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Cerebral deposition due to excrete promotion indicated by cerebrospinal fluid metabolic pathway impairment of neurotoxic protein

Research Project

Project/Area Number 18H02916
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 56010:Neurosurgery-related
Research InstitutionJuntendo University

Principal Investigator

ARAI HAJIME  順天堂大学, 医学部, 教授 (70167229)

Co-Investigator(Kenkyū-buntansha) 中島 円  順天堂大学, 医学部, 准教授 (50317450)
宮嶋 雅一  順天堂大学, 医学部, 教授 (60200177)
菅野 秀宣  順天堂大学, 医学部, 先任准教授 (90265992)
川村 海渡  順天堂大学, 医学部, 助手 (60814895)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2019: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywords脳代謝 / 認知症 / 脳脊髄液 / 水頭症 / 線毛運動 / アルツハイマー病 / 正常圧水頭症 / アミロイド蛋白 / タウ蛋白 / 脳クリアランス機構 / 脳室上衣細胞 / 神経変性 / 脳脊髄液代謝 / 認知障害 / 特発性正常圧水頭症 / アミロイドβオリゴマー / 進行性核上性麻痺 / パーキンソン病 / 脳老廃物クリアランス / 成人交通性水頭症 / 脳室上衣 / βアミロイド / βアミロイド蛋白 / 髄液 / アミロイドベータ蛋白 / アルツハイマー病理
Outline of Final Research Achievements

Cerebrospinal fluid (CSF) plays a crucial role in maintaining brain function by clearing waste products generated from brain activity. However, in elderly individuals, the elimination of neurotoxic proteins from the brain is hindered due to aging, which is closely associated with the onset of dementia. In this study, we focused on idiopathic normal pressure hydrocephalus (iNPH), a condition unique to the elderly, which arises from CSF malabsorption. We proposed a classification system to assess the severity of iNPH based on the prognosis of treatment through CSF drainage enhancement. This classification considers cognitive impairment, gait disturbance, urinary incontinence symptoms, as well as levels of phosphorylated tau and β amyloid (Aβ) neurotoxic proteins in CSF and blood. Furthermore, we developed an animal model of iNPH that simulates age-related development and demonstrated that the accumulation rate of pathological proteins can be delayed through accelerated CSF metabolism.

Academic Significance and Societal Importance of the Research Achievements

脳脊髄液の排泄障害は,加齢とともに誰しもが起こり得る生理的な変化である.脳脊髄液の代謝は脳の恒常性を保つため,必要不可欠であり,その障害はさまざまな神経変性に関与し,認知症の主要な原因の一つとして解明すべき課題である.本研究では,脳脊髄液の排泄障害を発症原因とした特発性正常圧水頭症病態に着目し,神経活動により産出されるβアミロイド,タウ蛋白などの神経毒性蛋白を測定し,脳脊髄液排泄促進による神経症状の改善と病態ステージを, 臨床研究の知見と線毛運動障害動物モデルによる実験から髄液排泄障害の重症度を提案した.脳脊髄液代謝の調整による脳老廃物の代謝,及び神経症候の変化について新たな知見を提供した.

Report

(4 results)
  • 2022 Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (76 results)

All 2022 2021 2020 2019 2018 Other

All Int'l Joint Research (2 results) Journal Article (35 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 35 results,  Open Access: 31 results) Presentation (31 results) (of which Int'l Joint Research: 10 results,  Invited: 13 results) Book (6 results) Remarks (2 results)

  • [Int'l Joint Research] University of Eastern Finland(フィンランド)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] University of Eastern Finland/Kuopio University Hospital/Oulu University(フィンランド)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Effect of comorbid Parkinson’s disease and Parkinson’s disease dementia on the course of idiopathic normal pressure hydrocephalus2022

    • Author(s)
      Sakurai Anri、Tsunemi Taiji、Shimada Tomoyo、Kawamura Kaito、Nakajima Madoka、Miyajima Masakazu、Hattori Nobutaka
    • Journal Title

