K, Ikegami K, Kobayashi H, Kubota C, Kurihara T, Miura T, Miyajima T, Naito F, Nanmo K, Obina T, Shibata T, Sugimura T, Takagi A, Kumada H, Matsumoto Y, Tanaka Su, Nagura N, Ohba T, Oguri H, Toyoshima T
  • Journal Title: Journals of Accelerator Conferences Website Volume: - Pages: 164-166
  • Open Access
• [Journal Article] A Novel Boron Lipid to Modify Liposomal Surfaces for Boron Neutron Capture Therapy (2021)
  • Author(s): Shirakawa Makoto、Zaboronok Alexander、Nakai Kei、Sato Yuhki、Kayaki Sho、Sakai Tomonori、Tsurubuchi Takao、Yoshida Fumiyo、Nishiyama Takashi、Suzuki Minoru、Tomida Hisao、Matsumura Akira
  • Journal Title: Cells Volume: 10 Issue: 12 Pages: 3421-3421
  • DOI: 10.3390/cells10123421
  • Peer Reviewed / Open Access
• [Journal Article] Gold Nanoparticles Permit In Situ Absorbed Dose Evaluation in Boron Neutron Capture Therapy for Malignant Tumors (2021)
  • Author(s): Zaboronok A., Taskaev S., Volkova O., Mechetina L., Kasatova A., Sycheva T., Nakai K., Kasatov D., Makarov A., Kolesnikov I., Shchudlo I., Bykov T., Sokolova E., Koshkarev A., Kanygin V., Kichigin A., Mathis B.J., Ishikawa E., Matsumura A.
  • Journal Title: Pharmaceutics Volume: 13 Issue: 9 Pages: 1490-1490
  • DOI: 10.3390/pharmaceutics13091490
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Optimization of preparation methods for high loading content and high encapsulation efficiency of BSH into liposomes (2021)
  • Author(s): Shirakawa Makoto、Nakai Kei、Sato Yuhki、Nakamura Shunji、Harada Mari、Ishihara Kazuki、Yoshida Fumiyo、Matsumura Akira、Tomida Hisao
  • Journal Title: Applied Radiation and Isotopes Volume: 169 Pages: 109260-109260
  • DOI: 10.1016/j.apradiso.2020.109260
  • Peer Reviewed
• [Journal Article] ホウ素中性子捕捉療法（BNCT）. (2021)
  • Author(s): 松村明，中井啓
  • Journal Title: SRL宝函 Volume: 41 Pages: 31-39
• [Journal Article] Monitoring patient movement with boron neutron capture therapy and motion capture technology (2020)
  • Author(s): Kumada Hiroaki, Takada Kenta, Terunuma Toshiyuki, Aihara Teruhito, Matsumura Akira, Sakurai Hideyuki, Sakae Takeji
  • Journal Title: Applied Radiation and Isotopes Volume: 163 Pages: 109208-109208
  • DOI: 10.1016/j.apradiso.2020.109208
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Evaluation of the characteristics of the neutron beam of a linac-based neutron source for boron neutron capture therapy (2020)
  • Author(s): Kumada Hiroaki, Takada Kenta, Tanaka Susumu, Matsumoto Yoshitaka, Naito Fujio, Kurihara Toshikazu, Sugimura Takashi, Sato Masaharu, Matsumura Akira, Sakurai Hideyuki, Sakae Takeji
  • Journal Title: Applied Radiation and Isotopes Volume: 165 Pages: 109246-109246
  • DOI: 10.1016/j.apradiso.2020.109246
