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Multistep carcinogenesis mechanism of renal cell carcinoma using human iPS cell-derived nephron induction and development of therapeutic platform

Research Project

Project/Area Number 18H02938
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 56030:Urology-related
Research InstitutionKumamoto University

Principal Investigator

Baba Masaya  熊本大学, 国際先端医学研究機構, 准教授 (10347304)

Co-Investigator(Kenkyū-buntansha) 神波 大己  熊本大学, 大学院生命科学研究部(医), 教授 (20402836)
平山 明由  慶應義塾大学, 政策・メディア研究科(藤沢), 特任准教授 (00572405)
長嶋 洋治  東京女子医科大学, 医学部, 教授 (10217995)
岡田 誠治  熊本大学, ヒトレトロウイルス学共同研究センター, 教授 (50282455)
古屋 充子  横浜市立大学, 医学部, 准教授 (10361445)
矢尾 正祐  横浜市立大学, 医学研究科, 教授 (00260787)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2021: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Keywords腎細胞癌 / 発がん / ヒトiPS細胞 / がん抑制遺伝子 / がん遺伝子 / オルガノイド / 癌抑制遺伝子 / ドライバー遺伝子 / 多段階発癌 / 分化 / ドライバー遺伝子変異 / 腎オルガノイド
Outline of Final Research Achievements

Certain tumor suppressor genes and oncogenes have been identified as causing renal cell carcinoma. However, it has been impossible to confirm that alterations in these genes cause renal cell carcinoma in the human kidney. Therefore, we aim to establish an in vitro carcinogenesis model by generating kidney organoids using genetically modified human iPS cells.
FLCN tumor suppressor was found to be essential for normal nephron development. In addition, we have figured out that FLCN deficient RCCs are originated from collecting duct cells.

Academic Significance and Societal Importance of the Research Achievements

ヒトの腎臓がんで認めるがん抑制遺伝子やがん遺伝子の遺伝子変異をヒトiPS細胞に導入した。これらのiPS細胞を培養して腎臓に分化させることで、試験管内で腎臓がんを発生させることを目指した。本研究により、腎臓がんの原因とされていた遺伝子変異が本当にヒトの腎臓でがんを引き起こすか検証する事が可能となるとともに、腎臓がんの発がん機構の解明や薬剤感受性試験への展開などが期待される。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (50 results)

All 2022 2021 2020 2019 2018 Other

All Int'l Joint Research (7 results) Journal Article (16 results) (of which Int'l Joint Research: 12 results,  Peer Reviewed: 16 results,  Open Access: 16 results) Presentation (25 results) (of which Int'l Joint Research: 5 results) Remarks (2 results)

  • [Int'l Joint Research] National Cancer Institute / NIH(米国)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] National University of Singapore(シンガポール)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] National Cancer Institute, NIH/University of Washington(米国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] National Cancer Institute, NIH/University of Washington(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] National University of Singapore(シンガポール)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] National Cancer Institute, NIH(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Cancer Science Institute of Singapore(シンガポール)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Targeting chemoresistance in Xp11.2 translocation renal cell carcinoma using a novel polyamide?chlorambucil conjugate2022

    • Author(s)
      Funasaki Shintaro、Mehanna Sally、Ma Wenjuan、Nishizawa Hidekazu、Kamikubo Yasuhiko、Sugiyama Hiroshi、Ikeda Shuji、Motoshima Takanobu、Hasumi Hisashi、Linehan W. Marston、Schmidt Laura S.、Ricketts Chris、Suda Toshio、Oike Yuichi、Kamba Tomomi、Baba Masaya
    • Journal Title

      Cancer Science

      Volume: n/a Issue: 7 Pages: 2352-2367

    • DOI

      10.1111/cas.15364

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Seventh BHD international symposium: recent scientific and clinical advancement.2022

    • Author(s)
      Woodford MR, Andreou A, Baba M, van de Beek I, Di Malta C, Glykofridis I, Grimes H, Henske EP, Iliopoulos O, Kurihara M, Lazor R, Linehan WM, Matsumoto K, Marciniak SJ, Namba Y, Pause A, Rajan N, Ray A, Schmidt LS, Shi W, Steinlein OK, Thierauf J, Zoncu R, Webb A, Mollapour M.
    • Journal Title

      Oncotarget

      Volume: 13 Issue: 1 Pages: 173-181

    • DOI

      10.18632/oncotarget.28176

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] t(6; 11) renal cell carcinoma. A case report successfully diagnosed by using fluorescence in situ hybridization.2021

    • Author(s)
      Nishizawa H, Baba M, Furuya M, Kato I, Kurahashi R, Honda Y, Mikami Y, Nagashima Y, Eto M, Kamba T.
    • Journal Title

      IJU Case Rep.