      Journal of Neurosurgery

      Volume: Online ahead of print Issue: 5 Pages: 1-8

    • DOI

      10.3171/2022.1.jns212282

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Water Diffusivity Changes Along the Perivascular Space After Lumboperitoneal Shunt Surgery in Idiopathic Normal Pressure Hydrocephalus2022

    • Author(s)
      Kikuta Junko、Kamagata Koji、Taoka Toshiaki、Takabayashi Kaito、Uchida Wataru、Saito Yuya、Andica Christina、Wada Akihiko、Kawamura Kaito、Akiba Chihiro、Nakajima Madoka、Miyajima Masakazu、Naganawa Shinji、Aoki Shigeki
    • Journal Title

      Frontiers in Neurology

      Volume: 13 Pages: 843883-843883

    • DOI

      10.3389/fneur.2022.843883

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Ptpn20 deletion in H-Tx rats enhances phosphorylation of the NKCC1 cotransporter in the choroid plexus: an evidence of genetic risk for hydrocephalus in an experimental study2022

    • Author(s)
      Xu Hanbing、Miyajima Masakazu、Nakajima Madoka、Ogino Ikuko、Kawamura Kaito、Akiba Chihiro、Kamohara Chihiro、Sakamoto Koichiro、Karagiozov Kostadin、Nakamura Eri、Tada Nobuhiro、Arai Hajime、Kondo Akihide
    • Journal Title

      Fluids and Barriers of the CNS

      Volume: 19 Issue: 1 Pages: 1-15

    • DOI

      10.1186/s12987-022-00341-z

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Editorial: Toward a better understanding of the pathophysiology and clinical management of idiopathic normal pressure hydrocephalus2022

    • Author(s)
      Karagiozov Kostadin L.、Leinonen Ville、Miyajima Masakazu、Nakajima Madoka
    • Journal Title

      Frontiers in Neurology

      Volume: 13

    • DOI

      10.3389/fneur.2022.1013720

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reconsidering Ventriculoperitoneal Shunt Surgery and Postoperative Shunt Valve Pressure Adjustment: Our Approaches Learned From Past Challenges and Failures2022

    • Author(s)
      Yamada Shigeki、Ishikawa Masatsune、Nakajima Madoka、Nozaki Kazuhiko
    • Journal Title

      Frontiers in Neurology

      Volume: 12 Pages: 798488-798488

    • DOI

      10.3389/fneur.2021.798488

    • NAID

      120007188662

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Guidelines for Management of Idiopathic Normal Pressure Hydrocephalus (Third Edition): Endorsed by the Japanese Society of Normal Pressure Hydrocephalus2021

    • Author(s)
      NAKAJIMA Madoka、YAMADA Shigeki、MIYAJIMA Masakazu、Kazunari Ishii, ..... Chihiro Akiba, Kaito Kawamura, ...Hajime Arai. The research committee of idiopathic normal pressure hydrocephalus
    • Journal Title

      Neurologia medico-chirurgica

      Volume: 61 Issue: 2 Pages: 63-97

    • DOI

      10.2176/nmc.st.2020-0292

    • NAID

      130007986452

    • ISSN
      0470-8105, 1349-8029
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Elevated CSF LRG and Decreased Alzheimer’s Disease Biomarkers in Idiopathic Normal Pressure Hydrocephalus2021

    • Author(s)
      Vanninen Aleksi、Nakajima Madoka、Miyajima Masakazu、Rauramaa Tuomas、Kokki Merja、Musialowicz Tadeusz、Makinen Petra M.、Herukka Sanna-Kaisa、Koivisto Anne M.、Jaaskelainen Juha E.、Hiltunen Mikko、Leinonen Ville
    • Journal Title

      Journal of Clinical Medicine

      Volume: 10 Issue: 5 Pages: 1105-1105

    • DOI

      10.3390/jcm10051105

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cerebrospinal Fluid Amyloid-β Oligomer Levels in Patients with Idiopathic Normal Pressure Hydrocephalus2021

    • Author(s)
      Kawamura Kaito、Miyajima Masakazu、Nakajima Madoka、Kanai Mitsuyasu、Motoi Yumiko、Nojiri Shuko、Akiba Chihiro、Ogino Ikuko、Xu Hanbing、Kamohara Chihiro、Yamada Shinya、Karagiozov Kostadin、Ikeuchi Takeshi、Kondo Akihide、Arai Hajime
    • Journal Title

