| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2021: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Outline of Final Research Achievements |
This year, we crossed Dmp1cre::Sirt6f/f mice (Sirt6cKO) with PAI-1KO mice to generate Dmp1cre::Sirt6f/f;;PAI-1-/- mice (dKO mice) to verify the signal cross-talk between Sirt6 and PAI-1. dKO mice showed reduced FGF 23, and SOST expression was reduced to levels comparable to controls. Aged PAI-1KO mice had more bone mass and higher blood phosphorus levels than wild-type mice of the same week of age. These results indicate that FGF 23 and SOST expression is regulated by SIRT6 and that the mechanism is at least partly mediated by PAI-1 regulation.
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