Elucidation of mechanism for the enhancement of osteoclast differentiation under hypoxia and development of new therapeutic approach for bone resorption in rheumatoid arthritis

• Project/Area Number: 18H02926
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 56020:Orthopedics-related
• Research Institution: Kyoto University
• Principal Investigator: Murata Koichi 京都大学, 医学研究科, 特定助教 (60806793)
• Co-Investigator(Kenkyū-buntansha): 吉富 啓之 京都大学, 医学研究科, 准教授 (50402920) ; 寺尾 知可史 国立研究開発法人理化学研究所, 生命医科学研究センター, チームリーダー (60610459) ; 伊藤 宣 京都大学, 医学研究科, 特定教授 (70397537)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000); Fiscal Year 2020: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2019: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000); Fiscal Year 2018: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
• Keywords: 破骨細胞 / 低酸素 / 関節リウマチ / 骨粗鬆症 / 炎症性疾患 / SNP

Outline of Final Research Achievements

The purpose of this study was to comprehensively elucidate the mechanism of promoting osteoclast differentiation under hypoxia and to search for a therapeutic method for bone destruction specific to rheumatoid arthritis. We found that KDM1a is important using specific siRNAs and inhibitors. KDM1a is mTOR-dependently induced by RANKL stimulation during osteoclastogenesis. KDM1a regulated metabolism in HIF1-mediated osteoclast differentiation not only under hypoxia but also under normoxia. Furthermore, it regulated the expression of E2F1 regulating the cell cycle and metabolism in osteoclast differentiation. The HIF-mediated osteoclast differentiation pathway of KDM1a was found to be important in inflammatory bone resorption, including rheumatoid arthritis.

Academic Significance and Societal Importance of the Research Achievements

関節リウマチは炎症性疾患で、骨軟骨破壊を来して、機能障害を引き起こす。近年様々な薬剤が開発されたものの、骨破壊は完全には制御できておらず、既存の治療は副作用や長期使用に問題がある。今回、骨を破壊する細胞の主軸である破骨細胞の分化において、KDM1aが重要であることが分かった。KDM1aを介した炎症部位特異的な骨破壊の機序が明らかになり、今後関節リウマチの新たな骨破壊の治療法になる可能性がある。

Research Products

• [Journal Article] Predictive Value of Heterogeneously Enhanced Magnetic Resonance Imaging Findings With Computed Tomography Evidence of Calcification for Severe Motor Deficits in Spinal Meningioma (2021)
  • Author(s): Ono Kosei、Shimizu Takayoshi、Fujibayashi Shunsuke、Otsuki Bungo、Murata Koichi、Sakamoto Akio、Matsuda Shuichi
  • Journal Title: Neurospine Volume: 18 Issue: 1 Pages: 163-169
  • DOI: 10.14245/ns.2040494.247
  • Peer Reviewed
• [Journal Article] Letter to the Editor concerning “Impact of spinal alignment and stiffness on impingement after total hip arthroplasty: a radiographic study of pre? and post?operative spinopelvic alignment” by Hagiwara S, et al. (2020)
  • Author(s): Murata Koichi、Otsuki Bungo、Fujibayashi Shunsuke、Shimizu Takayoshi、Matsuda Shuichi
  • Journal Title: European Spine Journal Volume: 29 Issue: 12 Pages: 3245-3246
  • DOI: 10.1007/s00586-020-06633-y
  • Peer Reviewed
• [Journal Article] Fluctuation in anti-cyclic citrullinated protein antibody level predicts relapse from remission in rheumatoid arthritis: KURAMA cohort (2020)
  • Author(s): Murata Koichi、Ito Hiromu、Hashimoto Motomu、Murakami Kosaku、Watanabe Ryu、Tanaka Masao、Yamamoto Wataru、Matsuda Shuichi
  • Journal Title: Arthritis Research & Therapy Volume: 22 Issue: 1 Pages: 268-268
  • DOI: 10.1186/s13075-020-02366-x
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• [Journal Article] The limitations of mono‐ and combination antibiotic therapies on immature biofilms in a murine model of implant‐associated osteomyelitis (2020)
  • Author(s): Tomizawa Takuya、Nishitani Kohei、Ito Hiromu、Okae Yu、Morita Yugo、Doi Kohei、Saito Motoo、Ishie Shinichiro、Yoshida Shigeo、Murata Koichi、Yoshitomi Hiroyuki、Kuroda Yutaka、Matsuda Shuichi
  • Journal Title: Journal of Orthopaedic Research Volume: 39 Issue: 2 Pages: 449-457
  • DOI: 10.1002/jor.24956
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• [Journal Article] A VCP modulator, KUS121, as a promising therapeutic agent for post-traumatic osteoarthritis. (2020)
  • Author(s): Saito M, Nishitani K, Ikeda HO, Yoshida S, Iwai S, Ji X, Nakahata A, Ito A, Nakamura S, Kuriyama S, Yoshitomi H, Murata K, Aoyama T, Ito H, Kuroki H, Kakizuka A, Matsuda S.
