| Budget Amount *help |
¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Fiscal Year 2021: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2019: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2018: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Outline of Final Research Achievements |
We proceeded with the Japonica array analysis of the trio of pregnant women, husbands, and children (152 pairs with gestational hypertension nephropathy and 280 pairs of controls). In addition, genome-wide association analysis considering trio interaction revealed genomic variants that are presumed to be involved in the pathogenesis, and we proceeded with validation analysis. In addition, genome analysis including imputation is underway to conduct more complex genome-wide association analysis using trio family tree information. We have completed metabolomic analysis using NMR and mass spectrography of plasma collected from the cohort study (593 cases of preeclampsia and 509 controls), and are constructing prediction equations using information from questionnaires and other sources. Furthermore, integrated analysis is underway to unravel the genetic-environmental interactions by combining genomic and plasma metabolomic information.
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