      Journal of Alzheimer's Disease

      Volume: 83 Issue: 1 Pages: 179-190

    • DOI

      10.3233/jad-210226

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Total transferrin in cerebrospinal fluid is a novel biomarker for spontaneous intracranial hypotension2021

    • Author(s)
      Iijima Junko、Hoshi Kyoka、Ito Hiromi、Kanno Mayumi、Murakami Yuta、Takahashi Koichi、Matsumoto Kana、Yamaguchi Yoshiki、Nakajima Madoka、Miyajima Masakazu、Arai Hajime、Kanai Mitsuyasu、Kitazume Shinobu、Honda Takashi、Hashimoto Yasuhiro
    • Journal Title

      FUKUSHIMA JOURNAL OF MEDICAL SCIENCE

      Volume: 67 Issue: 2 Pages: 64-70

    • DOI

      10.5387/fms.2020-19

    • NAID

      130008079104

    • ISSN
      0016-2590, 2185-4610
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tap Test Can Predict Cognitive Improvement in Patients With iNPH-Results From the Multicenter Prospective Studies SINPHONI-1 and -22021

    • Author(s)
      Nakajima M, Yamada S, Miyajima M, Kawamura K, Akiba C, Kazui H, Mori E, Ishikawa M, and the SINPHONI-2 Investigators.
    • Journal Title

      Frontiers in Neurology.

      Volume: 12 Pages: 769216-769216

    • DOI

      10.3389/fneur.2021.769216

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ependymal ciliary motion and their role in congenital hydrocephalus.2021

    • Author(s)
      K. Sakamoto, M. Nakajima, K. Kawamura, E. Nakamura, N. Tada, A. Kondo, H. Arai, M. Miyajima
    • Journal Title

      Child's Nervous System

      Volume: 37(11) Issue: 11 Pages: 3355-3364

    • DOI

      10.1007/s00381-021-05194-9

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differentiating comorbidities and predicting prognosis in idiopathic normal pressure hydrocephalus using cerebrospinal fluid biomarkers2021

    • Author(s)
      Nakajima Madoka、Kawamura Kaito、Akiba Chihiro、Sakamoto Koichiro、Xu Hambing、Kamohara Chihiro、Ogino Ikuko、Karagiozov Kostadin、Tange Yuichi、Shimoji Kazuaki、Yamada Shinya、Kondo Akihide、Arai Hajime、Miyajima Masakazu
    • Journal Title

      Croatian Medical Journal

      Volume: 62 Issue: 4 Pages: 387-398

    • DOI

      10.3325/cmj.2021.62.387

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 実地医家が認知症をよりよく知るために 特発性正常圧水頭症(iNPH)診療ガイドライン第3版―解説2021

    • Author(s)
      中島 円
    • Journal Title

      Medical Practice

      Volume: 38 Pages: 1160-1165

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 「特発性正常圧水頭症 Up to Date」わが国におけるiNPH診療ガイドライン作成のこれまで2021

    • Author(s)
      秋葉ちひろ,中島 円,宮嶋雅一
    • Journal Title

      精神医学

      Volume: 63 Pages: 1247-1255

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The prevalence and clinical associations of disproportionately enlarged subarachnoid space hydrocephalus (DESH), an imaging feature of idiopathic normal pressure hydrocephalus in community and memory clinic based Singaporean cohorts2020

    • Author(s)
      Akiba Chihiro、Gyanwali Bibek、Villaraza Steven、Nakajima Madoka、Miyajima Masakazu、Cheng Ching-Yu、Wong Tien Yin、Venketasubramanian Narayanaswamy、Hilal Saima、Chen Christopher
    • Journal Title

      Journal of the Neurological Sciences

      Volume: 408 Pages: 116510-116510

    • DOI

      10.1016/j.jns.2019.116510

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Novel Deep Learning Approach with a 3D Convolutional Ladder Network for Differential Diagnosis of Idiopathic Normal Pressure Hydrocephalus and Alzheimer’s Disease2020