      Volume: 4 Issue: 6 Pages: 375-378

    • DOI

      10.1002/iju5.12353

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Blood and lymphatic systems are segregated by the FLCN tumor suppressor2020

    • Author(s)
      Tai-Nagara I, Hasumi Y, Kusumoto D, Hasumi H, Okabe K, Ando T, Matsuzaki F, Itoh F, Saya H, Liu C, Li W, Mukouyama Y, Linehan WM, Liu X, Hirashima M, Suzuki Y, Funasaki S, Satou Y, Furuya M, Baba M, Kubota Y.
    • Journal Title

      Nat. Commun.

      Volume: 11 Issue: 1 Pages: 6314-6314

    • DOI

      10.1038/s41467-020-20156-6

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Establishment of bone marrow-derived M-CSF receptor-dependent self-renewing macrophages2020

    • Author(s)
      Nasser H, Adhikary P, Abdel-Daim A, Noyori O, Panaampon J, Kariya R, Okada S, Ma W, Baba M, Takizawa H, Yamane M, Niwa H, Suzu S.
    • Journal Title

      Cell Death Discovery

      Volume: 63 Issue: 1 Pages: 63-63

    • DOI

      10.1038/s41420-020-00300-3

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A FLCN-TFE3 Feedback Loop Prevents Excessive Glycogenesis and Phagocyte Activation by Regulating Lysosome Activity2020

    • Author(s)
      Mitsuhiro Endoh, Masaya Baba, Tamie Endoh, Akiyoshi Hirayama, Ayako Nakamura-Ishizu, Terumasa Umemoto, Michihiro Hashimoto, Kunio Nagashima, Tomoyoshi Soga, Martin Lang , Laura S Schmidt , W Marston Linehan, Toshio Suda
    • Journal Title

      Cell Reports

      Volume: 30 Issue: 6 Pages: 1823-1834

    • DOI

      10.1016/j.celrep.2020.01.042

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] FLCN Alteration Drives Metabolic Reprogramming Towards Nucleotide Synthesis and Cyst Formation in Salivary Gland2020

    • Author(s)
      Isono Y, Furuya M, Kuwahara T, Sano D, Suzuki K, Jikuya R, Mitome T, Otake S, Kawahara T, Ito Y, Muraoka K, Nakaigawa N, Kimura Y, Baba M, Nagahama K, Takahata H, Saito I, Schmidt LS, Linehan WM, Kodama T, Yao M, Oridate N, Hasumi H.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 522 Issue: 4 Pages: 931-938

    • DOI

      10.1016/j.bbrc.2019.11.184

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dual functions of angiopoietin-like protein 2 signaling in tumor progression and anti-tumor immunity.2019

    • Author(s)
      Horiguchi H, Kadomatsu T, Kurahashi R, Hara C, Miyata K, Baba M, Osumi H, Terada K, Araki K, Takai T, Kamba T, Linehan WM, Moroishi T, Oike Y.
    • Journal Title

      Genes Dev

      Volume: 33 Issue: 23-24 Pages: 1641-1656

    • DOI

      10.1101/gad.329417.119

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Folliculin Interacting Protein 1 Maintains Metabolic Homeostasis during B Cell Development by Modulating AMPK, mTORC1, and TFE3.2019

    • Author(s)
      Ramirez JA, Iwata T, Park H, Tsang M, Kang J, Cui K, Kwong W, James RG, Baba M, Schmidt LS, Iritani BM.
    • Journal Title

      J Immunol.

      Volume: 203 Issue: 11 Pages: 2899-2908

    • DOI

      10.4049/jimmunol.1900395

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] TFE3 Xp11.2 translocation renal cell carcinoma mouse model reveals novel therapeutic targets and identifies GPNMB as a diagnostic marker for human disease.2019

    • Author(s)
      Baba M, Furuya M, Motoshima T, Lang M, Funasaki S, Ma W, Sun HW, Hasumi H, Huang Y, Kato I, Kadomatsu T, Satou Y, Morris N, Karim BO, Ileva L, Kalen JD, Wilan Krisna LA, Hasumi Y, Sugiyama A, Kurahashi R, Nishimoto K, Oyama M, Nagashima Y, Kuroda N, Araki K, Eto M, Yao M, Kamba T, Suda T, Oike Y, Schmidt LS, Linehan WM
    • Journal Title