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 20787-20787
  • DOI: 10.1038/s41598-020-77735-2
  • NAID: 120006940250
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• [Journal Article] Long-term Radiographic Outcome of Occipitocervical Fixation (2020)
  • Author(s): Shimizu Takayoshi、Fujibayashi Shunsuke、Otsuki Bungo、Takemoto Mitsuru、Murata Koichi、Matsuda Shuichi
  • Journal Title: Spine Volume: 46 Issue: 3 Pages: 152-159
  • DOI: 10.1097/brs.0000000000003757
  • Peer Reviewed
• [Journal Article] Cervical Myelopathy Caused by Invagination of Floating Anomalous C2 and C3 Laminae in the Spinal Canal (2020)
  • Author(s): Nakashima Takaki、Otsuki Bungo、Shimizu Takayoshi、Fujibayashi Shunsuke、Murata Koichi、Matsuda Shuichi
  • Journal Title: Spine Surgery and Related Research Volume: 4 Issue: 3 Pages: 274-276
  • DOI: 10.22603/ssrr.2019-0073
  • NAID: 130007881350
  • Peer Reviewed
• [Journal Article] Comparison of the efficacy and safety of biologic agents between elderly-onset and young-onset RA patients: the ANSWER cohort study (2020)
  • Author(s): Jinno Sadao、Onishi Akira、Dubreuil Maureen、Akashi Kengo、Hashimoto Motomu、Yamamoto Wataru、Murata Koichi、Takeuchi Tohru、Kotani Takuya、Maeda Yuichi、Ebina Kosuke、Son Yonsu、Amuro Hideki、Hara Ryota、Katayama Masaki、Saegusa Jun、Morinobu Akio
  • Journal Title: Rheumatology International Volume: 40 Issue: 12 Pages: 1987-1995
  • DOI: 10.1007/s00296-020-04660-y
  • NAID: 120006897895
  • Peer Reviewed
• [Journal Article] Analysis of the Factors Affecting Lumbar Segmental Lordosis After Lateral Lumbar Interbody Fusion (2020)
  • Author(s): Otsuki Bungo、Fujibayashi Shunsuke、Takemoto Mitsuru、Kimura Hiroaki、Shimizu Takayoshi、Murata Koichi、Matsuda Shuichi
  • Journal Title: Spine Volume: 45 Issue: 14 Pages: E839-E846
  • DOI: 10.1097/brs.0000000000003432
  • Peer Reviewed
• [Journal Article] Drug retention of 7 biologics and tofacitinib in biologics-na?ve and biologics-switched patients with rheumatoid arthritis: the ANSWER cohort study (2020)
  • Author(s): Ebina Kosuke、Hirano Toru、Maeda Yuichi、Yamamoto Wataru、Hashimoto Motomu、Murata Koichi、Takeuchi Tohru、Shiba Hideyuki、Son Yonsu、Amuro Hideki、Onishi Akira、Akashi Kengo、Hara Ryota、Katayama Masaki、Yamamoto Keiichi、Kumanogoh Atsushi、Hirao Makoto
  • Journal Title: Arthritis Research & Therapy Volume: 22 Issue: 1 Pages: 1-1
  • DOI: 10.1186/s13075-020-02232-w
  • Peer Reviewed / Open Access
• [Journal Article] Indirect Decompression Through Oblique Lateral Interbody Fusion for Revision Surgery After Lumbar Decompression (2020)
  • Author(s): Shimizu Takayoshi、Fujibayashi Shunsuke、Otsuki Bungo、Murata Koichi、Matsuda Shuichi
  • Journal Title: World Neurosurgery Volume: 141 Pages: e389-e399
  • DOI: 10.1016/j.wneu.2020.05.151
  • Peer Reviewed