    • Author(s)
      Irie Ryusuke、Otsuka Yujiro、Hagiwara Akifumi、Kamagata Koji、Kamiya Kouhei、Suzuki Michimasa、Wada Akihiko、Maekawa Tomoko、Fujita Shohei、Kato Shimpei、Nakajima Madoka、Miyajima Masakazu、Motoi Yumiko、Abe Osamu、Aoki Shigeki
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 19 Issue: 4 Pages: 351-358

    • DOI

      10.2463/mrms.mp.2019-0106

    • NAID

      130007948913

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Functional MRI and Structural Connectome Analysis of Language Networks in Japanese-English Bilinguals2020

    • Author(s)
      Mitsuhashi Takumi、Sugano Hidenori、Asano Keiko、Nakajima Takayuki、Nakajima Madoka、Okura Hidehiro、Iimura Yasushi、Suzuki Hiroharu、Tange Yuichi、Tanaka Toshihisa、Aoki Shigeki、Arai Hajime
    • Journal Title

      Neuroscience

      Volume: 431 Pages: 17-24

    • DOI

      10.1016/j.neuroscience.2020.01.030

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cerebrospinal fluid over-drainage associated with upper cervical myelopathy: Successful treatment using a gravitational add-on valve in two cases2020

    • Author(s)
      Hara Takeshi、Nakajima Madoka、Sugano Hidenori、Karagiozov Kostadin、Miyajima Masakazu、Arai Hajime
    • Journal Title

      Interdisciplinary Neurosurgery

      Volume: 19 Pages: 100586-100586

    • DOI

      10.1016/j.inat.2019.100586

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cerebrospinal fluid leak presented with the C1-C2 sign caused by spinal canal stenosis: a case report2020

    • Author(s)
      Akiba Chihiro、Bandai Hideki、Ito Yoshitaka、Maeda Tsuyoshi、Yamaguchi Keisuke、Nakajima Madoka、Miyajima Masakazu
    • Journal Title

      BMC Neurology

      Volume: 20 Issue: 1 Pages: 151-151

    • DOI

      10.1186/s12883-020-01697-1

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neuropsychological tests are useful for predicting comorbidities of idiopathic normal pressure hydrocephalus2020

    • Author(s)
      Kamohara Chihiro、Nakajima Madoka、Kawamura Kaito、Akiba Chihiro、Ogino Ikuko、Xu Hanbing、Karagiozov Kostadin、Arai Hajime、Miyajima Masakazu
    • Journal Title

      Acta Neurologica Scandinavica

      Volume: 142 Issue: 6 Pages: 623-631

    • DOI

      10.1111/ane.13306

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protein tyrosine phosphatase receptor type Q in cerebrospinal fluid reflects ependymal cell dysfunction and is a potential biomarker for adult chronic hydrocephalus2020

    • Author(s)
      Nakajima M.、Rauramaa T.、Makinen P. M.、Hiltunen M.、Herukka S.‐K.、Kokki M.、Musialowicz T.、Jyrkkanen H.‐K.、Danner N.、Junkkari A.、Koivisto A. M.、Jaaskelainen J. E.、Miyajima M.、Ogino I.、Furuta A.、Akiba C.、Kawamura K.、Kamohara C.、Sugano H.、Tange Y.、Karagiozov K.、Leinonen V.、Arai H.
    • Journal Title

      European Journal of Neurology

      Volume: 28 Issue: 2 Pages: 389-400

    • DOI

      10.1111/ene.14575

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A multi-center, prospective study on the progression rate of asymptomatic ventriculomegaly with features of idiopathic normal pressure hydrocephalus on magnetic resonance imaging to idiopathic normal pressure hydrocephalus.2020

    • Author(s)
      Kimihira L, Iseki C, Takahashi Y, Sato H, Kato H, Kazui H, Kuriyama N, Nakajima M, Miyajima M, Endo K, Kobayashi Y, Saegusa T, Takeda Y, Sato S, Tomogane Y, Baba T, Miyake H, Matsumae M, Onozuka S, Murai H, Kajimoto Y, Kimura T, Kobayashi M, Yamazaki M, Arai H, Kato T.
    • Journal Title

      J Neurol Sci

      Volume: 419 Pages: 117166-117166

    • DOI

      10.1016/j.jns.2020.117166

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ventricular volumetry and free-water corrected diffusion tensor imaging of the anterior thalamic radiation in idiopathic normal pressure hydrocephalus.2019

    • Author(s)
      Saito A, Kamagata K, Ueda R, Nakazawa M, Andica C, Irie R, Nakajima M, Miyajima M, Hori M, Tanaka F, Arai H, Aoki S.
    • Journal Title

      J Neuroradiol.