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Verification for dose estimation performance of a Monte-Carlo based treatment planning system in University of Tsukuba (2020)
  • Author(s): Kumada Hiroaki, Takada Kenta, Aihara Teruhito, Matsumura Akira, Sakurai Hideyuki, Sakae Takeji
  • Journal Title: Applied Radiation and Isotopes Volume: 166 Pages: 109222-109222
  • DOI: 10.1016/j.apradiso.2020.109222
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Neutron beam performance of iBNCT as linac-based neutron source for boron neutron capture therapy (2020)
  • Author(s): Kumada H, Tanaka S, Naito F, Kurihara T, Sugimura T, Sakurai H, Matsumura A, Sakae T
  • Journal Title: EPJ Web of Conference Volume: 231 Pages: 1-4
  • DOI: 10.1051/epjconf/202023101003
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Accelerator based boron neutron capture therapy for malignant glioma a pilot neutron irradiation study using boron phenylalanine sodium borocaptate. (2020)
  • Author(s): Zavjalov E; Zaboronok A; Kanygin V; Kasatova A; Kichigin A; Mukhamadiyarov R; Razumov I; Sycheva T; Mathis BJ; Maezono SEB; Matsumura A; Taskaev S
  • Journal Title: International Journal of Radiation Biology Volume: on line publishment Issue: 7 Pages: 1-11
  • DOI: 10.1080/09553002.2020.1761039
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Beam performance of the iBNCT as a compact linac-based BNCT neutron source developed by University of Tsukuba (2019)
  • Author(s): Kumada Hiroaki、Takada Kenta、Naito Fujio、Kurihara Toshikazu、Sugimura Takashi、Matsumoto Yoshitaka、Sakurai Hideyuki、Matsumura Akira、Sakae Takeji
  • Journal Title: AIP Conference Proceedings Volume: 2160 Pages: 1-10
  • DOI: 10.1063/1.5127705
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Polycomplexes of Hyaluronic Acid and Borates in a Solid State and Solution: Synthesis, Characterization and Perspectives of Application in Boron Neutron Capture Therapy (2018)
  • Author(s): Zelenetskii Alexander、Uspenskii Sergey、Zaboronok Alexander、Cherkaev Georgij、Shchegolihin Alexander、Mathis Bryan、Selyanin Mikhail、Yamamoto Tetsuya、Matsumura Akira
  • Journal Title: Polymers Volume: 10 Issue: 2 Pages: 181-181
  • DOI: 10.3390/polym10020181
  • NAID: 120007134320
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Radiobiological response of U251MG, CHO-K1 and V79 cell lines to accelerator-based boron neutron capture therapy (2017)
  • Author(s): Sato Eisuke、Zaboronok Alexander、Yamamoto Tetsuya、Nakai Kei、Taskaev Sergey、Volkova Olga、Mechetina Ludmila、Taranin Alexander、Kanygin Vladimir、Isobe Tomonori、Mathis Bryan J、Matsumura Akira
  • Journal Title: Journal of Radiation Research Volume: 59 Issue: 2 Pages: 101-107