• [Journal Article] Repair of Iliac Crest Defects with a Hydroxyapatite/Collagen Composite (2020)
  • Author(s): Murata Koichi、Fujibayashi Shunsuke、Otsuki Bungo、Shimizu Takayoshi、Matsuda Shuichi
  • Journal Title: Asian Spine Journal Volume: 14 Issue: 6 Pages: 808-813
  • DOI: 10.31616/asj.2019.0310
  • Peer Reviewed
• [Journal Article] Cervical spinal computed tomography utilizing model-based iterative reconstruction reduces radiation to an equivalent of three cervical X-rays (2020)
  • Author(s): Masamoto Kazutaka、Fujibayashi Shunsuke、Otsuki Bungo、Fukushima Yasuhiro、Koizumi Koji、Shimizu Takayoshi、Shimizu Yu、Murata Koichi、Ikeda Norimasa、Matsuda Shuichi
  • Journal Title: European Spine Journal Volume: 29 Issue: 11 Pages: 2804-2813
  • DOI: 10.1007/s00586-020-06426-3
  • Peer Reviewed
• [Journal Article] Increased circulating adiponectin is an independent disease activity marker in patients with rheumatoid arthritis: A?cross-sectional study using the KURAMA database (2020)
  • Author(s): Minamino Hiroto、Katsushima Masao、Yoshida Tamami、Hashimoto Motomu、Fujita Yoshihito、Shirakashi Mirei、Yamamoto Wataru、Murakami Kosaku、Murata Koichi、Nishitani Kohei、Tanaka Masao、Ito Hiromu、Inagaki Nobuya、Matsuda Shuichi
  • Journal Title: PLOS ONE Volume: 15 Issue: 3 Pages: 0229998-0229998
  • DOI: 10.1371/journal.pone.0229998
  • Peer Reviewed / Open Access
• [Journal Article] Accuracy of fluoroscopic guidance with the coaxial view of the pedicle for percutaneous insertion of lumbar pedicle screws and risk factors for pedicle breach (2020)
  • Author(s): Murata Koichi、Fujibayashi Shunsuke、Otsuki Bungo、Shimizu Takayoshi、Masamoto Kazutaka、Matsuda Shuichi
  • Journal Title: Journal of Neurosurgery: Spine Volume: 1 Issue: 1 Pages: 1-8
  • DOI: 10.3171/2020.5.spine20291
  • Peer Reviewed / Open Access
• [Journal Article] Intake frequency of vegetables or seafoods negatively correlates with disease activity of rheumatoid arthritis. (2020)
  • Author(s): Murakami K, Murakami I*, Hashimoto M, Tanaka M, Ito H, Fujii T, Torii M, Ikeda K, Kuwabara A, Tanaka K, Yoshida A, Akizuki S, Nakashima R, Yoshifuji H, Ohmura K, Usui T, Morita S, Mimori T
  • Journal Title: PLoS One Volume: 15 Issue: 2 Pages: 0228852-0228852
  • DOI: 10.1371/journal.pone.0228852
  • NAID: 120006993973
  • Peer Reviewed / Open Access
• [Journal Article] Drug tolerability and reasons for discontinuation of seven biologics in elderly patients with rheumatoid arthritis -The ANSWER cohort study- (2019)
  • Author(s): Ebina Kosuke、Hashimoto Motomu、Yamamoto Wataru、Hirano Toru、Hara Ryota、Katayama Masaki、Onishi Akira、Nagai Koji、Son Yonsu、Amuro Hideki、Yamamoto Keiichi、Maeda Yuichi、Murata Koichi、Jinno Sadao、Takeuchi Tohru、Hirao Makoto、Kumanogoh Atsushi、Yoshikawa Hideki
  • Journal Title: PLOS ONE Volume: 14 Issue: 5 Pages: 0216624-0216624
  • DOI: 10.1371/journal.pone.0216624