      Volume: 印刷中 Issue: 4 Pages: 312-317

    • DOI

      10.1016/j.neurad.2019.04.003

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] In Reply: Lumboperitoneal Shunts for the Treatment of Idiopathic Normal Pressure Hydrocephalus: A Comparison of Small-Lumen Abdominal Catheters to Gravitational Add-On Valves in a Single Center.2019

    • Author(s)
      Nakajima M, Miyajima M, Akiba C, Ogino I, Kawamura K, Sugano H, Hara T, Tange Y, Fusegi K, Karagiozov K, Arai H.
    • Journal Title

      Oper Neurosurg (Hagerstown).

      Volume: 16 Issue: 1 Pages: E29-E31

    • DOI

      10.1093/ons/opy329

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Shunt malfunction and calcification of abdominal fascia tissue resulting in the obstruction of the abdominal catheter: case report.2019

    • Author(s)
      Nakajima M, Hara T, Miyajima M, Akiba C, Kawamura K, Sugano H, Tange Y, Shimoji K, Karagiozov K, Arai H.
    • Journal Title

      World Neurosurg.

      Volume: 印刷中 Pages: 96-98

    • DOI

      10.1016/j.wneu.2019.01.285

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Background Risk Factors Associated with Shunt Intervention for Possible Idiopathic Normal Pressure Hydrocephalus: A Nationwide Hospital-Based Survey in Japan.2019

    • Author(s)
      Nakajima M, Kuriyama N, Miyajima M, Ogino I, Akiba C, Kawamura K, Kurosawa M, Watanabe Y, Fukushima W, Mori E, Kato T, Sugano H, Tange Y, Karagiozov K, Arai H.
    • Journal Title

      J Alzheimers Dis.

      Volume: 68 Issue: 2 Pages: 735-744

    • DOI

      10.3233/jad-180955

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Detection of lesions depends on the DARTEL template used in group comparisons with voxel-based morphometry2019

    • Author(s)
      Goto Masami、Kamatgata Koji、Saito Asami、Abe Osamu、Motoi Yumiko、Miyajima Masakazu、Nakajima Madoka
    • Journal Title

      Acta Radiologica

      Volume: 61 Issue: 2 Pages: 236-243

    • DOI

      10.1177/0284185119855735

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regional dissociation between the cerebral blood flow and gray matter density alterations in idiopathic normal pressure hydrocephalous: results from SINPHONI-2 study.2019

    • Author(s)
      Takahashi R, Ishii K, Tokuda T, Nakajima M, Okada T; SINPHONI-2 Investigators.
    • Journal Title

      Neuroradiology.

      Volume: 61 Issue: 1 Pages: 37-42

    • DOI

      10.1007/s00234-018-2106-1

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lumboperitoneal Shunts for the Treatment of Idiopathic Normal Pressure Hydrocephalus: A Comparison of Small-Lumen Abdominal Catheters to Gravitational Add-On Valves in a Single Center.2018

    • Author(s)
      Nakajima M, Miyajima M, Akiba C, Ogino I, Kawamura K, Sugano H, Hara T, Tange Y, Fusegi K, Karagiozov K, Arai H.
    • Journal Title

      Oper Neurosurg (Hagerstown)

      Volume: 15 Issue: 6 Pages: 634-642

    • DOI

      10.1093/ons/opy044

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rapid increase of 'brain-type' transferrin in cerebrospinal fluid after shunt surgery for idiopathic normal pressure hydrocephalus: a prognosis marker for cognitive recovery.2018

    • Author(s)
      Murakami Y, Matsumoto Y, Hoshi K, Ito H, Fuwa TJ, Yamaguchi Y, Nakajima M, Miyajima M, Arai H, Nollet K, Kato N, Nishikata R, Kuroda N, Honda T, Sakuma J, Saito K, Hashimoto Y.
    • Journal Title

      J Biochem.