  • DOI: 10.1093/jrr/rrx071
  • NAID: 120007134126
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Development of a multimodal Monte Carlo based treatment planning system, Radiation Protection Dosimetry (2017)
  • Author(s): Kumada H, Takada K, Sakurai Y, Suzuki M, Takata T, Sakurai H, Matsumura A, Sakae T
  • Journal Title: Radiation Protection Dosimetry Volume: 26 Issue: 1-4 Pages: 1-5
  • DOI: 10.1093/rpd/ncx218
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] ホウ素中性子捕捉療法のためのBPAを構成成分とするイオン液体の開発 (2023)
  • Author(s): 河本紗季、河上清香、坂居知憲、寺田莉子、鮫島未森、佐藤雄己、熊田博明、榮武二、松村明、亀川展幸、竹内亮太、堀均、鈴木実、白川真
  • Organizer: 日本薬学会第143年会
• [Presentation] 加速器BNCT装置(iBNCT001)による非臨床試験～試験体制と結果について～ (2023)
  • Author(s): 松本弘貴
  • Organizer: 第14回Quantum Medicine研究会
• [Presentation] フェニルボロン酸含有超高分子を用いた新規ホウ素製剤の有効性評価 (2023)
  • Author(s): 竹内春, 菅原裕, 東大志, 伊藤帆夏, 本山敬一, 松本孔貴
  • Organizer: つくば医工連携フォーラム2022
• [Presentation] イオン液体を溶媒としたBoronopheniyalanine製剤のin vitro および in vivo 評価 (2022)
  • Author(s): 坂居知憲、寺田莉子、鮫島未森、河上清香、佐藤雄己、亀川展幸、竹内亮太、堀均、Zaboronok Alexander、中井啓、熊田博明、榮武二、松村明、鈴木実、白川真
  • Organizer: 日本薬学会第142年会
• [Presentation] 第５のがん治療法～ホウ素中性子捕捉療法～ (2022)
  • Author(s): 白川真
  • Organizer: 第13回川崎医科大学学術集会
• [Presentation] BPAを構成成としたイオン液体のin vitroおよびin vivo評価 (2022)
  • Author(s): 坂居知憲、寺田莉子、鮫島未森、佐藤雄己、Alexander Zaboronok、鶴淵隆夫、中井啓、熊田博明、榮武二、松村明、亀川展幸、竹内亮太、堀均、鈴木実、白川真
  • Organizer: 第18回日本中性子捕捉療法学会
• [Presentation] 新たながん治療法を追いかけて～ホウ素中性子捕捉療法の現状と今後の展開～ (2022)
  • Author(s): 白川 真
  • Organizer: 第61回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
• [Presentation] イオン液体の難溶性ホウ素薬剤への応用 (2022)
  • Author(s): 白川真、坂居知憲、寺田莉子、河本紗季、佐藤雄己、ザボロノク・アレクサンドル、松村明、亀川展幸、竹内亮太、堀均、鈴木実
  • Organizer: 第 12 回イオン液体討論会
• [Presentation] BPA を構成成分としたイオン液体の開発 (2022)
  • Author(s): 白川真, 河本紗季, 河上清香, 坂居知憲, 佐藤雄己, Alexander Z, 鶴淵隆夫, 中井啓, 熊田博明, 榮武二, 松村明, 亀川展幸, 竹内亮太, 堀均, 鈴木実
  • Organizer: 第 18 回日本中性子捕捉療法学会学術大会
• [Presentation] 筑波大学における BNCT 臨床研究今昔 （いまむかし） (2022)
  • Author(s): 中井啓, 熊田博明, 松本孔貴, 松村明, 櫻井英幸
  • Organizer: 第 18 回日本中性子捕捉療法学会学術大会
  • Invited
• [Presentation] BPA を構成成分としたイオン液体の in vitro および in vivo 評価 (2022)
  • Author(s): 坂居知憲, 寺田莉子, 鮫島未森, 佐藤雄己, Alexander Z, 鶴淵隆夫, 中井啓, 熊田博明, 榮武二, 松 村明, ⻲川展幸, 竹内亮太, 堀均, 鈴木実, 白川真
  • Organizer: 第 18 回日本中性子捕捉療法学会学術大会
• [Presentation] 小型 OSL 線量計「nanoDot」を用いた BNCT における γ線測定の検討 (2022)
  • Author(s): 橋爪拓弥, 水下美穂子, 熊田博明, 関口寛, 中井啓
  • Organizer: 第 18 回日本 中性子捕捉療法学会学術大会
  • Invited
• [Presentation] Response of Normal Tissue to reactor based BNCT (2022)
  • Author(s): Nakai K, Kumada H, Aihara T, Matsumura A, Sakurai H
  • Organizer: 2nd International Congress of ASIAN ONCOLOGY SOCIETY
  • Int'l Joint Research
• [Presentation] 粒子線治療としての BNCT のこれから (2022)
  • Author(s): 熊田博明, 中井啓