  • NAID: 120006879476
  • Peer Reviewed / Open Access
• [Journal Article] Drug tolerability and reasons for discontinuation of seven biologics in 4466 treatment courses of rheumatoid arthritis?the ANSWER cohort study (2019)
  • Author(s): Ebina Kosuke、Hashimoto Motomu、Yamamoto Wataru、Hirano Toru、Hara Ryota、Katayama Masaki、Onishi Akira、Nagai Koji、Son Yonsu、Amuro Hideki、Yamamoto Keiichi、Maeda Yuichi、Murata Koichi、Jinno Sadao、Takeuchi Tohru、Hirao Makoto、Kumanogoh Atsushi、Yoshikawa Hideki
  • Journal Title: Arthritis Research & Therapy Volume: 21 Issue: 1 Pages: 91-91
  • DOI: 10.1186/s13075-019-1880-4
  • Peer Reviewed / Open Access
• [Journal Article] Regulation of Immune Responses and Chronic Inflammation by Fibroblast-Like Synoviocytes (2019)
  • Author(s): Yoshitomi Hiroyuki
  • Journal Title: Frontiers in Immunology Volume: 10 Pages: 1395-1395
  • DOI: 10.3389/fimmu.2019.01395
  • NAID: 120006786922
  • Peer Reviewed / Open Access
• [Journal Article] Shared epitope defines distinct associations of cigarette smoking with levels of anticitrullinated protein antibody and rheumatoid factor (2019)
  • Author(s): Ishikawa Yuki、Ikari Katsunori、Hashimoto Motomu、Ohmura Koichiro、Tanaka Masao、Ito Hiromu、Taniguchi Atsuo、Yamanaka Hisashi、Mimori Tsuneyo、Terao Chikashi
  • Journal Title: Annals of the Rheumatic Diseases Volume: 78 Issue: 11 Pages: 1480-1487
  • DOI: 10.1136/annrheumdis-2019-215463
  • Peer Reviewed
• [Journal Article] Does Abatacept Increase Postoperative Adverse Events in Rheumatoid Arthritis Compared with Conventional Synthetic Disease-modifying Drugs? (2019)
  • Author(s): Ito Hiromu、Tsuji Shigeyoshi、Nakayama Masanori、Mochida Yuichi、Nishida Keiichiro、Ishikawa Hajime、Kojima Toshihisa、Matsumoto Takumi、Kubota Ayako、Mochizuki Takeshi、Sakuraba Koji、et al.、the JOSRA Consortium
  • Journal Title: The Journal of Rheumatology Volume: 47 Issue: 4 Pages: 502-509
  • DOI: 10.3899/jrheum.181100
  • Peer Reviewed
• [Journal Article] Evaluation of risk factors for atherosclerosis using carotid ultrasonography in Japanese patients with rheumatoid arthritis (2019)
  • Author(s): Yamamoto Hiroko、Nakajima Toshiki、Kawahara Rie、Nakabo Shuichiro、Hashimoto Motomu、Yamamoto Wataru、Masuda Izuru、Ito Hiromu、Mimori Tsuneyo、Fujii Yasutomo
  • Journal Title: International Journal of Rheumatic Diseases Volume: 22 Issue: 7 Pages: 1312-1318
  • DOI: 10.1111/1756-185x.13591
  • Peer Reviewed
• [Journal Article] Strain-specific manifestation of lupus-like systemic autoimmunity caused by ZAP70 mutation (2019)
  • Author(s): Takashi Matsuo, Motomu Hashimoto, Shimon Sakaguchi, Noriko Sakaguchi, Yoshinaga Ito, Masaki Hikida, Tatsuaki Tsuruyama, Kaoru Sakai, Hideki Yokoi, Mirei Shirakashi, Masao Tanaka, Hiromu Ito, Hajime Yoshifuji, Koichiro Ohmura, Takao Fujii, and Tsuneyo Mimori