      Molecular Cancer Research

      Volume: 印刷中 Issue: 8 Pages: 1613-1626

    • DOI

      10.1158/1541-7786.mcr-18-1235

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] MiR-204-5p: a novel candidate urinary biomarker of Xp11.2 translocation renal cell carcinoma.2019

    • Author(s)
      Kurahashi R, Kadomatsu T, Baba M, Hara C, Itoh H, Miyata K, Endo M, Morinaga J, Terada K, Araki K, Eto M, Schmidt LS, Kamba T, Linehan WM, Oike Y.
    • Journal Title

      Cancer Science

      Volume: 印刷中 Issue: 6 Pages: 1897-1908

    • DOI

      10.1111/cas.14026

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] RBM 10 ‐ TFE 3 Renal Cell Carcinoma Characterized by Paracentric Inversion with Consistent Closely Split Signals in Break‐apart Fluorescence in situ Hybridization: Study of Ten Cases and a Literature Review2019

    • Author(s)
      Kato Ikuma、Furuya Mitsuko、Baba Masaya、Kameda Yoichi、Yasuda Masanori、Nishimoto Koshiro、Oyama Masafumi、Yamasaki Toshinari、Ogawa Osamu、Niino Hitoshi、Nakaigawa Noboru、Yano Yuta、Sakamoto Kazumasa、Urata Yoji、Mikami Kazuya、Yamasaki Shigetaka、Tanaka Reiko、Takagi Toshio、Kondo Tsunenori、Nagashima Yoji
    • Journal Title

      Histopathology

      Volume: 印刷中 Issue: 2 Pages: 254-265

    • DOI

      10.1111/his.13866

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Editorial Comment to Annexin A1 expression is correlated with malignant potential of renal cell carcinoma.2019

    • Author(s)
      Baba M.
    • Journal Title

      International Journal of Urology

      Volume: 26 Issue: 2 Pages: 291-291

    • DOI

      10.1111/iju.13899

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Folliculin Regulates Osteoclastogenesis Through Metabolic Regulation2018

    • Author(s)
      3.Baba M, Endoh M, Ma W, Toyama H, Hirayama A, Nishikawa K, Takubo K, Hano H, Hasumi H, Umemoto T, Hashimoto M, Irie N, Esumi C, Kataoka M, Nakagata N, Soga T, Yao M, Kamba T, Minami T, Ishii M, and Suda T.
    • Journal Title

      Journal of Bone and Mineral Research

      Volume: 33 Issue: 10 Pages: 1785-1798

    • DOI

      10.1002/jbmr.3477

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] BHD-associated kidney cancer exhibits unique molecular characteristics and a wide variety of variants in chromatin remodeling genes2018

    • Author(s)
      Hasumi Hisashi、Furuya Mitsuko、Tatsuno Kenji、Aburatani Hiroyuki、Linehan W Marston、Yao Masahiro, et al.
    • Journal Title

      Human Molecular Genetics

      Volume: 印刷中 Issue: 15 Pages: 2712-2724

    • DOI

      10.1093/hmg/ddy181

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Splice-site mutation causing partial retention of intron in the FLCN gene in Birt- Hogg-Dube syndrome: a case report2018

    • Author(s)
      Furuya M, Kobayashi H, Baba M, Ito T, Tanaka R, Nakatani Y
    • Journal Title

      BMC Medical Genomics

      Volume: 42 Issue: 1 Pages: 42-42

    • DOI

      10.1186/s12920-018-0359-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 低酸素応答経路の活性化によるXp11.2転座型腎細癌発がんメカニズムの解明2022

    • Author(s)
      Shintaro Funasaki, Wenjuan Ma, Takanobu Motoshima, Yorifumi Satou, Yuichi Oike, Toshio Suda, Tomomi Kamba, Masaya Baba
    • Organizer
      第81 回日本癌学会学術総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] CRISPR/Cas9ゲノムワイドスクリーニングを用いた融合遺伝子TFE3による 発がんメカニズムの解明2022

    • Author(s)
      西澤秀和
    • Organizer
      第31回泌尿器科分子・細胞研究会
    • Related Report
      2021 Annual Research Report
  • [Presentation] CRISPR/Cas9 genome wide screening mediated clarification of carcinogenesis by a fusion TFE32022

    • Author(s)
      西澤秀和、舟崎慎太郎、元島崇信、矢津田旬二、馬場理也、神波大己
    • Organizer
      第81回日本癌学会学術総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Xp11.2転座型腎細胞癌の薬剤耐性回避メカニズムの解明と転座型TFE3の活性抑制による新しい治療薬の開発2021