  • Organizer: 日本量子医科学会 第 2 回学術大会
• [Presentation] 基調講演１ (2022)
  • Author(s): 鈴木実, 中井啓
  • Organizer: 第 18 回日本中性子捕捉療法学会学術大 会
  • Invited
• [Presentation] Convection Enhanced Delivery を用いるホウ素薬剤の送達と脳腫瘍に対する中性子捕捉療法 (2022)
  • Author(s): 川端信司, 辻野晃平, 柏木秀基, 福尾祐介, 平松亮, 中井啓, 西村開, 中村浩之, 鰐渕昌彦
  • Organizer: 第 18 回日本中性子捕捉療法学会学術大会
• [Presentation] Progress on Non-clinical Trials Using a Newly Developed Accelerator Neutron Source at the Unive rsity of Tsukuba (2022)
  • Author(s): Nakai K
  • Organizer: NCI Workshop on Neutron Capture Therapy for Cancer
  • Int'l Joint Research
• [Presentation] がん選択的ホウ素中性子捕捉療法を企図した超分子ホウ素薬剤の構築 (2022)
  • Author(s): 松本孔貴
  • Organizer: 日本バイオマテリアル学会2022年度九州ブロック
• [Presentation] 中性子ビーム特性ガイドライン策定委員介、生物WGからの活動報告 (2022)
  • Author(s): 鈴木実, 松本孔貴, 益谷美都子
  • Organizer: 第10回BNCT講習会
• [Presentation] BNCT加速器の現状報告2022 (2022)
  • Author(s): 杉村高志, 池上清, 帯名崇, 久保田親, 栗原俊一, 小林仁, 佐藤将春, 柴田崇統, 高木昭, 内藤富士雄, 南茂, 今朝雄, 方志高, 福井佑治, 福田将史, 二ツ川健太, 三浦太一, 宮島司, 熊田博明, 田中進, 松本孔貴, 大場俊幸, 名倉信明, 豊島寿一, 小栗英知
  • Organizer: 第19回日本加速器学会年会
• [Presentation] Commissioning status of the iBNCT accelerator (2022)
  • Author(s): Sato M, Fang Z, Fukuda MK, Fukui Y, Futatsukawa K, Ikegami K, Kobayashi H, Kubota C, Kurihara T, Miura T, Miyajima T, Naito F, Nanmo K, Obina T, Shibata T, Sugimura T, Takagi A, Kumada H, Matsumoto Y, Tanaka Su, Nagura N, Ohba T, Oguri H, Toyoshima T
  • Organizer: LINAC 2022 conference
  • Int'l Joint Research
• [Presentation] Current development status of the linac-based BNCT device of the iBNCT Tsukuba Project (2022)
  • Author(s): Kumada H
  • Organizer: International Conference on Accelerators for Research and Sustainable Development
  • Int'l Joint Research
• [Presentation] Status of Boron Neutron Capture Therapy in Japan. Boron Neutron Capture Therapy (Part I)-Current and Future Clinical Aspects. (2022)
  • Author(s): Matsumura A
  • Organizer: Educational Webinar Lecture. Sponsored by Cosylab (Slovenia)
  • Int'l Joint Research / Invited
• [Presentation] Clinical Experience of BNCT in glioblastoma and current BNCT accelerator project in Tsukuba. (2022)
  • Author(s): Matsumura A
  • Organizer: First Russian BNCT Conference
  • Int'l Joint Research / Invited
• [Presentation] initiatives towards Clinical BNCT in Japan, Introduction (2022)
  • Author(s): Matsumura A
  • Organizer: NCI Workshop on Neutron Capture Therapy for Cancer
  • Int'l Joint Research / Invited
• [Presentation] 新規水溶性溶媒「イオン液体」を用いたBPA製剤としてのin vitroおよびin vivo評価 (2021)
  • Author(s): 坂居知憲、寺田莉子、佐藤雄己、鮫島未森、河上清香、亀川展幸、竹内亮太、中井啓、Zaboronok Alexander、熊田博明、榮武二、鈴木実、堀均、松村明、白川真
  • Organizer: 第17回日本中性子捕捉療法学会
• [Presentation] Evaluation of novel boron cluster conjugated PEG derivative for BNCT (2021)