      Volume: 164 Issue: 3 Pages: 205-213

    • DOI

      10.1093/jb/mvy043

    • NAID

      40021678439

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Change of Amyloid-β 1-42 Toxic Conformer Ratio After Cerebrospinal Fluid Diversion Predicts Long-Term Cognitive Outcome in Patients with Idiopathic Normal Pressure Hydrocephalus2018

    • Author(s)
      Akiba C, Nakajima M, Miyajima M, Ogino I, Motoi Y, Kawamura K, Adachi S, Kondo A, Sugano H, Tokuda T, Irie K, Arai H
    • Journal Title

      J Alzheimers Dis.

      Volume: 25 Issue: 3 Pages: 989-1002

    • DOI

      10.3233/jad-180059

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Shunt intervention for possible idiopathic normal pressure hydrocephalus improves patient outcomes: a nationwide hospital-based survey in Japan.2018

    • Author(s)
      Nakajima M, Miyajima M, Ogino I, Akiba C, Kawamura K, Kurosawa M, Kuriyama N, Watanabe Y, Fukushima W, Mori E, Kato T, Sugano H, Karagiozov K, Arai H
    • Journal Title

      Frontiers in Neurology

      Volume: 9 Pages: 421-421

    • DOI

      10.3389/fneur.2018.00421

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Preoperative phosphorylated tau measurement of cerebrospinal fluid can predict cognitive function 3 years after shunt surgery in patients with idiopathic normal pressure hydrocephalus.2018

    • Author(s)
      Madoka Nakajima, Masakazu Miyajima, Ikuko Ogino, Chihiro Akiba, Kaito Kawamura, Yoshinao Harada, Takeshi Hara, Hidenori Sugano, Kostadin Karagiozov, Takeshi Ikeuchi, Takahiko Tokuda, Hajime Arai
    • Journal Title

      J Alzheimers Dis.

      Volume: 66 Issue: 1 Pages: 319-331

    • DOI

      10.3233/jad-180557

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 正常圧水頭症:治療法の現状と今後の課題2018

    • Author(s)
      宮嶋雅一、萬代秀樹、伊藤敬孝、上田哲也、秋葉ちひろ、中島 円、新井 一
    • Journal Title

      脳神経外科速報

      Volume: 28 Pages: 662-667

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] iNPH-シャント治療介入の適応とタイミング,医療経済効果.2018

    • Author(s)
      中島 円
    • Journal Title

      Dementia Japan

      Volume: 32 Pages: 225-232

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] 特発性正常圧水頭症に対するドパミントランスポーターシンチグラフィはシャント治療後の精神運動速度・実行機能を予測し得る2021

    • Author(s)
      蒲原千尋,中島 円,川村海渡,秋葉ちひろ,徐 寒冰,荻野郁子,宮嶋雅一
    • Organizer
      第22回日本正常圧水頭症学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] iNPH治療のオーバービュー2021

    • Author(s)
      中島 円
    • Organizer
      第22回日本正常圧水頭症学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 正常圧水頭症に対するシャント手術-VPシャントのトピックス2021

    • Author(s)
      中島 円
    • Organizer
      第41回日本脳神経外科コングレス総会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 治療可能な認知症(特発性正常圧水頭症:iNPH). 特発性正常圧水頭症の診断と認知症状に対するシャント治療効果2021

    • Author(s)
      中島 円
    • Organizer
      第10回日本認知症予防学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] LP shunts: Why and How.2021

    • Author(s)
      Madoka Nakajima
    • Organizer
      Hydrocephalus 2021
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] iNPHの診断と治療 ―最新ガイドライン、バイオマーカー2021

    • Author(s)
      中島 円
    • Organizer
      日本脳神経外科学会 第80回学術総会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 認知機能障害を有する特発性正常圧水頭症患者に対する シャント治療介入短期効果予測2021