    • Author(s)
      Shintaro Funasaki, Sally Mehanna, Yasuhiko Kamikubo, Hiroshi Sugiyama, Shuji Ikeda, Yuichi Oike, Tomomi Kamba, Masaya Baba
    • Organizer
      第80回日本癌学会学術総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] t(6; 11) translocation renal cell carcinoma,successfully diagnosed by using FISH2021

    • Author(s)
      西澤秀和、倉橋竜磨、脊川卓也、元島崇信、村上洋嗣、杉山豊、矢津田旬二、山口隆大、 馬場理也、神波大己
    • Organizer
      The 37th KOREA-JAPAN Urological Congress
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] SILAC(Stable Isotope Labeling using Amino Acids in Cell Culture)による新規pVHL標的タンパク質の探索2021

    • Author(s)
      西澤秀和、上園英太、舟崎慎太郎、元島崇信、矢津田旬二、馬場理也、神波大己
    • Organizer
      第80回日本癌学会学術総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Xp11.2転座型腎細胞癌で発現するキメラTFE3転写因子による低酸素応答経路の調節2021

    • Author(s)
      西澤秀和、元島崇信、馬文娟、舟崎慎太郎、蓮見壽史、佐藤賢文、古屋充子、長嶋洋治、 尾池雄一、馬場理也、神波大己
    • Organizer
      第109回日本泌尿器科学術会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Flcn role in blood and lymphatic system2021

    • Author(s)
      Masaya Baba
    • Organizer
      BHD Symposium 2021
    • Related Report
      2021 Annual Research Report
  • [Presentation] 腎臓の初期発生におけるFLCNの機能解明2021

    • Author(s)
      上園 英太、Luh Ade Wilan Krisna、倉岡 将平、舟崎 慎太郎、Wenjuan Ma、 西中村 隆一、神波大己、馬場 理也
    • Organizer
      第30回泌尿器科分子・細胞研究会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Regulation of hypoxia response pathway by chimeric TFE3 transcription factors found in Xp11.2 translocation renal cell carcinoma2020

    • Author(s)
      Wenjuan Ma, Takanobu Motoshima, Shintaro Funasaki, Yorifumi Satou, Tan Benjy Jek Yang, Hisashi Hasumi, Mitsuko Furuya, Masahiro Yao, W. Marston Linehan, Yuichi Oike, Toshio Suda, Tomomi Kamba, Masaya Baba
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] TFE3再構成腎細胞癌32例の臨床病理学的解析(Clinicopathological Analyses of 32 Cases of TFE3-rearranged Renal Cell Carcinomas)2019

    • Author(s)
      古屋 充子, 馬場 理也, 加藤 生真, 矢尾 正祐, 近藤 恒徳, 長嶋 洋治
    • Organizer
      日本癌学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Xp11転座型腎細胞癌と診断された7例の免疫染色によるPD-L1及びPD-L2の発現解析2019

    • Author(s)
      上園 英太, 馬場 理也, 菰原 義弘, 黒田 直人, 元島 崇信, 神波 大己
    • Organizer
      腎癌研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 腕内逆位(paracentric inversion)によって融合するRBM10-TFE3腎細胞癌10例の病態解析2019

    • Author(s)
      古屋 充子, 馬場 理也, 加藤 生真, 安田 政実, 西本 紘嗣郎, 小山 政史, 山崎 俊成, 小川 修, 中井川 昇, 蓮見 壽史, 坂本 和優, 三 神 一哉, 高木 敏男, 近藤 恒徳, 矢尾 正祐, 長嶋 洋治
    • Organizer
      腎癌研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Xp11.2転座腎細胞癌モデルマウスの解析による新規治療標的分子の同定2019

    • Author(s)
      馬場 理也, 元島 崇信, 馬 文娟, 蓮見 壽史, 佐藤 賢文, 古屋 充子, 長嶋 洋治, 矢尾 正祐, 尾池 雄一, Schmidt Laura S, Linehan W. Marston, 神波 大己
    • Organizer
      日本泌尿器科学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Metabolic regulation by TFE3 in cell proliferation and differentiation2019

    • Author(s)
      Masaya Baba
    • Organizer
      The 2nd KU-KAIST Joint Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Molecular Characteristics of Renal Cell Carcinomas in Patients with Birt-Hogg-Dube Syndrome2018