  • Journal Title: The Journal of Immunology Volume: 印刷中 Issue: 11 Pages: 3161-3172
  • DOI: 10.4049/jimmunol.1801159
  • Peer Reviewed / Open Access
• [Journal Article] Elderly onset of early rheumatoid arthritis is a risk factor for bone erosions, refractory to treatment: KURAMA cohort. (2018)
  • Author(s): Murata K, Ito H, Hashimoto M, Nishitani K, Murakami K, Tanaka M, Yamamoto W, Mimori T, Matsuda S
  • Journal Title: Int J Rheum Dis. Volume: -
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• [Journal Article] Human Sox4 facilitates the development of CXCL13-producing helper T cells in inflammatory environments. (2018)
  • Author(s): Yoshitomi H, Kobayashi S, Miyagawa-Hayashino A, Okahata A, Doi K, Nishitani K, Murata K, Ito H, Tsuruyama T, Haga H, Matsuda S, Toguchida J
  • Journal Title: Nature Communications Volume: 9 Issue: 1 Pages: 3762-3762
  • DOI: 10.1038/s41467-018-06187-0
  • NAID: 120006523829
  • Peer Reviewed / Open Access
• [Journal Article] Correlation Between Intraoperative Anterior Stability and Flexion Gap in Total Knee Arthroplasty (2018)
  • Author(s): Nakamura Shinichiro、Kuriyama Shinichi、Nishitani Kohei、Ito Hiromu、Murata Koichi、Matsuda Shuichi
  • Journal Title: The Journal of Arthroplasty Volume: 33 Issue: 8 Pages: 2480-2484
  • DOI: 10.1016/j.arth.2018.03.030
  • Peer Reviewed
• [Journal Article] Effect of medication adherence on disease activity among Japanese patients with rheumatoid arthritis. (2018)
  • Author(s): Nakagawa S, Nakaishi M, Hashimoto M, Ito H, Yamamoto W, Nakashima R, Tanaka M, Fujii T, Omura T, Imai S, Nakagawa T, Yonezawa A, Imai H, Mimori T, Matsubara K.
  • Journal Title: PLoS One Volume: 13 Issue: 11 Pages: e0206943-e0206943
  • DOI: 10.1371/journal.pone.0206943
  • NAID: 120006539574
  • Peer Reviewed / Open Access
• [Journal Article] Factors associated with the achievement of biological disease-modifying antirheumatic drug-free remission in rheumatoid arthritis: the ANSWER cohort study (2018)
  • Author(s): Hashimoto Motomu、Furu Moritoshi、Yamamoto Wararu、Fujimura Takanori、Hara Ryota、Katayama Masaki、Ohnishi Akira、Akashi Kengo、Yoshida Shuzo、Nagai Koji、Son Yonsu、Amuro Hideki、Hirano Toru、Ebina Kosuke、Uozumi Ryuji、Ito Hiromu、Tanaka Masao、Ohmura Koichiro、Fujii Takao、Mimori Tsuneyo
  • Journal Title: Arthritis Research & Therapy Volume: 20 Issue: 1
  • DOI: 10.1186/s13075-018-1673-1
  • NAID: 120006501233
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• [Journal Article] Genetic determinants and an epistasis of LILRA3 and HLA-B*52 in Takayasu arteritis. (2018)
  • Author(s): Terao C, Yoshifuji H, Matsumura T, Naruse TK, Ishii T, Nakaoka Y, Kirino Y, Matsuo K, Origuchi T, Shimizu M, Maejima Y, Amiya E, Tamura N, Kawaguchi T, Takahashi M, Setoh K, Ohmura K, Watanabe R, Horita T, Atsumi T, Matsukura M, Miyata T, et al.
