| Project/Area Number |
18H02921
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 56020:Orthopedics-related
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| Research Institution | National Rehabilitation Center for Persons with Disabilities (2020)
Tokyo Medical and Dental University (2018-2019) |
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Principal Investigator |
Ochi Hiroki 国立障害者リハビリテーションセンター(研究所), 研究所 運動機能系障害研究部, 研究員 (30582283)
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| Co-Investigator(Kenkyū-buntansha) |
佐藤 信吾 東京医科歯科大学, 医学部附属病院, 講師 (40462220)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2019: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2018: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
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| Keywords | 骨細胞 / 感覚神経 / 組織透明化 / 神経 / メカニカルストレス |
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| Outline of Final Research Achievements |
The purpose of this study was to elucidate the mechanical stress response mechanism of bone by focusing on the sensory nervous system and osteocyte network. In this study, the loss of sensory nerves in bone tissue caused a significant decrease in bone mass. Furthermore, sensory nerve ablation in bone tissue induced the suppression of bone mass increase during reloading after hindlimb unloading. We identify the mechanical stress response gene, and we generated the osteocyte-specific deficient mice. The osteocyte-specific deficient mice showed a high bone mass, but no bone loss due to tail suspension was observed.
These results suggest that sensory nerves and osteocytes may play important roles in the mechanical stress response of bone.
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| Academic Significance and Societal Importance of the Research Achievements |
感覚神経－骨細胞ネットワークに着目し、骨のメカニカルストレス応答機構を解明しようとする試みは極めて独創的である。さらに、本研究の結果からメカニカルストレスに応答する新たな骨代謝調節機構を明らかにすることで、骨形成をターゲットとし、骨リモデリングのバランスを積極的に調節する新規骨形成促進薬開発の分子基盤構築に有用な情報を提供することができると考えられる。
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