    • Author(s)
      Mitsuko Furuya, Hasumi Hisashi, Ikuma Kato, Masaya Baba, Yoji Nagashima, Yasuhiro Iribe, Yukio Nakatani, Masahiro Yao
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Genetic, epidemiologic and clinicopathologic studies of Japanese patients with Birt-Hogg-Dube syndrome, 2018 update2018

    • Author(s)
      Yasuhiro Iribe, Masahiro Yao, Yoji Nagashima, Masaya Baba, Yukio Nakatani, Mitsuko Furuya
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Studies to uncover the molecular mechanism for cancer development in Xp11. 2 translocation renal cell carcinoma2018

    • Author(s)
      Masaya Baba, Wenjaun Ma, Takanobu Motoshima, Yorifumi Satou, Hisashi Hasumi, Tsuyoshi Kadomatsu, Mitsuko Furuya, Yoji Nagashima, Masahiro Yao, Masatoshi Eto, W Marston Linehan, Yuichi Oike, Tomomi Kamba
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Novel urinary biomarker for Xp11. 2 translocation renal cell carcinoma2018

    • Author(s)
      Ryoma Kurahashi, Tsuyoshi Kadomatsu, Masaya Baba, Chiaki Hara, Motoyoshi Endo, Yuichi Oike, Tomomi Kamba
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Clinicopathological Analyses of 17 Cases of Xp11Translocation Renal Cell Carcinomas2018

    • Author(s)
      Mitsuko Furuya, Masaya Baba, Ikuma Kato, Tsunenori Kondo, Yoji Nagashima, Takao Kamai, Toshinari Yamasaki, Osamu Ogawa, Koushiro Nishimoto, Masafumi Koyama, Tomomi Kamba, Takanobu Motoshima, Masatoshi Eto
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Regulation of hypoxia response pathway by chimeric TFE3s in Xp11. 2 translocation renal cell carcinoma2018

    • Author(s)
      Wenjuan Ma, Takanobu Motoshima, Yorifumi Satou, Hisashi Hasumi, Tsuyoshi Kadomatsu, Ryoma Kurahashi, Mitsuko Furuya, Masahiro Yao, Laura S Schmidt, W Marston Linehan, Yuichi Oike, Tomomi Kamba, Masaya Baba
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Characterization of chimeric TFE3 transcription factors found in Xp11.2 translocation renal cell carcinoma2018

    • Author(s)
      Takanobu Motoshima, Yorifumi Satou, Paola Miyazato, Hisashi Hasumi, Ying Huang, Tsuyoshi Kadomatsu, Masahiro Yao, Yoji Nagashima, Mitsuko Furuya, Yuchi Oike, Laura S Schmidt, Tomomi Kamba, W Marston Linehan, Masaya Baba
    • Organizer
      American Urological Association's 2018 Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Genetic regulation of RUNX2 induce apoptotic cell death through regulating the expression of SOX2 in CRPC-NE cells2018

    • Author(s)
      Yuki Noguchi, Natsuki Wariishi, Shiina Iwai, Gengo Kashiwazaki, Junichi Taniguchi, Toshikazu Bando, Masaya Baba, Souichi Adachi, Hiroshi Sugiyama, Yasuhiko Kamikubo
    • Organizer
      AACR Annual Meeting 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] BHD-associated kidney cancer exhibits unique molecular characteristics and a wide variety of mutations in chromatin remodeling genes2018

    • Author(s)
      Ryosuke Jikuya, Mitsuko Furuya, Masaya Baba, Hiroyuki Aburatani, Adam R Metwalli, Laura S Schmidt, W Marston Linehan, Masahiro Yao, Hisashi Hasumi
    • Organizer
      AACR Annual Meeting 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Xp11.2転座型腎細胞癌で認めるキメラTFE3転写因子の機能解析 (6/2018

    • Author(s)
      馬場理也、元島崇信、馬 文娟、蓮見壽史、黄 榮、佐藤賢文、宮里パオラ、長嶋洋治、古屋充子、矢尾正祐、神波大己
    • Organizer
      第106回日本泌尿器科学会総会
    • Related Report
      2018 Annual Research Report
  • [Remarks]

    • URL

      https://ircms.kumamoto-u.ac.jp/publications/2022/04/targeting-chemoresistance-in-xp112-translocation-renal-cell-carcinoma-using-a-novel-polyamide-chlora.html

    • Related Report
      2021 Annual Research Report
  • [Remarks] International Research Center for Medical Sciences

    • URL

      http://ircms.kumamoto-u.ac.jp/

    • Related Report
      2018 Annual Research Report

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Published: 2018-04-23   Modified: 2023-01-30  

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