  • Journal Title: Proc Natl Acad Sci U S A Volume: 115 Issue: 51 Pages: 13045-13050
  • DOI: 10.1073/pnas.1808850115
  • Peer Reviewed / Open Access
• [Journal Article] Significant joint-destructive association of HLA-DRB1*04:05 independent of DAS28 in rheumatoid arthritis (2018)
  • Author(s): Tsuji Hideaki、Ikari Katsunori、Ohmura Koichiro、Yano Koichiro、Furu Moritoshi、Hashimoto Motomu、Ito Hiromu、Fujii Takao、Yamamoto Wataru、Taniguchi Atsuo、Yamanaka Hisashi、Mimori Tsuneyo、Terao Chikashi
  • Journal Title: Annals of the Rheumatic Diseases Volume: 78 Issue: 2 Pages: 284-286
  • DOI: 10.1136/annrheumdis-2018-214022
  • Peer Reviewed
• [Presentation] Real-world effectiveness of denosumab on clinical fracture reduction in patients with rheumatoid arthritis-ANSWER cohort study (2020)
  • Author(s): Koichi Murata, Motomu Hashimoto, Kosuke Ebina, Kengo Akashi, Akira Onishi, Koji Nagai, Ayaka Yoshikawa, Masaki Katayama, Yonsu Son, Hideki Amuro, Ryota Hara, Wataru Yamamoto, Kosaku Murakami, Masao Tanaka, Hiromu Ito, and Shuichi Matsuda
  • Organizer: 第64回日本リウマチ学会総会・学術集会
• [Presentation] デノスマブの使用は関節温存足趾形成術において骨癒合を遷延させうる (2020)
  • Author(s): 村田 浩一、伊藤 宣、西谷 江平、橋本 求、村上 孝作、田中 真生、松田 秀一
  • Organizer: 第64回日本リウマチ学会総会・学術集会
• [Presentation] 関節リウマチ患者に対するデノスマブ使用による 骨折低減効果 -ANSWER Cohortデータでの検討 (2020)
  • Author(s): 村田 浩一、橋本 求、蛯名 耕介、明石 健吾、大西 輝、永井 孝治、吉川 紋佳、片山 昌紀、孫 瑛洙、安室 秀樹、原 良太、山本 渉、村上 孝作、田中 真生、伊藤 宣、松田 秀一
  • Organizer: 第39回日本骨代謝学会学術集会
• [Presentation] 光超音波イメージングによる関節リウマチ手指関節滑膜の可視化 (2019)
  • Author(s): 村田 浩一、布留 守敏、伊藤 宣、橋本 求、田中 真生、西谷 江平、村上 孝作、三森 経世、松田 秀一
  • Organizer: 第63回日本リウマチ学会学術総会
• [Presentation] 関節リウマチの家族歴は病初期の疾患活動性や治療の反応性に影響するか -ANSWER Cohortデータでの検討 (2019)
  • Author(s): 村田 浩一、橋本 求、孫 瑛洙、安室 秀樹、永井 孝治、武内 徹、片山 昌紀、前田 悠一、蛯名 耕介、原 良太、神野 定男、大西 輝、山本 渉、村上 孝作、田中 真生、伊藤 宣、三森 経世、松田 秀一
  • Organizer: 第63回日本リウマチ学会学術総会
• [Presentation] COMMD1は低酸素依存性に破骨細胞分化に関与し、関節リウマチの骨破壊を制御する (2019)
  • Author(s): 村田 浩一
  • Organizer: 第92回日本整形外科学会学術総会
• [Presentation] 高齢発症の関節リウマチの病初期において臨床的寛解でも骨破壊を完全には抑制できない (2019)
  • Author(s): 村田 浩一、伊藤 宣、橋本 求、田中 真生、西谷 江平、村上 孝作、三森 経世、松田 秀一
  • Organizer: 第92回日本整形外科学会学術総会
• [Presentation] 関節リウマチの家族歴は病初期の疾患活動性や治療の反応性に影響するか -ANSWER Cohortデータでの検討 (2019)