  • Author(s): Shirakawa M, Sato Y, Sakai T, Terada R, Sameshima M, Kamegawa N, Takeuchi R, Nakai K, Zaboronok A, Tsurubuchi T, Yoshida F, Kumada H, Sakae T, Suzuki M, Hori H and Matsumura A
  • Organizer: 19th International Congress of Neutron Capture Therapy (ICNCT-19)
  • Int'l Joint Research
• [Presentation] 難溶性ホウ素化合物BPAに対する新規溶媒であるイオン液体のin vitroおよびin vivo評価 (2021)
  • Author(s): 坂居知憲、寺田莉子、鮫島未森、佐藤雄己、Zaboronok Alexander、河上清香、亀川展幸、竹内亮太、中井啓、熊田博明、榮武二、松村明、鈴木実、堀均、白川真
  • Organizer: 第60回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
• [Presentation] ホウ素中性子捕捉療法(BNCT)のための新規薬剤の合成と評価 (2021)
  • Author(s): 白川真、佐藤雄己、重永章、中井啓、熊田博明、榮武二、松村明、鈴木実、竹内亮太、堀均
  • Organizer: 第60回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
• [Presentation] 当院頭頚部カンファレンスにおける BNCT 一般化に向けた取り組み (2021)
  • Author(s): 中井啓, 熊田博明, 松本孔貴, 中村雅俊, 馬場敬一郎, 清水翔星, 斎藤高, 松本信, 中山雅博, 福澤智, 内田文彦, 山縣憲司, 櫻井英幸
  • Organizer: 第 17 回日本中性子捕捉療法学会学術大会
• [Presentation] つくばグループの直線型加速器ベース BNCT 照射装置・実証機 iBNCT001 の ビーム特性測定 (2021)
  • Author(s): 熊田博明, 李宜諾, 田中進, 中井啓, 松本孔貴, 高田健太, 内藤富士雄, 栗原俊一, 杉村高志, 佐藤将春, 松村明, 櫻井英幸, 榮武二. つくばグループの直線型加速器ベース BNCT 照射装置・実証機 iBNCT001 の ビーム特性測定
  • Organizer: 第 17 回日本中性子捕捉療法学会学術大会
• [Presentation] Current Beam Performance of iBNCT001, the demonstrator of a linac-based BNCT device in University of Tsukuba (2021)
  • Author(s): Kumada H, Li Y, Tanaka S, Matsumoto Y, Takada K, Naito F, Kurihara T, Sugimura T, Sato M, Nakai K, Matsumura A, Sakurai H, Sakae T
  • Organizer: 19th International Congress on Neutron Capture Therapy
  • Int'l Joint Research
• [Presentation] Towards clinical trial of iBNCT project (2021)
  • Author(s): Matsumura A, Kumada H, Li Y, Tanaka S, Matsumoto Y, Nakai K, Sakae T, Hashimoto K, Naito F, Kurihara T, Sugimura T, Sato M, Kamiya Y, Sakurai H
  • Organizer: 19th International Congress of Neutron Capture Therapy
  • Int'l Joint Research / Invited
• [Presentation] Evaluation of novel boron cluster conjugated PEG derivative for BNCT (2021)
  • Author(s): Shirakawa M, Sato Y, Sakai T, Terada R, Sameshima M, Kamegawa N, Takeuchi R, Nakai K, Zaboronok A, Tsurubuchi T, Yoshida F, Kumada H, Sakae T, Suzuki M, Hori H, Matsumura A
  • Organizer: 19th International Congress on Neutron Capture Therapy
  • Int'l Joint Research
• [Presentation] Acute sklin reaction of BNCT (2021)
  • Author(s): Nakai K, Aihara T, Yamamoto T, Kumada H, Matsumoto Y, Sakurai H, Matsumura
  • Organizer: PTCOG59 (59th Annual Conference of the Particle Therapy Co- Operative Group)
  • Int'l Joint Research
• [Presentation] Application and follow up for BNCT in four patients with recurrent Head and Neck Cancer (2021)
