| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2019: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
Osteoporosis is developed by various causes such as menopause and aging, and is defined as a skeletal disorder characterized by compromised bone strength predisposing to an increased risk of fracture. Mechanisms underlying bone loss owing to gonadal dysfunction such as menopause was recently clarified, however, those underlying aging dependent bone loss remained unclear. We utilized tip toe walk (ttw) mouse, which is a natural loss of function mutation mouse of ectonucleotide pyrophosphatase/phosphodiesterase 1 (Enpp1), a transmembrane protein, and clarified that ttw mice exhibited significant bone loss under a feeding of high phosphate diet. We also found that ectopic ossification was seen in ttw mice fed a high phosphate diet. Thus, we concluded that Enpp1 was requited to regulate calcium homeostasis through regulating phosphate metabolism.
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