  • Author(s): 村田 浩一、橋本 求、孫 瑛洙、安室 秀樹、永井 孝治、武内 徹、片山 昌紀、前田 悠一、蛯名 耕介、原 良太、神野 定男、大西 輝、山本 渉、村上 孝作、田中 真生、伊藤 宣、三森 経世、松田 秀一
  • Organizer: 第5回日本骨免疫学会
• [Presentation] Hypoxia-sensitive COMMD1 Integrates Signaling and Cellular Metabolism in Human Osteoclast Precursors and Suppresses Osteoclastogenesis (2019)
  • Author(s): Koichi Murata, Chikashi Terao, Hiromu Ito, Koichiro Ohmura, Tsuneyo Mimori, Shuichi Matsuda, Kyung-Hyun Park-Min, and Lionel B. Ivashkiv
  • Organizer: 第16回bone biology forum
• [Presentation] Denosumab may delay bone healing in joint-preserving foot arthroplasty in rheumatoid arthritis (2019)
  • Author(s): Koichi Murata, Hiromu Ito, Kohei Nishitani, Shuichi Matsuda
  • Organizer: RCOST2019
  • Int'l Joint Research
• [Presentation] 関節リウマチの発症年齢は病初期の疾患活動性やTNF阻害剤の反応性に影響する (2018)
  • Author(s): 村田 浩一、伊藤 宣、橋本 求、田中 真生、西谷 江平、村上 孝作、三森 経世、松田 秀一
  • Organizer: 第62回日本リウマチ学会総会・学術集会
• [Presentation] COMMD1は低酸素依存性に破骨細胞分化に関与し、関節リウマチの骨破壊を制御する (2018)
  • Author(s): 村田 浩一、寺尾 知可史、伊藤 宣、大村 浩一郎、松田 秀一、三森 経世、松田 文彦、Park-min Kyung-hyung、Lionel B. Ivashkiv
  • Organizer: 第91回日本整形外科学会学術総会
• [Presentation] 関節リウマチの発症年齢は病初期の疾患活動性や薬剤の反応性に影響する (2018)
  • Author(s): 村田 浩一、伊藤 宣、橋本 求、田中 真生、西谷 江平、村上 孝作、三森 経世、松田 秀一
  • Organizer: 第91回日本整形外科学会学術総会
• [Presentation] Hypoxia-sensitive COMMD1 Integrates Signaling and Cellular Metabolism in Human Osteoclast Precursors and Suppresses Osteoclastogenesis (2018)
  • Author(s): Koichi Murata, Chikashi Terao, Hiromu Ito, Koichiro Ohmura, Tsuneyo Mimori, Shuichi Matsuda, Kyung-Hyun Park-Min, and Lionel B. Ivashkiv
  • Organizer: 7th international conference on osteoimmunology
  • Int'l Joint Research
• [Presentation] 高齢発症の関節リウマチは薬剤の良好な反応性にも関わらず骨破壊の危険因子である (2018)
  • Author(s): 村田 浩一、伊藤 宣、橋本 求、田中 真生、西谷 江平、村上 孝作、三森 経世、松田 秀一
  • Organizer: 第４回日本骨免疫学会
• [Presentation] COMMD1は低酸素依存性に破骨細胞分化に関与し、関節リウマチの骨破壊を制御する (2018)
  • Author(s): 村田 浩一、寺尾 知可史、伊藤 宣、大村 浩一郎、松田 秀一、三森 経世、松田 文彦、Park-min Kyung-hyung、Lionel B. Ivashkiv
  • Organizer: 第36回日本骨代謝学会
  • Invited
• [Presentation] COMMD1は低酸素依存性に破骨細胞分化に関与し、関節リウマチの骨破壊を制御する (2018)
  • Author(s): 村田 浩一、寺尾 知可史、伊藤 宣、大村 浩一郎、松田 秀一、三森 経世、松田 文彦、Park-min Kyung-hyung、Lionel B. Ivashkiv
  • Organizer: 第33回日本整形外科学科学会基礎学術集会