    • Author(s)
      中島 円
    • Organizer
      日本脳神経外科学会 第80回学術総会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] LP shunt: What should I know2021

    • Author(s)
      Madoka Nakajima
    • Organizer
      WFNS Foundation Asian Congress of Neurological Surgeons Autumn WEB Seminar
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] LP shunt for idiopathic Normal Pressure Hydrocephalus2021

    • Author(s)
      Madoka Nakajima
    • Organizer
      Asian Congress of Neurological Surgeons Webinar
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 認知機能障害を有する特発性正常圧水頭症患者に対するシャント治療介入短期効果予測2021

    • Author(s)
      中島 円
    • Organizer
      第40回日本認知症学会学術集会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] DNAH14改変マウスにおける脳室上衣線毛機能障害と遅発性慢性水頭症の発現2020

    • Author(s)
      川村海渡,中島 円,宮嶋雅一,秋葉ちひろ,蒲原千尋,荻野郁子, 新井 一
    • Organizer
      第21回日本正常圧水頭症学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] iNPHの概念とGL第3版作成コンセプト2020

    • Author(s)
      中島 円
    • Organizer
      第21回日本正常圧水頭症学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] iNPH: ガイドラインに沿った診断の現状と課題2020

    • Author(s)
      中島 円
    • Organizer
      第40回日本脳神経外科コングレス総会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] シャント治療の予後因子を考慮した 特発性正常圧水頭症重症度分類の提案2020

    • Author(s)
      中島 円
    • Organizer
      第79回日本脳神経外科学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] “改善する認知症” 特発性正常圧水頭症(iNPH)を見落とさない為の最新EBMを知る~iNPHガイドライン第3版 改定のポイントとStroop Test アプリケーションの有用性~.2020

    • Author(s)
      中島 円
    • Organizer
      第39回日本認知症学会学術集会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Neuropsychological tests are useful for predicting comorbidities of iNPH2020

    • Author(s)
      中島 円
    • Organizer
      第39回日本認知症学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] iNPHと併存する神経変性疾患について2019

    • Author(s)
      中島 円
    • Organizer
      第14回新潟県脳機能解析研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Diagnosis of idiopathic normal pressure hydrocephalus using protein tyrosine phosphatase receptor type Q concentration in the cerebrospinal fluid2019

    • Author(s)
      Madoka Nakajima
    • Organizer
      Hydrocephalus 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 特発性正常圧水頭症におけるPTPR type Qの髄液診断価値と脳内での役割―日本とフィンランドの多国間分析2019

    • Author(s)
      中島 円
    • Organizer
      日本脳神経外科学会第78回総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 特発性正常圧水頭症におけるPTPR type Qの髄液診断価値と脳内の役割2019

    • Author(s)
      中島 円
    • Organizer
      第38回日本認知症学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Endoscopic third ventriculostomy for the management of communicating hydrocephalus in adults2019

    • Author(s)
      .Madoka Nakajima, Masakazu Miyajima, Kaito Kawamura, Kazuaki Shimoji, Yuichi Tange, Hajime Arai
    • Organizer
      9th IFNE
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] iNPH患者における髄液中アミロイドβ高分子オリゴマーの定量的評価2019

    • Author(s)
      川村海渡、中島円、宮嶋雅一、荻野郁子、蒲原千尋、新井一
    • Organizer
      第20回日本正常圧水頭症学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 特発性正常圧水頭症におけるPTPRQ髄液診断の汎用性の検証.2019

    • Author(s)
      中島 円,宮嶋雅一,秋葉ちひろ,蒲原千尋,川村海渡,荻野郁子, 新井 一
    • Organizer
      第20回日本正常圧水頭症学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Brain Localization of Leucine-Rich a2-Glycoprotein and Role.2018

    • Author(s)
      Nakajima M
    • Organizer
      8th Kuopio Alzheimer Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Leucine-rich α2-glycoprotein overexpression in the brain contribute to age-related memory impairment.2018

    • Author(s)
      Nakajima M, Akiba C, Miyajima M
    • Organizer
      FENS 11th Forum of Neuroscience
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] xMAP platformによる術前髄液のリン酸化タウ蛋白測定は特発性正常圧水頭症患者のシャント術後3年後の認知機能を予測し得る2018

