| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2022: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2021: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2020: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2019: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2018: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Outline of Final Research Achievements |
Research using genetically modified mice has contributed to understanding mechanisms that regulate chondrocyte differentiation. However, the extent to which findings obtained from mouse experiments works in human tissues has not been well known. To understand molecular mechanisms that regulate differentiation of chondrocytes in human tissues, we analyzed differentiation of cells in human iPS cell-derived cartilage that were subjected various conditions. We created cartilage from iPS cells from primates including human. The cartilage was analyzed under the conditions such as transplantation into articular cartilage defects, transplantation into bone defects, transplantation into nucleotomized spaces in intervertebral discs, and endochondral bone formation. The findings obtained in the research contribute to understanding molecular mechanisms that regulate differentiation of human chondrocytes in tissue.
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