  • Author(s): Nakamura M, Nakai K, Baba K, Saito T, Okawa A, Nakayama M, Ohnishi K, Yamagata K, Mizumoto M, Okumura T, Sakurai H
  • Organizer: PTCOG59 (59th Annual Conference of the Particle Therapy Co-Operative Group)
  • Int'l Joint Research
• [Presentation] 脳神経外科における最新放射線治療、（教育講演） (2021)
  • Author(s): 松村明
  • Organizer: 第24回日本臨床脳神経外科学会
  • Invited
• [Presentation] Beam Design Considerations for BNCT device, Technical Meeting on Advances in Boron Neutron Capture Therapy (2020)
  • Author(s): H. Kumada, Y. Sakurai, H. Tanaka, Y. Kiyanagi
  • Organizer: IAEA, Web Congress
  • Int'l Joint Research
• [Presentation] Beam performance of the linac-based neutron source for BNCT in University of Tsukuba (2020)
  • Author(s): H. Kumada, Y. Li, S. Tanaka, F. Naito, T. Kurihara, T. Sugimura, M. Sato, H. Sakurai, T. Sakae
  • Organizer: UCANS_Web-2020
  • Int'l Joint Research
• [Presentation] BNCT治療装置の国際標準化について (2020)
  • Author(s): 熊田博明
  • Organizer: 令和2年度京都大学複合原子力科学研究所専門研究会，オンライン開催
• [Presentation] 次世代がん放射線治療：BNCTの研究開発最前線－世界をリードする医療用加速器中性子源技術 (2020)
  • Author(s): 熊田博明
  • Organizer: 中部原子力懇談会
• [Presentation] Feasibility of Newly constructed LINAC based BNCT for malignant melanomas (2019)
  • Author(s): Nakai Kei; Kumada H; Aihara T; Matsumura A; Sakurai H
  • Organizer: PTCOG58 MANCHESTER 2019
  • Int'l Joint Research
• [Presentation] Verification of performance for dose estimation for BNCT by the Monte Carlo based multi-modal treatment planning system (2019)
  • Author(s): Kumada H ; Takada K; Tanaka S; MATSUMURA, A; Sakurai H; Sakae T
  • Organizer: PTCOG58 MANCHESTER 2019
• [Presentation] Physical characteristic measurements for the neutron beam generated by the linac-based neutron source for BNCT in University of Tsukuba (2019)
  • Author(s): Kumada H; Takada K; Tanaka S; Matsumoto Y; Naito F; Kurihara T; Nakai K; Matsumura A; Sakurai H; Sakae T
  • Organizer: PTCOG58 MANCHESTER 2019
  • Int'l Joint Research
• [Presentation] 大気マイクロPXEによるBNCT応用技術細胞内ホウ素可視化の試み (2019)
  • Author(s): 中井啓; 吉田文代; 松村明; 江夏昌志; 山田尚文; 山縣諒平; 佐藤隆博
  • Organizer: QST高崎サイエンスフェスタ
• [Presentation] マイクロビームPIGEを用いた細胞内外ホウ素分布測定の試み Nal検出器とHPGeの検出器の比較 (2019)
  • Author(s): 中井啓; 吉田文代; 松村明; 江夏昌志; 山田尚文; 山縣諒平; 佐藤隆博; 松本孔貴; 櫻井英幸
  • Organizer: 第16回日本中性子捕捉療法学会学術大会
• [Presentation] Study on Application of BNCT to skin malignant melanoma in Japan (2019)
  • Author(s): Nakai Kei; Kumada H; Matsumoto Y; Matsumura A; Sakurai H
  • Organizer: YBNCT to Helsinki 2019(FINISH SOCIETY FOR NEUTRON CAPTURE THERAPY Offers to organize the 10th YBNCT meeting)
  • Int'l Joint Research
• [Presentation] In vivo Evaluation of Novel Boron containing compound A-1 for BNCT (2019)
  • Author(s): Tsurubuchi T; Matsumoto K; Ubagai R; Nakai Kei; Yoshida F...