    • Author(s)
      中島 円, 宮嶋雅一, 秋葉ちひろ, 新井 一
    • Organizer
      日本脳神経外科学会第77回総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 特発性正常圧水頭症患者の初期髄液中p-Tauはシャント術後3年後の認知機能を予測した.2018

    • Author(s)
      中島 円, 秋葉ちひろ, 宮嶋雅一
    • Organizer
      第37回日本認知症学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 特発性正常圧水頭症患者の病理学的考察.2018

    • Author(s)
      中島 円, 秋葉ちひろ, 宮嶋雅一
    • Organizer
      第37回日本認知症学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Correlation between disproportionately enlarged subarachnoid-space hydrocephalus MRI findings and clinical improvement after shunt operation in idiopathic normal pressure hydrocephalus.2018

    • Author(s)
      Koichi Miyazaki, Kazunari Ishii, Ryuichi Takahashi, Takahiko Tokuda, Madoka Nakajima, Takaharu Okada, Hiroaki Kazui, Masakazu Miyajima, Etsuro Mori, Masatsune Ishikawa
    • Organizer
      Hydrocephalus 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Early stage p-tau measurement of cerebrospinal fluid can predict cognitive function 3 years after shunt surgery in patients with idiopathic normal pressure hydrocephalus.2018

    • Author(s)
      Madoka Nakajima, Masakazu Miyajima, Ikuko Ogino, Chihiro Akiba, Kaito Kawamura, Hajime Arai
    • Organizer
      Hydrocephalus 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The Neuropsychological tests predict comorbidity of idiopathic normal pressure hydrocephalus with Alzheimer's disease pathology and Parkinson's syndrome.2018

    • Author(s)
      Chihiro Kamohara, Masakazu Miyajima, Madoka Nakajima, Ikuko Ogino, Hajime Arai
    • Organizer
      Hydrocephalus 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Book] 脳神経外科 Vol.50 No.22022

    • Author(s)
      喜多 大輔
    • Total Pages
      232
    • Publisher
      医学書院
    • ISBN
      9784260044875
    • Related Report
      2020 Annual Research Report
  • [Book] Annual Review 神経2022

    • Author(s)
      中島 円
    • Total Pages
      332
    • Publisher
      中外医学社
    • ISBN
      9784498328822
    • Related Report
      2020 Annual Research Report
  • [Book] 最新主要文献でみる 脳神経外科学レビュー 2023-’242022

    • Author(s)
      新井 一、齊藤延人、若林俊彦
    • Total Pages
      440
    • Publisher
      総合医学社
    • ISBN
      9784883787494
    • Related Report
      2020 Annual Research Report
  • [Book] 特発性正常圧水頭症診療ガイドライン 第3版2020

    • Author(s)
      新井 一, 他.
    • Total Pages
      136
    • Publisher
      メディカルレビュー社
    • ISBN
      9784779223761
    • Related Report
      2020 Annual Research Report
  • [Book] 特発性正常圧水頭症診療ガイドライン 第3版 (監修)2020

    • Author(s)
      「特発性正常圧水頭症の診療ガイドライン作成に関する研究」班 / 日本正常圧水頭症学会 監修
    • Total Pages
      136
    • Publisher
      メディカルレビュー社
    • ISBN
      9784779223761
    • Related Report
      2019 Annual Research Report
  • [Book] 最新主要文献でみる 脳神経外科学レビュー2019

    • Author(s)
      新井一 齊藤延人 若林俊彦 (監修)
    • Total Pages
      382
    • Publisher
      総合医学社
    • ISBN
      9784883786794
    • Related Report
      2019 Annual Research Report
  • [Remarks] 機能Group/順天堂大学

    • URL

      https://functionalneurosurgeryjuntendouniversity.wordpress.com

    • Related Report
      2018 Annual Research Report
  • [Remarks] 神経機能外科疾患治療について

    • URL

      https://www.juntendo.ac.jp/hospital/clinic/noge/about/disease/kanja12.html

    • Related Report
      2018 Annual Research Report

URL: 

Published: 2018-04-23   Modified: 2024-01-30  

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