  • Organizer: YBNCT to Helsinki 2019(FINISH SOCIETY FOR NEUTRON CAPTURE THERAPY Offers to organize the 10th YBNCT meeting)
  • Int'l Joint Research
• [Presentation] Development status of the iBNCT device as a linac-based neutron source of the University of Tsukuba (2019)
  • Author(s): Kumada H; Tanaka K; Matsumoto Y; Tanaka S; Nito F; Kuriha..
  • Organizer: YBNCT to Helsinki 2019 (FINNISH SOCIETY FOR NEUTRON CAPTURE THERAPY Offers to organize the 10th YBNCT meeting)
  • Int'l Joint Research
• [Presentation] Experience of BNCT for Glioblastoma and current status of accelerator based BNCT. Recent Progress in Boron Neutron Capture Therapy (2019)
  • Author(s): Matsumura A
  • Organizer: American Association for Cancer Research 2019
  • Int'l Joint Research / Invited
• [Presentation] A rising hospital-based radiation modality on demand for a broad interdisciplinary collaboration to be implemented in Germany (2019)
  • Author(s): Sauerwein W, Hey-Hawkins E, Matsumura A, Beck-Sickinger A, Gutberlet T, Itami J, Igawa K, Bruckel T, German BNCT Group
  • Organizer: STRAHLEN-THERAPIE UND ONKOLOGIE, 2019
  • Int'l Joint Research
• [Presentation] 国際中性子捕捉療法学会の現状と課題. (2019)
  • Author(s): 松村 明
  • Organizer: 第16回日本中性子捕捉療法学会学術大会
  • Invited
• [Presentation] Clinical experience of BNCT in glioblastoma and current BNCT accelerator project in Tsukuba (2019)
  • Author(s): Matsumura A
  • Organizer: 1st Ru BNCT CONFERENCE
  • Int'l Joint Research / Invited
• [Presentation] Absorbed dose evaluation using complex boron compounds for BNCT (2019)
  • Author(s): Zaboronok A; Uspenskii S; Khaptakhanova P; Zelenetskii AN; Kurkin T; Volkova O; Mechetina L; Taranin A; Selyanin M; Taskaev S; Kanygin V; Mathis BJ; Tsurubuchi T; Matsumura A
  • Organizer: 1st Ru BNCT CONFERENCE
  • Int'l Joint Research
• [Presentation] Experience of BNCT for glioblastoma and current status of accelerator based BNCT (2019)
  • Author(s): Matsumura Akira
  • Organizer: AACR Annual Meeting 2019
  • Int'l Joint Research / Invited
• [Presentation] Current status of i-BNCT project at Tsukuba & Tokai (2018)
  • Author(s): Matsumura Akira
  • Organizer: International Congress on Neutron Capture Therapy
  • Int'l Joint Research / Invited
• [Presentation] Difference in BPA uptake between glioma stem cells and their cancerous cells (2018)
  • Author(s): Yoshida Fumiyo, Kurita Tadashi, Endo Keita, Nakai Kei, Shirakawa Makoto, Alexander Zaboronok, Ishikawa Eiichi, Matsumura Akira
  • Organizer: International Congress on Neutron Capture Therapy
  • Int'l Joint Research
• [Presentation] Hybrid gold and boron nanoparticles for treatment and boron dose estimation in boron neutron capture therapy for malignant glioma (2018)
  • Author(s): Alexander Zaboronok, Kei Nakai,Takao Tsurubuchi, Fumiyo Yoshida, Eiichi Ishikawa, Bryan J. Mathis, Tetsuya Yamamoto, Akira Matsumura
  • Organizer: International Congress on Neutron Capture Therapy
  • Int'l Joint Research
• [Presentation] Boron analysis and imaging of 2hr-BPA-exposured cells by using micro proton particle induced gamma-ray emission (PIGE) (2018)
  • Author(s): Nakai Kei, Endo Keita, Yoshida Fumiyo, Koka Masashi, Yamada Naoto, Satoh Takahiro, Matsumura Akira
  • Organizer: International Congress on Neutron Capture Therapy
  • Int'l Joint Research